D3-5

D3-5

Bio-Tech Pharmacal4.7 (546 ratings)
Format:Capsule Quantity: 250 Capsule(s) · 250 servings
Goals
$15.36 $0.06 per serving

Product analysis

94 out of 100

D3-5 offers focused vitamin D support for normal immune function and bone nutrition, especially when intake is low.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality100

Vitamin D is supplied as D3, a favorable choice of form. Its usefulness still depends on your nutritional needs.

Ingredient Transparency100

The amount and vitamin D form are clearly identified. That makes it easy to compare with your other supplements.

Value For Money100

The vitamin D serving offers favorable value. Its simple formula keeps the purchase focused on one nutrient.

Customer Satisfaction78

Customer feedback is strongly positive across several hundred ratings. That offers a useful picture of satisfaction without proving a health benefit.

Product Focus80

The formula concentrates on vitamin D and its related nutritional roles. Its clearest use is addressing a shortfall, with broader benefits less certain.

Format
Capsule
Container
250 Capsule(s)
Per serving
$0.06
Customer rating
4.7 · 546 ratings
Report analysis

Goals

Immunity
Impact
Highest effect
A Ingredient FitC PathwaysA+ EvidenceA+ Formulation Logic
Vitamin D · 5000 IU

Vitamin D provides a nutrient involved in normal immune regulation. Its value includes filling low intake, but routine supplementation does not establish prevention of respiratory infections. Deficiency correction is a different situation from routine prevention, and the larger amount does not imply greater immune protection.

How this product is rated for Immunity

Ingredient fit93

Vitamin D supplies a focused nutritional contribution.
Goal fit
Vitamin D supplies a focused nutritional contribution.
Dose adequacy
Vitamin D reaches the saved comparison range; the larger amount adds no further contribution.

Pathways60

Lymphocyte function and immune regulation receives the strongest saved coverage. Lymphocyte regulation is the main covered area.
Depth
Lymphocyte function and immune regulation receives the strongest saved coverage.
Breadth
Lymphocyte regulation is the main covered area.

Evidence100

Vitamin D anchors the saved evidence finding; the supplied scientific limits determine what immune benefits can be expected.
Evidence strength
Vitamin D anchors the saved evidence finding, without establishing broad infection prevention.
Studied preparation
The counted preparations with substantial known amounts are accepted; no additional form advantage is established.

Formulation logic100

The counted nutrients work independently or have their required partner; no configured conflict was found.
Partner coverage
The counted nutrients work independently or have their required partner.
Conflicts
No configured ingredient conflict was found.
Effective doses
The counted nutrient provides a meaningful amount under the saved criteria.
Study evidence
Vitamin D Supportive 85 studies
Longevity
Impact
High effect
A Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin D · 5000 IU

Vitamin D can improve muscle strength when deficiency is present, supporting function relevant to aging. Trials in adults with adequate vitamin D have not established the same benefit. This serving exceeds the nutritional reference intake, but that does not demonstrate stronger anti-aging effects or a general slowing of aging.

How this product is rated for Longevity

Ingredient fit93

The ingredient mix and amounts give a focused match to the saved findings. Ingredient roles must still be interpreted within their specific human findings.
Goal fit
The formula is focused on its included ingredient, although its stated uses extend beyond aging.
Dose adequacy
The declared amount meets the saved amount comparison; this does not establish an effective human anti-aging dose.

Pathways0

No reviewed pathway receives a contribution here. Nutritional deficiency correction remains a separate, conditional role.
Depth
No reviewed pathway receives a contribution from this formula.
Breadth
No pathway reaches the saved coverage threshold.

Evidence83

The saved evidence finding recognizes the included ingredient forms and amounts. The supplied human context supports only specific outcomes or correction of low intake, rather than general aging reversal.
Evidence strength
Vitamin D supplies the strongest saved evidence finding here; the specific population and outcome limits still apply.
Studied preparation
The included forms meet the saved preparation comparison. This does not extend their findings to general anti-aging effects.

Formulation logic100

The formula has no identified evaluated conflict, and partner requirements are met. The counted amounts meet the saved threshold without establishing a combined benefit.
Partner coverage
The included ingredients can contribute alone or have their required partner; no added benefit from combining them is established.
Conflicts
No evaluated ingredient conflict was identified in the supplied findings.
Effective doses
The counted ingredients meet the saved amount threshold, which is not a proven minimum dose for anti-aging benefits.
Study evidence
Vitamin D Supportive 50 studies
Testosterone Support
Impact
High effect
A Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin D · 5000 IU

Vitamin D can address a nutritional shortfall, with a testosterone signal in initially deficient overweight men. That finding does not establish a testosterone increase in people with adequate vitamin D.

How this product is rated for Testosterone Support

Ingredient fit93

The ingredients and declared amounts provide a nutritional connection to this goal, with the limits described below.
Goal fit
The formula centers on an ingredient connected to this goal, although it is also associated with other uses.
Dose adequacy
The counted ingredient amounts reach the saved amount comparison range; this does not establish a testosterone-raising dose.

Pathways0

The included nutrient does not produce direct coverage of the tracked hormone pathways.
Depth
No direct hormone pathway receives coverage from the counted nutrients.
Breadth
None of the tracked hormone pathways reaches the coverage threshold.

Evidence81

The strongest included evidence and preparation matches have different meanings: a match alone does not establish routine hormone benefit.
Evidence strength
Vitamin D leads the included evidence, with benefits dependent on population and initial nutrient status.
Studied preparation
The counted preparations receive a study match in the saved findings, without proving that every listed form independently raises testosterone.

Formulation logic100

The counted ingredients meet the saved companion and amount checks; the configured zinc concern is considered separately.
Partner coverage
No required companion is missing for the counted ingredients; this does not imply an added benefit from combining them.
Conflicts
No configured conflict is triggered; the high-zinc-without-copper conditions are not met.
Effective doses
All counted ingredients clear the saved minimum amount threshold, which is a comparison cutoff rather than a proven effective testosterone dose.
Study evidence
Vitamin D Supportive 56 studies
Inflammation
Impact
Highest effect
A Ingredient FitC- PathwaysA EvidenceA+ Formulation Logic
Vitamin D · 5000 IU

Vitamin D has a connection to inflammatory signalling, but its human findings are mixed. One large trial found no systemic inflammatory-marker reduction after one year; a later analysis found a temporary hsCRP reduction that did not persist, while other cytokines were unchanged. This does not establish broad clinical anti-inflammatory benefit, and a larger serving does not resolve that uncertainty.

How this product is rated for Inflammation

Ingredient fit93

The formula contains relevant ingredients, with focus and amount findings reflecting its broader composition.
Goal fit
The relevant ingredients give this formula a focused connection to this goal.
Dose adequacy
The counted ingredients reach the saved amount references; this does not establish clinical benefit.

Pathways57

The saved findings are concentrated in one pathway, giving a limited range of connections to this broad goal.
Depth
The strongest saved connection is inflammatory gene signalling.
Breadth
Only one pathway reaches the saved coverage threshold, so the connection is narrow.

Evidence93

The saved evidence findings reflect ingredient and preparation matches. Human findings remain limited by population, outcome or preparation differences.
Evidence strength
Vitamin D provides the strongest saved evidence finding among the counted ingredients, while its specific human-evidence limitations still apply.
Studied preparation
The counted preparations match the saved preparation criteria; this does not remove the limitations of the underlying human findings.

Formulation logic100

The counted ingredients meet the saved minimum amounts and most partner requirements, with no matched conflict recorded.
Partner coverage
The counted ingredients can contribute alone or meet the saved partner requirements.
Conflicts
No matched conflict was recorded in the supplied calculation.
Effective doses
All counted ingredients reach the saved minimum amount threshold; this threshold is not proof of an effective clinical dose.
Study evidence
Vitamin D Supportive 101 studies
Everyday Health
Impact
Highest effect
A Ingredient FitC- PathwaysB+ EvidenceA+ Formulation Logic
Vitamin D · 5000 IU

Vitamin D provides a nutritional contribution to bone and mineral metabolism when intake is low. The declared D3 amount meets the saved amount criterion for the selected serving. This does not establish extra general-health benefit or disease prevention when intake is adequate. The listed form and an amount above a nutritional reference do not demonstrate added efficacy.

How this product is rated for Everyday Health

Ingredient fit93

Vitamin D supplies a leading contribution in a formula concentrated on the counted ingredients. The counted ingredient amounts meet the full saved comparison for one serving; higher amounts do not imply greater benefit.
Goal fit
Vitamin D supplies a leading contribution in a formula concentrated on the counted ingredients.
Dose adequacy
The counted ingredient amounts meet the full saved comparison for one serving; higher amounts do not imply greater benefit.

Pathways57

The strongest saved coverage concerns bone and mineral metabolism. The saved findings cover bone and mineral metabolism.
Depth
The strongest saved coverage concerns bone and mineral metabolism.
Breadth
The saved findings cover bone and mineral metabolism.

Evidence82

Vitamin D leads the saved evidence finding, which concerns conditional nutritional usefulness rather than better outcomes above adequate intake. The counted declarations meet the saved preparation checks; no chemical-form or delivery superiority is established.
Evidence strength
Vitamin D leads the saved evidence finding, which concerns conditional nutritional usefulness rather than better outcomes above adequate intake.
Studied preparation
The counted declarations meet the saved preparation checks; no chemical-form or delivery superiority is established.

Formulation logic100

The counted ingredients meet the saved partner requirements. No configured ingredient conflict was found in the supplied facts.
Partner coverage
The counted ingredients meet the saved partner requirements.
Conflicts
No configured ingredient conflict was found in the supplied facts.
Effective doses
All ingredients counted by this rule meet its minimum amount criterion; that is not a proven effective treatment dose.
Study evidence
Vitamin D Supportive 115 studies
Energy
Impact
High effect
A Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Vitamin D · 5000 IU

Vitamin D may help fatigue in vitamin-D-deficient adults, but the supplied trial used a different treatment regimen. The 5,000 IU serving receives the saved amount credit without establishing routine fatigue relief in people with adequate vitamin D. That amount is not evidence of a stronger energy effect or a tested daily fatigue-treatment dose.

How this product is rated for Energy

Ingredient fit93

Vitamin D provides the main connection to energy. The declared serving determines the amount contribution.
Goal fit
Vitamin D connects the formula to energy through its relevant role.
Dose adequacy
The declared amount reaches the configured range; this does not establish extra benefit from higher intake.

Pathways0

The contribution concerns nutritional sufficiency; none of the separately evaluated alertness, exercise or other energy pathways is covered.
Depth
No separately evaluated energy pathway has a qualifying contribution.
Breadth
None of the separately evaluated pathways reaches the coverage threshold.

Evidence95

Vitamin D anchors the saved evidence finding. The counted preparation meets the saved preparation criteria, which does not establish additional benefit in all users.
Evidence strength
Vitamin D supplies the strongest qualifying evidence contribution; its benefit remains limited to the relevant population and context.
Studied preparation
The qualifying ingredients meet the saved preparation criteria; this alone does not prove benefit for the complete product.

Formulation logic100

No required partner is missing and no configured conflict was found. The counted ingredients meet the saved minimum amount threshold.
Partner coverage
The counted ingredients can contribute without a missing required partner.
Conflicts
No configured ingredient conflict was identified.
Effective doses
All counted ingredients meet the saved minimum amount threshold; this is not proof of a clinical fatigue effect.
Study evidence
Vitamin D Supportive 32 studies

Ingredients

IngredientAmount per servingScore
Vitamin D3 (Cholecalciferol)
5000 IU 84
Gluten Free Adults 18–50 Kosher Dairy Free Sugar Free Halal
Report overview
A- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyA+ Value
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  2. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  3. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  4. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  5. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  6. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledEveryday Health forVitamin D
  7. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsEveryday Health forVitamin D
  8. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledEveryday Health forVitamin D
  9. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledEveryday Health forVitamin D
  10. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledEveryday Health forVitamin D
  11. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
    Martineau AR; Jolliffe DA; Greenberg L; Aloia JF; Bergman P; Dubnov-Raz G; Esposito S; Ganmaa D; Ginde AA; Goodall EC; Grant CC; Janssens W; Jensen ME; Kerley CP; Laaksi I; Manaseki-Holland S; Mauger D; Murdoch DR; Neale R; Rees JR; Simpson S; Stelmach I; Trilok Kumar G; Urashima M; Camargo CA; Griffiths CJ; Hooper RL · Health technology assessment (Winchester, England) · 2020
    Meta-analysis11,321 participants25 studies pooledImmunity forVitamin D
  12. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
    Zhu Z; Zhu X; Gu L; Zhan Y; Chen L; Li X · Frontiers in nutrition · 2022
    Meta-analysis4,859 participants10 studies pooledImmunity forVitamin D
  13. Vitamin D3 and deconvoluting a rash.
    Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
    Randomized trial28 participantsImmunity forVitamin D
  14. Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.
    Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
    Randomized trial110 participantsImmunity forVitamin D
  15. Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication guidelines for overcoming the unpublished data.
    Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
    Meta-analysis50,554 participants65 studies pooledImmunity forVitamin D
  16. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
    Zhou A; Hyppönen E · International journal of epidemiology · 2023
    Observational study294,970 participantsInflammation forVitamin D
  17. Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial.
    El Amrousy D; El Ashry H; Hodeib H; Hassan S · Journal of clinical gastroenterology · 2021
    Randomized trial120 participantsInflammation forVitamin D
  18. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
    Gao YQ; Gao YH; Xing JH · World journal of diabetes · 2025
    Randomized trial120 participantsInflammation forVitamin D
  19. Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.
    Yang F; Sun M; Sun C; Li J; Yang X; Bi C; Wang M; Pu L; Wang J; Wang C; Xie M; Yao Y; Jin L · Scientific reports · 2020
    Cross-sectional study9,809 participantsInflammation forVitamin D
  20. Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.
    Zhang C; Cui J; Li S; Shen J; Luo X; Yao Y; Shi H · BMC geriatrics · 2024
    Cohort study3,072 participantsInflammation forVitamin D