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Niacinamide

Thorne
4.7
★ ★ ★ ★ ★
(2362 ratings)
Niacin 500 mg
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Score80
A transparent, non-flushing niacinamide capsule with reasonable skin relevance, but limited heart utility and high-dose considerations.
How scoring works
Quantity:180 Capsule(s) • (180 servings)
Goals:
Skin Health

Score 80

A transparent, non-flushing niacinamide capsule with reasonable skin relevance, but limited heart utility and high-dose considerations.
How scoring works
$26.00($0.14 per serving)
iHerb
$ 26.00
Vitacost
$ 26.00
Pure Formulas
$ 26.00
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Analysis

Niacinamide supports cellular energy and may contribute to normal skin-barrier function without causing the classic niacin flush. The single active and exact amount are easy to assess.

Oral skin benefits are less established than topical use, and the capsule provides no collagen or hydration support. Niacinamide also does not have the lipid effects associated with nicotinic acid.

The product fits adults who want a clearly identified niacinamide capsule and accept a substantial amount. Long-term use should account for liver health, glucose control, and other supplemental B3 sources.

Who is it for
  • Adults seeking high-dose niacinamide
  • People wanting a non-flushing capsule
  • Users focused on a single B3 pathway
Best for
  • Niacinamide supplementation
  • Skin-barrier nutrient support
  • Cellular energy metabolism

Pros

  • Form and amount are fully disclosed
  • Non-flushing form
  • Simple single-capsule design

Cons

  • Moderate rather than low serving cost
  • No complementary skin ingredients
  • Poor fit for lipid management

Warnings

  • Long-term high-dose niacinamide may affect liver enzymes
  • People with impaired glucose control should seek guidance before regular use
  • The amount may cause nausea or digestive discomfort

Nutrient quality

75 High impact

Niacinamide is a usable non-flushing vitamin B3 form supplied well above nutritional requirements. Its heart-health fit is limited, and the elevated amount reduces balance for routine use.

Ingredient transparency

87 Highest impact

The active amount and serving size are clear, with no proprietary blend hiding the formula. Non-active ingredients and complete usage directions are not supplied.

Customer satisfaction

71 High impact

The average rating is very strong, with a large review count supporting the signal. No detailed reviews are supplied to assess repeated complaints or intended-use experiences.

Value for money

83 Highest impact

The long supply and simple formula provide reasonable practical value. Premium positioning is harder to justify for a common niacinamide form at an elevated amount.

Report analysis

Goals

Skin Health
Skin Health
Impact
Highest effect
B- Goal FitA Strength of SupportC CoverageA- Formula Quality

Niacinamide may support skin barrier function and a balanced inflammatory response. The clearly stated amount is substantial and avoids the classic niacin flush.

Oral evidence for visible skin outcomes is less established than topical use, so expectations should remain modest. The single-active formula offers good depth but no direct collagen or hydration ingredient.

Study evidence
Niacin Supportive 61 studies

Ingredients

IngredientAmount per serving
Niacin (Niacinamide)
 500 mg
Gluten Free Adults 18–50
Report overview
Niacin (Niacinamide) · 500 mg OverallScore86
A Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyC Value

A clearly labeled 500 mg niacinamide dose aligns well with skin and general niacin use without the classic niacin flush. The capsule uses standard immediate release rather than specialized delivery. Its moderate serving cost offers fair value for a full-dose single-ingredient product.

View ingredientView products
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81 Performance

Niacinamide 500 mg

Nature's Way
<p>A focused niacinamide capsule provides transparent non-flushing vitamin B3 with useful skin-oriented coverage. Compared with the original, it keeps a non-flushing vitamin B3 emphasis while improving dose clarity or everyday practicality; however, the amount is high for routine nutrition and does not substitute for nicotinic acid in lipid-focused use.</p>
82 Performance

Niacinamide 500 mg

Solaray
<p>Clearly named niacinamide offers a non-flushing form suited more to skin and NAD metabolism than lipid management. Compared with the original, it keeps a non-flushing vitamin B3 emphasis while improving dose clarity or everyday practicality; however, the amount exceeds basic nutritional needs and long-term unsupervised use is less suitable.</p>
85 Performance

Niacin 100 mg

Source Naturals
<p>A moderate niacinamide tablet provides clearly identified vitamin B3 without typical nicotinic-acid flushing. Compared with the original, it keeps a non-flushing vitamin B3 emphasis while improving dose clarity or everyday practicality; however, the form is intended for nutritional or skin support rather than lipid-focused effects.</p>
86 Budget

Niacinamide B-3 100 mg

Source Naturals
<p>A clearly identified moderate niacinamide tablet offers simple non-flushing vitamin B3 support with excellent serving economics. Serving cost is lower than the original, but it does not provide nicotinic acid’s lipid-focused effects and complete excipient details are missing.</p>
80 Budget

Niacinamide 500 mg

Best Naturals
<p>Clearly identified niacinamide provides a non-flushing option with useful skin and NAD-metabolism alignment. Serving cost is lower than the original, but the amount is well above basic nutritional needs and is not equivalent to nicotinic acid for lipid-focused use.</p>
82 Budget

Niacinamide 500 mg

NOW
<p>A simple niacinamide capsule provides clearly named non-flushing vitamin B3 with strong skin-goal alignment. Serving cost is lower than the original, but the amount remains high for routine nutrition and does not offer nicotinic acid’s lipid-related effects.</p>
80 Value

Niacinamide 500 mg

21st Century
<p>A low-cost niacinamide tablet supplies non-flushing vitamin B3 with a simple active formula. Its lower serving cost and clearer active design support practical value compared with the original, although the high amount is poorly suited to casual long-term use and is not equivalent to nicotinic acid for lipid goals.</p>
82 Value

No Flush Niacin (Inositol Hexanicotinate) 800 mg

Life Extension
<p>Clearly named inositol hexanicotinate provides substantial flush-free niacin exposure with economical serving value. Its quality-adjusted serving economics and clearer active design support practical value compared with the original, although its cardiovascular effects may be less direct and reliable than those of nicotinic acid.</p>
81 Value

B-Complex with Folic Acid plus Vitamin C

Nature's Bounty
<p>A broad B-complex with vitamin C provides practical daily B-vitamin coverage at very low serving cost. Its lower serving cost and clearer active design support practical value compared with the original, although several forms are conventional, thiamine entries are duplicated, and it is not a dedicated niacin or performance formula.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes).
    Guyton JR; Slee AE; Anderson T; Fleg JL; Goldberg RB; Kashyap ML; Marcovina SM; Nash SD; O'Brien KD; Weintraub WS; Xu P; Zhao XQ; Boden WE · Journal of the American College of Cardiology · 2013
    Randomized trial3,414 participantsCardiovascular Support forNiacin
  2. Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis.
    Mainville L; Smilga AS; Fortin PR · Journal of cutaneous medicine and surgery · 2022
    Meta-analysis3,039 participants29 studies pooledSkin Health forNiacin
  3. Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.
    D'Andrea E; Hey SP; Ramirez CL; Kesselheim AS · JAMA network open · 2020
    Meta-analysis35,760 participants17 studies pooledCardiovascular Support forNiacin
  4. Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.
    Allen NC; Martin AJ; Snaidr VA; Eggins R; Chong AH; Fernandéz-Peñas P; Gin D; Sidhu S; Paddon VL; Banney LA; Lim A; Upjohn E; Schaider H; Ganhewa AD; Nguyen J; McKenzie CA; Prakash S; McLean C; Lochhead A; Ibbetson J; Dettrick A; Landgren A; Allnutt KJ; Allison C; Davenport RB; Mumford BP; Wong B; Stagg B; Tedman A; Gribbin H; Edwards HA; De Rosa N; Stewart T; Doolan BJ; Kok Y; Simpson K; Low ZM; Kovitwanichkanont T; Scolyer RA; Dhillon HM; Vardy JL; Chadban SJ; Bowen DG; Chen AC; Damian DL · The New England journal of medicine · 2023
    Randomized trial158 participantsSkin Health forNiacin
  5. Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar.
    Jenkins DJA; Spence JD; Giovannucci EL; Kim YI; Josse RG; Vieth R; Sahye-Pudaruth S; Paquette M; Patel D; Blanco Mejia S; Viguiliouk E; Nishi SK; Kavanagh M; Tsirakis T; Kendall CWC; Pichika SC; Sievenpiper JL · Journal of the American College of Cardiology · 2021
    Meta-analysisCardiovascular Support forNiacin
  6. A Foodborne Outbreak Traced to Niacin Overenrichment.
    Hudson PJ; Vogt RL · Journal of food protection · 2023
    Case-control study21 participantsSkin Health forNiacin
  7. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  8. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.
    Chiu PC; Chan CC; Lin HM; Chiu HC · Journal of cosmetic dermatology · 2008
    Randomized trial52 participantsSkin Health forNiacin
  9. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  10. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
    Hakozaki T; Minwalla L; Zhuang J; Chhoa M; Matsubara A; Miyamoto K; Greatens A; Hillebrand GG; Bissett DL; Boissy RE · The British journal of dermatology · 2002
    Randomized trial138 participantsSkin Health forNiacin
  11. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group · Atherosclerosis · 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  12. Niacinamide: A B vitamin that improves aging facial skin appearance.
    Bissett DL; Oblong JE; Berge CA · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial50 participantsSkin Health forNiacin
  13. Effectiveness of niacin supplementation for patients with type 2 diabetes: A meta-analysis of randomized controlled trials.
    Xiang D; Zhang Q; Wang YT · Medicine · 2020
    Meta-analysis2,110 participants8 studies pooledCardiovascular Support forNiacin
  14. Nicotinamide for Skin Cancer Chemoprevention.
    Breglio KF; Knox KM; Hwang J; Weiss R; Maas K; Zhang S; Yao L; Madden C; Xu Y; Hartman RI; Wheless L · JAMA dermatology · 2025
    Cohort study33,822 participantsSkin Health forNiacin
  15. Niacin improves lipid profile but not endothelial function in patients with coronary artery disease on high dose statin therapy.
    Philpott AC; Hubacek J; Sun YC; Hillard D; Anderson TJ · Atherosclerosis · 2013
    Randomized trial66 participantsCardiovascular Support forNiacin
  16. Niacin intake and risk of skin cancer in US women and men.
    Park SM; Li T; Wu S; Li WQ; Weinstock M; Qureshi AA; Cho E · International journal of cancer · 2017
    Cohort study114,116 participantsSkin Health forNiacin
  17. Effects of HDL-modifiers on cardiovascular outcomes: a meta-analysis of randomized trials.
    Verdoia M; Schaffer A; Suryapranata H; De Luca G · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2015
    Meta-analysis69,515 participants18 studies pooledCardiovascular Support forNiacin
  18. Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide.
    Kawada A; Konishi N; Oiso N; Kawara S; Date A · The Journal of dermatology · 2008
    Randomized trial30 participantsSkin Health forNiacin
  19. Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial.
    Elam MB; Hunninghake DB; Davis KB; Garg R; Johnson C; Egan D; Kostis JB; Sheps DS; Brinton EA · JAMA · 2000
    Randomized trial468 participantsCardiovascular Support forNiacin
  20. Chemoprevention of keratinocyte carcinomas and actinic keratoses in adults who were immunocompetent: a systematic review.
    Susanto A; Morgan E; Lindsay D; Collins LG · Clinical and experimental dermatology · 2026
    Systematic review7,355 participants11 studies pooledSkin Health forNiacin
  21. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
    Chen AC; Martin AJ; Choy B; Fernández-Peñas P; Dalziell RA; McKenzie CA; Scolyer RA; Dhillon HM; Vardy JL; Kricker A; St George G; Chinniah N; Halliday GM; Damian DL · The New England journal of medicine · 2015
    Randomized trial386 participantsSkin Health forNiacin