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Arginine Alpha Ketoglutarate

notesDescription

Arginine Alpha Ketoglutarate (AAKG) is a complex of the amino acid L-arginine and alpha-ketoglutarate, an important intermediate in the Krebs cycle responsible for energy production in cells. This combination is believed to enhance the bioavailability and effectiveness of L-arginine, which is a precursor to nitric oxide (NO). Nitric oxide plays a crucial role in vasodilation, improving blood flow, and nutrient delivery to muscles. Athletes and bodybuilders commonly use AAKG as a supplement to support enhanced exercise performance, muscle pump, and recovery. The increased blood flow facilitated by nitric oxide can lead to better oxygen and nutrient transport to working muscles, potentially aiding in endurance and reducing fatigue. Alpha-ketoglutarate also has a role in amino acid metabolism and energy production, further contributing to its appeal in athletic contexts. Beyond sports performance, L-arginine, and by extension AAKG, may support cardiovascular health by improving endothelial function and maintaining healthy blood pressure levels already within the normal range. It is also involved in immune function and wound healing. The alpha-ketoglutarate component is also known for its role in ammonia detoxification and can contribute to the synthesis of other amino acids.

ecoSources
Arginine (a component of AAKG) is found in red meat, poultry, fish, dairy products, nuts, seeds, and legumes.Alpha-ketoglutarate (a component of AAKG) is produced naturally in the body as an intermediate in the Krebs cycle and is present in some fermented foods. AAKG itself is a synthesized compound.
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check_circleOptimal Dosage
Minimum2000 Gram(s)
Maximum6000 Gram(s)
report_problemSafety & Toxicity
Toxicity Threshold12000 Gram(s)
Toxicity EffectDiarrhea, stomach pain, bloating
track_changesGoals
Energy
boltEnergy
Impact
Situational effect
Typical dose:1.5–3 grams
The arginine component increases nitric oxide, improving circulation and nutrient delivery to muscles. The AKG component is an intermediate in the Krebs cycle. This combination is most relevant for reducing fatigue during physical exertion, rather than for general daily energy.
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sync_altInteractions

add_circle_outlinePositive Interactions

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Citrulline
As a precursor to L-arginine, Citrulline can enhance and sustain nitric oxide production, complementing AAKG's effects on blood flow and performance.
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Creatine
Both AAKG and Creatine support athletic performance; AAKG's improved blood flow may aid in creatine transport and absorption by muscles.
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Glutamine
An amino acid vital for muscle recovery, immune function, and gut health, Glutamine can complement AAKG's role in muscle support and overall well-being.
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Vitamin C
Vitamin C is important for nitric oxide synthesis and endothelial function, potentially enhancing AAKG's cardiovascular benefits and NO-boosting effects.
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Coenzyme Q-10
Supports energy production and cardiovascular health, which aligns with AAKG's purported benefits for performance and heart function, offering synergistic support.

remove_circle_outlineNegative Interactions

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Magnesium
Magnesium can have a blood pressure-lowering effect, potentially augmenting the hypotensive actions of Arginine Alpha Ketoglutarate.
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Hawthorn
Hawthorn is known for its hypotensive properties, which could lead to an additive decrease in blood pressure when combined with AAKG.
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Ginkgo
Ginkgo may influence blood flow and blood pressure, potentially increasing the risk of excessive blood pressure reduction in conjunction with AAKG.
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sellPrice per product
Average$35.97
Median$39.99
restaurantPrice per serving
Average$1.01
Median$0.98
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bar_chartPaired ingredients

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