Niacin 250 mg

Niacin 250 mg

21st Century4.6 (3,353 ratings)
Format:Tablet Quantity: 110 Tablet(s) · 110 servings
Goals
$4.67 $0.04 per serving

Product analysis

53 out of 100

Niacin 250 mg supplies vitamin B3 with a possible connection to blood-lipid changes. Its unspecified form makes it difficult to relate the product to findings for nicotinic acid.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality24

The niacin form is not stated, limiting a meaningful quality comparison. Calcium is identified, but its comparative form quality remains unresolved.

Ingredient Transparency81

Both amounts are stated, which helps with tracking intake. The niacin form is missing, leaving the main ingredient harder to compare.

Value For Money40

Niacin offers limited value under the available form-and-cost comparison. Calcium value remains unresolved, so the combination has no clear cost advantage.

Customer Satisfaction85

Customer ratings are favorable across thousands of reviews. The substantial feedback indicates satisfaction without establishing heart benefits.

Product Focus59

The intended heart-related role depends on findings for a specific niacin form, which is not identified here. Blood-lipid changes also do not establish fewer cardiovascular events.

Format
Tablet
Container
110 Tablet(s)
Per serving
$0.04
Customer rating
4.6 · 3,353 ratings
Report analysis

Goals

Cardiovascular Support
Impact
Moderate effect
C Ingredient FitF PathwaysB- EvidenceA+ Formulation Logic
Niacin · 250 mg

Niacin 250 mg lists niacin without a specific form, while the supplied marker evidence centers on nicotinic acid. The product has partial support for triglyceride metabolism, but that route does not reach the breadth comparison; calcium is an unrelated active. Its amount is below the higher reference point used for full dose support.

How this product is rated for Cardiovascular Support

Ingredient fit62

Niacin is relevant, but calcium is unrelated to the goal and the product links to other goals.
Goal fit
Niacin is the only relevant active; calcium and other goal links dilute focus.
Dose adequacy
The declared amount gives partial dose support, below the higher reference point.

Pathways17

Niacin has some link to triglyceride metabolism, but the pathway remains short of broad coverage.
Depth
Triglyceride metabolism is the strongest route, with only partial coverage.
Breadth
No target route reaches the breadth comparison's required coverage.

Evidence74

The strongest marker evidence is for nicotinic acid, with an evidence ceiling below the goal's highest.
Evidence strength
Niacin has the strongest evidence among the ingredients here, but not the goal's top ceiling.
Studied preparation
The effective ingredient amount is matched to a preparation represented in research.

Formulation logic100

Niacin needs no partner under the supplied evidence, and no conflict was identified.
Partner coverage
The credited ingredient can work alone.
Conflicts
No applicable conflict was identified in the saved facts.
Effective doses
The declared amount reaches the minimum dose comparison, though not the higher reference point.
Study evidence
Niacin Supportive 136 studies
Heart Health
Impact
Moderate effect
C Ingredient FitF PathwaysC EvidenceA+ Formulation Logic

Niacin at 250 mg relates to lipid metabolism. The supplied evidence distinguishes lipid changes from cardiovascular outcomes: higher-dose nicotinic acid changed blood lipids without demonstrating added event benefit in the reviewed treatment setting.

How this product is rated for Heart Health

Ingredient fit62

The relevant ingredients provide a moderate heart-health focus alongside other purposes. The assessed amounts receive partial dose support in the saved findings.
Goal fit
The relevant ingredients provide a moderate heart-health focus alongside other purposes.
Dose adequacy
The assessed amounts receive partial dose support in the saved findings.

Pathways9

The strongest saved contribution relates to triglyceride metabolism, with limited coverage. No reviewed pathway reaches the saved coverage threshold, so support remains narrow.
Depth
The strongest saved contribution relates to triglyceride metabolism, with limited coverage.
Breadth
No reviewed pathway reaches the saved coverage threshold, so support remains narrow.

Evidence62

Vitamin B3 (Niacin) provides the strongest effective ingredient evidence in the saved assessment; its support remains bounded to the reviewed nutritional or surrogate outcomes.
Evidence strength
Vitamin B3 (Niacin) provides the strongest effective ingredient evidence in the saved assessment; its support remains bounded to the reviewed nutritional or surrogate outcomes.
Studied preparation
The effective ingredients match preparations accepted in the saved review.

Formulation logic100

The reviewed contributors work independently or have their required partners. No matched ingredient conflict was recorded in the saved assessment.
Partner coverage
The reviewed contributors work independently or have their required partners.
Conflicts
No matched ingredient conflict was recorded in the saved assessment.
Effective doses
All assessed contributors meet the saved minimum dose threshold.
Study evidence
Niacin Supportive 105 studies

Ingredients

IngredientAmount per servingScore
Niacin
250 mg 43
Calcium (Calcium Carbonate)
125 mg
Gluten Free Adults 18–50
Report overview
Niacin · 250 mg OverallScore43
D+ Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyD- Value
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  2. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  3. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group · Atherosclerosis · 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  4. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group.
    Guyton JR; Blazing MA; Hagar J; Kashyap ML; Knopp RH; McKenney JM; Nash DT; Nash SD · Archives of internal medicine · 2000
    Randomized trial173 participantsCardiovascular Support forNiacin
  5. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia.
    Knopp RH; Alagona P; Davidson M; Goldberg AC; Kafonek SD; Kashyap M; Sprecher D; Superko HR; Jenkins S; Marcovina S · Metabolism: clinical and experimental · 1998
    Randomized trial223 participantsCardiovascular Support forNiacin
  6. Differential effect of two nicotinic acid preparations on low-density lipoprotein subclass distribution in patients classified as low-density lipoprotein pattern A, B, or I.
    Superko HR; McGovern ME; Raul E; Garrett B · The American journal of cardiology · 2004
    Randomized trial180 participantsHeart Health forNiacin
  7. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  8. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
    Thoenes M; Oguchi A; Nagamia S; Vaccari CS; Hammoud R; Umpierrez GE; Khan BV · International journal of clinical practice · 2008
    Randomized trial50 participantsHeart Health forNiacin
  9. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  10. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials.
    Sahebkar A · Vascular medicine (London, England) · 2014
    Meta-analysis441 participants7 studies pooledHeart Health forNiacin