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FertilityBlend Men

The Daily Wellness Company
4.5
★ ★ ★ ★ ★
(2798 ratings)
Vitamin E 150 IU
Selenium 70 mcg
Folate 400 mcg
Product Image
Score45
A basic antioxidant and mineral base wrapped around an undisclosed proprietary blend. The missing ingredient-level detail prevents a confident fertility, safety, or value assessment.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Anti-Inflammatory Support
Immunity
Hair Health
General Health

Score 45

A basic antioxidant and mineral base wrapped around an undisclosed proprietary blend. The missing ingredient-level detail prevents a confident fertility, safety, or value assessment.
How scoring works
$32.99($1.09 per serving)
iHerb
$ 36.99
Amazon
$ 32.99
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Analysis

The disclosed nutrients cover antioxidants and basic micronutrients that can support general reproductive nutrition. Zinc is useful, while folic acid, cyanocobalamin, and sodium selenite are conventional rather than standout forms.

A 900 mg proprietary blend accounts for much of the serving without revealing its components or their amounts in the supplied data. Efficacy, safety, and interaction potential therefore cannot be judged for the formula’s main differentiator.

Two capsules are manageable, but the serving remains costly for what can be assessed. A transparent male fertility formula with individually listed actives would be easier to evaluate and use responsibly.

Who is it for
  • Men considering a fertility-focused supplement
  • Users whose clinician has reviewed the proprietary blend
  • Adults seeking antioxidant nutrients with zinc
Best for
  • Basic antioxidant coverage
  • Zinc and selenium supplementation
  • Use only when full blend details are available

Pros

  • Provides vitamin C and natural vitamin E
  • Includes 15 mg zinc
  • Two-capsule serving
  • Supplies folic acid and selenium

Cons

  • Proprietary blend hides ingredients and amounts
  • Uses conventional folate and B12 forms
  • Selenium is sodium selenite
  • Weak value for the disclosed formula

Warnings

  • The undisclosed blend cannot be screened for medicine interactions or allergens from the supplied data.
  • High vitamin E intake may add to bleeding risk with anticoagulant or antiplatelet medicines.
  • Zinc can reduce absorption of tetracycline and quinolone antibiotics if taken too close together.
  • Men using fertility medicines or being evaluated for infertility should have the complete blend reviewed by their clinician.

Nutrient quality

49 Lower impact

Many nutrients use conventional forms with limited absorption advantages. Visible vitamins and minerals are useful, but hidden blend doses cannot be assessed.

.

Ingredient transparency

39 Lower impact

The proprietary blend has only a total weight and hides individual doses. A complete excipient list is not available in the supplied data.

.

Customer satisfaction

71 High impact

The average rating is moderately positive. The large rating volume provides a reliable satisfaction signal.

.

Value for money

25 Situational impact

The supply provides weak value per effective serving. Numerous weak or opaque additions reduce practical value.

.
Report analysis

Goals

Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Moderate effect
C+ Goal FitB- Strength of SupportC+ CoverageD Formula Quality
Vitamin E · 150 IUVitamin C · 120 mg

Natural vitamin E, vitamin C, zinc, and selenium support antioxidant defenses that may help regulate inflammatory stress. The natural d-alpha form is a meaningful quality strength.

The formula lacks mixed tocopherols and tocotrienols, narrowing vitamin E coverage. A large proprietary botanical blend hides individual ingredients and doses, making the wider contribution difficult to assess.

Study evidence
Selenium Supportive 34 studies
Vitamin C Supportive 50 studies
Vitamin E Supportive 20 studies
Zinc Supportive 64 studies
Immunity
Immunity
Impact
Moderate effect
B- Goal FitC- Strength of SupportC CoverageC- Formula Quality
Vitamin C · 120 mgZinc · 15 mgSelenium · 70 mcg

Zinc reaches a meaningful immune-support amount and is joined by vitamin C, vitamin E, and selenium. These nutrients provide antioxidant and cellular support within a fertility-focused formula.

Vitamin C and selenium are modest, while a large proprietary botanical blend prevents dose assessment. Its immune contribution is secondary and less transparent than its label breadth suggests.

Study evidence
Selenium Mixed 37 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 21 studies
Zinc Supportive 73 studies
Hair Health
Hair Health
Impact
Moderate effect
D+ Goal FitC- Strength of SupportC- CoverageF Formula Quality
Zinc · 15 mgVitamin C · 120 mg

Zinc, folate, vitamin B12, selenium, and antioxidant vitamins can support hair when intake is inadequate. The formula is designed for male fertility and hides a large botanical blend, so its hair-specific contribution is uncertain.

Zinc gluconate and disclosed vitamin amounts allow partial assessment, while individual botanicals cannot be judged. The product lacks keratin, iron, vitamin D, lysine, and a clearly identified androgen-targeting active.

Study evidence
Folate Mixed 15 studies
Selenium Disputed 7 studies
Zinc Supportive 22 studies
General Health
General Health
Impact
Moderate effect
D+ Goal FitD Strength of SupportC- CoverageD Formula Quality
Folate · 400 mcgVitamin B12 · 6 mcgSelenium · 70 mcgZinc · 15 mgVitamin C · 120 mg

The formula combines vitamins, zinc, selenium, and a botanical blend around male fertility rather than broad everyday health. Several nutrients still support antioxidant defenses and normal reproductive physiology.

Standard folic acid, cyanocobalamin, sodium selenite, and an undisclosed 900 mg proprietary blend limit form quality and transparency. The specialized purpose and hidden botanical amounts make it a weak choice for someone seeking balanced foundational nutrition.

Study evidence
Folate Supportive 80 studies
Selenium Supportive 70 studies
Zinc Supportive 60 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 120 mg
Vitamin E (D-Alpha-Tocopherol)
 150 IU
Vitamin B6 (Pyridoxine Hydrochloride)
 2 mg
Vitamin B12 (Cyanocobalamin)
 6 mcg
Folate (Folic Acid)
 400 mcg
Zinc (Zinc Gluconate)
 15 mg
Selenium (Sodium Selenite)
 70 mcg
Proprietary Blend
900 mg
Men 18–50
Report overview
Vitamin E (D-Alpha-Tocopherol) · 150 IU OverallScore63
D Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD- Value

The natural d-alpha-tocopherol form and moderate dose are well aligned with general antioxidant support. The formula lacks mixed tocopherols and tocotrienols, limiting the range of vitamin E compounds. Its above-median cost is also hard to justify without those premium additions.

View ingredientView products
Selenium (Sodium Selenite) · 70 mcg OverallScore45
F Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

The disclosed sodium selenite is an inorganic selenium source with lower retention than preferred organic forms. The modest dose supports basic daily intake but falls short of the main clinical target and leaves a wide safety margin. The cost adjusted to the target dose is very high when adjusted to the target selenium dose. Other value comes from fertility-support ingredients rather than selenium alone.

View ingredientView products
Folate (Folic Acid) · 400 mcg OverallScore36
F Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value

Synthetic folic acid requires several conversion steps and offers less certainty for people with reduced folate conversion. The listed amount can supply a generally useful folate intake, but the label does not state DFE and may obscure actual biological potency. The formula includes some vitamin B12, though its modest dose and the high cost for a basic folic acid blend limit its appeal.

View ingredientView products
Loading alternative details
81 Performance

Natural E-400

Protocol For Life Balance
<p>Natural vitamin E with mixed tocopherols and selenium creates a focused antioxidant formula. Clearer active ingredients make the formula easier to assess than the original’s large proprietary fertility blend. It is not a direct substitute for a complete male preconception plan.</p>
65 Performance

ProFlo Prostate Health Complex

Urinozinc
<p>Standardized saw palmetto is present at a meaningful amount, but the undisclosed Pro-Flo blend prevents a full assessment of the formula. Clearer active ingredients make the formula easier to assess than the original’s large proprietary fertility blend. It is not a direct substitute for a complete male preconception plan.</p>
55 Performance

Enzyme Nutrition Multi-Vitamin Two Daily

Enzymedica
<p>Natural mixed vitamin E, vitamin D3, beta-carotene, and a broad multivitamin base offer useful nutritional coverage. Clearer active ingredients make the formula easier to assess than the original’s large proprietary fertility blend. It is not a direct substitute for a complete male preconception plan.</p>
68 Budget

Men's Daily Adult Gummy

Equate
<p>The gummy covers several vitamins but omits many minerals and supplies only small amounts of zinc and vitamin D. Its lower serving cost improves economy compared with the original. It provides general nutrition rather than replacing a male fertility-specific formula.</p>
69 Budget

VitaCraves Men's Gummies

Bayer One A Day
<p>The gummy offers convenient broad vitamin coverage with useful biotin, selenium, and iodine. Its lower serving cost improves economy compared with the original. It provides general nutrition rather than replacing a male fertility-specific formula.</p>
75 Budget

Multi Adult Gummies

Nature Made
<p>Broad vitamin coverage and very low serving cost make this a practical basic multivitamin gummy. Its lower serving cost improves economy compared with the original. It provides general nutrition rather than replacing a male fertility-specific formula.</p>
73 Value

Muti Vitamin Raspberry Flavor

Yum-V's Complete
<p>Vitamin D3, vitamin C, folate, and several B vitamins create useful basic adult coverage. Lower serving cost and more visible nutrient information improve practical value over the original’s opaque premium blend. The candidate is not a direct male fertility replacement.</p>
43 Value

Fertility Blend Women

The Daily Wellness Company
<p>Several vitamins and minerals support preconception nutrition, but magnesium oxide, folic acid, cyanocobalamin, and sodium selenite are less favorable forms. Lower serving cost and more visible nutrient information improve practical value over the original’s opaque premium blend. The candidate is not a direct male fertility replacement.</p>
40 Value

RM-10 Ultra

Garden of Life
<p>Selenium, lycopene, folate, vitamin B12, and mushroom ingredients may support general nutrition and immune function. Lower serving cost and more visible nutrient information improve practical value over the original’s opaque premium blend. The candidate is not a direct male fertility replacement.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Selenium supplementation for the primary prevention of cardiovascular disease.
    Rees K; Hartley L; Day C; Flowers N; Clarke A; Stranges S · The Cochrane database of systematic reviews · 2013
    Meta-analysis19,715 participants12 studies pooledGeneral Health forSelenium
  2. Serum folate deficiency and the risks of dementia and all-cause mortality: a national study of old age.
    Rotstein A; Kodesh A; Goldberg Y; Reichenberg A; Levine SZ · Evidence-based mental health · 2022
    Cohort study27,188 participantsGeneral Health forFolate
  3. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledGeneral Health forFolate
  4. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis.
    Bjelakovic G; Nikolova D; Gluud LL; Simonetti RG; Gluud C · JAMA · 2007
    Meta-analysis232,606 participants68 studies pooledGeneral Health forSelenium
  5. Effect of long-term selenium supplementation on mortality: Results from a multiple-dose, randomised controlled trial.
    Rayman MP; Winther KH; Pastor-Barriuso R; Cold F; Thvilum M; Stranges S; Guallar E; Cold S · Free radical biology & medicine · 2019
    Randomized trial491 participantsGeneral Health forSelenium
  6. A randomized controlled trial examining the addition of folic acid to iron supplementation in the treatment of postpartum anemia.
    Van Der Woude DA; De Vries J; Van Wijk EM; Verzijl JM; Pijnenborg JM · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2015
    Randomized trial112 participantsGeneral Health forFolate
  7. Circulating Selenium and Cardiovascular or All-Cause Mortality in the General Population: a Meta-Analysis.
    Xiang S; Dai Z; Man C; Fan Y · Biological trace element research · 2021
    Meta-analysis25,667 participants12 studies pooledGeneral Health forSelenium
  8. Association of folate intake with cardiovascular-disease mortality and all-cause mortality among people at high risk of cardiovascular-disease.
    Xu X; Wei W; Jiang W; Song Q; Chen Y; Li Y; Zhao Y; Sun H; Yang X · Clinical nutrition (Edinburgh, Scotland) · 2022
    Cohort study14,234 participantsGeneral Health forFolate
  9. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  10. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  11. Association Between Folate and Health Outcomes: An Umbrella Review of Meta-Analyses.
    Bo Y; Zhu Y; Tao Y; Li X; Zhai D; Bu Y; Wan Z; Wang L; Wang Y; Yu Z · Frontiers in public health · 2021
    Meta-analysis108 studies pooledGeneral Health forFolate
  12. Selenium, antioxidants, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials.
    Jenkins DJA; Kitts D; Giovannucci EL; Sahye-Pudaruth S; Paquette M; Blanco Mejia S; Patel D; Kavanagh M; Tsirakis T; Kendall CWC; Pichika SC; Sievenpiper JL · The American journal of clinical nutrition · 2021
    Meta-analysis43 studies pooledGeneral Health forSelenium
  13. Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.
    Bedson E; Bell D; Carr D; Carter B; Hughes D; Jorgensen A; Lewis H; Lloyd K; McCaddon A; Moat S; Pink J; Pirmohamed M; Roberts S; Russell I; Sylvestre Y; Tranter R; Whitaker R; Wilkinson C; Williams N · Health technology assessment (Winchester, England) · 2015
    Randomized trial475 participantsGeneral Health forFolate
  14. Selenium intake and multiple health-related outcomes: an umbrella review of meta-analyses.
    Wang P; Chen B; Huang Y; Li J; Cao D; Chen Z; Li J; Ran B; Yang J; Wang R; Wei Q; Dong Q; Liu L · Frontiers in nutrition · 2024
    Systematic reviewGeneral Health forSelenium
  15. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  16. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  17. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  18. The association of low selenium and renal insufficiency with coronary heart disease and all-cause mortality: NHANES III follow-up study.
    Eaton CB; Abdul Baki AR; Waring ME; Roberts MB; Lu B · Atherosclerosis · 2011
    Cohort study10,531 participantsGeneral Health forSelenium
  19. Adjunctive folate for major mental disorders: A systematic review.
    Zheng W; Li W; Qi H; Xiao L; Sim K; Ungvari GS; Lu XB; Huang X; Ning YP; Xiang YT · Journal of affective disorders · 2021
    Meta-analysis1,520 participants14 studies pooledGeneral Health forFolate
  20. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  21. Selenium and the course of mild Graves' orbitopathy.
    Marcocci C; Kahaly GJ; Krassas GE; Bartalena L; Prummel M; Stahl M; Altea MA; Nardi M; Pitz S; Boboridis K; Sivelli P; von Arx G; Mourits MP; Baldeschi L; Bencivelli W; Wiersinga W; European Group on Graves' Orbitopathy · The New England journal of medicine · 2011
    Randomized trial159 participantsAnti-Inflammatory Support forSelenium
  22. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial.
    Asemi Z; Jamilian M; Mesdaghinia E; Esmaillzadeh A · Nutrition (Burbank, Los Angeles County, Calif.) · 2016
    Randomized trial70 participantsAnti-Inflammatory Support forSelenium
  23. Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease.
    Farrokhian A; Bahmani F; Taghizadeh M; Mirhashemi SM; Aarabi MH; Raygan F; Aghadavod E; Asemi Z · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2017
    Randomized trial60 participantsAnti-Inflammatory Support forSelenium
  24. The effects of selenium supplementation on cardiovascular risk factors in patients with metabolic diseases ‒ A systematic review and meta-analysis of randomized controlled trials.
    Qiu W; Huang N; Zhang K; Qiu H; Guo Z; Han F; Sun X; Hou N; Kan C · Nutricion hospitalaria · 2026
    Meta-analysis656 participants11 studies pooledAnti-Inflammatory Support forSelenium
  25. Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Kamali A; Amirani E; Asemi Z · Biological trace element research · 2020
    Randomized trial33 participantsAnti-Inflammatory Support forSelenium
  26. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  27. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  28. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  29. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  30. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  31. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  32. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  33. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  34. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  35. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  36. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent.
    Bao B; Prasad AS; Beck FW; Fitzgerald JT; Snell D; Bao GW; Singh T; Cardozo LJ · The American journal of clinical nutrition · 2010
    Randomized trial40 participantsAnti-Inflammatory Support forZinc
  37. Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
    Nazari M; Nikbaf-Shandiz M; Pashayee-Khamene F; Bagheri R; Goudarzi K; Hosseinnia NV; Dolatshahi S; Omran HS; Amirani N; Ashtary-Larky D; Asbaghi O; Ghanavati M · Biological trace element research · 2024
    Meta-analysis23 studies pooledAnti-Inflammatory Support forZinc
  38. The Effects of Zinc Supplementation on C-Reactive Protein and Inflammatory Cytokines: A Meta-Analysis and Systematical Review.
    Ceylan MN; Akdas S; Yazihan N · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Meta-analysis73 studies pooledAnti-Inflammatory Support forZinc
  39. The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Hosseini R; Montazerifar F; Shahraki E; Karajibani M; Mokhtari AM; Dashipour AR; Ferns GA; Jalali M · Biological trace element research · 2021
    Randomized trial46 participantsAnti-Inflammatory Support forZinc
  40. Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis.
    Nazari M; Ashtary-Larky D; Nikbaf-Shandiz M; Goudarzi K; Bagheri R; Dolatshahi S; Omran HS; Amirani N; Ghanavati M; Asbaghi O · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
    Meta-analysis75 studies pooledAnti-Inflammatory Support forZinc
  41. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  42. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  43. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  44. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledGeneral Health forSelenium
  45. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  46. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  47. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  48. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  49. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  50. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  51. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate
  52. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  53. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  54. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  55. Beyond Efficacy: 0.6% Selenium Disulfide Shampoo Matches 2% Ketoconazole for Seborrheic Dermatitis with Superior Cosmesis.
    Farris PK; Barbosa V; Houshman EB; Kovylkina N · Journal of drugs in dermatology : JDD · 2026
    Randomized trial87 participantsHair Health forSelenium
  56. Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis.
    Turcu G; Artenie C; Nowicka D; Arenbergerová M; Lazaridou E; Khobzei K; Ataseven A; Part M; Leclerc-Mercier S · European journal of dermatology : EJD · 2023
    Observational study1,407 participantsHair Health forSelenium
  57. A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.
    Barbosa V; Melo DF; Vañó-Galván S; Lutchmanen-Kolanthan V; Sant'Anna B; Leclerc-Mercier S; Reygagne P · Skin appendage disorders · 2025
    Randomized trial64 participantsHair Health forSelenium
  58. Changes of serum trace elements level in patients with alopecia areata: A meta-analysis.
    Jin W; Zheng H; Shan B; Wu Y · The Journal of dermatology · 2018
    Meta-analysis764 participantsHair Health forSelenium
  59. Scientific opinion on the tolerable upper intake level for selenium.
    EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D; Bohn T; Castenmiller J; de Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Peláez C; Pentieva K; Siani A; Thies F; Tsabouri S; Vinceti M; Aggett P; Crous Bou M; Cubadda F; Ciccolallo L; de Sesmaisons Lecarré A; Fabiani L; Titz A; Naska A · EFSA journal. European Food Safety Authority · 2023
    Systematic reviewHair Health forSelenium
  60. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  61. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  62. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  63. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  64. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  65. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  66. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  67. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  68. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  69. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  70. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  71. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  72. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  73. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  74. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  75. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects.
    Meydani SN; Barklund MP; Liu S; Meydani M; Miller RA; Cannon JG; Morrow FD; Rocklin R; Blumberg JB · The American journal of clinical nutrition · 1990
    Randomized trial32 participantsImmunity forVitamin E
  76. Immunomodulatory effects of palm-derived tocotrienol-rich fraction in healthy volunteers following influenza vaccination: A randomised clinical trial.
    Chen S; Ahmad B; Palanisamy UD; Hafid SRA; Selvaduray KR; Radhakrishnan AK · Nutrition research (New York, N.Y.) · 2026
    Randomized trial150 participantsImmunity forVitamin E
  77. Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers.
    Mahalingam D; Radhakrishnan AK; Amom Z; Ibrahim N; Nesaretnam K · European journal of clinical nutrition · 2011
    Randomized trialImmunity forVitamin E
  78. Vitamin E and beta-carotene supplementation and hospital-treated pneumonia incidence in male smokers.
    Hemilä H; Virtamo J; Albanes D; Kaprio J · Chest · 2004
    Randomized trial29,133 participantsImmunity forVitamin E
  79. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial.
    Meydani SN; Meydani M; Blumberg JB; Leka LS; Siber G; Loszewski R; Thompson C; Pedrosa MC; Diamond RD; Stollar BD · JAMA · 1997
    Randomized trial88 participantsImmunity forVitamin E
  80. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  81. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  82. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  83. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  84. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc