Vinpocetine

Description

Vinpocetine is a semi-synthetic derivative of vincamine, an alkaloid found in the Vinca minor plant, commonly known as the lesser periwinkle. Although derived from a plant, vinpocetine itself is not found naturally but rather synthesized in a laboratory. It is widely utilized as a nootropic supplement, aiming to enhance brain health and cognitive performance by improving the brain's microcirculation. The mechanism of action for Vinpocetine is thought to involve the selective inhibition of phosphodiesterase type 1 (PDE1), leading to increased cerebral cyclic GMP (cGMP) levels. This action can result in the relaxation of smooth muscle in blood vessels, thereby improving cerebral blood flow and oxygen utilization in the brain. It also possesses neuroprotective and anti-inflammatory properties, contributing to overall brain resilience. Vinpocetine is commonly supplemented for its purported benefits in enhancing memory, concentration, and overall cognitive function. It is particularly investigated for its potential role in supporting brain health in conditions where cerebral circulation might be compromised, contributing to better nutrient and oxygen delivery to neural tissues and potentially aiding in neurological recovery.

Optimal Dosage
Minimum2 mg
Maximum10 mg
Safety & Toxicity
Upper Limit (UL)10 mg
Toxicity Threshold20 mg
Toxicity EffectNausea, dizziness, flushing
Goals
Productivity Boost
Productivity Boost
Impact
High effect
Typical dose:10–30 mg
Vinpocetine enhances cerebral metabolism and circulation, delivering more oxygen and glucose to neurons. This action can improve memory, alertness, and processing speed, making it effective for periods of intense mental work.
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Mental Focus
Mental Focus
Impact
Moderate effect
Typical dose:10–30 mg
Vinpocetine is a synthetic compound derived from the periwinkle plant that acts as a cerebral vasodilator, increasing blood flow and nutrient delivery to the brain. While this can support overall brain health and may lead to modest improvements in mental clarity, the clinical evidence for it as a primary focus-enhancer is not as strong as other nootropics.
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Brain Health
Brain Health
Impact
Situational effect
Typical dose:5–30 mg
Vinpocetine is a synthetic compound that acts as a vasodilator, specifically increasing blood flow in the brain. While this can be beneficial in certain conditions related to poor cerebral circulation, its general use as a top-tier cognitive enhancer is not supported by strong evidence, and it carries regulatory warnings in some regions. Its effectiveness is highly situational.
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Vision Support
Vision Support
Impact
Situational effect
Typical dose:15–60 mg
The benefits of Vinpocetine for vision are largely extrapolated from its known effects on cerebral blood flow. There is a lack of robust clinical trials demonstrating a significant and reliable effect on visual outcomes in the general population. Its use is speculative and therefore situational.
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Interactions

Negative Interactions

Ginkgo
May increase the risk of bleeding when combined with Vinpocetine due to additive antiplatelet effects.
Turmeric
May increase the risk of bleeding when combined with Vinpocetine due to additive antiplatelet effects.
Curcumin
May increase the risk of bleeding when combined with Vinpocetine due to additive antiplatelet effects.
Fish Oil
Can have antiplatelet effects, potentially increasing bleeding risk when combined with Vinpocetine.
EPA (Eicosapentaenoic Acid)
Can have antiplatelet effects, potentially increasing bleeding risk when combined with Vinpocetine.
DHA
Can have antiplatelet effects, potentially increasing bleeding risk when combined with Vinpocetine.
Omega-3
Can have antiplatelet effects, potentially increasing bleeding risk when combined with Vinpocetine.
Vitamin E
High doses may increase the risk of bleeding when combined with Vinpocetine due to mild antiplatelet effects.
Magnesium
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Potassium
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
L-Carnitine
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Coenzyme Q-10
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
GABA
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Taurine
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Melatonin
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Valerian
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Ashwagandha
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Hawthorn
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Green Tea
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Product stats
Price per product
Average$24.96
Median$26.59
Price per serving
Average$0.18
Median$0.12
Price distribution
Price per serving distribution
Price per
Paired ingredients