Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
Qualitative study5 participantsflagEnergy forscienceVitamin B12
- Vitamin B12 Supplementation: Is More Always Better?
Yepes-Calderón M; Doorenbos CSE; Stegmann ME; Touw DJ; Harmsen HJM; Heiner-Fokkema MR; van Spronsen FJ; Corpeleijn E; Bakker SJL · Nutrients · 2026
Narrative reviewflagEnergy forscienceVitamin B12
- Sleep symptoms associated with intake of specific dietary nutrients.
Grandner MA; Jackson N; Gerstner JR; Knutson KL · Journal of sleep research · 2014
Cross-sectional study4,552 participantsflagEnergy forscienceTheobromine
- Effect of L-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study.
Boon MR; Hanssen MJW; Brans B; Hülsman CJM; Hoeks J; Nahon KJ; Bakker C; van Klinken JB; Havekes B; Schaart G; Jazet IM; Rensen PCN; van Marken Lichtenbelt WD · Diabetologia · 2019
Randomized trial20 participantsflagEnergy forscienceArginine
- The Effects of Arginine-Based Supplements on Fatigue Levels following COVID-19 Infection: A Prospective Study in Romania.
Turcu-Stiolica A; Ionele CM; Ungureanu BS; Subtirelu MS · Healthcare (Basel, Switzerland) · 2023
Non-randomized trial505 participantsflagEnergy forscienceArginine
- Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
Randomized trial115 participantsflagMental Focus forscienceVitamin B12
- The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people.
Eussen SJ; Ueland PM; Clarke R; Blom HJ; Hoefnagels WH; van Staveren WA; de Groot LC · The British journal of nutrition · 2007
Randomized trial195 participantsflagMental Focus forscienceVitamin B12
- Promising, but Not Completely Conclusive-The Effect of l-Theanine on Cognitive Performance Based on the Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.
Mátyus RO; Szikora Z; Bodó D; Vargáné Szabó B; Csupor É; Csupor D; Tóth B · Journal of clinical medicine · 2025
Meta-analysis148 participants5 studies pooledflagMental Focus forscienceTheanine
- Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
Randomized trial48 participantsflagMental Focus flagProductivity Boost forscienceTheanine
- Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
Cross-sectional study20,665 participantsflagCardiovascular Support flagHeart Health forscienceVitamin B12
- Methylmalonic acid, vitamin B12, and mortality risk in patients with preexisting coronary heart disease: a prospective cohort study.
Guo J; Liu X; Wang Z; Lu R; Liu Y; Zhang Y; Tian W; Fang S; Wang S; Yu B · Nutrition journal · 2023
Cohort study1,755 participantsflagCardiovascular Support forscienceVitamin B12
- Effect of cocoa and theobromine consumption on serum HDL-cholesterol concentrations: a randomized controlled trial.
Neufingerl N; Zebregs YE; Schuring EA; Trautwein EA · The American journal of clinical nutrition · 2013
Randomized trial152 participantsflagCardiovascular Support forscienceTheobromine
- Relationships between consumption of theobromine in cocoa products and cardiovascular risk factors in 2015-2020 National health and nutrition examination survey.
Ponsuporn W; Naumovski N; McKune AJ; Khemacheewakul J; Leksawasdi N; Rachtanapun P; Taesuwan S · European journal of nutrition · 2026
Cross-sectional study8,531 participantsflagCardiovascular Support forscienceTheobromine
- L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease.
Yin WH; Chen JW; Tsai C; Chiang MC; Young MS; Lin SJ · Clinical nutrition (Edinburgh, Scotland) · 2006
Randomized trial31 participantsflagCardiovascular Support forscienceArginine
- Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis.
Rodrigues-Krause J; Krause M; Rocha IMGD; Umpierre D; Fayh APT · Nutrients · 2019
Meta-analysis13 studies pooledflagCardiovascular Support forscienceArginine
- B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.
Wang Z; Zhu W; Xing Y; Jia J; Tang Y · Nutrition reviews · 2022
Meta-analysis46,175 participants95 studies pooledflagBrain Health forscienceFolate
- Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial.
Catena A; Muñoz-Machicao JA; Torres-EspÃnola FJ; MartÃnez-ZaldÃvar C; Diaz-Piedra C; Gil A; Haile G; Györei E; Molloy AM; Decsi T; Koletzko B; Campoy C · The American journal of clinical nutrition · 2016
Randomized trial136 participantsflagBrain Health forscienceFolate
- Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.
Liu Y; Yu Z; Cai Z; Zhao L; Wang Y; Guo Y; Su X; Miao Y; Yi B; Wang Y; Zhang X · The journal of prevention of Alzheimer's disease · 2025
Randomized trial220 participantsflagBrain Health forscienceFolate
- Circulating folate concentrations and the risk of mild cognitive impairment: A prospective study on the older Chinese population without folic acid fortification.
Fu J; Liu Q; Zhu Y; Sun C; Duan H; Huang L; Zhou D; Wang Z; Zhao J; Li Z; Ma F; Li W; Liu H; Zhang X; Chen Y; Wang G; Du Y; Huang G · European journal of neurology · 2022
Cohort study3,974 participantsflagBrain Health forscienceFolate
- Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment.
Jang S; Han JW; Shin J; Kim TH; Kwak KP; Kim K; Kim BJ; Kim SG; Kim JL; Kim TH; Moon SW; Park JY; Park JH; Byun S; Suh SW; Seo J; So Y; Ryu SH; Youn JC; Lee KH; Lee DY; Lee DW; Lee SB; Lee JJ; Lee JR; Jeong H; Jeong HG; Jhoo JH; Han K; Hong JW; Kim KW · Psychiatry investigation · 2020
Cohort study3,910 participantsflagBrain Health forscienceFolate
- Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
Randomized trial30 participantsflagBrain Health forscienceTheanine
- A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
Randomized trialflagBrain Health flagStress Relief forscienceTheanine
- Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
Meta-analysis50 studies pooledflagBrain Health flagMental Focus forscienceTheanine
- Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
Randomized trial27 participantsflagBrain Health forscienceTheanine
- Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
Randomized trialflagBrain Health flagMental Focus flagProductivity Boost forscienceTheanine
- Combination of Vinpocetine and Dexamethasone Alleviates Cognitive Impairment in Nasopharyngeal Carcinoma Patients following Radiation Injury.
Zhang P; Cao Y; Chen S; Shao L · Pharmacology · 2021
Randomized trial60 participantsflagBrain Health forscienceVinpocetine
- Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients: a PET study.
Szilágyi G; Nagy Z; Balkay L; Boros I; Emri M; Lehel S; Márián T; Molnár T; Szakáll S; Trón L; Bereczki D; Csiba L; Fekete I; Kerényi L; Galuska L; Varga J; Bönöczk P; Vas A; Gulyás B · Journal of the neurological sciences · 2005
Randomized trial13 participantsflagBrain Health forscienceVinpocetine
- Role of sodium channel inhibition in neuroprotection: effect of vinpocetine.
Bönöczk P; Gulyás B; Adam-Vizi V; Nemes A; Kárpáti E; Kiss B; Kapás M; Szántay C; Koncz I; Zelles T; Vas A · Brain research bulletin · 2001
Narrative reviewflagBrain Health forscienceVinpocetine
- Effect of vinpocetine (cognitolâ„¢) on cognitive performances of a nigerian population.
Ogunrin A · Annals of medical and health sciences research · 2014
Non-randomized trial112 participantsflagBrain Health flagMental Focus forscienceVinpocetine
- [Study of the effects of vinpocetin on cognitive functions].
Valikovics A; Csányi A; Németh L · Ideggyogyaszati szemle · 2012
Clinical trialflagBrain Health forscienceVinpocetine
- Reassessment of the effect of oral l-arginine on blood pressure: A systematic review and meta-analysis based on ambulatory blood pressure monitoring.
Shi Y; Liu Y; Zhou Z; Xu S; Luo P · Nitric oxide : biology and chemistry · 2026
Meta-analysis202 participants5 studies pooledflagCardiovascular Support forscienceArginine
- Effect of Long-Term L-Arginine Supplementation on Arterial Compliance and Metabolic Parameters in Patients with Multiple Cardiovascular risk Factors: Randomized, Placebo-Controlled Study.
Guttman H; Zimlichman R; Boaz M; Matas Z; Shargorodsky M · Journal of cardiovascular pharmacology · 2024
Randomized trial90 participantsflagCardiovascular Support forscienceArginine
- Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials.
Bai Y; Sun L; Yang T; Sun K; Chen J; Hui R · The American journal of clinical nutrition · 2009
Meta-analysis492 participants13 studies pooledflagCardiovascular Support forscienceArginine
- Oral L-Arginine Administration Improves Anthropometric and Biochemical Indices Associated With Cardiovascular Diseases in Obese Patients: A Randomized, Single Blind Placebo Controlled Clinical Trial.
Dashtabi A; Mazloom Z; Fararouei M; Hejazi N · Research in cardiovascular medicine · 2016
Randomized trial90 participantsflagCardiovascular Support forscienceArginine
- Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
Cohort study115,664 participantsflagCardiovascular Support forscienceFolate
- Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
Cohort study3,530 participantsflagCardiovascular Support forscienceFolate
- Effect of folic acid on endothelial function following acute myocardial infarction.
Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
Randomized trial40 participantsflagCardiovascular Support forscienceFolate
- Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
Randomized trial24 participantsflagCardiovascular Support forscienceFolate
- 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
Non-randomized trial20 participantsflagCardiovascular Support forscienceFolate
- Real world effectiveness of Hawthorn special extract WS 1442 in a retrospective cohort study from Germany.
Wyss C; Gündling PW; Kostev K · Scientific reports · 2024
Cohort study9,100 participantsflagCardiovascular Support forscienceHawthorn
- Hawthorn (Crataegus spp.) Clinically Significantly Reduces Blood Pressure in Hypertension: A Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.
Szikora Z; Mátyus RO; Szabó BV; Csupor D; Tóth B · Pharmaceuticals (Basel, Switzerland) · 2025
Meta-analysis428 participants6 studies pooledflagCardiovascular Support flagHeart Health forscienceHawthorn
- A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan) in the treatment of patients with congestive heart failure NYHA II.
Degenring FH; Suter A; Weber M; Saller R · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2003
Randomized trial143 participantsflagCardiovascular Support forscienceHawthorn
- [Crataegus Special Extract WS 1442. Assessment of objective effectiveness in patients with heart failure (NYHA II)].
Weikl A; Assmus KD; Neukum-Schmidt A; Schmitz J; Zapfe G; Noh HS; Siegrist J · Fortschritte der Medizin · 1996
Randomized trial136 participantsflagCardiovascular Support forscienceHawthorn
- Prospective, comparative cohort studies and their contribution to the benefit assessments of therapeutic options: heart failure treatment with and without Hawthorn special extract WS 1442.
Habs M · Forschende Komplementarmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine · 2005
Cohort study952 participantsflagCardiovascular Support forscienceHawthorn
- Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
Cohort study493 participantsflagCardiovascular Support forscienceVitamin B12
- Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
Cross-sectional study1,197 participantsflagCardiovascular Support forscienceVitamin B12
- Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
Cohort study202 participantsflagCardiovascular Support forscienceVitamin B12
- Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
Systematic reviewflagCardiovascular Support forscienceVitamin B12
- Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
Cohort studyflagCardiovascular Support forscienceVitamin B6
- Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
Randomized trial124 participantsflagCardiovascular Support forscienceVitamin B6
- Pyridoxine improves endothelial function in cardiac transplant recipients.
Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
Randomized trial31 participantsflagCardiovascular Support forscienceVitamin B6
- Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
Cohort study80,082 participantsflagCardiovascular Support forscienceVitamin B6
- Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
Randomized trial3,023 participantsflagCardiovascular Support forscienceVitamin B6
- Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.
Kavcı Z; Ozan M; Buzdağlı Y; Savaş A; Uçar H · Journal of the International Society of Sports Nutrition · 2024
Randomized trial15 participantsflagEnergy forscienceArginine
- Isolated but not combined ergogenic effects of caffeine and L-arginine during an isokinetic knee extension.
Zart S; Brachtendorf M; Becker S; Fröhlich M · Frontiers in nutrition · 2024
Randomized trial29 participantsflagEnergy forscienceArginine
- L-Arginine but not L-glutamine likely increases exogenous carbohydrate oxidation during endurance exercise.
Rowlands DS; Clarke J; Green JG; Shi X · European journal of applied physiology · 2012
Randomized trial8 participantsflagEnergy forscienceArginine
- A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
Case series3 participantsflagEnergy forscienceVitamin B12
- Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
Meta-analysis6,276 participants16 studies pooledflagEnergy forscienceVitamin B12
- Cobalamin deficiency: clinical picture and radiological findings.
Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
Narrative reviewflagEnergy forscienceVitamin B12
- Vitamin B12 Deficiency: Common Questions and Answers.
Patel H; McGuirk R · American family physician · 2025
Narrative reviewflagEnergy forscienceVitamin B12
- The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
Patel MN; Maheshvari J; Patel N · Cureus · 2025
Randomized trial105 participantsflagHair Health flagNail Health flagSkin Health forscienceBiotin
- Low serum biotinidase activity in children with valproic acid monotherapy.
Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
Clinical trial125 participantsflagHair Health flagSkin Health forscienceBiotin
- Vitamins A, B, C, and D: A Short Review for the Dermatologist.
Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
Narrative reviewflagHair Health forscienceBiotin
- The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
Narrative reviewflagHair Health forscienceBiotin
- The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
Randomized trial200 participantsflagHair Health forscienceZinc
- Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
Randomized trialflagHair Health forscienceZinc
- A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
Randomized trial40 participantsflagHair Health forscienceZinc
- BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
Case-control study216 participantsflagHair Health forscienceZinc
- Analysis of serum zinc and copper concentrations in hair loss.
Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
Case-control study342 participantsflagHair Health forscienceZinc
- Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
Randomized trial20,702 participantsflagHeart Health forscienceFolate
- Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
Case-control study985 participantsflagHeart Health forscienceFolate
- Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
Meta-analysis369,746 participants11 studies pooledflagHeart Health forscienceFolate
- Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
Meta-analysis423,304 participants25 studies pooledflagHeart Health forscienceFolate
- The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
Wondemagegn AT; Afework M · SAGE open medicine · 2022
Meta-analysis37 studies pooledflagHeart Health forscienceFolate
- [Actions of standardized extracts of Crataegus berries on exercise tolerance and quality of life in patients with congestive heart failure].
Rietbrock N; Hamel M; Hempel B; Mitrovic V; Schmidt T; Wolf GK · Arzneimittel-Forschung · 2001
Randomized trial88 participantsflagHeart Health forscienceHawthorn
- Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials.
Pittler MH; Schmidt K; Ernst E · The American journal of medicine · 2003
Meta-analysis632 participants13 studies pooledflagHeart Health forscienceHawthorn
- Clinical efficacy of crataegus extract WS 1442 in congestive heart failure NYHA class II.
Zapfe jun G · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2002
Randomized trial40 participantsflagHeart Health forscienceHawthorn
- Baseline severity but not gender modulates quantified Crataegus extract effects in early heart failure--a pooled analysis of clinical trials.
Eggeling T; Regitz-Zagrosek V; Zimmermann A; Burkart M · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
Meta-analysis687 participants10 studies pooledflagHeart Health forscienceHawthorn
- Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
Cross-sectional study469 participantsflagHeart Health forscienceVitamin B12
- Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
Cohort study1,950 participantsflagHeart Health forscienceVitamin B12
- Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
Non-randomized trial16 participantsflagHeart Health forscienceVitamin B12
- The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
Observational study596 participantsflagHeart Health forscienceVitamin B12
- Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
Meta-analysis199,055 participants115 studies pooledflagImmunity forscienceZinc
- Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
Randomized trial609 participantsflagImmunity forscienceZinc
- A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
Randomized trial64 participantsflagImmunity forscienceZinc
- The effect of zinc and vitamin A supplementation on immune response in an older population.
Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
Randomized trial136 participantsflagImmunity forscienceZinc
- The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
Systematic review13 studies pooledflagImmunity forscienceZinc
- Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
Clinical trial20 participantsflagMental Focus forscienceTheanine
- Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
Randomized trial30 participantsflagMental Focus flagProductivity Boost flagStress Relief forscienceTheanine
- Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
Randomized trial24 participantsflagMental Focus forscienceTheanine
- "Brain-specific" nutrients: a memory cure?
McDaniel MA; Maier SF; Einstein GO · Nutrition (Burbank, Los Angeles County, Calif.) · 2004
Narrative reviewflagMental Focus forscienceVinpocetine
- Psychopharmacological effects of vinpocetine in normal healthy volunteers.
Subhan Z; Hindmarch I · European journal of clinical pharmacology · 1985
Randomized trial12 participantsflagMental Focus forscienceVinpocetine
- l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
Randomized trial60 participantsflagMood Support forscienceTheanine
- L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
Randomized trial60 participantsflagMood Support flagStress Relief forscienceTheanine
- The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
Systematic review9 studies pooledflagMood Support forscienceTheanine
- Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
Randomized trial168 participantsflagMood Support flagStress Relief forscienceTheanine
- Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
Randomized trial20 participantsflagMood Support forscienceTheanine
- Biotin for the treatment of nail disease: what is the evidence?
Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
Narrative reviewflagNail Health forscienceBiotin
- Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
Other32 participantsflagNail Health forscienceBiotin
- Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
Randomized trial50 participantsflagNail Health forscienceBiotin
- Vitamins and minerals: their role in nail health and disease.
Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
Narrative reviewflagNail Health forscienceBiotin flagNail Health forscienceZinc
- Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
Meta-analysis1,168 participants31 studies pooledflagProductivity Boost forscienceTheanine
- Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
Narrative reviewflagProductivity Boost forscienceTheanine
- Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS · International journal of dermatology · 2021
Non-randomized trial60 participantsflagSkin Health forscienceBiotin
- Generalized seborrhoeic dermatitis. Clinical and therapeutic data of 25 patients.
Messaritakis J; Kattamis C; Karabula C; Matsaniotis N · Archives of disease in childhood · 1976
Non-randomized trial25 participantsflagSkin Health forscienceBiotin
- Holocarboxylase synthetase deficiency: novel clinical and molecular findings.
Tammachote R; Janklat S; Tongkobpetch S; Suphapeetiporn K; Shotelersuk V · Clinical genetics · 2010
Case series4 participantsflagSkin Health forscienceBiotin
- The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
Hakozaki T; Minwalla L; Zhuang J; Chhoa M; Matsubara A; Miyamoto K; Greatens A; Hillebrand GG; Bissett DL; Boissy RE · The British journal of dermatology · 2002
Randomized trial138 participantsflagSkin Health forscienceNiacin
- Niacinamide: A B vitamin that improves aging facial skin appearance.
Bissett DL; Oblong JE; Berge CA · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
Randomized trial50 participantsflagSkin Health forscienceNiacin
- The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.
Chiu PC; Chan CC; Lin HM; Chiu HC · Journal of cosmetic dermatology · 2008
Randomized trial52 participantsflagSkin Health forscienceNiacin
- A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
Chen AC; Martin AJ; Choy B; Fernández-Peñas P; Dalziell RA; McKenzie CA; Scolyer RA; Dhillon HM; Vardy JL; Kricker A; St George G; Chinniah N; Halliday GM; Damian DL · The New England journal of medicine · 2015
Randomized trial386 participantsflagSkin Health forscienceNiacin
- Nicotinamide for Skin Cancer Chemoprevention.
Breglio KF; Knox KM; Hwang J; Weiss R; Maas K; Zhang S; Yao L; Madden C; Xu Y; Hartman RI; Wheless L · JAMA dermatology · 2025
Cohort study33,822 participantsflagSkin Health forscienceNiacin
- Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
Meta-analysis2,088 participants20 studies pooledflagSkin Health forscienceZinc
- Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
Cohort study23 participantsflagSkin Health forscienceZinc
- Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
Randomized trial30 participantsflagSkin Health forscienceZinc
- A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
Randomized trial90 participantsflagSkin Health forscienceZinc
- Evidence-Based Nutritional Interventions in Wound Care.
Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
Systematic review2,339 participants36 studies pooledflagSkin Health forscienceZinc
- Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
Randomized trial34 participantsflagStress Relief forscienceTheanine