Histidine

Description

Histidine is one of the 20 common amino acids, and it is considered 'essential' in humans, meaning the body cannot synthesize it and it must be obtained through diet or supplements. It is a fundamental building block for proteins and plays a significant role in various physiological processes, particularly those involving growth and tissue repair. Its unique imidazole side chain gives it a buffering capacity, allowing it to help regulate pH levels in the body, especially within muscle tissue. A key function of Histidine is its role as a precursor to histamine, a potent compound involved in immune responses, allergic reactions, stomach acid secretion, and neurotransmission. It is also a precursor to carnosine, a dipeptide found in high concentrations in muscle and brain tissue, known for its antioxidant and anti-glycation properties. Additionally, Histidine contributes to the formation of myelin sheaths, which protect nerve cells and ensure efficient nerve signal transmission, and is involved in red blood cell production as a component of hemoglobin. Beyond these specific roles, Histidine contributes to overall immune system function, helps protect the body from damage due to radiation and heavy metals through chelation, and is important for healthy digestive function. Its diverse roles underscore its importance in maintaining overall health, from neurological function to physical repair and immune defense.

Sources
Meat (beef, pork, poultry)Fish (tuna, salmon)EggsDairy products (milk, cheese)Legumes (lentils, beans)Nuts (peanuts, almonds)Seeds (chia, sesame)Grains (rice, wheat, oats)
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Optimal Dosage
Minimum500 mg
Maximum1500 mg
Safety & Toxicity
Product stats
Price per product
Average$24.05
Median$19.44
Price per serving
Average$0.77
Median$0.60
Price per 10 mg
Average$0.10
Median$0.12
Price distribution
Price per serving distribution
Price per 10 mg
Reference amount: 10 mg
Forms
Paired ingredients
Ingredient forms
L-Histidine Hydrochloride (5)82
L-Histidine Hydrochloride is a common and highly bioavailable salt form of L-Histidine. L-Histidine is an alpha-amino acid that serves as a precursor to histamine, a neurotransmitter, and carnosine, an antioxidant and anti-glycating agent. This form is often used in dietary supplements due to its good solubility and stability, ensuring efficient delivery of histidine for various physiological roles, including its involvement in immune response and neurological functions.
Pros
  • High bioavailability of L-Histidine.
  • Excellent water solubility, facilitating absorption.
  • Good stability for use in formulations.
  • Provides an essential amino acid for human health.
Cons
  • May cause mild gastrointestinal upset in some individuals, especially at higher doses.
  • The hydrochloride content might add a slight acidic load, though typically negligible in standard supplementation.
Per product
Avg$23.24
Med$29.99
Per serving
Avg$0.12
Med$0.12
Per 100 mg
Avg$0.32
Med$0.32
Price distribution
L-Histidine Hydrochloride Monohydrate (1)81
L-Histidine Hydrochloride Monohydrate is a hydrated salt form of L-Histidine, containing one molecule of water per molecule of L-Histidine Hydrochloride. This form is highly water-soluble and stable, making it suitable for dietary supplements. L-Histidine is an alpha-amino acid crucial for various physiological processes, including immune function, tissue repair, and acting as a precursor to important compounds like histamine and carnosine, which contribute to neurological function and antioxidant defense. The hydration state has minimal impact on the bioavailability of the histidine itself.
Pros
  • Excellent bioavailability of L-Histidine.
  • Highly water-soluble, aiding absorption.
  • Stable form, suitable for various formulations.
  • Provides the essential amino acid Histidine for biological functions.
Cons
  • Contains water of hydration, meaning slightly less L-Histidine by weight compared to the anhydrous form.
  • May cause mild gastrointestinal upset in sensitive individuals, especially at high doses.
Per product
Avg$52.00
Med$52.00
Per serving
Avg$1.73
Med$1.73
Per 100 mg
Avg$1.15
Med$1.15
Price distribution
L-Histidine Monohydrochoride (1)82
L-Histidine Monohydrochloride is a salt form of the amino acid L-Histidine, chemically equivalent to L-Histidine Hydrochloride. It is characterized by its high solubility in water and good stability, making it an excellent choice for dietary supplements. L-Histidine is a conditionally essential amino acid involved in numerous bodily functions, including its role as a precursor to histamine (a neurotransmitter) and carnosine (an antioxidant), which are important for immune function, tissue repair, and supporting neurological health.
Pros
  • High bioavailability of L-Histidine.
  • Excellent water solubility, facilitating absorption.
  • Good stability for use in formulations.
  • Provides an essential amino acid for human health.
Cons
  • May cause mild gastrointestinal upset in sensitive individuals or at high doses.
  • The hydrochloride content might slightly impact acid-base balance at very high doses, but typically negligible.
Per product
Avg$25.69
Med$25.69
Per serving
Avg$0.43
Med$0.43
Per 100 mg
Avg$0.13
Med$0.13
Price distribution