Vision Support title image

Vision Support

Skin, Hair & Vision

Vision support focuses on the nutritional needs of the eyes and the comfort of using them throughout the day. Clear sight depends on several specialized tissues working together, while visual tasks place different demands on focus and the eye surface. Your priority may be everyday comfort, retinal nutrition, or maintaining normal vision over time. Different nutrients have distinct roles in this picture. Certain carotenoids form part of the eye’s pigment system, vitamin A contributes to normal visual processes, and DHA is a component of retinal tissue. Targeted formulations bring together selected ingredients according to the aspect of eye nutrition they are intended to support. The most useful approach reflects your circumstances and regular eye care. Comfort during screen work, the demands of changing light, and longer-term nutritional priorities are separate considerations. Keeping the purpose clear helps you choose suitable support and place everyday observations alongside the information provided by professional eye assessments.

Warnings

  • Sudden vision changes need prompt care: Sudden loss of vision, new flashes, or other abrupt visual changes need prompt assessment. Do not wait for an eye supplement to work or assume the symptoms reflect a vitamin shortage.
  • Check the exact eye formulation: Beta-carotene-containing eye supplements may be unsuitable for current or former smokers. AREDS2 suitability also depends on the stage of macular degeneration. Choose with an eye-care professional.
  • Check medicine interactions: Ask a pharmacist or clinician to review your exact products alongside your medicines. The ingredient, amount, and treatment determine which combinations are suitable.
  • Avoid overlapping high doses: Count nutrients from multivitamins, individual supplements, and fortified products together. Keep the combined amounts within appropriate limits for your circumstances.
Ingredient overview

Goal guidance

Lifestyle changes

Take breaks from sustained near work, use comfortable lighting, and keep prescriptions and eye checks up to date. Protect your eyes appropriately outdoors and during activities with an injury risk.

Diet changes

Include leafy vegetables, other colorful plants, and suitable sources of dietary fats. Choose targeted eye nutrients according to your usual intake and eye-care needs.

Who this is for

Adults interested in eye nutrition, visual comfort, and maintaining normal vision through everyday and age-related demands.

Who should be careful

Discuss eye formulations with an eye-care professional, especially with a diagnosed condition or smoking history. Beta-carotene may be unsuitable for current or former smokers; sudden vision changes need prompt assessment.

Expected timeline

Comfort during visual tasks can be followed day to day, while nutritional support is a longer-term routine. Use regular eye assessments to track changes that are not easy to judge yourself.

Common mistakes

Relying on supplements while overlooking screen breaks, lighting, or an outdated prescription can leave practical needs unmet. Match nutritional support to your situation and keep eye care consistent.

Ingredients

carotenoids Other Nutrients
Impact
Highest effect
Typical dose10–24 mg / day

Lutein and Zeaxanthin are the only carotenoids that accumulate in the macula, forming the macular pigment. This pigment acts like internal sunglasses, filtering high-energy blue light and neutralizing free radicals, which is critical for slowing the progression of age-related macular degeneration (AMD) as shown in the AREDS2 clinical trials.

Focuses on
Macular pigmentBlue light filteringAntioxidant activityRetinal healthEye protection
Most relevant for
Individuals interested in eye health nutrients that require more direct clinical evidence to confirm specific vision benefits.

Potential benefits

  • Macular Pigment Support.Unconfirmed. Carotenoids are contextually associated with maintaining macular pigment, but the specific benefit for vision support is unproven in this context.
  • Blue Light Filtering.Unconfirmed. It is suggested that certain carotenoids filter high-energy blue light, though this effect is not confirmed by supplied research.
  • Oxidative Stress Reduction.Unconfirmed. These nutrients may act as antioxidants in the eye, but their role in improving vision outcomes is currently unconfirmed.

Limitations

  • Missing Research.No linked clinical studies or research summaries were provided to establish a direct benefit for vision support.
  • Unproven Efficacy.The impact of these carotenoids on long-term retinal health and AMD progression remains unverified without supporting data.

Study evidence

No published studies for this goal yet.

View ingredient ->
Vitamin C Vitamins
Impact
Highest effect
Typical dose250–1000 mg / day

The eye's lens and aqueous humor have very high concentrations of Vitamin C to combat oxidative stress from UV light. Studies, including the AREDS trials, show that Vitamin C, as part of an antioxidant cocktail, can slow the progression of AMD and may reduce the risk of cataract formation.

Focuses on
AMD progression supportCataract risk reductionPost-surgical recoveryAntioxidant protectionLens health
Most relevant for
Most relevant for aging adults and individuals post-cataract surgery seeking to maintain eye health through antioxidant support.

Potential benefits

  • Post-Surgical Recovery Support.Daily oral supplementation may help reduce postoperative astigmatism and improve patient comfort following cataract surgery.
  • Support for AMD Progression.Unconfirmed. High dietary intake of Vitamin C is associated with a decreased risk of early age-related macular degeneration (AMD) progressing to late-stage disease.
  • Cataract Risk Reduction.Unconfirmed. Long-term intake or high serum levels of Vitamin C are associated with a lower likelihood of developing age-related cataracts in some populations.

Limitations

  • No Prevention of AMD.High-certainty evidence indicates that Vitamin C supplementation does not prevent the initial development of age-related macular degeneration in healthy individuals.
  • Mixed Cataract Findings.Clinical results are inconsistent, with some large-scale studies showing no significant benefit for preventing cataracts or reducing the need for extraction.
  • Dependency on Other Nutrients.Evidence for slowing eye disease often involves Vitamin C as part of a multi-nutrient antioxidant formula, making its independent effect difficult to isolate.
Things to consider

While generally regarded as safe, clear evidence of benefit for preventing the onset of eye disease is lacking, and some multivitamin trials have reported minor side effects like skin rashes.

Study evidence

24 studies

Higher vitamin C intake or levels are associated with better eye-health outcomes in some studies, but results are inconsistent. Controlled evidence does not show that vitamin C supplements prevent age-related macular degeneration, and broader claims about preserving vision or preventing cataracts remain unproven.

View ingredient ->
Vitamin E Vitamins
Impact
Highest effect
Typical dose200–400 IU / day

Vitamin E works synergistically with Vitamin C and other antioxidants to protect the delicate fatty acids in the retina from free radical damage. Its inclusion in the AREDS/AREDS2 formula highlights its clinical efficacy in slowing the progression of age-related macular degeneration.

Focuses on
Macular healthCataract riskAntioxidant protectionRetinal function
Most relevant for
Individuals with existing intermediate or advanced macular degeneration using specific multi-nutrient antioxidant formulas.

Potential benefits

  • AMD Progression Support.Unconfirmed. Vitamin E is a component of clinical formulas used to slow the progression of advanced age-related macular degeneration, though its independent benefit for this goal is unproven as it was studied in combination with other antioxidants.
  • Dietary Health Associations.Unconfirmed. While higher dietary intake of vitamin E is associated with lower risks of cataracts in population studies, the benefit of vitamin E supplements for preventing eye disease is unproven as clinical trials have shown no effect.

Limitations

  • Ineffective for Prevention.Extensive randomized controlled trials have consistently shown that vitamin E supplements alone do not prevent the initial development of cataracts or age-related macular degeneration.
  • Adverse Effects in Retinitis Pigmentosa.Clinical research indicates that supplemental vitamin E may accelerate the decline of retinal function in individuals with retinitis pigmentosa.
  • Potential Late-Stage Risks.Some evidence suggests that high-dose vitamin E intake may paradoxically be associated with an increased risk of developing late-stage macular degeneration and hemorrhagic stroke.
Things to consider

Avoid use for vision support if you have retinitis pigmentosa. High doses may increase the risk of certain types of stroke or interact with blood-thinning medications.

Study evidence

35 studies

Vitamin E alone has not prevented age-related macular degeneration or cataracts in randomized trials. Combination eye supplements can slow progression in selected people with existing macular degeneration, but their benefit cannot be assigned to vitamin E alone; harm has been reported in retinitis pigmentosa.

View ingredient ->
Zinc Minerals
Impact
Highest effect
Typical dose25–80 mg / day

Zinc is highly concentrated in the retina and is a critical cofactor for many enzymes involved in eye function. It plays a key role in transporting Vitamin A from the liver to the retina, which is necessary for producing melanin, a pigment that protects the eye. It is a cornerstone of the AREDS/AREDS2 formula for AMD.

Focuses on
AMD progressionRetinal healthVision loss preventionDark adaptationDeficiency restoration
Most relevant for
Individuals with intermediate age-related macular degeneration or those at high risk for advanced vision loss.

Potential benefits

  • Slows AMD Progression.Strong evidence from major clinical trials indicates that zinc, especially in specific antioxidant formulations, significantly reduces the risk of intermediate macular degeneration progressing to advanced stages.
  • Reduces Vision Loss Risk.Zinc supplementation is associated with a lower likelihood of losing significant visual acuity in people who already show signs of macular damage.
  • Supports Dark Adaptation.In individuals with nutritional deficiencies, zinc can help restore night vision and improve the eyes ability to adjust to low-light conditions, often working alongside Vitamin A.

Limitations

  • Inconclusive for Prevention.There is no strong evidence that zinc supplements prevent the initial onset of macular degeneration in healthy eyes or those with very early signs of the disease.
  • Variable Genetic Response.Preliminary research suggests that individual genetic markers may influence whether zinc provides a protective benefit or potentially increases risk, though this is not yet a standard clinical guide.
  • Not a Cure for Vision Loss.Zinc is used to slow future deterioration; it has not been shown to restore sight in eyes that have already reached advanced stages of disease or geographic atrophy.
Things to consider

High doses may cause gastrointestinal discomfort or increase the risk of genitourinary issues in men. Supplementing with high-dose zinc typically requires copper to prevent a zinc-induced copper deficiency.

Study evidence

39 studies

Zinc-containing supplements can help slow progression of age-related macular degeneration in people at higher risk of advanced disease. This does not establish sharper vision for healthy eyes or prevention of the condition, and benefits from antioxidant combinations cannot be attributed entirely to zinc.

View ingredient ->
Astaxanthin Other Nutrients
Impact
High effect
Typical dose4–12 mg / day

Astaxanthin is a unique and potent antioxidant that can effectively reach the inner eye tissues. It helps protect against light-induced damage, improves blood flow to the retina, and has been shown in clinical studies to reduce symptoms of eye fatigue, strain, and blurred vision associated with digital screen use.

Focuses on
Digital eye strainVisual fatigueEye comfortScreen-related stress
Most relevant for
People who frequently use digital screens and experience eye fatigue or strain.

Potential benefits

  • Relief from digital eye strain.Clinical studies indicate supplementation can reduce subjective symptoms of fatigue and discomfort associated with prolonged screen use.
  • Support for middle-aged visual sharpness.Research suggests it may help maintain visual acuity specifically after screen-induced stress in adults aged 40 and older.
  • Dry eye symptom relief.Unconfirmed. Preliminary findings suggest potential improvements in tear film stability and eye comfort, though this remains unconfirmed due to a lack of controlled comparison groups in the studies.

Limitations

  • Inconsistent visual performance.Benefits do not reliably extend to baseline visual sharpness, the eyes' ability to focus, or tracking moving objects.
  • Variable age-related benefits.Certain protective effects on visual acuity after screen use were observed in older adults but not in those under age 40.
  • No effect on myopia progression.Systematic reviews indicate that supplementation does not consistently slow the progression of nearsightedness or axial eye elongation.

Study evidence

7 studies

Astaxanthin may reduce eye strain associated with screen use, but improvements in visual performance are uneven. The available research is more supportive of relief from visual fatigue than of consistently sharper vision, myopia control or broad protection against eye disease.

View ingredient ->
Copper Minerals
Impact
High effect
Typical dose1–2 mg / day

High-dose zinc supplementation, as recommended in the AREDS2 formula for vision support, can interfere with copper absorption and lead to a deficiency. Including a small amount of copper is not for direct vision benefits but is a crucial safety and efficacy measure to balance the zinc intake.

Focuses on
AMD Progression RiskNutritional BalanceGlaucoma Risk AssociationMineral Support
Most relevant for
People using high-dose zinc supplements for age-related macular health who need to prevent mineral imbalances.

Potential benefits

  • Nutritional Balance with Zinc.Prevents mineral deficiency caused by high-dose zinc supplementation, which is a standard safety measure in eye health protocols like AREDS2.
  • Macular Health Association.Unconfirmed. Observational studies link higher dietary copper intake to a reduced risk of progressing to late-stage age-related macular degeneration, though this is not proven for copper supplements alone.
  • Glaucoma Risk Support.Unconfirmed. Some longitudinal research indicates that higher copper intake may be associated with a lower incidence of glaucoma, though further clinical validation is required.

Limitations

  • Isolated Efficacy Unknown.Copper is rarely studied as a standalone supplement for vision; its benefits are typically observed as part of multi-nutrient antioxidant formulas.
  • Myopia Progression Risk.Higher blood levels of copper have been associated with increased myopia progression in children, suggesting a complex role in eye growth.
  • Observational Data Constraints.Much of the supportive evidence is based on dietary intake rather than supplementation, which may reflect overall healthier eating habits.
Things to consider

Supplemental copper is primarily used to offset the copper-depleting effects of high-dose zinc and is not intended to improve visual sharpness on its own.

Study evidence

7 studies

Higher dietary copper intake is associated with lower risk of some age-related eye problems, but this does not prove that copper supplements improve vision. Benefits from multi-nutrient eye supplements cannot be assigned to copper alone, and blood-level findings are not uniformly favorable.

View ingredient ->

Studies

Explore published research for this goal.

Sources

Up to five highest-ranked published examples per ingredient. Study counts and charts include all published studies for the connection.

  1. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVitamin C
  2. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVitamin C
  3. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVitamin C
  4. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVitamin CVitamin E
  5. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVitamin C
  6. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2018
    Meta-analysis55,614 participants4 studies pooledVitamin E
  7. Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study.
    Christen WG; Liu S; Glynn RJ; Gaziano JM; Buring JE · Archives of ophthalmology (Chicago, Ill. : 1960) · 2008
    Cohort study35,551 participantsVitamin E
  8. Long-term nutrient intake and 5-year change in nuclear lens opacities.
    Jacques PF; Taylor A; Moeller S; Hankinson SE; Rogers G; Tung W; Ludovico J; Willett WC; Chylack LT · Archives of ophthalmology (Chicago, Ill. : 1960) · 2005
    Cohort study408 participantsVitamin E
  9. Dietary intake of antioxidants and risk of age-related macular degeneration.
    van Leeuwen R; Boekhoorn S; Vingerling JR; Witteman JC; Klaver CC; Hofman A; de Jong PT · JAMA · 2005
    Cohort study4,765 participantsVitamin E
  10. Antioxidant vitamin and mineral supplements for age-related macular degeneration.
    Evans JR · The Cochrane database of systematic reviews · 2002
    Systematic review170 participants7 studies pooledZinc
  11. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2023
    Meta-analysis3,790 participants5 studies pooledZinc
  12. Oral zinc in macular degeneration.
    Newsome DA; Swartz M; Leone NC; Elston RC; Miller E · Archives of ophthalmology (Chicago, Ill. : 1960) · 1988
    Randomized trial151 participantsZinc
  13. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.
    Age-Related Eye Disease Study Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2001
    Randomized trial3,640 participantsZinc
  14. Effect of vitamin A and zinc supplementation on the nutriture of children in Northeast Thailand.
    Udomkesmalee E; Dhanamitta S; Sirisinha S; Charoenkiatkul S; Tuntipopipat S; Banjong O; Rojroongwasinkul N; Kramer TR; Smith JC · The American journal of clinical nutrition · 1992
    Randomized trial133 participantsZinc
  15. Benefits and Safety of Astaxanthin in the Treatment of Mild-To-Moderate Dry Eye Disease.
    Tian L; Wen Y; Li S; Zhang P; Wang Y; Wang J; Cao K; Du L; Wang N; Jie Y · Frontiers in nutrition · 2022
    Single-arm trial60 participantsAstaxanthin
  16. Astaxanthin (AstaReal®) Improved Acute and Chronic Digital Eye Strain in Children: A Randomized Double-Blind Placebo-Controlled Trial.
    Hecht KA; Marwah M; Wood V; Nishida Y; Bach AE; Gerson J; Hom MM; Schnackenberg J; Raote S; Srivastava S; Negi P; Caston E · Advances in therapy · 2025
    Randomized trial64 participantsAstaxanthin
  17. Effects of diet containing astaxanthin on visual function in healthy individuals: a randomized, double-blind, placebo-controlled, parallel study.
    Sekikawa T; Kizawa Y; Li Y; Miura N · Journal of clinical biochemistry and nutrition · 2023
    Randomized trial60 participantsAstaxanthin
  18. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential.
    Kidd P · Alternative medicine review : a journal of clinical therapeutic · 2012
    Narrative reviewAstaxanthin
  19. Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
    Martinez-Perez C; Oliveira AP · Nutrients · 2026
    Systematic review9 studies pooledAstaxanthin
  20. What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review.
    Pameijer EM; Heus P; Damen JAA; Spijker R; Hooft L; Ringens PJ; Imhof SM; van Leeuwen R · Acta ophthalmologica · 2023
    Systematic review27 studies pooledCopper
  21. Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
    Agrón E; Mares J; Clemons TE; Swaroop A; Chew EY; Keenan TDL; AREDS and AREDS2 Research Groups · Ophthalmology · 2021
    Cohort study8,242 participantsCopper
  22. Association between late age-related macular degeneration and dietary intake of copper, iron, zinc and selenium: a 2005-2008 NHANES cross-sectional observational study.
    Lu Y; Li C; Liu Y; Wu T; Lu P · BMC ophthalmology · 2025
    Observational study4,996 participantsCopper
  23. Associations between dietary nutrient intake and the risk of multiple age-related ocular diseases: evidence from longitudinal analysis.
    Yang Y; Zou H · The journal of nutrition, health & aging · 2026
    Cohort study103,192 participantsCopper
  24. Dietary habits and dietary nutrient intake in patients with age-related macular degeneration: A case-control study.
    Šalková Kráľová J; Kolář P; Kapounová Z; Veselý P; Derflerová Brázdová Z · Central European journal of public health · 2023
    Case-control study151 participantsCopper
  25. Dietary omega-3 LCPUFA intake in the prevention of neovascular age-related macular degeneration: a systematic review and meta-analysis.
    Meng XT; Shi YY; Hong-Yan Z · Nutricion hospitalaria · 2022
    Meta-analysis5 studies pooledEPA (Eicosapentaenoic Acid)
  26. Dietary omega-3 polyunsaturated fatty acids and fish intake and risk of age-related macular degeneration.
    Jiang H; Shi X; Fan Y; Wang D; Li B; Zhou J; Pei C; Ma L · Clinical nutrition (Edinburgh, Scotland) · 2022
    Meta-analysis21 studies pooledEPA (Eicosapentaenoic Acid)
  27. Dietary fatty acid intake, plasma fatty acid levels, and the risk of age-related macular degeneration (AMD): a dose-response meta-analysis of prospective cohort studies.
    Zhong Y; Wang K; Jiang L; Wang J; Zhang X; Xu J; Yao K · European journal of nutrition · 2021
    Meta-analysis167,581 participants11 studies pooledEPA (Eicosapentaenoic Acid)
  28. Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women.
    Christen WG; Schaumberg DA; Glynn RJ; Buring JE · Archives of ophthalmology (Chicago, Ill. : 1960) · 2011
    Cohort study38,022 participantsEPA (Eicosapentaenoic Acid)
  29. Can Omega-3 Fatty Acids Serve as a Preventive Strategy for Age-Related Macular Degeneration? A Systematic Review and Meta-Analysis.
    Chen KY; Chan HC; Chan CM · The Journal of nutrition · 2026
    Meta-analysis18 studies pooledEPA (Eicosapentaenoic Acid)
  30. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa.
    Berson EL; Rosner B; Sandberg MA; Hayes KC; Nicholson BW; Weigel-DiFranco C; Willett W · Archives of ophthalmology (Chicago, Ill. : 1960) · 1993
    Randomized trial601 participantsVitamin A
  31. Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial.
    Toshida H; Funaki T; Ono K; Tabuchi N; Watanabe S; Seki T; Otake H; Kato T; Ebihara N; Murakami A · Drug design, development and therapy · 2018
    Randomized trial66 participantsVitamin A
  32. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.
    Imdad A; Mayo-Wilson E; Haykal MR; Regan A; Sidhu J; Smith A; Bhutta ZA · The Cochrane database of systematic reviews · 2022
    Meta-analysis1,223,856 participants47 studies pooledVitamin A
  33. Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity.
    Mactier H; McCulloch DL; Hamilton R; Galloway P; Bradnam MS; Young D; Lavy T; Farrell L; Weaver LT · The Journal of pediatrics · 2012
    Randomized trial89 participantsVitamin A
  34. Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy.
    Owsley C; McGwin G; Jackson GR; Heimburger DC; Piyathilake CJ; Klein R; White MF; Kallies K · Investigative ophthalmology & visual science · 2006
    Randomized trial104 participantsVitamin A
  35. Dietary flavonoids and the prevalence and 15-y incidence of age-related macular degeneration.
    Gopinath B; Liew G; Kifley A; Flood VM; Joachim N; Lewis JR; Hodgson JM; Mitchell P · The American journal of clinical nutrition · 2019
    Cohort study2,856 participantsFlavonoid
  36. The effect of flavonoids on visual function in patients with glaucoma or ocular hypertension: a systematic review and meta-analysis.
    Patel S; Mathan JJ; Vaghefi E; Braakhuis AJ · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016
    Meta-analysisFlavonoid
  37. Dietary flavonoids are associated with longitudinal treatment outcomes in neovascular age-related macular degeneration.
    Detaram HD; Liew G; Lewis JR; Bondonno NP; Bondonno CP; Van Vu K; Burlutsky G; Hodgson JM; Mitchell P; Gopinath B · European journal of nutrition · 2021
    Cohort study547 participantsFlavonoid
  38. Dietary Flavonoid Intake and Chronic Sensory Conditions: A Scoping Review.
    Tang D; Tran Y; Shekhawat GS; Gopinath B · Antioxidants (Basel, Switzerland) · 2025
    Scoping review10 studies pooledFlavonoid
  39. Effects of Flavonoid Supplementation on Common Eye Disorders: A Systematic Review and Meta-Analysis of Clinical Trials
    Sergio Davinelli, Sawan Ali, Giovanni Scapagnini, Ciro Costagliola · Frontiers in Nutrition · 2021
    Meta-analysis724 participants11 studies pooledFlavonoid
  40. The Associations of Plasma Carotenoids and Vitamins With Risk of Age-Related Macular Degeneration: Results From a Matched Case-Control Study in China and Meta-Analysis.
    Jiang H; Fan Y; Li J; Wang J; Kong L; Wang L; Li Z; Ma M; Shi X; Liu S; Shi J; Zhu H; Liu X; Ma L · Frontiers in nutrition · 2022
    Meta-analysis9 studies pooledLycopene
  41. Serum carotenoids and risk of age-related macular degeneration in a chinese population sample.
    Zhou H; Zhao X; Johnson EJ; Lim A; Sun E; Yu J; Zhang Y; Liu X; Snellingen T; Shang F; Liu N · Investigative ophthalmology & visual science · 2011
    Case-control study263 participantsLycopene
  42. Serum antioxidants and age-related macular degeneration in a population-based case-control study.
    Mares-Perlman JA; Brady WE; Klein R; Klein BE; Bowen P; Stacewicz-Sapuntzakis M; Palta M · Archives of ophthalmology (Chicago, Ill. : 1960) · 1995
    Case-control study334 participantsLycopene
  43. Association between serum carotenoid concentrations and risk of major age-related eye diseases among middle-aged and older adults.
    Che S; Ma Y; Cao J · Frontiers in medicine · 2025
    Cross-sectional study1,478 participantsLycopene
  44. Plasma antioxidant vitamins and carotenoids and age-related cataract
    Gale CR, Hall NF, Phillips DI, Martyn CN · Ophthalmology · 2001
    Cross-sectional study372 participantsLycopene
  45. One-year outcomes of resveratrol supplement with aflibercept versus aflibercept monotherapy in wet age-related macular degeneration.
    Datseris I; Bouratzis N; Kotronis C; Datseris I; Tzanidaki ME; Rouvas A; Gouliopoulos N · International journal of ophthalmology · 2023
    Randomized trial50 participantsResveratrol
  46. Resveratrol Supplementation in Wet AMD: Association With Fewer Intravitreal Injections and Reduced Macular Fibrosis.
    Datseris I; Rouvas A; Tzanidaki ME; Kardara M; Geros V; Gouliopoulos N · Clinical ophthalmology (Auckland, N.Z.) · 2025
    Cohort study50 participantsResveratrol
  47. Efficacy and safety of vitamin supplements with resveratrol in diabetic macular edema: Long-term results of a comparative study
    Irini Chatziralli, Eleni Dimitriou, Alexandros Chatzirallis, Evaggelia Aissopou, Dimitrios Kazantzis, George Theodossiadis, Panagiotis Theodossiadis · European Journal of Ophthalmology · 2022
    Non-randomized trial45 participantsResveratrol
  48. Effect of Resveratrol-Based Nutritional Supplement on Choroidal Thickness: A Pilot Study
    Shuaishuai Wang, Nived Moonasar, Xiao Xiao, Tiemei Yin, Robert N Weinreb, Xufang Sun · Current Eye Research · 2016
    Randomized trial34 participantsResveratrol
  49. U.S. Multicenter Clinical Trial of Corneal Collagen Crosslinking for Treatment of Corneal Ectasia after Refractive Surgery.
    Hersh PS; Stulting RD; Muller D; Durrie DS; Rajpal RK; U.S. Crosslinking Study Group · Ophthalmology · 2017
    Randomized trial179 participantsRiboflavin
  50. United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment.
    Hersh PS; Stulting RD; Muller D; Durrie DS; Rajpal RK; United States Crosslinking Study Group · Ophthalmology · 2017
    Randomized trial205 participantsRiboflavin
  51. EpiSmart Crosslinking for Keratoconus: A Phase 2 Study.
    Epstein RJ; Belin MW; Gravemann D; Littner R; Rubinfeld RS · Cornea · 2023
    Randomized trial2,228 participantsRiboflavin
  52. Prospective Randomized Trial of Corneal Cross-linking Riboflavin Dosing Frequencies for Treatment of Keratoconus and Corneal Ectasia.
    Price MO; Fairchild K; Feng MT; Price FW · Ophthalmology · 2019
    Randomized trial510 participantsRiboflavin
  53. Corneal collagen cross-linking for keratoconus: results of 3-year follow-up in Pakistani population.
    Khan WA; Zaheer N; Khan S · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2015
    Non-randomized trial66 participantsRiboflavin
  54. A randomized, double-masked study on the treatment of retinal vein occlusion with troxerutin
    Glacet-Bernard A, Coscas G, Chabanel A, Zourdani A, Lelong F, Samama MM · American Journal of Ophthalmology · 1994
    Randomized trial53 participantsRutin
  55. Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction: A vehicle-controlled, randomized clinical trial.
    Watson SL; Jones LW; Stapleton F; Hinds M; Ng A; Tan J; Alster Y; Bosworth C; Rafaeli O; DePuy V; CELESTIAL STUDY Group · The ocular surface · 2026
    Randomized trial245 participantsSelenium
  56. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledSelenium
  57. Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction over six months of treatment: A Phase 2, vehicle-controlled, randomized extension trial.
    Downie LE; Craig JP; Stapleton F; Tan J; Jones LW; Ng A; Hinds M; Bosworth C; Alster Y · The ocular surface · 2025
    Randomized trial245 participantsSelenium
  58. AZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial.
    Stapleton F; Hinds M; Tan J; Jones L; Chalmers R; Bosworth C; Alster Y · The ocular surface · 2025
    Randomized trial67 participantsSelenium
  59. The effect of a biweekly novel selenium sulfide-containing topical treatment in symptomatic contact lens wearers: An exploratory study.
    Stapleton F; Jia T; DePuy V; Bosworth C; Gleeson M; Tan J · The ocular surface · 2025
    Randomized trial14 participantsSelenium
  60. Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration.
    Merle BMJ; Silver RE; Rosner B; Seddon JM · Investigative ophthalmology & visual science · 2017
    Cohort study2,146 participantsVitamin D
  61. Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis.
    Annweiler C; Drouet M; Duval GT; Paré PY; Leruez S; Dinomais M; Milea D · Maturitas · 2017
    Meta-analysis11 studies pooledVitamin D
  62. Low serum vitamin D is associated with axial length and risk of myopia in young children.
    Tideman JW; Polling JR; Voortman T; Jaddoe VW; Uitterlinden AG; Hofman A; Vingerling JR; Franco OH; Klaver CC · European journal of epidemiology · 2017
    Cohort study2,666 participantsVitamin D
  63. The effect of vitamin D supplementation on the outcome of treatment with bevacizumab in diabetic macular edema: a randomized clinical trial.
    Fekri S; Soheilian M; Roozdar S; Abtahi SH; Nouri H · International ophthalmology · 2022
    Randomized trial83 participantsVitamin D
  64. Vitamin D Deficiency and Dry Eye Disease: A Retrospective Cohort Study.
    Shmushkevich SB; Bajrami S; Beauchamp B; Kane JS; Mutawe DL; Hollinger JC; Marks VA; Parekh PK; Rothman AL; Ansari ZA; Williams BK; Galor A · American journal of ophthalmology · 2026
    Cohort study12,095,004 participantsVitamin D
  65. Effect of Ginkgo biloba extracts in the prevention of posterior capsule opacification after cataract surgery: A randomized clinical trial.
    Amiri AA; Jafari R; Amiri AA; Rad HA; Daneshvar F; Charati JY; Amiri AA · Oman journal of ophthalmology · 2025
    Randomized trial144 participantsGinkgo
  66. Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma.
    Quaranta L; Bettelli S; Uva MG; Semeraro F; Turano R; Gandolfo E · Ophthalmology · 2003
    Randomized trial27 participantsGinkgo
  67. [Ginkgo extract in impaired vision--treatment with special extract EGb 761 of impaired vision due to dry senile macular degeneration].
    Fies P; Dienel A · Wiener medizinische Wochenschrift (1946) · 2002
    Randomized trial99 participantsGinkgo
  68. Short-term effects of Ginkgo biloba extract on peripapillary retinal blood flow in normal tension glaucoma.
    Park JW; Kwon HJ; Chung WS; Kim CY; Seong GJ · Korean journal of ophthalmology : KJO · 2012
    Randomized trial30 participantsGinkgo
  69. [The course of color vision in early diabetic retinopathy treated with Ginkgo biloba extract. A preliminary double-blind versus placebo study].
    Lanthony P; Cosson JP · Journal francais d'ophtalmologie · 1989
    Randomized trial29 participantsGinkgo
  70. Effects of taurine supplementation on VDT work induced visual stress.
    Zhang M; Bi LF; Ai YD; Yang LP; Wang HB; Liu ZY; Sekine M; Kagamimori S · Amino acids · 2005
    Randomized trial25 participantsTaurine
  71. [Effect of vasoactive agents on visual functions and ocular blood flow in patients with early manifestations of age-related macular degeneration].
    Avetisov SE; Kiseleva TN; Lagutina IuM; Kravchuk EA · Vestnik oftalmologii · 2007
    Non-randomized trial40 participantsVinpocetine