No Flush Niacin (Inositol Hexanicotinate) 800 mg
Life Extension
No Flush Niacin (Inositol Hexanicotinate) 800 mg
4.7
★ ★ ★ ★ ★
(3340 ratings)
Niacin 640 mg
Score 85.0
A high-dose, cost-effective no-flush niacin from a premium brand, ideal for broad B3 support without side effects, though less potent for cholesterol.
Quantity: 100 Capsule(s)Servings size: 1 Capsule(s) (100 servings)
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Mood Support
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Brain Health
Heart Health
Cardiovascular Support
leaderboard Score 85.0
A high-dose, cost-effective no-flush niacin from a premium brand, ideal for broad B3 support without side effects, though less potent for cholesterol.
insights Analysis
This product by Life Extension delivers a robust dose of niacin in the well-tolerated inositol hexanicotinate form, which is designed to provide Vitamin B3 benefits without the common skin flushing. It is particularly effective for supporting cellular metabolism, boosting energy, and promoting skin health due to its significant niacin content. What sets this product apart in its category is its excellent value, combining a higher dosage (640mg Niacin) with a lower price per serving compared to many alternatives. Online reviews frequently praise its effectiveness and lack of side effects, making it a highly regarded choice for those seeking comprehensive B3 supplementation without discomfort.
- Offers a high dose of niacin (640mg) in a single serving, enhancing efficacy.
- Excellent price-per-serving within the no-flush niacin market, providing superior value.
- Comes from Life Extension, a highly respected brand known for science-backed formulations and quality.
- Effectively prevents the undesirable 'niacin flush' reaction.
- Similar to other no-flush forms, it is generally less effective for significant cholesterol lowering than nicotinic acid.
- The higher per-bottle cost might be a barrier for initial purchase despite its long-term value.
- The very high dose might be excessive for individuals only seeking minimal daily niacin supplementation.
$15.00($0.15 per serving)
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bolt Effectiveness for goals
Niacin is known as one of the most effective agents for increasing high-density lipoprotein (HDL) cholesterol levels. It can significantly raise HDL, which is often considered beneficial for cardiovascular health. However, studies have shown that this increase in HDL does not always translate to a reduction in cardiovascular events.
While Niacin can contribute to lowering LDL cholesterol, its primary effect on lipids is typically a more significant reduction in triglycerides and an increase in HDL cholesterol. For LDL reduction, it is generally considered less potent than statins and often used in conjunction with other lipid-lowering therapies if prescribed.
Yes, Niacin is highly effective at reducing elevated triglyceride levels. It achieves this by decreasing the liver's production of very low-density lipoprotein (VLDL), which is a precursor to triglycerides and LDL cholesterol. This makes it a common consideration for individuals with hypertriglyceridemia.
Niacin, also known as vitamin B3, is primarily recognized for its role in preventing and treating pellagra, a deficiency disease. In supplement form, it has been extensively studied for its effects on cholesterol and triglyceride levels. Its physiological functions include energy metabolism and DNA repair.
Niacin can be used in combination with statins to further improve lipid profiles, particularly to increase HDL and lower triglycerides. However, some studies have shown that adding Niacin to statin therapy does not consistently provide additional cardiovascular benefits and may increase the risk of side effects such as myopathy (muscle pain) when taken with certain statins. Medical supervision is essential for this combination.
schedule Dosage, timing & forms
Nicotinic acid is the form most commonly associated with the 'niacin flush' and is often used at higher doses for specific health support under medical supervision. Niacinamide (nicotinamide) generally does not cause flushing and is often preferred for general vitamin B3 supplementation, though it has different metabolic effects compared to nicotinic acid. Their applications can differ significantly.
'Flush-free' niacin, often inositol hexanicotinate, is a form where niacin is chemically bound to inositol, a sugar-like compound. This bond leads to a slow, gradual release of niacin in the body, significantly reducing or eliminating the rapid vasodilation that causes the common flushing sensation. It's often chosen by individuals sensitive to the flush.
To minimize the niacin flush from immediate-release nicotinic acid, individuals can start with a very low dose and gradually increase it over time. Taking it with a non-fatty meal, avoiding hot beverages or alcohol around the time of dosing, and potentially taking aspirin 30 minutes beforehand (if medically appropriate and advised) can also help. Slow and steady increases in dosage are key.
Immediate-release niacin (nicotinic acid) is absorbed quickly, leading to a rapid peak effect and often a pronounced, but temporary, flush. Extended-release forms are designed to release niacin slowly over several hours, which can help reduce the intensity and duration of the flush and may allow for less frequent dosing. The slower release aims to improve tolerance.
Niacin is available in several forms, including nicotinic acid (immediate-release and extended-release), niacinamide (nicotinamide), and inositol hexanicotinate (often marketed as 'no-flush' niacin). Each form has distinct properties and effects within the body. The choice of form can influence how it is absorbed and its potential side effects.
health_and_safety Safety & interactions
The niacin flush is a common side effect characterized by redness, itching, warmth, and tingling, primarily on the face, neck, and chest. It is caused by the release of prostaglandins, which dilate blood vessels. Taking niacin with food, starting with a low dose and gradually increasing it, or taking a low-dose aspirin before niacin may help reduce the flush.
High doses of niacin, particularly sustained-release forms, have been associated with elevated liver enzymes and, in rare cases, liver toxicity. Regular monitoring of liver function by a healthcare professional is often recommended when taking high-dose niacin. Individuals with pre-existing liver conditions should avoid niacin unless specifically advised by a doctor.
Yes, niacin can interact with several medications. It may enhance the effects of blood pressure-lowering drugs, potentially causing hypotension, and can increase the risk of myopathy when taken with statins. Niacin might also interact with blood thinners, antidiabetic medications, and gout medications. Consulting a healthcare provider about all current medications before starting niacin is important.
Individuals with active liver disease, severe hypotension, active peptic ulcer disease, or active bleeding should generally avoid niacin supplements. Those with a history of gout, diabetes, or gallbladder disease should also use niacin with caution and under medical supervision. Consultation with a healthcare provider is essential to determine suitability.
High doses of niacin, particularly nicotinic acid, can sometimes increase blood glucose levels. This effect is more pronounced in individuals with diabetes or prediabetes. People managing their blood sugar should monitor their levels closely if taking niacin and discuss its use with a healthcare provider.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Niacin | 640 mg |
Inositol Hexanicotinate | 800 mg |
Inositol | 160 mg |
Categories
Niacin 85.0
This product represents a high-quality Niacin option due to its potent dose and 'no-flush' characteristic, making it comfortable for daily use. Its excellent value for a leading brand places it highly within the Niacin collection, particularly for those prioritizing general health and avoiding side effects.
Goals
Skin Health 90.0
With a substantial 640mg of niacin, this product offers excellent support for skin health, aiding in barrier function, reducing redness, and promoting a healthy complexion without inducing the uncomfortable flush associated with other niacin forms. The higher dosage could provide more noticeable benefits for those seeking skin improvements.
Energy 88.0
Niacin is fundamental for energy production, as it is converted into NAD+, a crucial coenzyme in cellular respiration. The generous 640mg dosage in this no-flush form ensures ample supply of B3 to support efficient energy metabolism, helping to combat fatigue and maintain vitality without causing disruptive side effects.
Metabolism Boost 88.0
As a key player in metabolic pathways for fats, carbohydrates, and proteins, niacin is essential for converting nutrients into energy. This high-dose no-flush product provides significant support for these metabolic processes, aiding in nutrient utilization and promoting an efficient internal environment for overall metabolic function.
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