Proline
Proline is a unique, cyclic non-essential amino acid, meaning the body can synthesize it, though dietary intake also contributes. Its distinctive structure plays a critical role in forming the triple helix of collagen, the most abundant protein in the human body. This makes Proline indispensable for maintaining the structural integrity of various tissues. The primary function of Proline is its involvement in collagen synthesis, which is vital for the strength and elasticity of skin, tendons, ligaments, cartilage, and bones. It contributes significantly to tissue repair and regeneration, making it important for wound healing and recovery from injuries. Beyond structural support, Proline is also involved in various metabolic processes, including protein synthesis and cellular energy production. It is often sought for its benefits in promoting healthy skin, supporting joint mobility, and aiding in the body's natural healing processes.
Meat (beef, chicken, pork)FishDairy products (milk, cheese, yogurt)EggsBone brothLegumesAsparagusMushrooms
Cheapest Proline supplements
Compare the cheapest Proline amino acid supplements for supporting both bone and skin health, helping you find the best value.
Best Proline supplements
Discover the best Proline supplements for supporting bone health and promoting radiant skin.
Value Proline amino acid supplements
Compare the best value Proline amino acid supplements designed to support your bone and skin health goals effectively.
Minimum500 mg
Maximum1000 mg
Impact
High effect
Typical dose:500–2000 mg
Proline is a critical building block for the collagen that forms about 30% of bone mass. Supplementing with proline supports the synthesis of this flexible framework. Its priority should be high, logically placed just below supplementing with whole collagen peptides.
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Impact
High effect
Typical dose:500–2000 mg
Proline is one of the primary amino acids that make up the structure of collagen. Supplementing with proline can provide the necessary raw materials to support the body's production of collagen, which is essential for skin firmness and elasticity. Its effect is most pronounced when paired with other cofactors like Vitamin C.
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Vitamin C
Vitamin C is an essential cofactor for the enzymes involved in collagen synthesis, working synergistically with Proline to form stable collagen fibers.
Collagen
Proline is a major constituent of collagen; supplementing with both can enhance the body's collagen stores and synthesis.
Glycine
Glycine is another primary amino acid in collagen, working alongside Proline to build and maintain connective tissues.
Lysine
Lysine is important for collagen cross-linking, which enhances collagen's strength and stability, complementing Proline's role in collagen formation.
Lysine
Lysine is important for collagen cross-linking, which enhances collagen's strength and stability, complementing Proline's role in collagen formation.
Copper
Copper is required for lysyl oxidase, an enzyme that helps cross-link collagen and elastin, thus supporting the structural integrity built by Proline.
Zinc
Zinc plays a role in protein synthesis and wound healing, both of which are processes where Proline's role in collagen formation is crucial.
Hyaluronic Acid
Both Proline (via collagen) and Hyaluronic Acid contribute to skin hydration, elasticity, and joint lubrication, offering synergistic benefits for connective tissue health.
75 Value 
Liga-Tend
Country Life
4.7
★★★★★
(21 ratings)
Proline: 250 mg
This product offers a combination of amino acids, minerals, and digestive enzymes designed to support joint health, bone strength, and the integrity of connective tissues.
62 Best 
Pure L-Proline 500 Milligrams
Montiff
4.6
★★★★★
(5 ratings)
Proline: 500 mg
A simple L-Proline supplement in capsule form, offering a modest 500mg dose for those looking to support collagen synthesis.
80 Budget 
Double Strength Hyaluronic Acid 100 mg
NOW
4.7
★★★★★
(26611 ratings)
Proline: 100 mg
A well-regarded capsule formula containing hyaluronic acid, L-Proline, and other supportive ingredients for skin and bone health, but at a less economical price per serving than the larger package.
90 Budget 
Skin Nails & Hair
Solgar
4.7
★★★★★
(81002 ratings)
Proline: 50 mg
This Solgar supplement provides a concentrated blend of key nutrients like MSM, silicon, and amino acids, specifically formulated to support the structural integrity and appearance of skin, nails, and hair.
88 Best 
Ortho C+ Lemon Flavor
AOR Advanced Orthomolecular Research Premium
4.1
★★★★★
(18 ratings)
Proline: 2000 mg
This is a high-potency Vitamin C blend featuring key minerals and amino acids like Lysine and Proline, aiming to support immunity, collagen formation, and bone health.
88 Value 
Vegan Hair Skin & Nails
NOW Solutions
4.7
★★★★★
(4158 ratings)
Proline: 200 mg
A comprehensive vegan blend featuring targeted nutrients and quality mineral forms to support the health and appearance of hair, skin, and nails.
80 Budget 
Liquid Hyaluronic Acid
NOW
4.6
★★★★★
(5127 ratings)
Proline: 100 mg
This liquid supplement effectively combines hyaluronic acid with collagen precursors and essential vitamins for targeted support of skin, joint, and connective tissue health.
82 Value 
Pro-Rite
Carlson
4.9
★★★★★
(815 ratings)
Proline: 500 mg
This Carlson supplement combines L-Lysine and L-Proline, two amino acids often used together, in a simple capsule format.
84 Value 
Pro-Rite
Carlson
4.9
★★★★★
(869 ratings)
Proline: 500 mg
This larger bottle of Carlson Pro-Rite provides a good value for a combined L-Lysine and L-Proline supplement in capsule form.
90 Best 
L-Proline 2000 mg
Nutricost
4.8
★★★★★
(377 ratings)
Proline: 2000 mg
A high-potency liquid L-Proline supplement, providing 2000mg per serving for robust collagen support, offered at an excellent value.
88 Budget 
Clincally Advanced Hair Skin & Nails
NOW Solutions
4.7
★★★★★
(4874 ratings)
Proline: 100 mg
This is a comprehensive supplement that combines a wide range of essential vitamins and minerals with targeted ingredients like keratin, MSM, and hyaluronic acid to support the health and appearance of hair, skin, and nails.
72 Best 
MacroMeal Ultimate Chocolate Protein Powder
MacroLife Naturals
4.4
★★★★★
(19 ratings)
Proline: 2123 mg
This is a multi-source protein powder enhanced with greens, digestive enzymes, and probiotics, aiming for broad nutritional support in a convenient chocolate-flavored drink.
78 Best 
MacroMeal Ultimate Vanilla Protein Powder
MacroLife Naturals
3.9
★★★★★
(8 ratings)
Proline: 2086 mg
MacroMeal Ultimate Vanilla is a multi-source protein powder packed with greens, fruits, enzymes, and probiotics, designed for broad nutritional support and muscle maintenance.
68 Best 
MacroMeal Ultimate Vanilla Protein Powder
MacroLife Naturals
4.1
★★★★★
(32 ratings)
Proline: 1259 mg
A plant-based protein powder with added superfoods, digestive enzymes, and probiotics, delivering comprehensive nutritional support in a vanilla flavor.
65 Best 
MacroMeal Ultimate Vanilla Protein Powder
MacroLife Naturals
4.5
★★★★★
(22 ratings)
Proline: 1259 mg
This is a plant-based, multi-ingredient protein powder with superfoods and digestive support, available in a smaller, more expensive-per-serving vanilla package.
77 Best 
MacroMeal Ultimate Chocolate Protein Powder
MacroLife Naturals
4.5
★★★★★
(8 ratings)
Proline: 2123 mg
MacroMeal Ultimate Chocolate is a comprehensive protein powder with added greens, fruits, enzymes, and probiotics, aiming for broad nutritional support and muscle upkeep in a chocolate flavor.
78 Best 
Caprotein
Mt. Capra
4.6
★★★★★
(883 ratings)
Proline: 813 mg
Caprotein is a goat milk protein powder that supplies a full range of amino acids and calcium, aiming to support muscle, bone health, energy, and overall wellness.
70 Best 
Pegan Thin Seed Protein 20 g Triple Chocolate
Julian Bakery
4.5
★★★★★
(56 ratings)
Proline: 960 mg
<p>This Julian Bakery seed protein offers 20g of protein with a full amino acid profile, fitting Pegan and Vegan diets, though it comes at a premium price.</p>
72 Budget 
Beauty Blossom Complex
Solumeve
4.6
★★★★★
(1780 ratings)
Proline: 100 mg
This complex provides key ingredients like hyaluronic acid and L-proline, along with plant extracts, to support skin hydration, joint comfort, and general beauty goals.
80 Budget 
Hyaluronic Acid Complex
California Gold Nutrition
4.7
★★★★★
(4692 ratings)
Proline: 100 mg
This complex provides hyaluronic acid, L-proline, and antioxidant plant extracts to help support skin hydration, joint comfort, and overall beauty from within.
Average$30.84
Median$29.33
Average$1.18
Median$0.85
Average$0.66
Median$0.49
Reference amount: 100 mg