Natural E-400

Natural E-400

Protocol For Life Balance4.9 (238 ratings)
Format:Softgel Quantity: 120 Softgel(s) · 120 servings
Goals
$37.00 $0.30 per serving

Product analysis

74 out of 100

Natural E-400 pairs natural vitamin E forms with selenium, which supports normal antioxidant and immune functions and may help when intake is low. The proportions of the vitamin E forms are not disclosed, making the mix harder to compare.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality92

Natural vitamin E forms and selenium yeast are favorable choices for ingredient quality. The vitamin E mix remains less precise because the proportions of its forms are unknown.

Ingredient Transparency80

Ingredient amounts and forms are named, making much of the label clear. The proportions within the vitamin E mix are missing, so the exact balance cannot be checked.

Value For Money44

Value is strongest for the natural vitamin E forms. Selenium is relatively expensive for the amount supplied, making the combination less attractive if selenium is your main aim.

Customer Satisfaction78

Customer feedback is especially positive. A few hundred ratings give it a broader base of feedback, although they do not establish health benefits.

Product Focus69

Normal antioxidant and immune functions are the clearest roles, especially when selenium intake is low. Extra benefits for eye, heart or inflammation-related concerns remain uncertain when intake is adequate.

Format
Softgel
Container
120 Softgel(s)
Per serving
$0.30
Customer rating
4.9 · 238 ratings
Report analysis

Goals

Impact
High effect
B- Ingredient FitD PathwaysB- EvidenceA- Formulation Logic
Vitamin E · 48 mg
Study evidence
Selenium Supportive 15 studies
Vitamin E Disputed 35 studies
Inflammation
Impact
Moderate effect
C+ Ingredient FitF PathwaysC- EvidenceA- Formulation Logic
Vitamin E · 48 mg
Study evidence
Selenium Supportive 34 studies
Vitamin E Supportive 20 studies
Immunity
Impact
High effect
B- Ingredient FitD+ PathwaysA- EvidenceA- Formulation Logic
Selenium · 100 mcg
Study evidence
Selenium Mixed 37 studies
Vitamin E Supportive 21 studies
Everyday Health
Impact
Highest effect
A Ingredient FitC PathwaysB+ EvidenceA+ Formulation Logic
Selenium · 100 mcg
Study evidence
Selenium Supportive 70 studies
Cardiovascular Support
Impact
Moderate effect
B- Ingredient FitF PathwaysC+ EvidenceA- Formulation Logic
Selenium · 100 mcgVitamin E · 48 mg
Study evidence
Selenium Supportive 107 studies
Vitamin E Mixed 79 studies

Ingredients

IngredientAmount per servingScore
Vitamin E (D-Alpha-Tocopherol)
400 IU 85
Selenium (Selenium Yeast)
100 mcg 74
natural Mixed Tocopherols (D-Beta Tocopherol, D-Delta-Tocopherol, D-Gamma-Tocopherol)
48 mg 85
Gluten Free Adults 18–50 Dairy Free
Report overview
B Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value
A serving provides 400 IU of vitamin E. The cost per serving is low. The vitamin E includes D-Alpha-Tocopherol, D-Beta-Tocopherol, D-Delta-Tocopherol, D-Gamma-Tocopherol, a natural form. Mixed tocopherols include gamma and delta forms.
How this ingredient is rated

Active Ingredient Quality & Bioavailability77

The vitamin E includes D-Alpha-Tocopherol, D-Beta-Tocopherol, D-Delta-Tocopherol, D-Gamma-Tocopherol, a natural form. Mixed tocopherols include gamma and delta forms.
Natural (d-alpha) vs. Synthetic (dl-alpha)
The vitamin E includes D-Alpha-Tocopherol, D-Beta-Tocopherol, D-Delta-Tocopherol, D-Gamma-Tocopherol, a natural form.
Mixed Tocopherol Isomer Diversity
Mixed tocopherols include gamma and delta forms.
Tocotrienol Complex Inclusion
Tocotrienols are not listed in the available information.

Dose, Safety & Label Transparency85

A serving provides 400 IU of vitamin E. The proportions of the listed forms are unknown.
Therapeutic Dosage Range
A serving provides 400 IU of vitamin E.
Label Transparency and Isomer Specificity
The proportions of the listed forms are unknown.

Value100

The cost per serving is low.
Cost per Natural-Form Therapeutic Serving
The cost per serving is low.
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
A serving provides 100 mcg of selenium, with a relatively high cost per 200 mcg. The selenium comes from Selenium-enriched Yeast. The yeast source is named, but no branded source is specified.
How this ingredient is rated

Active Ingredient Quality & Bioavailability81

The selenium comes from Selenium-enriched Yeast. The yeast source is named, but no branded source is specified.
Selenium Chemical Form
The selenium comes from Selenium-enriched Yeast.
Form Transparency & Isomer Specificity
The yeast source is named, but no branded source is specified.

Dose, Safety & Label Transparency88

A serving provides 100 mcg of selenium. The amount leaves room below the stated adult upper limit, though food also supplies selenium.
Dosage Efficacy Sweet Spot
A serving provides 100 mcg of selenium.
Safety Margin & UL Adherence
The 100 mcg serving leaves room below the stated adult upper limit, though food also supplies selenium.

Value30

The cost per 200 mcg of selenium is relatively high.
Price per 200 mcg Serving
The cost per 200 mcg of selenium is relatively high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial.
    Rayman MP; Stranges S; Griffin BA; Pastor-Barriuso R; Guallar E · Annals of internal medicine · 2011
    Randomized trial501 participantsCardiovascular Support forSelenium
  2. Association of selenium and cadmium with heart failure and mortality based on the National Health and Nutrition Examination Survey.
    Xing X; Xu M; Yang L; Shao C; Wang Y; Qi M; Niu X; Gao D · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2023
    Cohort study15,689 participantsCardiovascular Support forSelenium
  3. Higher serum selenium concentration is associated with lower risk of all-cause and cardiovascular mortality among individuals with chronic kidney disease: A population-based cohort study of NHANES.
    Zhu D; Zhong Q; Lin T; Song T · Frontiers in nutrition · 2023
    Cohort study3,063 participantsCardiovascular Support forSelenium
  4. Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis.
    Kuria A; Tian H; Li M; Wang Y; Aaseth JO; Zang J; Cao Y · Critical reviews in food science and nutrition · 2021
    Meta-analysis13 studies pooledCardiovascular Support forSelenium
  5. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledCardiovascular Support Everyday Health forSelenium
  6. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis.
    Loffredo L; Perri L; Di Castelnuovo A; Iacoviello L; De Gaetano G; Violi F · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Meta-analysis16 studies pooledCardiovascular Support forVitamin E
  7. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
    Chen B; Li Y; Li Z; Hu X; Zhen H; Chen H; Nie C; Hou Y; Zhu S; Xiao L; Li T · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
    Randomized trial90 participantsCardiovascular Support forVitamin E
  8. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
    Lonn E; Bosch J; Yusuf S; Sheridan P; Pogue J; Arnold JM; Ross C; Arnold A; Sleight P; Probstfield J; Dagenais GR; HOPE and HOPE-TOO Trial Investigators · JAMA · 2005
    Randomized trial9,541 participantsCardiovascular Support forVitamin E
  9. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.
    Liu Z; He Z; Xing Y · Journal of nutritional science · 2026
    Cohort study34,955 participantsCardiovascular Support forVitamin E
  10. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
    Chin SF; Ibahim J; Makpol S; Abdul Hamid NA; Abdul Latiff A; Zakaria Z; Mazlan M; Mohd Yusof YA; Abdul Karim A; Wan Ngah WZ · Nutrition & metabolism · 2011
    Randomized trial62 participantsCardiovascular Support forVitamin E
  11. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledEveryday Health forSelenium
  12. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledEveryday Health Eye Health forSelenium
  13. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsEveryday Health forSelenium
  14. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledEveryday Health forSelenium
  15. Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction: A vehicle-controlled, randomized clinical trial.
    Watson SL; Jones LW; Stapleton F; Hinds M; Ng A; Tan J; Alster Y; Bosworth C; Rafaeli O; DePuy V; CELESTIAL STUDY Group · The ocular surface · 2026
    Randomized trial245 participantsEye Health forSelenium
  16. Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction over six months of treatment: A Phase 2, vehicle-controlled, randomized extension trial.
    Downie LE; Craig JP; Stapleton F; Tan J; Jones LW; Ng A; Hinds M; Bosworth C; Alster Y · The ocular surface · 2025
    Randomized trial245 participantsEye Health forSelenium
  17. AZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial.
    Stapleton F; Hinds M; Tan J; Jones L; Chalmers R; Bosworth C; Alster Y · The ocular surface · 2025
    Randomized trial67 participantsEye Health forSelenium
  18. The effect of a biweekly novel selenium sulfide-containing topical treatment in symptomatic contact lens wearers: An exploratory study.
    Stapleton F; Jia T; DePuy V; Bosworth C; Gleeson M; Tan J · The ocular surface · 2025
    Randomized trial14 participantsEye Health forSelenium
  19. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2018
    Meta-analysis55,614 participants4 studies pooledEye Health forVitamin E
  20. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsEye Health forVitamin E