Studies

Explore research connecting ingredients and health goals.

12 ingredient–goal connections

GoalReported findings
SupportiveMixedNo effectAdverseUnclassified

Nail HealthandBiotin

8published studies

Supportive

The available research suggests that biotin can help some people with brittle, splitting nails. Reported improvements include stronger or thicker nails and less splitting, but much of this evidence comes from uncontrolled observations and small clinical reports. Some people reported no change, so a reliable response cannot be assumed.

Controlled research provides additional support, although interpretation depends on the treatment used. Studies have examined biotin alongside a protective nail lacquer or as part of botanical preparations, sometimes with silica. These findings do not all isolate the effect of ordinary biotin supplementation.

The clearest relevance is to existing nail brittleness rather than enhancing already healthy nails. Nail problems can also reflect physical damage, environmental exposure or underlying conditions, so they are not automatically evidence of a biotin-related problem. Better controlled research is needed to clarify who benefits and how consistently.

8 linked studies · Sep 27, 2026

Study types

  • Narrative review4
  • Randomized trial2
  • Case series1
  • Other1

Published by year

  • 4Earlier
  • 02010
  • 02011
  • 02012
  • 02013
  • 02014
  • 02015
  • 02016
  • 02017
  • 12018
  • 02019
  • 12020
  • 02021
  • 02022
  • 02023
  • 02024
  • 12025
  • 12026

Findings over time

Numbers above bars show study counts. Earlier groups years before 2010.

20261 study

  • Supportive1
  • Mixed0
  • No effect0
  • Adverse0
  • Unclassified0

Population over time

Reported participants by publication year. Select a year to see the total and reporting coverage.

— Participant count not reported. Earlier groups years before 2010.

2025105 reported participants

Counts reported by 1 of 1 studies.

Totals sum reported counts across studies and reviews; participants may overlap between sources.

Explore this goal

Showing 5 top-ranked studies for Biotin and Nail Health.

Top studies

Biotin · Nail HealthHighest ranked first
  1. Biotin for the treatment of nail disease: what is the evidence?
    2018Narrative review

    The Journal of dermatological treatment

    Finding The review reports improvement in brittle-nail firmness, hardness, and thickness in clinical trials of oral biotin.

    SupportiveView source for Biotin for the treatment of nail disease: what is the evidence? (opens in a new tab)
  2. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
    1991Other32 participants

    Journal of the American Academy of Dermatology

    Finding Nail thickness increased significantly by 25% in the eight brittle-nail patients assessed before and after biotin treatment.

    SupportiveView source for Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy. (opens in a new tab)
  3. Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
    2020Randomized trial50 participants

    Dermatologic therapy

    SupportiveView source for Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial. (opens in a new tab)
  4. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    2025Randomized trial105 participants

    Cureus

    SupportiveView source for The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study. (opens in a new tab)
  5. Vitamins and minerals: their role in nail health and disease.
    2007Narrative review

    Journal of drugs in dermatology : JDD

    Finding The review reports that brittle nail syndrome appears to abate with 2.5 mg of biotin daily; this is a review-level report rather than a controlled efficacy estimate.

    SupportiveView source for Vitamins and minerals: their role in nail health and disease. (opens in a new tab)

Counts reflect published studies in our database, not the strength of a benefit. A study may appear in more than one connection.