Benfotiamine 150 + Alpha-Lipoic Acid 300
Doctor's Best
Benfotiamine 150 + Alpha-Lipoic Acid 300
4.6
★ ★ ★ ★ ★
(2237 ratings)
Thiamin 150 mg
Leucine 10.5 mg
Score 85.0
Doctor's Best Benfotiamine 150 + Alpha-Lipoic Acid 300 offers a synergistic blend of a highly bioavailable B1 derivative and a powerful antioxidant, ideal for nerve and metabolic support. Its formulation targets cellular energy and oxidative stress effectively.
Quantity: 60 Veggie Cap(s)Servings size: 1 Veggie Capsule(s) (60 servings)
Selected goals:
Other goals:
Energy
Brain Health
Cognitive Support
Cardiovascular Support
Testosterone Support
leaderboard Score 85.0
Doctor's Best Benfotiamine 150 + Alpha-Lipoic Acid 300 offers a synergistic blend of a highly bioavailable B1 derivative and a powerful antioxidant, ideal for nerve and metabolic support. Its formulation targets cellular energy and oxidative stress effectively.
insights Analysis
This product combines Benfotiamine, a highly bioavailable form of Vitamin B1, with Alpha-Lipoic Acid (ALA), a potent antioxidant. Benfotiamine is particularly effective for supporting nerve health and glucose metabolism due to its fat-soluble nature, allowing for better absorption and tissue penetration than standard thiamine. ALA complements this by acting as a universal antioxidant and further supporting metabolic health, making this combination popular for addressing neuropathy symptoms and managing blood sugar. The inclusion of a tiny, insignificant amount of L-Leucine (10mg) is peculiar and does not contribute meaningfully to muscle-related goals.
- Contains Benfotiamine, a highly bioavailable form of Vitamin B1.
- Includes Alpha-Lipoic Acid (ALA), a strong antioxidant and metabolic supporter.
- Synergistic combination for nerve health and glucose metabolism.
- Reputable brand with positive user reviews.
- The L-Leucine quantity (10mg) is negligible and offers no functional benefit for muscle-related goals.
- Price per serving is higher compared to standalone Benfotiamine products, though justified by the ALA inclusion.
$17.32($0.28 per serving)
 iHerb | $ 17.32 | |
 Vitacost | $ 18.99 | |
 Pure Formulas | $ 20.08 |
bolt Effectiveness for goals
Leucine is an essential branched-chain amino acid (BCAA) primarily known for its critical role in stimulating muscle protein synthesis (MPS). It acts as a signaling molecule, initiating the molecular pathways necessary for muscle growth and repair. This makes it crucial for maintaining and building muscle mass.
Leucine is a crucial branched-chain amino acid (BCAA) that acts as a potent stimulator of muscle protein synthesis (MPS). It activates the mTOR pathway, a key regulator of muscle growth and repair. This makes it particularly important for individuals looking to build or maintain muscle mass.
Thiamin, or vitamin B1, is crucial for converting carbohydrates into energy, supporting the metabolism of glucose, amino acids, and lipids. It plays an essential role in numerous cellular functions, particularly nerve and muscle function. This makes it vital for energy production and overall cell health.
Leucine plays a significant role in reducing muscle protein breakdown and promoting muscle protein synthesis, both essential processes for recovery. Supplementing with leucine after exercise may help decrease muscle soreness and accelerate the repair of muscle tissue. This contributes to faster recovery and readiness for subsequent training.
Thiamin is crucial for converting carbohydrates into energy and plays a vital role in nerve function, muscle contraction, and heart health. It acts as a coenzyme in metabolic reactions essential for glucose metabolism. Maintaining adequate thiamin levels supports overall cellular energy production.
schedule Dosage, timing & forms
The recommended daily allowance (RDA) for thiamin for adult men is 1.2 mg per day, and for adult women, it is 1.1 mg per day. These recommendations are designed to meet the nutritional needs of most healthy individuals. Pregnant and lactating women may have slightly higher requirements.
Leucine is often recommended to be taken around workouts, particularly before or after, to help optimize muscle protein synthesis. It can also be beneficial between meals, especially if dietary protein intake is low. Spreading intake throughout the day can help maintain elevated leucine levels.
Yes, consuming Leucine immediately before, during, or after resistance exercise is a common strategy to maximize muscle protein synthesis. Some research suggests that consistent Leucine intake throughout the day, particularly during periods between meals, may also be beneficial. The 'Leucine threshold' concept highlights the importance of consuming a sufficient amount to trigger synthesis.
Thiamin is found in various foods, including whole grains, fortified cereals, pork, fish, and legumes. Nuts, seeds, and certain vegetables like peas and asparagus also contribute to dietary thiamin intake. A balanced diet typically provides sufficient thiamin for most individuals.
For muscle protein synthesis, common effective doses of Leucine range from 2.5 to 5 grams per serving. Doses are often part of a larger essential amino acid (EAA) or branched-chain amino acid (BCAA) supplement blend. Individual needs can vary based on activity level and dietary protein intake.
health_and_safety Safety & interactions
Yes, certain medications may interact with Thiamin. Diuretics, particularly loop diuretics, can increase Thiamin excretion, potentially leading to deficiency. Some chemotherapy agents may also interfere with Thiamin metabolism. It's advisable to consult a healthcare professional if you are taking medications.
Thiamin is water-soluble, and excess amounts are typically excreted in the urine. Due to this, adverse effects from oral thiamin supplementation are rare, even at high doses. In very rare cases, extremely high intravenous doses have been associated with allergic reactions.
Chronic alcohol consumption can significantly impair Thiamin absorption and utilization, often leading to Thiamin deficiency. While alcohol does not make Thiamin supplementation unsafe, individuals who consume alcohol regularly may require higher Thiamin intake. Supplementation is often crucial for alcoholics to prevent or treat deficiency-related complications.
Thiamin is generally considered safe when taken at recommended doses, and side effects are rare. In very high doses or with intravenous administration, some individuals might experience mild upset stomach or allergic reactions, though these are uncommon. Oral supplementation typically does not cause adverse effects.
Thiamin is a water-soluble vitamin, so excess amounts are typically excreted through urine. Acute toxicity from oral Thiamin supplementation is extremely rare and has not been reported even at very high doses. However, excessively high intravenous doses could potentially lead to adverse effects, though this is not relevant for oral supplements.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| Alpha-Lipoic Acid | 300 mg |
| Benfotiamine | 150 mg |
| L-Leucine | 10.5 mg |
Categories
Thiamin 95.0
The product contains Benfotiamine, which is a highly bioavailable and fat-soluble derivative of Thiamin (Vitamin B1). This form is superior for absorption and tissue penetration compared to conventional thiamin, making it an excellent choice for Thiamin supplementation.
Leucine 10.0
The product contains a mere 10mg of L-Leucine, an amount that is functionally insignificant and provides no benefits related to L-Leucine's primary roles in muscle protein synthesis or recovery, which are achieved with gram-level dosages.
Goals
Metabolism Boost 95.0
Benfotiamine plays a key role in glucose metabolism, preventing harmful advanced glycation end-product (AGE) formation, while Alpha-Lipoic Acid improves insulin sensitivity and glucose uptake. This makes it highly effective for boosting metabolic health.
Energy 90.0
Both Benfotiamine (as B1) and Alpha-Lipoic Acid are crucial cofactors in cellular energy production pathways, enhancing glucose utilization and overall metabolic efficiency. This combination can significantly support sustained energy levels.
Brain Health 90.0
Benfotiamine's ability to cross the blood-brain barrier helps protect brain cells from metabolic stress, while Alpha-Lipoic Acid provides potent antioxidant support for neuronal health. This synergistic action contributes to overall brain integrity and function.
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