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B12 Methylcobalamin 1000 mcg

Natural Factors
4.8
★ ★ ★ ★ ★
(10260 ratings)
Vitamin B12 1000 mcg
Product Image
Score87
A strong 1,000 mcg methylcobalamin tablet with a simple, transparent formula. It is a focused B12 option rather than broad wellness support.
How scoring works
Quantity:90 Tablet(s) • (90 servings)
Goals:
General Health
Energy
Productivity Boost
Hair Health

Score 87

A strong 1,000 mcg methylcobalamin tablet with a simple, transparent formula. It is a focused B12 option rather than broad wellness support.
How scoring works

Also available as

2 options
180 servings 1 Tablet(s) • 180 Tablet(s) • 180 servings $17.47 ($0.09 per serving) 10000.00mcg • 30 Tablet(s) servings • Cherry Flavor 10000.00mcg • 30 Tablet(s) • 30 servings $13.27 ($0.44 per serving)
$10.47($0.11 per serving)
Vitacost
$ 10.47
Amazon
$ 10.47
iHerb
$ 10.47
Report prices

Analysis

Methylcobalamin supplies a directly usable B12 form for normal nerve signaling, red blood cell formation, and energy metabolism. The 1,000 mcg amount provides substantial oral support without reaching extreme megadose levels.

The single-active tablet makes the label easy to assess and use. No folate or other B vitamins are included, so users can add B12 without duplicating a full complex.

The formula fits routine supplementation when dietary intake is low or a higher oral amount is desired. Adequate B12 status limits the likelihood of further energy or hair benefits.

Who is it for
  • Adults seeking methylcobalamin
  • People with low dietary B12
  • Users who want a simple tablet
Best for
  • Routine B12 support
  • Supporting normal nerve function
  • Single-nutrient supplementation

Pros

  • Active methylcobalamin form
  • Practical 1,000 mcg amount
  • Clear single-active label

Cons

  • No complementary folate or B6
  • Benefit depends on B12 need
  • Fixed tablet dose

Nutrient quality

93 Highest impact

A well-regarded vitamin form supports good ingredient quality. The amount is meaningful without a major safety imbalance.

Ingredient transparency

85 Highest impact

Active amounts are clearly disclosed and no proprietary blend is shown. Inactive ingredients and full daily-use directions are missing from the supplied data.

Customer satisfaction

73 High impact

The average rating is strong and supported by a large evidence base. No specific feedback is supplied to judge repeated complaints or whether experience matches the intended use.

Value for money

95 Highest impact

The supply provides strong cost efficiency for the active amount. A focused formula avoids unnecessary nutrient extras.

Report analysis

Goals

General Health
General Health
Impact
Highest effect
A Goal FitA Strength of SupportC- CoverageA Formula Quality
Vitamin B12 · 1000 mcg

Methylcobalamin provides a bioactive B12 form for red blood cell formation, nerve function, and cellular energy metabolism. The 1,000 mcg chewable serving is substantial and fully disclosed.

The focused formula is useful for people with higher B12 needs, including some older adults and people eating little or no animal food. It does not provide broad nutrient coverage, and the amount is far above ordinary daily requirements.

Study evidence
Vitamin B12 Adverse 66 studies
Energy
Energy
Impact
Highest effect
A- Goal FitA+ Strength of SupportC- CoverageA Formula Quality
Vitamin B12 · 1000 mcg

Vitamin B12 supports normal red-blood-cell formation and cellular energy metabolism. The substantial serving is most relevant for users with low intake, impaired absorption, or deficiency.

Methylcobalamin is a preferred bioactive B12 form with clear amount disclosure. People with adequate B12 status should not expect a stimulant-like energy effect from the high serving.

Study evidence
Vitamin B12 Disputed 14 studies
Productivity Boost
Productivity Boost
Impact
High effect
C+ Goal FitA+ Strength of SupportD CoverageA Formula Quality
Vitamin B12 · 1000 mcgVitamin B12 · 1000 mcg

The 1,000 mcg serving of vitamin B12 may support energy metabolism and mental clarity when low B12 status contributes to fatigue. People with adequate B12 status should not expect a direct stimulant-like productivity effect.

Methylcobalamin is clearly named, allowing the active form to be judged. The single-active formula is focused but covers only a foundational nutrient pathway.

Study evidence
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies
Hair Health
Hair Health
Impact
Moderate effect
F Goal FitA+ Strength of SupportF CoverageB+ Formula Quality

Vitamin B12 may support hair health when a deficiency disrupts normal cell turnover, but it is not a direct hair-growth active. People with adequate B12 status are unlikely to gain a meaningful hair benefit.

Methylcobalamin and the 1,000 mcg amount are clearly disclosed. The single-nutrient formula does not support structural protein, hormonal, or scalp pathways.

Study evidence
Vitamin B12 Disputed 17 studies

Ingredients

IngredientAmount per serving
Vitamin B12 (Methylcobalamin)
 1000 mcg
Gluten Free Adults 18–50 Vegetarian
Report overview
Vitamin B12 (Methylcobalamin) · 1000 mcg OverallScore91
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

Methylcobalamin supplies a substantial dose with complete form and amount disclosure. The chewable tablet is convenient, though it is less specifically absorption-focused than a lozenge or sublingual liquid. Cost efficiency is strong for a bioactive form.

View ingredientView products
Loading alternative details
89 Performance

Methyl B-12 1000 mcg & Methyl Folate 400 mcg plus P-5-P Lemon Flavor

Jarrow Formulas
<p>Methylcobalamin, folate, and active vitamin B6 support linked energy and methylation pathways with clearly stated amounts. The 1,000 mcg amount matches the original dose while using methylcobalamin in a focused formula.</p>
87 Performance

Fully Active B12 1500 mcg

Doctor's Best
<p>1,500 mcg of bioactive methylcobalamin provides a focused, easy-to-assess vitamin B12 option. The 1,500 mcg amount exceeds the original 1,000 mcg serving, so it fits a defined higher-intake need better than routine maintenance.</p>
87 Performance

B12 Energizer+ Natural Cherry Flavor

Advanced Nutrition by Zahler
<p>5,000 mcg of bioactive methylcobalamin provides a focused, easy-to-assess vitamin B12 option. The 5,000 mcg amount exceeds the original 1,000 mcg serving, so it fits a defined higher-intake need better than routine maintenance.</p>
86 Budget

Vitamin B12 2000 mcg

Nutricost
<p>A lower serving cost provides 2,000 mcg of methylcobalamin in a clearly disclosed formula. The 2,000 mcg amount exceeds the original 1,000 mcg serving, so it fits a defined higher-intake need better than routine maintenance.</p>
86 Budget

Quick Dissolve B-12 Methylcobalamin 2500 mcg

Nature's Bounty
<p>A lower serving cost provides 2,500 mcg of methylcobalamin in a clearly disclosed formula. The 2,500 mcg amount exceeds the original 1,000 mcg serving, so it fits a defined higher-intake need better than routine maintenance.</p>
87 Budget

B12 Methylcobalamin 1000 mcg

Natural Factors
<p>A lower serving cost provides 1,000 mcg of methylcobalamin in a clearly disclosed formula. The 1,000 mcg amount matches the original dose while using methylcobalamin in a focused formula.</p>
87 Value

Chewable Fully Active B12 Chocolate Mint Flavor 1000 mcg

Doctor's Best
<p>1,000 mcg of methylcobalamin supplies a bioactive form without low-value nutrient extras. The favorable serving cost strengthens value, and the 1,000 mcg amount matches the original dose while using methylcobalamin in a focused formula.</p>
85 Value

Vegan B12 2500 mcg

DEVA
<p>2,500 mcg of methylcobalamin supplies a bioactive form without low-value nutrient extras. The favorable serving cost strengthens value, and the 2,500 mcg amount exceeds the original 1,000 mcg serving, so it fits a defined higher-intake need better than routine maintenance.</p>
83 Value

Sublingual Methylcobalamin 1000 mcg

Solgar
<p>1,000 mcg of methylcobalamin supplies a bioactive form without low-value nutrient extras. The favorable serving cost strengthens value, and the 1,000 mcg amount matches the original dose while using methylcobalamin in a focused formula.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  2. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  3. Vitamin B12 Supplementation: Is More Always Better?
    Yepes-Calderón M; Doorenbos CSE; Stegmann ME; Touw DJ; Harmsen HJM; Heiner-Fokkema MR; van Spronsen FJ; Corpeleijn E; Bakker SJL · Nutrients · 2026
    Narrative reviewEnergy forVitamin B12
  4. Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients With Fibromyalgia.
    Munipalli B; Strothers S; Rivera F; Malavet P; Mitri G; Abu Dabrh AM; Dawson NL · Mayo Clinic proceedings. Innovations, quality & outcomes · 2022
    Observational study2,142 participantsEnergy forVitamin B12
  5. Megaloblastic anaemia: prevalence and causative factors.
    Khanduri U; Sharma A · The National medical journal of India · 2008
    Observational study175 participantsEnergy forVitamin B12
  6. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  7. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forVitamin B12
  8. Dermatological findings of vitamin B12 deficiency and resolving time of these symptoms.
    Demir N; Doğan M; Koç A; Kaba S; Bulan K; Ozkol HU; Doğan SZ · Cutaneous and ocular toxicology · 2014
    Single-arm trial57 participantsHair Health forVitamin B12
  9. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  10. Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center.
    Arslan H; Gündüz Ö · Dermatology practical & conceptual · 2023
    Observational study973 participantsHair Health forVitamin B12
  11. A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid function tests, zinc, copper, biotin, and selenium levels.
    Durusu Turkoglu IN; Turkoglu AK; Soylu S; Gencer G; Duman R · Journal of cosmetic dermatology · 2024
    Case-control study180 participantsHair Health forVitamin B12
  12. Micronutrient levels and thyroid functions in scarring alopecias: Do they play a role in disease pathogenesis?
    Gönülal Bak R; Çetin C; Kılınç F; Akbaş A; Aksoy Saraç G · Cutaneous and ocular toxicology · 2025
    Case-control study136 participantsHair Health forVitamin B12
  13. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  14. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  17. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  18. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  19. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  20. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  21. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  22. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  23. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsProductivity Boost forVitamin B12
  24. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  25. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  26. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  27. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  28. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  29. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsProductivity Boost forVitamin B12
  30. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  31. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12