Studies
Explore research connecting ingredients and health goals.
17 ingredient–goal connections
Eye HealthandRiboflavin
69published studies
The supplied evidence mainly concerns corneal cross-linking, a medical procedure combining riboflavin applied to the eye with ultraviolet light. Controlled trials and pooled research support this approach for slowing progressive keratoconus and related corneal weakening. Vision may improve as well, although stabilization of the cornea is an important benefit even when visual acuity changes little.
The treatment’s results depend on the procedure used. Comparisons of protocols show differences in corneal flattening and disease control, and some approaches that leave the surface layer intact have been less effective. Even effective protocols do not guarantee improved visual acuity for every patient.
Corneal haze, temporary visual changes, surface damage, and occasional loss of vision have been reported, reflecting risks of the combined procedure. These findings should not be interpreted as effects of taking riboflavin orally. Overall, this evidence supports riboflavin’s role within a specific eye treatment, but does not demonstrate routine vision benefits from a riboflavin supplement.
69 linked studies · 22 sampled for detail · Sep 27, 2026
Study types
- Single-arm trial13
- Cohort study10
- Randomized trial9
- Narrative review8
- Case series7
- Observational study7
- Non-randomized trial5
- Clinical trial3
- Meta-analysis3
- Cross-sectional study2
- Systematic review2
Published by year
- 5Earlier
- 02010
- 22011
- 42012
- 22013
- 62014
- 72015
- 52016
- 62017
- 52018
- 22019
- 32020
- 12021
- 82022
- 52023
- 32024
- 32025
- 22026
Findings over time
Numbers above bars show study counts. Earlier groups years before 2010.
20262 studies
- Supportive1(50%)
- Mixed0(0%)
- No effect1(50%)
- Adverse0(0%)
- Unclassified0(0%)
Population over time
Reported participants by publication year. Select a year to see the total and reporting coverage.
— Participant count not reported. Earlier groups years before 2010.
2026109 reported participants
Counts reported by 2 of 2 studies.
Totals sum reported counts across studies and reviews; participants may overlap between sources.
Showing 5 top-ranked studies for Riboflavin and Eye Health.
Top studies
Riboflavin · Eye HealthHighest ranked first- U.S. Multicenter Clinical Trial of Corneal Collagen Crosslinking for Treatment of Corneal Ectasia after Refractive Surgery.SupportiveView source for U.S. Multicenter Clinical Trial of Corneal Collagen Crosslinking for Treatment of Corneal Ectasia after Refractive Surgery. (opens in a new tab)
Ophthalmology
- United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment.SupportiveView source for United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment. (opens in a new tab)
Ophthalmology
- EpiSmart Crosslinking for Keratoconus: A Phase 2 Study.SupportiveView source for EpiSmart Crosslinking for Keratoconus: A Phase 2 Study. (opens in a new tab)
Cornea
- Prospective Randomized Trial of Corneal Cross-linking Riboflavin Dosing Frequencies for Treatment of Keratoconus and Corneal Ectasia.SupportiveView source for Prospective Randomized Trial of Corneal Cross-linking Riboflavin Dosing Frequencies for Treatment of Keratoconus and Corneal Ectasia. (opens in a new tab)
Ophthalmology
- Corneal collagen cross-linking for keratoconus: results of 3-year follow-up in Pakistani population.SupportiveView source for Corneal collagen cross-linking for keratoconus: results of 3-year follow-up in Pakistani population. (opens in a new tab)
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
Counts reflect published studies in our database, not the strength of a benefit. A study may appear in more than one connection.