Studies

Explore research connecting ingredients and health goals.

29 ingredient–goal connections

GoalReported findings
SupportiveMixedNo effectAdverseUnclassified

LongevityandHyaluronic Acid

76published studies

Supportive

The available research supports Hyaluronic Acid injections for improving selected cosmetic signs of skin aging. Dermal fillers can soften facial folds and restore volume, while injections intended to improve skin quality have shown benefits for hydration and appearance. Effects on elasticity are less consistent, and results depend on the formulation, injection site and technique.

Many trials compare different fillers rather than testing Hyaluronic Acid against no treatment. Some also use composite products containing other ingredients, making it difficult to isolate Hyaluronic Acid's contribution. Cosmetic improvements can persist, but durability varies and does not mean that the underlying aging process has been reversed.

These findings apply to locally injected products and do not establish comparable benefits from oral supplements or topical skincare. They also provide no evidence of longer life or slower whole-body aging. Injection-site reactions such as swelling are common in some trials, while delayed adverse effects are reported less frequently; those procedure-related risks should remain distinct from the safety of oral products.

76 linked studies · 15 sampled for detail · Sep 27, 2026

Study types

  • Randomized trial31
  • Narrative review14
  • Single-arm trial13
  • Case series3
  • Meta-analysis3
  • Non-randomized trial3
  • Systematic review3
  • Clinical trial2
  • Cohort study2
  • Observational study2

Published by year

  • 5Earlier
  • 32010
  • 12011
  • 22012
  • 02013
  • 12014
  • 42015
  • 22016
  • 12017
  • 02018
  • 22019
  • 22020
  • 72021
  • 42022
  • 92023
  • 42024
  • 92025
  • 202026

Findings over time

Numbers above bars show study counts. Earlier groups years before 2010.

202620 studies

  • Supportive18
  • Mixed2
  • No effect0
  • Adverse0
  • Unclassified0

Population over time

Reported participants by publication year. Select a year to see the total and reporting coverage.

— Participant count not reported. Earlier groups years before 2010.

20264,604 reported participants

Counts reported by 17 of 20 studies. 3 without a reported count.

Totals sum reported counts across studies and reviews; participants may overlap between sources.

Explore this goal

Showing 5 top-ranked studies for Hyaluronic Acid and Longevity.

Top studies

Hyaluronic Acid · LongevityHighest ranked first
  1. Effectiveness and Safety of a Cross-linked Hyaluronic Acid Plus Mannitol Filler for the Correction of Nasolabial Folds in Chinese Subjects: A Randomized, Blinded, Controlled Study.
    2026Randomized trial390 participants

    Aesthetic surgery journal

    SupportiveView source for Effectiveness and Safety of a Cross-linked Hyaluronic Acid Plus Mannitol Filler for the Correction of Nasolabial Folds in Chinese Subjects: A Randomized, Blinded, Controlled Study. (opens in a new tab)
  2. A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study.
    2023Randomized trial146 participants

    The Journal of dermatological treatment

    SupportiveView source for A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study. (opens in a new tab)
  3. Safety and Effectiveness of a Crosslinked Hyaluronic Acid Filler in Korean Patients for the Correction of Nasolabial Folds: A Randomized, Patient- and Evaluator-Blinded, Paired Study.
    2026Randomized trial100 participants

    Aesthetic surgery journal

    SupportiveView source for Safety and Effectiveness of a Crosslinked Hyaluronic Acid Filler in Korean Patients for the Correction of Nasolabial Folds: A Randomized, Patient- and Evaluator-Blinded, Paired Study. (opens in a new tab)
  4. Safety and Efficacy of Hyaluronic Acid-Based Filler for Neck Wrinkles: A Prospective, Multicenter, Randomized, Parallel-Controlled Non-Inferiority Trial.
    2026Randomized trial188 participants

    Clinical, cosmetic and investigational dermatology

    SupportiveView source for Safety and Efficacy of Hyaluronic Acid-Based Filler for Neck Wrinkles: A Prospective, Multicenter, Randomized, Parallel-Controlled Non-Inferiority Trial. (opens in a new tab)
  5. A randomized study showing improved skin quality and aesthetic appearance of dorsal hands after hyaluronic acid gel treatment in a Chinese population.
    2021Randomized trial100 participants

    Journal of cosmetic dermatology

    SupportiveView source for A randomized study showing improved skin quality and aesthetic appearance of dorsal hands after hyaluronic acid gel treatment in a Chinese population. (opens in a new tab)

Counts reflect published studies in our database, not the strength of a benefit. A study may appear in more than one connection.