Lithium
Description
Lithium, as a trace mineral, is distinct from the pharmaceutical drug lithium carbonate, which is prescribed at much higher doses for specific medical conditions. In its trace form, lithium is thought to support several physiological processes, particularly within the brain. Research suggests it may influence neurotransmitter activity, neurogenesis (the formation of new brain cells), and cellular signaling pathways. It is hypothesized to contribute to healthy mood regulation and support overall cognitive well-being. The exact mechanisms of action at trace levels are still being investigated, but its presence is considered important for optimal brain function and resilience.
Sources
GrainsVegetables (e.g., potatoes, tomatoes, cabbage)Drinking water (levels vary significantly by region)Dairy productsMeat
Timing & Intake
AnytimeWith food
Taking trace minerals with food can help prevent potential stomach upset and aid absorption.
Optimal Dosage
Minimum1 mg
Maximum5 mg
Safety & Toxicity
Toxicity Threshold100 mg
Toxicity EffectNeurological effects, tremors
Interactions
Positive Interactions
Magnesium
Magnesium is crucial for nerve function and can complement trace lithium's role in supporting brain health and cellular processes.
Omega-3
Omega-3 fatty acids (like EPA and DHA) are vital for brain cell membrane integrity and neurotransmitter function, which can be synergistic with lithium's brain-supporting effects.
EPA (Eicosapentaenoic Acid)
EPA, an Omega-3 fatty acid, supports neurological health and may work synergistically with trace lithium for mood and cognitive support.
DHA
DHA, a key Omega-3 fatty acid, is critical for brain structure and function, potentially enhancing the neuroprotective and cognitive benefits of trace lithium.
Folate
Folate is essential for neurotransmitter synthesis and methylation processes in the brain, which are areas where trace lithium may also exert beneficial influences.
Vitamin B12
Vitamin B12 is vital for neurological health and contributes to processes that may be positively influenced by trace lithium, supporting overall brain function.
Vitamin D
Vitamin D plays a role in brain development and function, including mood regulation, and may complement the brain-supporting effects of trace lithium.
Recommended products
Best 
Lithium (Orotate) 20 mg
Vital Nutrients
Lithium: 20 mg
A straightforward Lithium Orotate product providing a 20 mg dose, suitable for those looking for a single, higher-dose lithium supplement.
Value 
Lithium Orotate 5 mg
KAL
Lithium: 5 mg
A well-regarded and affordable 5 mg Lithium Orotate supplement in VegCap form, suitable for general daily mood support.
Value 
Lithium Orotate Natural Lemon Lime Flavor
KAL
Lithium: 4 mg
A flavored liquid Lithium Orotate supplement at 4 mg per serving, ideal for flexible dosing or for those who dislike capsules.
Best 
Lithium Orotate 5 mg
KAL
Lithium: 5 mg
A high-value 5 mg Lithium Orotate supplement in VegCap form, offering a substantial 120 servings for extended use and budget-friendly daily mood support.
Best 
Lithium Aspartate 5 mg
Solaray
Lithium: 5 mg
A 5 mg Lithium Aspartate supplement from Solaray, offering an alternative chelated form for those seeking mood support.
Value 
Lithium Orotate 5 mg
Swanson
Lithium: 5 mg
An economical 5 mg Lithium Orotate supplement in capsule form from Swanson, great for budget-conscious users seeking mood support.
Best 
Ez Doze
Dr. Emil Nutrition
Lithium: 3.8 mg
Ez Doze is a multi-ingredient supplement blending vitamins, minerals, amino acids, and herbs often used for mood, stress, and sleep, but features a very high folate dose and St. John's Wort, which require caution.
Best 
Lithium (Orotate) 5 mg
Pure Encapsulations
Lithium: 5 mg
A premium blend combining 5 mg Lithium Orotate and 200 mg NAC for comprehensive mood support, from a brand known for its ingredient focus.
Product stats
Price per product
Average$22.63
Median$16.63
Price per serving
Average$0.40
Median$0.39
Price per 1 mg
Average$0.03
Median$0.03
Price distribution
Price per serving distribution
Price per 1 mg
Reference amount: 1 mg
Forms
Paired ingredients
Ingredient forms
Lithium Orotate (7) 85
Lithium orotate is a compound combining lithium with orotic acid. It is believed to facilitate better absorption and transport of lithium into cells, which may allow for lower dosages to achieve desired effects compared to other forms like lithium carbonate.
Natural sources of lithium are primarily found in trace amounts in drinking water, certain vegetables, grains, and dairy products. While not considered an essential nutrient, its role in neurological function is well-documented.
Positive effects include supporting mood stabilization, reducing anxiousness, promoting a sense of calm, and potentially offering neuroprotective benefits, particularly relevant for mood support. It may assist in balancing neurotransmitter activity.
Potential side effects, especially with higher doses, can include nausea, stomach upset, fatigue, mild tremor, and increased thirst. As with all forms of lithium, vigilance for side effects is important.
Warnings: Despite claims of gentler action, lithium orotate should still be used under the guidance of a healthcare professional, especially if taking other medications or if you have pre-existing health conditions like kidney or thyroid issues. It is not a substitute for prescription lithium medications for severe mood disorders. Avoid during pregnancy or breastfeeding unless specifically advised by a doctor.
Interactions: May interact with diuretics, NSAIDs, ACE inhibitors, angiotensin receptor blockers, certain antidepressants, and thyroid medications. Alcohol and caffeine can also affect lithium levels. Always discuss with your doctor before combining with other supplements or medications.
Pros
- Potentially higher bioavailability and cellular penetration compared to other forms.
- May be effective at lower doses, possibly leading to fewer side effects.
- Often used for general mood balance and cognitive support.
Cons
- Less research than pharmaceutical lithium carbonate for severe conditions.
- Orotic acid in very high doses could theoretically have side effects, though rare at supplemental levels.
- Requires careful dosing and professional guidance.
Per product
Avg$23.52
Med$13.99
Per serving
Avg$0.16
Med$0.14
Per 1 mg
Avg$0.03
Med$0.03
Price distribution
Lithium (1) 60
In supplemental contexts where the specific salt form is not specified (e.g., 'Lithium' as a standalone ingredient), it generally implies very low, trace amounts of lithium intended for general nutritional support rather than therapeutic use.
Lithium is naturally present in trace amounts in many environments, especially in water sources in certain regions, as well as in some fruits, vegetables, grains, and dairy. Its ubiquitous presence suggests a potential subtle biological role, even if not classified as an essential micronutrient.
Positive effects at these trace levels are often associated with promoting a sense of calm, supporting overall brain health, and contributing to general mental well-being and cognitive function. It's thought to play a role in neurotransmitter regulation.
Side effects are generally minimal at trace doses. However, sensitivity varies, and some individuals might experience mild gastrointestinal upset or fatigue, especially if doses are higher than recommended.
Warnings: Even at trace levels, it's prudent to consult a healthcare professional before beginning supplementation, particularly if you have underlying health issues, are pregnant, or breastfeeding. Avoid self-treating severe mood disorders with trace lithium.
Interactions: Though less pronounced at trace doses, general lithium interactions should still be considered. These include diuretics, NSAIDs, ACE inhibitors, and certain antidepressants. Always inform your doctor about all supplements you are taking.
Pros
- May support general mental well-being and cognitive function.
- Associated with promoting calmness and emotional balance.
- Available in various low-dose formulations.
Cons
- Ambiguity regarding the exact chemical form and its specific bioavailability.
- Efficacy for significant mood disorders is not established at trace levels.
- Potential for mild side effects if individual sensitivity is present or dose is too high.
Per product
Avg$17.27
Med$17.27
Per serving
Avg$0.57
Med$0.57
Per 1 mg
Avg$0.15
Med$0.15
Price distribution
Lithium Aspartate (1) 80
Lithium aspartate is a compound consisting of lithium bound to aspartic acid. It is proposed to offer enhanced bioavailability and absorption compared to traditional lithium salts, potentially allowing for lower effective doses for mood and cognitive support.
Lithium is a naturally occurring element found in trace amounts in water, soil, and various foods. While its exact biological function as a micronutrient is still under investigation, it's known for its profound effects on brain chemistry.
Positive effects include supporting mood stability, fostering a sense of relaxation, and contributing to overall brain health and cognitive function. It may help in balancing neurotransmitter activity crucial for mood regulation.
Potential side effects can include mild digestive upset, nausea, or fatigue, especially if doses are higher than suggested. Aspartic acid is an excitatory amino acid, but the amount in typical supplements is generally not a concern.
Warnings: As with all lithium supplements, it should be used with caution and preferably under the guidance of a healthcare provider. This is particularly important if you have kidney or thyroid issues, or are taking other medications. Not recommended for use during pregnancy or breastfeeding without medical consultation.
Interactions: Potential interactions exist with diuretics, non-steroidal anti-inflammatory drugs (NSAIDs), ACE inhibitors, angiotensin receptor blockers, certain antidepressants, and thyroid medications. Alcohol and caffeine consumption can also influence lithium levels. Always disclose all supplements to your doctor.
Pros
- Believed to have improved absorption, potentially allowing for lower effective doses.
- May support mood balance and promote calmness.
- Often used for general mental wellness and cognitive support.
Cons
- Less widely researched compared to pharmaceutical lithium carbonate.
- Aspartic acid component can be a concern for some, though typically benign at supplemental levels.
- Requires careful dosing and professional supervision.
Per product
Avg$12.89
Med$12.89
Per serving
Avg$0.12
Med$0.12
Per 1 mg
Avg$0.02
Med$0.02
Price distribution
