G.I. Integrity

G.I. Integrity

Pure Encapsulations4.8 (11 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 60 servings
Goals
$48.00 $0.80 per serving

Product analysis

53 out of 100

G.I. Integrity combines ingredients linked with support for the digestive lining, though the evidence is limited and depends on the preparation. Its glutamine contribution is relatively costly at the full serving price.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality35

Most sources are named, but their quality cannot all be judged confidently. N-acetyl glucosamine lists crab and shrimp sources without disclosing their proportions.

Ingredient Transparency73

Ingredient amounts and most sources are disclosed, helping serving comparisons. Glutamine form and the proportions of the N-acetyl glucosamine sources remain unclear.

Value For Money42

Value is mixed, with a moderate comparison for N-acetyl glucosamine. Glutamine is relatively costly and aloe offers limited value at the full serving price.

Customer Satisfaction72

Customer ratings are very positive but come from very few reviews. The small review base limits confidence about wider customer experience.

Product Focus58

The formula centers on digestive-lining support, where evidence remains preliminary or specific to selected clinical groups. A possible skin-hydration effect is narrower than a broad improvement in skin appearance.

Format
Capsule
Container
120 Capsule(s)
Per serving
$0.80
Customer rating
4.8 · 11 ratings
Report analysis

Goals

Gut Health
Impact
Moderate effect
C+ Ingredient FitF PathwaysD- EvidenceA+ Formulation Logic
Glutamine · 1000 mgN-Acetyl Glucosamine · 500 mg
Study evidence
Aloe Supportive 7 studies
Glutamine Supportive 37 studies
Skin Health
Impact
Moderate effect
D+ Ingredient FitF PathwaysA EvidenceA+ Formulation Logic
N-Acetyl Glucosamine · 500 mg
Study evidence

Ingredients

IngredientAmount per servingScore
L-Glutamine
1000 mg 59
N-Acetyl-D-Glucosamine (Crab, Shrimp)
500 mg 73
Gamma Oryzanol (Rice Bran)
150 mg
Aloe vera (Aloe barbadensis) extract (Polysaccharides)
50 mg 66
Gluten Free Adults 18–50
Report overview
C Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyC Value
G.I. Integrity provides 500 mg of N-acetyl-D-glucosamine per serving, with a moderate cost for the amount. The vegetarian claim conflicts with a shellfish disclosure, so the source needs clarification. The D form is specified.
How this ingredient is rated

Active Ingredient Quality & Bioavailability63

The D form is specified. The vegetarian claim conflicts with a shellfish disclosure, so the source needs clarification.
N-Acetyl-D-Glucosamine Isomer Specificity
The label specifies N-acetyl-D-glucosamine.
Source and Allergen Disclosure
The vegetarian claim conflicts with a shellfish disclosure, so the source needs clarification.

Dose, Safety & Label Transparency90

The serving provides 500 mg of N-acetyl-D-glucosamine, with the amount clearly listed.
NAG Potency per Serving
Each serving provides 500 mg of N-acetyl glucosamine.
Label Transparency and Blend Clarity
The ingredient amount is listed in milligrams.

Value60

The estimated cost for the amount of N-acetyl glucosamine is moderate; it uses the full serving price.
Price per 500mg of N-Acetyl Glucosamine
The estimated cost for the N-acetyl glucosamine amount is moderate, using the full serving price.
D- Composition And Label DisclosureA+ Composition And Label DisclosureD- Commercial Price And Usability
Each serving provides 50 mg of Aloe vera, at a higher whole-product cost per serving. The inner leaf is specified. The extract lists 10% polysaccharides.
How this ingredient is rated

Composition and Label Disclosure44

The aloe comes from the inner leaf. The extract lists 10% polysaccharides.
Aloe Part and Processing Disclosure
The aloe comes from the inner leaf.
Marker and Preparation Disclosure
The extract lists 10% polysaccharides.

Composition and Label Disclosure100

Both the amount and source are stated.
Individual Preparation Amount Disclosure
The serving lists 50 mg of Aloe vera.

Commercial Price and Usability40

The whole-product cost per serving is higher.
Commercial Price per Labeled Serving
The whole-product cost per serving is higher.
Glutamine · 1000 mg OverallScore59
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value
G.I. Integrity provides 1000 mg of L-glutamine per serving, at a very high cost for the amount. No glutamine grade is specified.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The label names L-glutamine, but does not specify a grade.
Glutamine Grade & Purity
The label names L-glutamine, but does not specify a grade.

Dose, Safety & Label Transparency70

The label states 1000 mg per serving.
Therapeutic Dosage Strength
Each serving contains 1000 mg of glutamine.
Label Transparency & Blends
The amount is individually stated.

Value15

The cost is very high for the amount of glutamine.
Price per Gram of L-Glutamine
The cost per gram of glutamine is very high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Prevention of acute radiation-induced Proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in Pelvic Cancer patients.
    Sahebnasagh A; Ghasemi A; Akbari J; Alipour A; Lashkardoost H; Ala S; Hosseinimehr SJ; Salehifar E · BMC complementary medicine and therapies · 2020
    Randomized trial42 participantsGut Health forAloe
  2. Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial.
    Sahebnasagh A; Ghasemi A; Akbari J; Alipour A; Lashkardoost H; Ala S; Salehifar E · Journal of alternative and complementary medicine (New York, N.Y.) · 2017
    Randomized trial20 participantsGut Health forAloe
  3. Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial.
    Sahebnasagh A; Saghafi F; Ghasemi A; Akbari J; Alipour A; Habtemariam S; Safdari M; Ghaleno HR; Salehifar E · Journal of gastrointestinal cancer · 2022
    Randomized trial20 participantsGut Health forAloe
  4. A Pilot Study of the Effect of Aloe barbadensis Mill. Extract (AVH200®) in Patients with Irritable Bowel Syndrome: a Randomized, Double-Blind, Placebo-Controlled Study.
    Størsrud S; Pontén I; Simrén M · Journal of gastrointestinal and liver diseases : JGLD · 2016
    Randomized trial68 participantsGut Health forAloe
  5. A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life.
    Hutchings HA; Wareham K; Baxter JN; Atherton P; Kingham JG; Duane P; Thomas L; Thomas M; Ch'ng CL; Williams JG · ISRN gastroenterology · 2011
    Randomized trial110 participantsGut Health forAloe
  6. Effect of perioperative glutamine-enriched nutritional support on patients with colorectal cancer: A systematic review and meta-analysis.
    Huang Y; Yang XZ; Qin SH; Zhang T; Xie M; Wang JW · World journal of gastrointestinal surgery · 2026
    Meta-analysis1,643 participants27 studies pooledGut Health forGlutamine
  7. Glutamine prevents diarrhea in colorectal cancer patients undergoing chemotherapy or chemoradiotherapy: a meta-analysis.
    Chen L; Wang D; Meng C; Sun H; Li R; Miao G; Liu P · BMC gastroenterology · 2025
    Meta-analysis311 participants5 studies pooledGut Health forGlutamine
  8. Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner.
    Pugh JN; Sage S; Hutson M; Doran DA; Fleming SC; Highton J; Morton JP; Close GL · European journal of applied physiology · 2018
    Randomized trial10 participantsGut Health forGlutamine
  9. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea.
    Yalçin SS; Yurdakök K; Tezcan I; Oner L · Journal of pediatric gastroenterology and nutrition · 2004
    Randomized trial128 participantsGut Health forGlutamine
  10. Improvement of intestinal permeability with alanyl-glutamine in HIV patients: a randomized, double blinded, placebo-controlled clinical trial.
    Leite RD; Lima NL; Leite CA; Farhat CK; Guerrant RL; Lima AA · Arquivos de gastroenterologia · 2013
    Randomized trial46 participantsGut Health forGlutamine
  11. A randomized, investigator-blinded, controlled pilot study to evaluate the safety and efficacy of a poly-N-acetyl glucosamine-derived membrane material in patients with venous leg ulcers.
    Kelechi TJ; Mueller M; Hankin CS; Bronstone A; Samies J; Bonham PA · Journal of the American Academy of Dermatology · 2012
    Randomized trial82 participantsSkin Health forN-Acetyl Glucosamine
  12. Poly-N-acetyl glucosamine nanofibers for negative-pressure wound therapies.
    Fulco I; Erba P; Valeri RC; Vournakis J; Schaefer DJ · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2016
    Randomized trial20 participantsSkin Health forN-Acetyl Glucosamine
  13. Preparation, characterization, and moisturizing effect of liposomes containing glucosamine and N-acetyl glucosamine.
    Malaekeh-Nikouei B; Golmohammadzadeh S; Salmani-Chamanabad S; Mosallaei N; Jamialahmadi K · Journal of cosmetic dermatology · 2014
    Clinical trialSkin Health forN-Acetyl Glucosamine
  14. The effect of N-acetyl-glucosamine on stratum corneum desquamation and water content in human skin.
    Mammone T; Gan D; Fthenakis C; Marenus K · Journal of cosmetic science · 2009
    Clinical trialSkin Health forN-Acetyl Glucosamine
  15. Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine.
    Bissett DL; Robinson LR; Raleigh PS; Miyamoto K; Hakozaki T; Li J; Kelm GR · Journal of cosmetic dermatology · 2007
    Randomized trial50 participantsSkin Health forN-Acetyl Glucosamine