Glycine
Glycine is an amino acid, the smallest and simplest of the 20 amino acids commonly found in proteins. It is considered a conditionally essential amino acid, meaning the body can typically produce it, but supplemental intake may be beneficial under certain conditions, such as stress or illness. It serves as a fundamental building block for proteins and polypeptides throughout the body. Beyond its role in protein structure, glycine is integral to various physiological processes. It is a precursor to several key biomolecules, including creatine, glutathione, porphyrins (components of hemoglobin), and bile salts. Glycine also acts as an inhibitory neurotransmitter in the central nervous system, particularly in the spinal cord and brainstem, contributing to relaxation and sleep regulation. Its diverse functions extend to supporting healthy sleep patterns, promoting collagen synthesis for skin and connective tissue health, and aiding in detoxification pathways. Glycine also plays a part in glucose metabolism and has been investigated for its potential to support gut health and reduce inflammation.
Meat (beef, pork, poultry)FishDairy products (milk, cheese)Legumes (beans, lentils)SpinachKaleCabbagePumpkinBananasGelatin/Collagen
Cheapest Glycine supplements
Explore our curated list of the cheapest Glycine supplements, helping you compare options to support detoxification, sleep, mood, and overall well-being without breaking the bank.
Best Glycine Supplements
Discover the best Glycine supplements to support detoxification, sleep, bone health, digestion, mood, anti-aging, and overall well-being for a healthier you.
Value Glycine supplements
Discover top value Glycine supplements to support detoxification, sleep, bone health, mood, and overall well-being, helping you choose the best option for your health needs.
Minimum1000 mg
Maximum3000 mg
Impact
High effect
Typical dose:1000–5000 mg
As a primary building block for collagen, glycine directly supports skin and joint integrity. Its role as a rate-limiting precursor for glutathione synthesis is critical for combating age-related oxidative stress. Furthermore, by acting as an inhibitory neurotransmitter, glycine improves sleep quality, which is essential for cellular repair, hormonal regulation, and cognitive restoration.
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Impact
High effect
Glycine acts as an immunomodulatory agent, calming immune cells like macrophages and reducing the production of key inflammatory messengers such as TNF-alpha. It is a fundamental component for managing systemic inflammation and supporting tissue repair.
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Impact
High effect
As the primary amino acid in the collagen that forms the bone matrix, Glycine is fundamentally important. A priority of 0 is a significant undervaluation; its priority should be high, just below whole collagen, reflecting its role as a key building block.
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Impact
High effect
Typical dose:1000–3000 mg
The liver uses glycine to conjugate (bind to) and neutralize specific toxins, such as salicylates and benzoate preservatives. It is a key amino acid for ensuring the body can process a wide range of common chemical exposures.
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Impact
High effect
Glycine is a primary component of collagen and plays a crucial role in synthesizing new connective tissue for gut repair. It also has direct cytoprotective and anti-inflammatory effects within the gastrointestinal tract.
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add_circle_outline Positive Interactions
Glutathione
Glycine is a key precursor required for the body's synthesis of Glutathione, enhancing its production.
Gluthathione
Glycine is a key precursor required for the body's synthesis of Gluthathione, enhancing its production.
Creatine
Glycine is one of the amino acids that the body uses to synthesize Creatine, supporting its natural production.
Collagen
As a primary amino acid in Collagen, Glycine supports its synthesis and structural integrity.
Vitamin C
Vitamin C is essential for the enzymatic steps in collagen synthesis, complementing Glycine's role as a collagen building block.
Proline
Proline, along with Glycine, is a major amino acid component of collagen, working synergistically for connective tissue health.
Cysteine
Cysteine, alongside Glycine and Glutamic Acid, is a precursor to Glutathione, enhancing its endogenous production.
Glutamic Acid
Glutamic Acid, alongside Glycine and Cysteine, is a precursor to Glutathione, enhancing its endogenous production.
remove_circle_outline Negative Interactions
Caffeine
Glycine's calming and sleep-promoting effects may counteract the stimulant properties of Caffeine.
Theanine
Both Glycine and Theanine possess calming effects; combining them might enhance drowsiness, particularly at higher doses.
Melatonin
Both Glycine and Melatonin can promote sleep; concurrent use may lead to increased drowsiness or sedation.
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NightRest With Melatonin
Source Naturals
4.5
★★★★★
(5135 ratings)
Glycine: 250 mg
This product provides a multi-ingredient approach to support nighttime relaxation and sleep, combining melatonin with calming amino acids and traditional herbal extracts for a comprehensive effect.
75 Budget 
Amino: Cuts Amino-Charged Energy Drink Grape
ALLMAX
4.3
★★★★★
(569 ratings)
Glycine: 345 mg
A versatile energy drink that provides a blend of amino acids for muscle support and natural caffeine for an energy and focus boost, suitable for pre-workout or anytime use.
72 Best 
MacroMeal Ultimate Chocolate Protein Powder
MacroLife Naturals
4.4
★★★★★
(19 ratings)
Glycine: 1956 mg
This is a multi-source protein powder enhanced with greens, digestive enzymes, and probiotics, aiming for broad nutritional support in a convenient chocolate-flavored drink.
82 Best 
Training Ground PRE Orange Mango
EFX Sports
4.6
★★★★★
(17 ratings)
Glycine: 2000 mg
This pre-workout liquid delivers a strong energy and focus blend with high doses of pump-supporting ingredients, making it suitable for intensive workouts.
78 Value 
DGL Deglycyrrhizinated Licorice Root Extract
Swanson Superior Herbs
4.6
★★★★★
(1190 ratings)
Glycine: 100 mg
A tablet blending DGL licorice extract for digestive comfort with a supportive touch of glycine.
88 Value 
Pharmaceutical Grade AjiPure Glycine 500 mg
Swanson Ultra
4.8
★★★★★
(1484 ratings)
Glycine: 500 mg
A 500 mg glycine capsule from Swanson Ultra, focusing on purity for general wellness and relaxation at a great price.
92 Best 
Sleep Nighttime Powder
youtheory
4.3
★★★★★
(40 ratings)
Glycine: 3000 mg
This sleep powder offers a robust blend of magnesium, a high dose of glycine, theanine, tryptophan, 5-HTP, and a microdose of melatonin, aiming to support relaxation and sleep.
70 Best 
Pegan Thin Seed Protein 20 g Triple Chocolate
Julian Bakery
4.5
★★★★★
(56 ratings)
Glycine: 2360 mg
<p>This Julian Bakery seed protein offers 20g of protein with a full amino acid profile, fitting Pegan and Vegan diets, though it comes at a premium price.</p>
98 Value 
Glycine 1000 mg
Life Extension
4.8
★★★★★
(14386 ratings)
Glycine: 1000 mg
A robust 1000 mg glycine capsule for those needing a higher dose to support sleep, detoxification, and overall wellness.
72 Budget 
DGL
Nature's Way
4.6
★★★★★
(2273 ratings)
Glycine: 150 mg
A DGL tablet featuring GutGard licorice extract and a small amount of glycine for targeted digestive support.
97 Best 
Glycine Powder
Vital Nutrients
4.9
★★★★★
(8 ratings)
Glycine: 4000 mg
A high-dose glycine powder, offering flexibility for varied dosages to support sleep, relaxation, and overall body function.
82 Value 
Glycine 500 mg
Country Life
4.9
★★★★★
(3588 ratings)
Glycine: 500 mg
A simple yet effective supplement combining glycine for broad body support with Vitamin B6 for enhanced metabolic and neurological functions.
78 Best 
MacroMeal Ultimate Vanilla Protein Powder
MacroLife Naturals
3.9
★★★★★
(8 ratings)
Glycine: 1910 mg
MacroMeal Ultimate Vanilla is a multi-source protein powder packed with greens, fruits, enzymes, and probiotics, designed for broad nutritional support and muscle maintenance.
85 Value 
Glycine 500 mg
Solgar
4.8
★★★★★
(2834 ratings)
Glycine: 500 mg
A simple capsule delivering 500 mg of pure glycine, useful for general wellness support including relaxation and digestive health.
77 Best 
MacroMeal Ultimate Chocolate Protein Powder
MacroLife Naturals
4.5
★★★★★
(8 ratings)
Glycine: 1956 mg
MacroMeal Ultimate Chocolate is a comprehensive protein powder with added greens, fruits, enzymes, and probiotics, aiming for broad nutritional support and muscle upkeep in a chocolate flavor.
82 Best 
Training Ground PRE Blueberry
EFX Sports
4.7
★★★★★
(23 ratings)
Glycine: 2000 mg
This pre-workout liquid delivers a strong energy and focus blend with high doses of pump-supporting ingredients, making it suitable for intensive workouts.
82 Value 
True Calm
NOW
4.6
★★★★★
(4456 ratings)
Glycine: 200 mg
This supplement blends amino acids, B vitamins, and valerian to support a calm mood and relaxation, making it useful for unwinding and general well-being.
88 Best 
R.E.M. Maintenance
Metabolic Maintenance
4.3
★★★★★
(37 ratings)
Glycine: 3500 mg
R.E.M. Maintenance delivers a powerful blend of glycine, magnesium, 5-HTP, inositol, and melatonin, making it a strong option for promoting relaxation and supporting a healthy sleep cycle.
94 Best 
Sleep Nighttime Powder
youtheory
4.3
★★★★★
(170 ratings)
Glycine: 3000 mg
This liquid sleep formula provides a strong mix of magnesium, a high dose of glycine, theanine, tryptophan, 5-HTP, and a gentle dose of melatonin, designed to promote relaxation and aid sleep.
88 Value 
Glycine Powder
Metabolic Maintenance
4.9
★★★★★
(219 ratings)
Glycine: 1000 mg
A pure glycine powder providing 1000mg per serving, offering flexible dosing for sleep, relaxation, and overall metabolic support.
75 Value 
Liga-Tend
Country Life
4.7
★★★★★
(21 ratings)
Glycine: 100 mg
This product offers a combination of amino acids, minerals, and digestive enzymes designed to support joint health, bone strength, and the integrity of connective tissues.
72 Value 
Prostabs Plus
Futurebiotics
4.7
★★★★★
(516 ratings)
Glycine: 173 mg
This supplement provides a blend of amino acids, zinc, lycopene, and botanical extracts in a convenient tablet form, intended to offer general men's health support.
82 Value 
Melatonin 2 mg
Metabolic Maintenance
4.7
★★★★★
(91 ratings)
Glycine: 210 mg
A capsule blending 2 mg melatonin with glycine to provide direct support for sleep and relaxation.
Average$37.14
Median$34.48
Average$1.32
Median$0.70
Average$0.53
Median$0.23
Reference amount: 100 mg
Magnesium Glycinate is a chelated compound where magnesium is bound to two molecules of the amino acid glycine. This specific chelation enhances magnesium's absorption and bioavailability in the intestine, making it less likely to cause the digestive upset (like diarrhea) often associated with other magnesium forms. The glycine component itself contributes to the supplement's benefits, acting as an inhibitory neurotransmitter that promotes relaxation and improves sleep quality. It is widely recognized for supporting sleep, stress relief, muscle relaxation, bone health, and overall magnesium repletion.
- High bioavailability and absorption of magnesium.
- Gentle on the stomach with minimal laxative effect.
- Glycine component provides additional calming and sleep-supportive benefits.
- Supports muscle relaxation and nerve function.
- Contributes to bone health and overall well-being.
- May be more expensive than other less bioavailable forms of magnesium.
- Can cause drowsiness in some individuals, particularly at higher doses.
- Not suitable for those specifically seeking a laxative effect from magnesium.
Avg$21.96
Med$21.96
Avg$0.24
Med$0.24
Avg$0.17
Med$0.17
Price distribution