Biotin & Folate

Biotin & Folate

Natures Plus4.7 (535 ratings)
Format:Tablet Quantity: 30 Tablet(s) · 30 servings
Goals

Product analysis

54 out of 100

Biotin & Folate may help hair affected by a biotin shortage, with limited evidence for brittle nails. Its biotin content compares less favorably with the serving cost.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality28

The folate form is named, but its form quality cannot be judged confidently. The biotin form remains unspecified, leaving that part of the comparison unclear.

Ingredient Transparency81

Both amounts are stated, making serving contents easy to check. Only the folate form is named.

Value For Money28

The biotin content offers limited value relative to the serving cost. Folate value remains uncertain, so the combination cannot be compared confidently as a whole.

Customer Satisfaction78

Customer feedback is very positive across several hundred reviews. That provides useful satisfaction context without confirming hair or nail improvements.

Product Focus80

The short formula focuses on hair affected by low biotin intake and possible brittle-nail support. Nail findings are limited, and extra hair growth is not established when biotin intake is adequate.

Format
Tablet
Container
30 Tablet(s)
Per serving
$0.48
Customer rating
4.7 · 535 ratings
Report analysis

Goals

Nail Health
Impact
Highest effect
B+ Ingredient FitB- PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 2500 mcg
Study evidence
Biotin Supportive 8 studies
Impact
High effect
A Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Biotin · 2500 mcg
Study evidence
Biotin Supportive 4 studies
Folate Mixed 15 studies

Ingredients

IngredientAmount per servingScore
Folate (Calcium L-5-Methyltetrahydrofolate)
800 mcg DFE
Biotin
2500 mcg 70
Gluten Free Adults 18–50 Vegetarian
Report overview
Biotin · 2500 mcg OverallScore70
B+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value
2,500 mcg of biotin per serving is clearly stated; the cost is high for the amount of biotin. The label lists biotin without specifying its isomer. No artificial colors or sweeteners are indicated.
How this ingredient is rated

Active Ingredient Quality & Bioavailability82

The label lists biotin without specifying its isomer. No artificial colors or sweeteners are indicated.
Biologically Active d-Biotin Isomer
The label lists biotin without specifying its isomer.
Excipient Purity
No artificial colors or sweeteners are indicated.

Dose, Safety & Label Transparency84

The serving provides 2,500 mcg of biotin. The amount is clearly listed.
Biotin Potency for Health Goals
The serving provides 2,500 mcg of biotin.
Label Transparency & Exact Disclosure
The label clearly lists 2,500 mcg of biotin per serving.

Value20

The cost is high for the amount of biotin.
Price per 5,000 mcg Biotin
The cost is high for the amount of biotin.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health Nail Health forBiotin
  2. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  3. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  4. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  5. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  6. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate
  7. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  8. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  9. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  10. Biotin for the treatment of nail disease: what is the evidence?
    Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
    Narrative reviewNail Health forBiotin
  11. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
    Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
    Other32 participantsNail Health forBiotin
  12. Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
    Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
    Randomized trial50 participantsNail Health forBiotin
  13. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forBiotin