Product Image

Microbiome

Host Defense MycoBotanicals
4.8
★ ★ ★ ★ ★
(104 ratings)
Hericium mushroom 570 mg
Reishi mushroom 570 mg
Product Image
Score64
A microbiome-focused powder with some lion’s mane, but too little cognitive specificity and disclosure for focus-oriented use.
How scoring works
Quantity:3 Ounce(s) • (33 servings)
Goals:

Score 64

A microbiome-focused powder with some lion’s mane, but too little cognitive specificity and disclosure for focus-oriented use.
How scoring works
$23.96($0.72 per serving)
Pure Formulas
$ 23.96
iHerb
$ 23.97
Report prices

Analysis

Lion’s mane supplies the main brain-related ingredient at a practical midrange amount. Reishi and turkey tail lean more toward immune support, while marshmallow, burdock, and the probiotic blend center the formula on digestive use.

The lion’s mane label does not identify fruiting body, extraction, beta-glucans, or erinacines. Without those details, its likely cognitive contribution is difficult to estimate.

The powder offers broad gut-and-mushroom coverage at a competitive serving cost. People shopping for focus, productivity, or memory would get a clearer fit from a dedicated lion’s mane product with active characterization.

Who is it for
  • Adults primarily seeking a microbiome and mushroom blend
  • Users who view cognitive support as a secondary benefit
Best for
  • Broad digestive and mushroom routines
  • Powder users not seeking acute focus

Pros

  • Practical lion’s mane amount
  • Includes reishi and turkey tail
  • Adds marshmallow and burdock
  • Contains a probiotic blend

Cons

  • Weak direct fit for cognitive goals
  • Lion’s mane part and extraction are unknown
  • No beta-glucan or erinacine data
  • Probiotic strains and counts are not disclosed

Warnings

  • Marshmallow may slow absorption of oral medicines, so separate the powder from prescriptions according to professional guidance.
  • Avoid use if any included mushroom has caused an allergic reaction.
  • The unspecified probiotic blend may be unsuitable for people who are severely immunocompromised.
  • Burdock and the mushroom blend may cause digestive changes when first introduced.

Nutrient quality

69 High impact

Mushroom quality and probiotic identity are weakly characterized; the botanicals have moderate amounts, but the probiotic blend lacks strains and viable counts. No disclosed amount appears excessive; the ingredients fit microbiome and immune support better than the listed cognitive goals; several actives broaden the formula but dilute its cognitive focus.

.

Ingredient transparency

55 Moderate impact

Most listed actives have specific amounts; no hidden blend obscures key doses except where noted. Common names are clear, but mushroom parts, extraction details, and probiotic strains are missing; serving directions and inactive ingredients are not supplied.

.

Customer satisfaction

70 High impact

The supplied aggregate average is favorable, though no individual feedback is available; the rating sample is moderate, but no individual feedback is supplied. Detailed feedback is absent, so repeated complaints cannot be assessed; real-world fit with the intended purpose remains uncertain.

.

Value for money

67 High impact

Broad coverage offers fair value despite weak active characterization; the serving cost is moderate for the stated botanical amounts. The wide ingredient mix dilutes value for users seeking focused cognitive support; more clearly standardized microbiome formulas may offer stronger category value.

.
Report analysis

Ingredients

IngredientAmount per serving
Marshmallow
580 mg
Burdock
580 mg
Turkey Tail
570 mg
Reishi
570 mg
Lions Mane
570 mg
Probiotic Blend
130 mg
Gluten Free Adults 18–50 Organic Vegetarian
Report overview
Hericium mushroom · 570 mg OverallScore44
F Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyB+ Value

The formula supplies 570 mg of Lion's Mane, a practical midrange amount within a broader botanical blend. The label does not identify fruiting body, extraction, or beta-glucan standardization. A competitive serving cost supports value, though active quality cannot be verified.

View ingredientView products
Loading alternative details
83 Performance

Lion's Mane Capsules

Real Mushrooms
<p>One gram of lion's mane extract identifies beta-glucans and provides a focused, well-specified formula, giving it a stronger fit for mushroom support within a gut-and-immune routine. The single-mushroom design omits the original formula's gut-support botanicals. It does not replace the original marshmallow, burdock, or probiotic blend.</p>
79 Performance

Lion's Mane 1500 mg

Nature's Answer
<p>A 1,500 mg organic lion's mane fruiting-body extract provides substantial cognitive-focused mushroom support, giving it a stronger fit for mushroom support within a gut-and-immune routine. Beta-glucan standardization is not supplied. It does not replace the original marshmallow, burdock, or probiotic blend.</p>
79 Performance

Super Reishi

Mushroom Wisdom
<p>Seven hundred milligrams of reishi fruiting-body double extract provides useful source and preparation detail, giving it a stronger fit for mushroom support within a gut-and-immune routine. Active-compound standardization remains incomplete. It does not replace the original marshmallow, burdock, or probiotic blend.</p>
78 Budget

Lion's Mane

Fungiology by California Gold Nutrition
<p>A practical lion's mane amount provides a very low-cost single-mushroom option while lowering the recurring cost. Repeated entries and missing fruiting-body and beta-glucan details weaken quality confidence. It does not replace the original marshmallow, burdock, or probiotic blend.</p>
82 Budget

Reishi Mushroom Extract

Double Wood Supplements
<p>One gram of reishi fruit extract provides a simple, very low-cost formula while lowering the recurring cost. Fruiting-body status, extraction ratio, and active-compound standardization are not identified. It does not replace the original marshmallow, burdock, or probiotic blend.</p>
83 Budget

Reishi Mushroom Extract 500 mg

Swanson Superior Herbs
<p>Five hundred milligrams of reishi extract with polysaccharide emphasis provides focused mushroom support while lowering the recurring cost. The polysaccharide percentage, fruiting-body source, and extraction ratio are not stated. It does not replace the original marshmallow, burdock, or probiotic blend.</p>
77 Value

Lion's Mane Mushroom 500 mg Full Spectrum

Swanson
<p>Five hundred milligrams of lion's mane provides a simple, low-cost cognitive option, creating a useful quality-to-cost trade-off for mushroom support within a gut-and-immune routine. Fruiting-body and beta-glucan details are missing. It does not replace the original marshmallow, burdock, or probiotic blend.</p>
78 Value

Lion's Mane

Pure Essence MyPure
<p>Five hundred milligrams of organic lion's mane extract offers focused mushroom support at low recurring cost, creating a useful quality-to-cost trade-off for mushroom support within a gut-and-immune routine. Fruiting-body source and active-compound standardization are not supplied. It does not replace the original marshmallow, burdock, or probiotic blend.</p>
81 Value

Reishi Mushroom 1500 mg

Nutricost
<p>A clearly stated 1,500 mg reishi amount offers straightforward quantity value, creating a useful quality-to-cost trade-off for mushroom support within a gut-and-immune routine. Mushroom part, extraction method, and active-compound potency are not identified. It does not replace the original marshmallow, burdock, or probiotic blend.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition.
    Grozier CD; Alves VA; Killen LG; Simpson JD; O'Neal EK; Waldman HS · International journal of exercise science · 2025
    Non-randomized trial24 participantsBrain Health Productivity Boost Cognitive Support forHericium mushroom
  2. Acute effects of a standardised extract of Hericium erinaceus (Lion's Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study.
    Surendran G; Saye J; Binti Mohd Jalil S; Spreadborough J; Duong K; Shatwan IM; Lilley D; Heinrich M; Dodd GF; Surendran S · Frontiers in nutrition · 2025
    Randomized trial18 participantsBrain Health Mental Focus forHericium mushroom
  3. A review of the effects of mushrooms on mood and neurocognitive health across the lifespan.
    Cha S; Bell L; Shukitt-Hale B; Williams CM · Neuroscience and biobehavioral reviews · 2024
    Systematic review34 studies pooledBrain Health forHericium mushroom
  4. Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance.
    La Monica MB; Raub B; Ziegenfuss EJ; Hartshorn S; Grdic J; Gustat A; Sandrock J; Ziegenfuss TN · Nutrients · 2023
    Randomized trialProductivity Boost Brain Health forHericium mushroom
  5. Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study.
    Li IC; Chang HH; Lin CH; Chen WP; Lu TH; Lee LY; Chen YW; Chen YP; Chen CC; Lin DP · Frontiers in aging neuroscience · 2024
    Randomized trialCognitive Support forHericium mushroom
  6. Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review.
    Menon A; Jalal A; Arshad Z; Nawaz FA; Kashyap R · Frontiers in nutrition · 2025
    Systematic review26 studies pooledCognitive Support forHericium mushroom
  7. The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study.
    Docherty S; Doughty FL; Smith EF · Nutrients · 2023
    Randomized trial41 participantsCognitive Support Brain Health forHericium mushroom
  8. Improvement of cognitive functions by oral intake of Hericium erinaceus.
    Saitsu Y; Nishide A; Kikushima K; Shimizu K; Ohnuki K · Biomedical research (Tokyo, Japan) · 2020
    Randomized trialBrain Health Cognitive Support forHericium mushroom
  9. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.
    Mori K; Inatomi S; Ouchi K; Azumi Y; Tuchida T · Phytotherapy research : PTR · 2009
    Randomized trial30 participantsBrain Health Cognitive Support forHericium mushroom
  10. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake.
    Nagano M; Shimizu K; Kondo R; Hayashi C; Sato D; Kitagawa K; Ohnuki K · Biomedical research (Tokyo, Japan) · 2010
    Randomized trial30 participantsBrain Health forHericium mushroom
  11. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
    Lewis JE; Poles J; Shaw DP; Karhu E; Khan SA; Lyons AE; Sacco SB; McDaniel HR · Journal of clinical and translational research · 2023
    Narrative reviewBrain Health forHericium mushroom
  12. Over the Counter Supplements for Memory: A Review of Available Evidence.
    Hersant H; He S; Maliha P; Grossberg G · CNS drugs · 2023
    Narrative reviewBrain Health forHericium mushroom