Mood Support

Mental & Cognitive Health

Enhancing emotional well-being and resilience; key for mental health and daily functioning.

Best effective

Lithium
Mineral
Lithium is a well-established treatment for bipolar disorder, helping to reduce the severity and frequency of both manic and depressive episodes. It is thought to affect neurotransmitter systems, including serotonin and dopamine, and stabilize neural activity.
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SAMe
Other
SAMe has shown antidepressant effects in several clinical trials, potentially by increasing neurotransmitter levels in the brain and improving cell membrane function, aiding in receptor binding.
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St. John's Wort
Botanical
Numerous studies have shown St. John's Wort to be effective in alleviating symptoms of depression, with some studies showing comparable results to certain antidepressant medications. It is believed to work by affecting the levels of neurotransmitters like serotonin, dopamine, and norepinephrine in the brain.
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Very effective

Phenylalanine
Amino Acid
Studies suggest that phenylalanine can influence neurotransmitter levels associated with mood regulation. While not a direct treatment for clinical depression, it can improve mood by affecting the production of dopamine and norepinephrine.
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Tryptophan
Amino Acid
Serotonin, synthesized from tryptophan, plays a significant role in emotional well-being. Studies suggest that increasing tryptophan intake can enhance mood and alleviate symptoms of mood disorders.
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Vitamin B6
Vitamin
B6 affects the production of serotonin and dopamine, two key neurotransmitters that can play a role in regulating moods. A deficiency has been linked to mood disorders.
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Decently effective

5-HTP
Amino Acid
Serotonin is well-established as a key neurotransmitter in mood regulation and low levels are often implicated in mood disorders. 5-HTP can be helpful for some individuals in boosting serotonin but is not a substitute for prescribed medical treatment.
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Acetyl L-Carnitine
Other
Studies suggest ALCAR might influence neurotransmitter activity and provide neuroprotective effects, which could positively impact mood regulation. It is not a replacement for conventional treatments but may be a supportive element.
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Ashwagandha
Botanical
Studies have indicated ashwagandha can help in alleviating symptoms of anxiety and depression, which can positively influence mood.
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Deanol
Other
Deanol may influence mood by affecting acetylcholine levels, which can in turn influence the release and uptake of other neurotransmitters like dopamine and serotonin, known to play a role in mood regulation. Some individuals report improved mood and a reduction in feelings of anxiety when using Deanol. However, the effects can be highly variable and are not well-documented.
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EPA (Eicosapentaenoic Acid)
Fatty Acid
EPA influences the production and regulation of neurotransmitters like serotonin and dopamine, which are crucial for mood regulation. Clinical studies have demonstrated a positive association between EPA intake and improved mood, especially in individuals experiencing symptoms of depression or anxiety. However, more research is needed to fully understand the mechanisms.
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Folate
Vitamin
Folate is a cofactor in the production of neurotransmitters like serotonin, dopamine, and norepinephrine, which play a big role in mood regulation. There is some indication that folate supplementation can improve symptoms of mood disorders, especially in those with a deficiency.
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GABA
Other
GABA's role in regulating brain excitability can contribute to a more balanced mood state. While not a direct treatment for mood disorders, it can be a supportive element in managing emotional regulation.
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Iron
Mineral
Iron is involved in the production of neurotransmitters like serotonin, dopamine, and norepinephrine, which are key regulators of mood. Iron deficiency can impair the synthesis of these neurotransmitters, leading to mood disturbances like irritability, anxiety, and depression. Supplementation can restore balance in neurotransmitter production, leading to improved mood.
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Omega-3
Fatty Acid
Research suggests that omega-3s may play a role in regulating neurotransmitters associated with mood, potentially offering a complementary approach to managing mood disorders.
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Rhodiola
Botanical
By balancing neurotransmitter levels, rhodiola may help to elevate mood.
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Tyrosine
Amino Acid
Some studies have shown tyrosine's potential in alleviating symptoms of mild depression or mood disturbances linked to stress or neurotransmitter imbalances.
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Valerian
Botanical
Valerian’s mood-enhancing properties stem from its calming effects which can indirectly help to improve one’s outlook. Individuals dealing with stress-induced mood disturbances may find it beneficial, although it is not a primary treatment for mood disorders.
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Vitamin B12
Vitamin
B12 impacts the synthesis of crucial mood-regulating neurotransmitters. While it's not a standalone treatment for mental health conditions, sufficient B12 levels can support balanced emotional well-being and prevent mood disturbances linked to deficiency.
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Vitamin D
Vitamin
Vitamin D receptors are present in areas of the brain associated with mood regulation. Some studies suggest that maintaining adequate levels of Vitamin D can support mood stability and well-being.
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Partially effective

Fish Oil
Fatty Acid
Omega-3s can affect neurotransmitter function and inflammation in the brain, potentially influencing mood regulation. While not a replacement for conventional treatment, fish oil supplementation may offer additional support for individuals experiencing mood disturbances.
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Gamma Linolenic Acid
Fatty Acid
Emerging research indicates that GLA might play a role in mood regulation. GLA affects neurotransmitter pathways, potentially influencing mood and emotional well-being.
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Ginger
Botanical
Research suggests ginger's anti-inflammatory properties might indirectly influence mood through the gut-brain axis. Some studies show a correlation between reduced inflammation and improved mood, though more research is needed to establish a strong link.
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Hericium mushroom
Botanical
There is emerging research to suggest Hericium mushrooms may help mood by interacting with the gut-brain axis. However, more research is needed to confirm the extent and reliability of this effect.
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Magnesium
Mineral
Magnesium is involved in the production and function of neurotransmitters like serotonin and dopamine, which affect mood. While it is not a direct treatment, some studies have shown that magnesium supplementation may contribute to better mood in individuals with deficiency.
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Theanine
Amino Acid
There is some evidence to suggest that L-theanine can improve mood by increasing the levels of serotonin and dopamine in the brain and helping to reduce anxiety and stress, which can indirectly affect mood.
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Theobromine
Other
Theobromine's ability to modulate dopamine and serotonin levels contributes to mood elevation and a sense of well-being. Its mild stimulant effects can also enhance alertness and reduce feelings of fatigue, which indirectly improves mood.
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Situationally effective

Fenugreek
Botanical
Research suggests that fenugreek may have a positive impact on mood, possibly due to its influence on hormone balance. This effect is not consistent across all individuals but may be noticeable in some.
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