Vinpocetine
Vinpocetine is a semi-synthetic derivative of vincamine, an alkaloid found in the Vinca minor plant, commonly known as the lesser periwinkle. Although derived from a plant, vinpocetine itself is not found naturally but rather synthesized in a laboratory. It is widely utilized as a nootropic supplement, aiming to enhance brain health and cognitive performance by improving the brain's microcirculation. The mechanism of action for Vinpocetine is thought to involve the selective inhibition of phosphodiesterase type 1 (PDE1), leading to increased cerebral cyclic GMP (cGMP) levels. This action can result in the relaxation of smooth muscle in blood vessels, thereby improving cerebral blood flow and oxygen utilization in the brain. It also possesses neuroprotective and anti-inflammatory properties, contributing to overall brain resilience. Vinpocetine is commonly supplemented for its purported benefits in enhancing memory, concentration, and overall cognitive function. It is particularly investigated for its potential role in supporting brain health in conditions where cerebral circulation might be compromised, contributing to better nutrient and oxygen delivery to neural tissues and potentially aiding in neurological recovery.
Minimum2 mg
Maximum10 mg
Upper Limit (UL)10 mg
Toxicity Threshold20 mg
Toxicity EffectNausea, dizziness, flushing
Impact
High effect
Vinpocetine enhances cerebral metabolism and circulation, delivering more oxygen and glucose to neurons. This action can improve memory, alertness, and processing speed, making it effective for periods of intense mental work.
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Impact
Moderate effect
Typical dose:5–30 mg
Vinpocetine is a synthetic compound derived from the periwinkle plant that acts as a cerebral vasodilator, increasing blood flow and nutrient delivery to the brain. While this can support overall brain health and may lead to modest improvements in mental clarity, the clinical evidence for it as a primary focus-enhancer is not as strong as other nootropics.
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Impact
Situational effect
Typical dose:5–30 mg
Vinpocetine is a synthetic compound that acts as a vasodilator, specifically increasing blood flow in the brain. While this can be beneficial in certain conditions related to poor cerebral circulation, its general use as a top-tier cognitive enhancer is not supported by strong evidence, and it carries regulatory warnings in some regions. Its effectiveness is highly situational.
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Impact
Situational effect
Typical dose:5–30 mg
The benefits of Vinpocetine for vision are largely extrapolated from its known effects on cerebral blood flow. There is a lack of robust clinical trials demonstrating a significant and reliable effect on visual outcomes in the general population. Its use is speculative and therefore situational.
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remove_circle_outline Negative Interactions
Ginkgo
May increase the risk of bleeding when combined with Vinpocetine due to additive antiplatelet effects.
Turmeric
May increase the risk of bleeding when combined with Vinpocetine due to additive antiplatelet effects.
Curcumin
May increase the risk of bleeding when combined with Vinpocetine due to additive antiplatelet effects.
Fish Oil
Can have antiplatelet effects, potentially increasing bleeding risk when combined with Vinpocetine.
EPA (Eicosapentaenoic Acid)
Can have antiplatelet effects, potentially increasing bleeding risk when combined with Vinpocetine.
DHA
Can have antiplatelet effects, potentially increasing bleeding risk when combined with Vinpocetine.
Omega-3
Can have antiplatelet effects, potentially increasing bleeding risk when combined with Vinpocetine.
Vitamin E
High doses may increase the risk of bleeding when combined with Vinpocetine due to mild antiplatelet effects.
Magnesium
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Potassium
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
L-Carnitine
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Coenzyme Q-10
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
GABA
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Taurine
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Melatonin
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Valerian
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Ashwagandha
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Hawthorn
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
Green Tea
May enhance blood pressure lowering effects, leading to excessively low blood pressure (hypotension) when combined with Vinpocetine.
73 Value 
Synaptin
Ecological Formulas
5.0
★★★★★
(5 ratings)
Vinpocetine: 2.5 mg
This product offers a combination of B-vitamin derivatives and herbal extracts specifically chosen to support cognitive function, mental focus, and overall brain health.
82 Best 
CogniAid
Designs for Health
5.0
★★★★★
(1 ratings)
Vinpocetine: 30 mg
This blend brings together several distinct ingredients to support various aspects of brain health, mental focus, and overall cognitive function.
68 Best 
MindBlend
Vitanica
5.0
★★★★★
(1 ratings)
Vinpocetine: 5 mg
MindBlend is a comprehensive blend of vitamins, phospholipids, and herbal extracts formulated to support a wide range of cognitive functions, mood, and stress response.
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Vinpocetine 10 mg
Source Naturals
4.7
★★★★★
(2285 ratings)
Vinpocetine: 10 mg
A straightforward Vinpocetine supplement in a common 10 mg tablet form, offering good value for consistent daily use.
82 Value 
Ginkgo with Vinpocetine
Swanson Superior Herbs
4.7
★★★★★
(340 ratings)
Vinpocetine: 10 mg
This product delivers a powerful combination of ginkgo's active compounds and vinpocetine, aiming for strong support for mental focus and brain circulation.
92 Value 
Herbal Extract Memory Complex
Swanson Ultra
4.6
★★★★★
(468 ratings)
Vinpocetine: 15 mg
This complex offers an exceptionally potent blend of ginkgo, vinpocetine, and huperzia serrata extract for multi-faceted and strong cognitive support.
78 Value 
Vinpocetine 10 mg
Swanson
4.8
★★★★★
(549 ratings)
Vinpocetine: 10 mg
A direct 10 mg Vinpocetine supplement in capsule form, intended to support mental focus and brain circulation.
79 Value 
Vinpocetine 30 mg Triple Strength
Swanson
4.8
★★★★★
(244 ratings)
Vinpocetine: 30 mg
A high-dose 30 mg Vinpocetine capsule designed for enhanced support of mental focus and cerebral blood flow.
73 Best 
Brain/Memory with Huperzine A
Vinco
4.3
★★★★★
(8 ratings)
Vinpocetine: 5 mg
This supplement combines several known cognitive support ingredients like Acetyl-L-Carnitine, Bacopa, Vinpocetine, and Huperzine A to assist with memory, focus, and overall brain function.
84 Best 
Ultimate Neuro Complex
Natural Factors 3 Brains
4.6
★★★★★
(361 ratings)
Vinpocetine: 10 mg
This complex provides a blend of compounds that can help support mental clarity, focus, and overall brain function for daily cognitive demands.
88 Value 
Vinpocetine 10 mg
Life Extension
4.7
★★★★★
(1511 ratings)
Vinpocetine: 10 mg
An exceptionally affordable 10 mg Vinpocetine tablet from Life Extension, offering good value for brain and vision support.
85 Best 
Cognitex Elite
Life Extension
4.7
★★★★★
(635 ratings)
Vinpocetine: 20 mg
A comprehensive blend featuring Vinpocetine and other compounds for broad-spectrum mental focus, brain health, and productivity support.
84 Best 
Cognitex Elite Pregnolone
Life Extension
4.6
★★★★★
(654 ratings)
Vinpocetine: 20 mg
A comprehensive brain support blend containing Vinpocetine, other cognitive nutrients, and Pregnenolone for multifaceted mental performance.
55 Best 
Clari-T
LifeSeasons
4.7
★★★★★
(210 ratings)
Vinpocetine: 20 mg
This product offers a multi-ingredient approach to cognitive support, though the specified 20mg of Huperzine A is a quantity that is considerably higher than typical use and should be carefully noted.
58 Value 
Vinpocetine 10 mg
Ecological Formulas
5.0
★★★★★
(2 ratings)
Vinpocetine: 10 mg
A 10 mg Vinpocetine capsule that provides a standard dose but comes at a higher price point with very little customer feedback.
79 Value 
Vinpocetine 10 mg
Source Naturals
4.7
★★★★★
(2295 ratings)
Vinpocetine: 10 mg
A reliable 10 mg Vinpocetine tablet from Source Naturals, offering a good supply for consistent brain and mental focus support.
72 Best 
Higher Mind
Source Naturals
4.3
★★★★★
(208 ratings)
Vinpocetine: 30 mg
Higher Mind is a multi-ingredient supplement formulated to support a wide range of cognitive functions, energy levels, and mood stability through its diverse blend of vitamins, minerals, amino acids, and herbal extracts.
83 Best 
MemorAll
XYMOGEN
5.0
★★★★★
(1 ratings)
Vinpocetine: 5 mg
MemorAll is a multi-ingredient supplement featuring a blend of highly bioavailable B vitamins, botanicals like Bacopa and Ginkgo, and compounds such as Huperzine A, Vinpocetine, and ALCAR, formulated to broadly support brain health and mental focus.
70 Best 
Vinpocetine 20 mg
Pure Encapsulations
4.3
★★★★★
(17 ratings)
Vinpocetine: 20 mg
A high-potency 20 mg Vinpocetine capsule, suitable for those desiring a stronger dose but at a premium price.
Average$30.85
Median$28.99
Average$1.38
Median$1.30