Niacin Inositol Hexanicotinate 500 mg

Niacin Inositol Hexanicotinate 500 mg

Nature's Bounty4.8 (237 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 120 servings
Goals
$16.53 $0.13 per serving

Product analysis

84 out of 100

Niacin Inositol Hexanicotinate 500 mg offers an inexpensive way to supplement niacin for normal skin nutrition when intake is low.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality93

Niacin is clearly identified as inositol hexanicotinate. That clarifies the form without establishing a separate quality advantage for its inositol component.

Ingredient Transparency100

Both listed amounts and their shared form are disclosed. That makes the ingredient description straightforward to compare.

Value For Money100

The niacin price comparison is favorable. The cost is low for the declared ingredient within that comparison.

Customer Satisfaction76

Customer ratings are very positive. The modest review base means the satisfaction picture remains less established than for widely reviewed options.

Product Focus30

Niacin has a nutritional role in maintaining skin when intake is inadequate. The inositol hexanicotinate form does not establish the same effects as other preparations or an extra cosmetic benefit.

Format
Capsule
Container
120 Capsule(s)
Per serving
$0.13
Customer rating
4.8 · 237 ratings
Report analysis

Goals

Skin Health
Impact
Moderate effect
B- Ingredient FitF PathwaysC EvidenceA+ Formulation Logic

Niacin contributes to normal skin nutrition, with its clearest value when intake is inadequate. The declared 400 mg in an inositol hexanicotinate form should not be assumed to reproduce the skin findings of other niacin preparations or provide added cosmetic benefit.

How this product is rated for Skin Health

Ingredient fit74

A skin-related ingredient sits alongside ingredients serving other purposes. The assessed amounts largely meet the saved benchmarks.
Goal fit
A skin-related ingredient sits alongside ingredients serving other purposes.
Dose adequacy
The assessed amounts largely meet the saved benchmarks.

Pathways0

No contribution is assigned to the four assessed skin processes in the saved findings. None of the assessed skin processes reaches the saved coverage benchmark.
Depth
No contribution is assigned to the four assessed skin processes in the saved findings.
Breadth
None of the assessed skin processes reaches the saved coverage benchmark.

Evidence61

The saved findings classify the assessed ingredients at qualifying amounts as studied preparations; that does not guarantee a visible benefit. Confidence also depends on how closely the supplied skin evidence applies to the ingredient and intended user.
Evidence strength
Vitamin B3 (Niacin) provides the strongest evidence contribution at an assessed amount in the saved findings. The ingredient’s normal function and the limits of the supplied human evidence still matter when judging practical skin benefits.
Studied preparation
The saved findings classify the assessed ingredients at qualifying amounts as studied preparations; that does not guarantee a visible benefit.

Formulation logic100

The assessed ingredients have no missing required partners or identified conflicts. All ingredients retained in this part of the assessment meet its saved minimum amount benchmark.
Partner coverage
The assessed ingredients can contribute without a missing required partner in the saved findings.
Conflicts
No ingredient conflicts were identified in the supplied assessment.
Effective doses
All ingredients retained in this part of the assessment meet its saved minimum amount benchmark.
Study evidence
Niacin Supportive 61 studies
Heart Health
Impact
Limited evidence
F Ingredient FitF PathwaysF EvidenceF Formulation Logic
Study evidence
Niacin Supportive 105 studies

Ingredients

IngredientAmount per servingScore
Niacin (Inositol Hexanicotinate)
400 mg 73
Inositol (Inositol Hexanicotinate)
100 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
C- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyA+ Value
Each serving provides 400 mg of niacin as inositol hexanicotinate, with a no-flush claim. The amount receives a provisional form-specific assessment, and a whole-product serving costs about $0.14.
How this ingredient is rated

Active Ingredient Quality & Bioavailability57

Inositol hexanicotinate is the identified form; its fit for the captured general context and its source receive cautious assessments.
Niacin Form & Goal Alignment
Inositol hexanicotinate receives a cautious assessment for the captured general context.
Precursor Source Quality
The evaluation treats the source provisionally; no premium-source verification is captured in the supplied facts.

Dose, Safety & Label Transparency75

The form and 400 mg of niacin per serving are identified. The saved facts record both a no-flush claim and a flushing warning, and the amount receives a provisional form-specific assessment.
Clarity of Chemical Form
The saved facts identify the form as inositol hexanicotinate.
Form-Specific Dosage Efficacy
The 400 mg of niacin per serving receives a provisional assessment for this form.
Flush Risk & Safety Labeling
The supplied facts record both a no-flush claim and a flushing warning for this product.

Value100

A whole-product serving costs about $0.14; that is the price of the serving, not a separate price for niacin.
Price Per Effective Serving
A whole-product serving costs about $0.14; that is the price of the serving, not a separate price for niacin.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Differential effect of two nicotinic acid preparations on low-density lipoprotein subclass distribution in patients classified as low-density lipoprotein pattern A, B, or I.
    Superko HR; McGovern ME; Raul E; Garrett B · The American journal of cardiology · 2004
    Randomized trial180 participantsHeart Health forNiacin
  2. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  3. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
    Thoenes M; Oguchi A; Nagamia S; Vaccari CS; Hammoud R; Umpierrez GE; Khan BV · International journal of clinical practice · 2008
    Randomized trial50 participantsHeart Health forNiacin
  4. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  5. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials.
    Sahebkar A · Vascular medicine (London, England) · 2014
    Meta-analysis441 participants7 studies pooledHeart Health forNiacin
  6. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
    Hakozaki T; Minwalla L; Zhuang J; Chhoa M; Matsubara A; Miyamoto K; Greatens A; Hillebrand GG; Bissett DL; Boissy RE · The British journal of dermatology · 2002
    Randomized trial138 participantsSkin Health forNiacin
  7. Niacinamide: A B vitamin that improves aging facial skin appearance.
    Bissett DL; Oblong JE; Berge CA · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial50 participantsSkin Health forNiacin
  8. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.
    Chiu PC; Chan CC; Lin HM; Chiu HC · Journal of cosmetic dermatology · 2008
    Randomized trial52 participantsSkin Health forNiacin
  9. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
    Chen AC; Martin AJ; Choy B; Fernández-Peñas P; Dalziell RA; McKenzie CA; Scolyer RA; Dhillon HM; Vardy JL; Kricker A; St George G; Chinniah N; Halliday GM; Damian DL · The New England journal of medicine · 2015
    Randomized trial386 participantsSkin Health forNiacin
  10. Nicotinamide for Skin Cancer Chemoprevention.
    Breglio KF; Knox KM; Hwang J; Weiss R; Maas K; Zhang S; Yao L; Madden C; Xu Y; Hartman RI; Wheless L · JAMA dermatology · 2025
    Cohort study33,822 participantsSkin Health forNiacin