Niacin
Niacin, also known as vitamin B3, is a water-soluble vitamin that is essential for numerous metabolic processes in the body. It plays a critical role in converting carbohydrates, fats, and proteins into energy, making it fundamental for cellular function and overall vitality. Niacin also participates in DNA repair and acts as an antioxidant. Beyond its energy-producing roles, Niacin is crucial for maintaining healthy skin, supporting the nervous system, and ensuring proper digestive function. It exists in several forms, including nicotinic acid and nicotinamide (niacinamide), each with slightly different physiological effects and applications, particularly concerning cholesterol management and skin health. Historically, Niacin has been used to treat pellagra, a disease caused by severe B3 deficiency. Today, it is recognized for its potential benefits in supporting cardiovascular health by influencing lipid profiles and contributing to cognitive function, though high doses should always be managed under professional guidance due to potential side effects.
Meat (poultry, beef, pork)Fish (tuna, salmon)Nuts (peanuts)LegumesGrains (brown rice, fortified cereals)MushroomsAvocados
Cheapest Niacin supplements
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Value Niacin supplements
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RDA (Men)16 mg
RDA (Women)14 mg
RDI16 mg
Minimum20 mg
Maximum100 mg
Upper Limit (UL)35 mg
Toxicity Threshold500 mg
Toxicity Effectflushing; hepatotoxicity at ≥1000 mg
Impact
Highest effect
Niacin (Vitamin B3) is critical for cellular energy production. As a precursor to NAD+ and NADP+, it is directly involved in glycolysis, the Krebs cycle, and the electron transport chain—the core pathways for generating ATP from carbohydrates, fats, and proteins. Its role is foundational for a high-functioning metabolism.
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Impact
High effect
Niacin is one of the most powerful supplements available for positively modulating the entire lipid panel, particularly for raising HDL. This strong clinical efficacy warrants a high priority, with the caveat that it should be used with awareness of the flushing side effect.
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Impact
Moderate effect
Niacin (Vitamin B3) promotes vasodilation, which widens blood vessels and improves circulation. Enhanced blood flow to the scalp ensures that hair follicles receive a richer supply of oxygen and essential nutrients, which is vital for robust hair growth and strength.
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Impact
Situational effect
Niacin (Vitamin B3) inhibits the production of VLDL (a precursor to LDL) in the liver and reduces the breakdown of HDL. While effective for lipid modification, its use is more situational due to the "niacin flush" side effect and studies showing it may not reduce cardiovascular events when added to statin therapy. Best used under medical supervision.
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Impact
Situational effect
Typical dose:250–750 mg
Supplementing with Niacinamide (a non-flushing form of Niacin/Vitamin B3) has been shown to increase the production of ceramides and other barrier lipids, enhancing barrier function. Its anti-inflammatory effects make it beneficial for conditions like acne and rosacea, improving overall skin tone and texture.
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add_circle_outline Positive Interactions
Vitamin B6
Both are B vitamins involved in numerous metabolic pathways, often working synergistically to support overall cellular function.
Folate
As part of the B-complex family, Niacin and Folate contribute to various metabolic processes and are often taken together for comprehensive B vitamin support.
Thiamin
Both Thiamin and Niacin are crucial for energy metabolism, converting carbohydrates into usable energy for the body.
Riboflavin
Riboflavin works alongside Niacin in electron transport and energy production, as both are cofactors for critical enzymes.
Vitamin B5
Vitamin B5 (Pantothenic Acid) works with Niacin in the formation of coenzyme A and supports various energy-yielding metabolic reactions.
Vitamin B12
Niacin and Vitamin B12, as members of the B-complex, collectively support cellular metabolism, red blood cell formation, and nervous system health.
Biotin
Biotin, another B vitamin, collaborates with Niacin in metabolic processes related to fat, carbohydrate, and protein metabolism.
Magnesium
Magnesium acts as a cofactor for many enzymes, including those involved in Niacin's metabolic pathways, enhancing its overall effectiveness.
Zinc
Zinc is involved in numerous enzymatic reactions and can support the functions of Niacin in cellular metabolism and immune health.
65 Value 
B Complex
Sundown
4.7
★★★★★
(18319 ratings)
Niacin: 20 mg
A budget-friendly, foundational B complex providing essential B vitamins at conservative daily doses suitable for general wellness support.
82 Value 
Super Vitamin B-Complex
Spring Valley
4.7
★★★★★
(6548 ratings)
Niacin: 25 mg
A comprehensive and potent B-complex with added Vitamin C, offering good value for broad wellness support.
75 Value 
Prenatal Multivitamin/Multimineral with Folate
Spring Valley
4.7
★★★★★
(2403 ratings)
Niacin: 20 mg
<p>This prenatal multivitamin delivers a key set of vitamins and minerals, including a good amount of folate and iron, tailored to support nutritional needs during pregnancy at a very affordable price.</p>
68 Budget 
One Daily Women's
Equate
4.7
★★★★★
(5571 ratings)
Niacin: 16 mg
This women's multivitamin offers a budget-conscious blend of essential vitamins and minerals, including a significant amount of Biotin, to support women's daily health needs.
65 Value 
Complete Multivitamin
Equate
4.7
★★★★★
(1663 ratings)
Niacin: 20 mg
This multivitamin offers a broad range of basic vitamins and minerals to support general daily health and fill common nutritional gaps at an economical price.
92 Best 
No Flush Niacin (Inositol Hexanicotinate) 800 mg
Life Extension
4.7
★★★★★
(3577 ratings)
Niacin: 640 mg
Life Extension offers a high 800mg dose of flush-free Inositol Hexanicotinate, providing 640mg elemental niacin for comprehensive metabolic and cardiovascular support.
75 Budget 
One Daily Women's Health
Equate
4.7
★★★★★
(5571 ratings)
Niacin: 20 mg
This multivitamin provides essential vitamins and minerals in a convenient daily tablet, formulated to help meet the general nutritional needs of women.
70 Budget 
One Daily Women's
21st Century
4.7
★★★★★
(34510 ratings)
Niacin: 16 mg
This women's multivitamin offers a comprehensive, budget-friendly blend of essential vitamins and minerals, including a high dose of Biotin, to support daily health and specific needs like hair and nail wellness.
68 Budget 
One Daily Men's Health
Equate
4.7
★★★★★
(2147 ratings)
Niacin: 18 mg
This is a comprehensive and budget-friendly multivitamin for men, providing a wide array of essential vitamins and minerals for daily nutritional support.
75 Value 
One Daily Essential
21st Century
4.7
★★★★★
(3224 ratings)
Niacin: 20 mg
A very affordable, basic daily multivitamin providing essential vitamins and some calcium for general wellness support.
88 Best 
Multigenics without Iron
Metagenics
4.8
★★★★★
(191 ratings)
Niacin: 420 mg
This is a comprehensive, high-potency multivitamin featuring good forms of many nutrients and is designed without iron, though its Vitamin D content is notably low and the serving size is substantial.
78 Best 
No-Flush Niacin 500 mg
Source Naturals
4.7
★★★★★
(779 ratings)
Niacin: 500 mg
Source Naturals No-Flush Niacin provides 500mg of Niacin as Inositol Hexanicotinate with Inositol, offering potent, flush-free B3 support for metabolic and cellular health.
70 Value 
Complete Multivitamin Adults 50+
Equate
4.7
★★★★★
(2059 ratings)
Niacin: 20 mg
This multivitamin for adults 50+ offers a foundational blend of essential vitamins, minerals, and key carotenoids like Lutein and Lycopene, supporting general health, bone density, and vision at a very accessible price.
78 Best 
ATP Cofactors
Optimox
4.8
★★★★★
(1088 ratings)
Niacin: 500 mg
A focused supplement providing high doses of Riboflavin and a non-flushing form of Niacin, aiming to support the body's energy metabolism and various cellular functions.
76 Value 
Niacin 250 mg
21st Century
4.6
★★★★★
(3304 ratings)
Niacin: 250 mg
An affordable Niacin supplement with a moderate 250 mg dose, plus calcium, well-suited for regular intake and those targeting specific wellness goals.
80 Value 
Niacinamide B-3 100 mg
Source Naturals
4.7
★★★★★
(1362 ratings)
Niacin: 100 mg
An excellent value, 100 mg flush-free niacinamide supplement, ideal for daily B3 support without skin discomfort.
80 Best 
Flush-Free Niacin 500 mg
Bluebonnet
4.7
★★★★★
(111 ratings)
Niacin: 500 mg
Bluebonnet Flush-Free Niacin delivers a high 500mg dose of elemental niacin from Inositol Hexanicotinate, offering comfortable and robust support for metabolic and cardiovascular health.
90 Best 
Niacin (Vitamin B3) 500 mg
Solgar
4.6
★★★★★
(835 ratings)
Niacin: 500 mg
Solgar Niacin 500 mg provides a powerful dose of nicotinic acid for strong cardiovascular and metabolic support, though users should anticipate the typical niacin flush.
78 Best 
Niacinamide 1500 mg
Source Naturals
4.5
★★★★★
(1133 ratings)
Niacin: 1500 mg
Source Naturals Niacinamide offers a substantial 1500mg dose of the non-flushing Vitamin B3, ideal for those seeking strong metabolic and skin health support without discomfort.
92 Best 
Niacin 500 mg
NOW
4.6
★★★★★
(9254 ratings)
Niacin: 500 mg
This NOW Niacin offers a powerful 500mg dose of nicotinic acid, providing robust cardiovascular and metabolic support, though users should prepare for the typical niacin flush.
88 Best 
Sustained-Release Niacin with niaXtend 500 mg
Doctor's Best
4.7
★★★★★
(717 ratings)
Niacin: 500 mg
This Doctor's Best product offers 500mg of sustained-release nicotinic acid for robust cardiovascular and metabolic support, aiming to minimize the niacin flush.
90 Best 
Heart Science
Source Naturals
4.6
★★★★★
(154 ratings)
Niacin: 500 mg
A highly comprehensive supplement packed with a wide array of vitamins, minerals, amino acids, and botanical extracts specifically formulated to support cardiovascular health and overall wellness.
80 Value 
Niacinamide 500 mg
21st Century
4.6
★★★★★
(8507 ratings)
Niacin: 500 mg
A high-value Niacinamide supplement providing a generous 500 mg dose of the 'no-flush' B3, plus calcium, at an accessible price.
68 Budget 
Healthy Eyes Extra
21st Century
4.7
★★★★★
(5538 ratings)
Niacin: 40 mg
This supplement combines vitamins, minerals, and Lutein to support vision health and general antioxidant status in a budget-friendly tablet form.
70 Budget 
One Daily Men's Health
Equate
4.7
★★★★★
(2147 ratings)
Niacin: 18 mg
This is a standard daily multivitamin for men, providing a broad mix of essential vitamins and minerals, including lycopene, in a convenient one-tablet dose for general nutritional support.
78 Value 
Niacinamide B-3 100 mg
Source Naturals
4.6
★★★★★
(11 ratings)
Niacin: 100 mg
A very economical, low-dose, flush-free niacinamide supplement for general Vitamin B3 support and daily metabolic functions.
Average$30.05
Median$25.56
Average$0.78
Median$0.56
Average$0.34
Median$0.16
Reference amount: 10 mg
Niacinamide, also known as nicotinamide, is one of the two primary forms of vitamin B3. Unlike nicotinic acid, it does not typically cause the vasodilation known as the 'niacin flush', making it a preferred choice for general supplementation and skincare. It plays a crucial role in cellular energy metabolism, DNA repair, and antioxidant processes. Topically, it's widely used to improve skin barrier function, reduce inflammation, and minimize pore appearance.
- Does not cause 'niacin flush'
- Well-tolerated for general supplementation
- Beneficial for skin health (topical and oral)
- Supports cellular metabolism and DNA repair
- Less effective than nicotinic acid for significant cholesterol lowering at therapeutic doses
- High doses can still cause digestive upset in some individuals
Avg$30.90
Med$26.00
Avg$0.79
Med$0.55
Avg$0.33
Med$0.15
Price distribution
Vitamin B3 is a vital water-soluble vitamin encompassing several forms, primarily nicotinic acid (niacin) and niacinamide (nicotinamide). It is a precursor to Nicotinamide Adenine Dinucleotide (NAD) and Nicotinamide Adenine Dinucleotide Phosphate (NADP), coenzymes involved in over 400 enzymatic reactions. These reactions are fundamental for converting food into energy, synthesizing fatty acids and cholesterol, DNA repair, and antioxidant defense, supporting nearly every cell in the body.
- Essential for over 400 enzymatic reactions
- Crucial for energy metabolism and ATP production
- Supports DNA repair and antioxidant systems
- Versatile in its forms, addressing different health needs
- Specific forms can have significant side effects (e.g., niacin flush from nicotinic acid)
- High doses of certain forms may require medical supervision
Avg$25.07
Med$21.54
Avg$0.48
Med$0.34
Avg$0.11
Med$0.05
Price distribution
Niacin, specifically nicotinic acid, is a form of Vitamin B3 that has a significant impact on blood lipid levels. At pharmacological doses, it is prescribed to lower LDL ('bad') cholesterol, total cholesterol, and triglycerides, while simultaneously increasing HDL ('good') cholesterol. This makes it a powerful agent for cardiovascular support. However, its use is often limited by the 'niacin flush', a temporary and harmless sensation of redness, warmth, itching, or tingling due to vasodilation.
- Highly effective at improving cholesterol and triglyceride levels
- Strong evidence for cardiovascular benefits
- Increases beneficial HDL cholesterol
- Causes the 'niacin flush' (redness, itching, warmth)
- Potential for liver toxicity at very high doses
- Can interact with certain medications and raise blood sugar
Avg$38.24
Med$29.99
Avg$0.96
Med$0.68
Avg$0.22
Med$0.12
Price distribution
Inositol Hexanicotinate (IHN), often called 'no-flush niacin', is a compound where six molecules of nicotinic acid are esterified to one molecule of inositol. This structure allows for a gradual release of niacin into the bloodstream, which significantly reduces or eliminates the characteristic 'niacin flush' associated with immediate-release nicotinic acid. It aims to provide the metabolic benefits of niacin without the uncomfortable side effects, though its lipid-modifying effects may be less potent than pure nicotinic acid.
- Significantly reduces or eliminates the 'niacin flush'
- Provides niacin benefits for general health and metabolism
- Generally well-tolerated
- May be less effective than immediate-release nicotinic acid for potent cholesterol lowering
- Higher cost compared to basic niacin
- Some individuals may still experience mild flushing at very high doses
Avg$34.37
Med$29.91
Avg$0.80
Med$0.66
Avg$1.44
Med$0.62
Price distribution
Niacinamide Ascorbate is a salt formed by combining niacinamide and ascorbic acid (Vitamin C). This compound aims to deliver the metabolic and skin health benefits of niacinamide, along with the powerful antioxidant and immune-supporting properties of Vitamin C. As it contains niacinamide, it is a non-flushing form of B3. This combination can be particularly beneficial for holistic skin health and cellular protection.
- Provides two essential vitamins in one compound
- Non-flushing form of B3
- Offers antioxidant support from Vitamin C
- Beneficial for skin health and collagen production
- Specific research on this combined compound is less extensive than on individual vitamins
- May be more expensive than separate supplements
- Dosing may be less flexible if specific high doses of one vitamin are needed
Avg$31.96
Med$28.99
Avg$0.80
Med$0.59
Avg$0.06
Med$0.05
Price distribution
Nicotinic Acid is the scientific name for the form of Vitamin B3 commonly known as niacin. It serves as a precursor to NAD and NADP, coenzymes vital for cellular energy production. Therapeutically, at higher doses, nicotinic acid is highly effective in improving blood lipid profiles by lowering LDL cholesterol and triglycerides, and significantly increasing HDL cholesterol. This powerful action contributes to its role in preventing cardiovascular disease, despite the common 'niacin flush' side effect.
- Potent effects on improving blood lipid profiles (lowers LDL, raises HDL)
- Established benefits for reducing cardiovascular risk
- Essential for energy metabolism
- Consistently causes the 'niacin flush' (redness, itching, warmth)
- Risk of liver toxicity at high doses, especially with sustained-release forms
- Can temporarily increase blood glucose levels
Avg$21.09
Med$20.23
Avg$0.34
Med$0.22
Avg$0.12
Med$0.09
Price distribution
Inositol Hexaniacinate is chemically identical to Inositol Hexanicotinate, a complex formed by binding six niacin molecules to an inositol molecule. This 'no-flush' niacin is formulated to hydrolyze slowly in the body, ensuring a gradual release of niacin. This controlled release significantly reduces or prevents the uncomfortable vasodilation (flush) typically associated with immediate-release nicotinic acid, while still providing the essential metabolic benefits of Vitamin B3.
- Effectively reduces or eliminates the 'niacin flush'
- Provides the benefits of niacin for general health and metabolism
- Generally well-tolerated by most individuals
- May have a less pronounced effect on lipid profiles compared to immediate-release nicotinic acid at equivalent doses
- Often more costly than standard niacin supplements
- Very high doses might still cause mild flushing in sensitive individuals
Avg$47.39
Med$30.80
Avg$0.83
Med$0.80
Avg$2.23
Med$0.84
Price distribution
When niacin is obtained from an 'Organic Food Blend', it means the vitamin is naturally present within a mix of organically grown fruits, vegetables, grains, or other plant-based ingredients. This approach aligns with consuming nutrients in their whole-food context, which can enhance absorption and utilization due to the presence of natural co-factors, fiber, and other beneficial compounds. The specific form of niacin (nicotinic acid or niacinamide) within the blend depends on the natural composition of the food sources.
- Natural and holistic source of niacin
- Often includes other beneficial vitamins, minerals, and antioxidants
- Good bioavailability from food matrix
- Generally well-tolerated
- Niacin concentration may be lower and less precise than isolated forms
- Difficult to achieve high therapeutic doses for specific conditions (e.g., severe dyslipidemia)
- Allergies or sensitivities to specific blend ingredients are possible
Avg$39.26
Med$36.20
Avg$0.86
Med$0.86
Avg$0.46
Med$0.44
Price distribution
Nicotinamide Adenine Dinucleotide (NAD+) and its reduced form NADH are ubiquitous coenzymes in all living cells, derived from Vitamin B3 (niacin). NAD+ is essential for over 400 enzymatic reactions, primarily acting as a crucial electron acceptor in metabolic pathways like glycolysis and the citric acid cycle, driving ATP production. Beyond energy metabolism, NAD+ is vital for DNA repair, gene expression regulation (via sirtuins), and cell signaling, playing a key role in cellular aging and resilience.
- Directly involved in cellular energy production (ATP)
- Crucial for DNA repair and maintenance
- Supports healthy aging and cellular longevity pathways (sirtuins)
- Fundamental to numerous metabolic processes
- NAD+ itself has poor bioavailability as a supplement; supplementation usually involves precursors like NMN or NR
- Direct NAD+ IV treatments can be costly and are not widely accessible for oral supplementation
Avg$10.34
Med$11.00
Avg$0.29
Med$0.30
Avg$0.18
Med$0.20
Price distribution
Saccharomyces cerevisiae, commonly known as brewer's yeast or nutritional yeast, is a rich natural source of B vitamins, including niacin. When niacin is obtained from S. cerevisiae, it is present in a food-matrix form, which typically enhances its bioavailability and absorption within the body. Yeast naturally synthesizes and concentrates B vitamins, providing them in a readily recognizable and utilized form for human physiology, along with other beneficial compounds found in yeast.
- Natural and bioavailable source of niacin
- Often rich in other B vitamins and micronutrients
- Generally well-tolerated and digestible
- Sustainable and widely available source
- Niacin content can vary and may be lower than isolated synthetic forms
- Not suitable for achieving very high therapeutic doses
- Individuals with yeast allergies or sensitivities should avoid
Avg$43.87
Med$38.24
Avg$0.34
Med$0.34
Avg$0.04
Med$0.04
Price distribution