Homocysteine Modulators

Homocysteine Modulators

Solgar4.8 (653 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 60 servings
Goals

Product analysis

66 out of 100

Homocysteine Modulators supplies B vitamins relevant to normal blood formation and nutrient metabolism. Conflicting B6 quantities leave the total unresolved, making dose comparison harder.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality52

The B6 source is identified, but its differing quantity declarations remain unresolved. Folate and betaine lack specific forms, and the named B12 does not establish an absorption advantage.

Ingredient Transparency78

Ingredient amounts are listed, but the B6 declarations differ and should not be added into an assumed total. Folate and betaine forms are unspecified.

Value For Money62

The B6 contribution appears economical, although its total amount remains unresolved. Separate value for folate and B12 is not established.

Customer Satisfaction80

Ratings indicate very positive satisfaction. The feedback base is useful but less extensive than for heavily reviewed formulas.

Product Focus73

The B vitamins share a role in processing homocysteine and supporting normal nutrition. Changes in that blood marker do not establish a predictable heart-health benefit.

Format
Capsule
Container
120 Capsule(s)
Per serving
$0.28
Customer rating
4.8 · 653 ratings
Report analysis

Goals

Impact
Highest effect
A Ingredient FitC PathwaysB+ EvidenceA+ Formulation Logic
Folate · 666 mcg DFEVitamin B12 · 500 mcg
Study evidence
Folate Supportive 80 studies

Ingredients

IngredientAmount per servingScore
Calories
5 Calorie(s)
Vitamin B6 (Pyridoxine Hydrochloride)
50 mg 75
Folate
666 mcg DFE
Vitamin B12 (Cyanocobalamin)
500 mcg 38
Trimethylglycine
1000 mg
Pyridoxal 5-Phosphate
6 mg 75
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Vegetarian
Report overview
A+ Ingredient Form & Label QualityF Dose, Safety & Label TransparencyA+ Value
Each serving provides 50 mg of vitamin B6, at a relatively low cost per milligram. The sources are pyridoxine hydrochloride and pyridoxal 5-phosphate. Their proportions are not disclosed.
How this ingredient is rated

Ingredient Form & Label Quality100

The sources are pyridoxine hydrochloride and pyridoxal 5-phosphate. Their proportions are not disclosed. The listed ingredients do not include artificial colors, titanium dioxide, or talc.
Vitamin B6 Form Identification
The sources are pyridoxine hydrochloride and pyridoxal 5-phosphate. Their proportions are not disclosed.
Clean Label and Excipient Purity
The listed ingredients do not include artificial colors, titanium dioxide, or talc.

Dose, Safety & Label Transparency37

The label states 50 mg of B6 per serving. The source is also named.
Vitamin B6 Dose & Safety Policy
Each serving provides 50 mg of vitamin B6. It is a relatively high amount.
Label Transparency
The label states the amount and source.

Value100

The cost per milligram of B6 is relatively low.
Vitamin B6 Price Efficiency
The cost per milligram of B6 is relatively low.
F Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value
Each serving provides 500 mcg of B12 at a high cost per 1,000 mcg. It uses Cyanocobalamin. The amount falls below the range used for higher needs.
How this ingredient is rated

Active Ingredient Quality & Bioavailability10

It uses Cyanocobalamin.
Bioactive B12 Form Selection
It uses Cyanocobalamin.

Dose, Safety & Label Transparency79

The serving provides 500 mcg, an intermediate amount. The label lists both the Cyanocobalamin form and its amount.
Therapeutic Dosage Level
The serving provides 500 mcg, an intermediate amount.
Label and Form Transparency
The label lists both the Cyanocobalamin form and its amount.

Value10

The cost per 1,000 mcg of B12 is high.
Price per 1,000 mcg B12
The cost per 1,000 mcg of B12 is high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsEveryday Health forFolate
  2. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsEveryday Health forFolate
  3. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsEveryday Health forFolate
  4. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewEveryday Health forFolate
  5. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledEveryday Health forFolate
  6. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsEveryday Health forVitamin B12
  7. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsEveryday Health forVitamin B12
  8. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsEveryday Health forVitamin B12
  9. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsEveryday Health forVitamin B12
  10. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsEveryday Health forVitamin B12