C-500 Complex

C-500 Complex

The Vitamin Shoppe4.7 (69 ratings)
Format:Capsule Quantity: 100 Capsule(s) · 100 servings
Goals
$12.99 $0.12 per serving

Product analysis

58 out of 100

C-500 Complex supplies vitamin C for normal immune function and collagen formation, with the clearest nutritional benefit when intake is low.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality40

The vitamin C form and flavonoid sources are identified, but a firm absorption-quality comparison is unavailable. The flavonoid proportions remain unclear.

Ingredient Transparency80

Amounts and forms are identified, but the flavonoid proportions are undisclosed. That limits comparison of the mixture despite clear serving amounts.

Value For Money48

The vitamin C cost sits around the middle of its comparison. A missing flavonoid comparison leaves the value of the full combination uncertain.

Customer Satisfaction71

Customer ratings are favorable, but come from a small review pool. Reviews describe satisfaction without establishing effectiveness or safety.

Product Focus68

Vitamin C provides the clearest support for normal immune function and collagen formation. Regular use may modestly shorten colds, while eye and inflammation findings have narrower applicability.

Format
Capsule
Container
100 Capsule(s)
Per serving
$0.12
Customer rating
4.7 · 69 ratings
Report analysis

Goals

Immunity
Impact
High effect
B- Ingredient FitD- PathwaysA+ EvidenceA+ Formulation Logic
Vitamin C · 500 mg

Vitamin C supports normal immune function, and regular supplementation has modest support for shortening colds rather than preventing infection. A single serving does not establish the repeated use studied in trials.

How this product is rated for Immunity

Ingredient fit74

Vitamin C provide the focused contribution to immunity here. The relevant amounts provide uneven contributions relative to the supplied comparisons; smaller amounts limit some contributions.
Goal fit
Vitamin C provide the focused contribution to immunity here.
Dose adequacy
The relevant amounts provide uneven contributions relative to the supplied comparisons; smaller amounts limit some contributions.

Pathways40

The strongest contribution concerns innate immune cell activity, based on the relevant ingredients and their amounts. The main contribution is concentrated in one immune-related area.
Depth
The strongest contribution concerns innate immune cell activity, based on the relevant ingredients and their amounts.
Breadth
The main contribution is concentrated in one immune-related area.

Evidence100

Vitamin C has the strongest supported contribution here, with modest regular-use cold-duration evidence rather than infection prevention.
Evidence strength
Vitamin C has the strongest supported contribution here, with modest regular-use cold-duration evidence rather than infection prevention.
Studied preparation
The counted preparations meet the supplied preparation comparison, without establishing superior effects from their forms or delivery methods.

Formulation logic100

The counted ingredients can contribute independently or have the partners required by the supplied findings. No configured ingredient conflict was identified from the supplied facts.
Partner coverage
The counted ingredients can contribute independently or have the partners required by the supplied findings.
Conflicts
No configured ingredient conflict was identified from the supplied facts.
Effective doses
The counted ingredients all meet the minimum amount comparison; this does not establish infection-prevention or treatment doses.
Study evidence
Vitamin C Supportive 53 studies
Everyday Health
Impact
Moderate effect
C- Ingredient FitF PathwaysB- EvidenceA+ Formulation Logic
Vitamin C · 500 mg

Vitamin C at 500 mg contributes to normal immune function and antioxidant protection. Its everyday-health role is nutritional support, with benefit depending on how it fits into overall intake.

How this product is rated for Everyday Health

Ingredient fit60

Relevant nutritional or stress-related ingredients sit alongside ingredients aimed at other purposes. The assessed amounts provide partial coverage of the saved comparison references.
Goal fit
Relevant nutritional or stress-related ingredients sit alongside ingredients aimed at other purposes.
Dose adequacy
The assessed amounts provide partial coverage of the saved comparison references.

Pathways17

The strongest assessed connection is to antioxidant and immune defence. The saved findings show limited coverage across the assessed health functions.
Depth
The strongest assessed connection is to antioxidant and immune defence.
Breadth
The saved findings show limited coverage across the assessed health functions.

Evidence74

Vitamin C provides the strongest evidence contribution in the saved assessment. The assessed ingredients match the preparation categories used in the saved review.
Evidence strength
Vitamin C provides the strongest evidence contribution in the saved assessment.
Studied preparation
The assessed ingredients match the preparation categories used in the saved review.

Formulation logic100

The assessed ingredients can contribute individually or have their required companions present. No configured ingredient conflict was identified in the supplied assessment. All ingredients counted in this finding meet the saved minimum amount threshold.
Partner coverage
The assessed ingredients can contribute individually or have their required companions present.
Conflicts
No configured ingredient conflict was identified in the supplied assessment.
Effective doses
All ingredients counted in this finding meet the saved minimum amount threshold.
Study evidence
Vitamin C Supportive 56 studies
Impact
Moderate effect
C- Ingredient FitF PathwaysA- EvidenceA+ Formulation Logic
Vitamin C · 500 mg

Vitamin C may help lower CRP, a marker of inflammation, when that marker is already elevated. A general reduction in inflammation isn't clear for adults without that condition. Taking a larger amount doesn't by itself mean you'll notice less pain or other inflammatory symptoms.

How this product is rated for Inflammation

Ingredient fit60

Vitamin C is the relevant ingredient, with benefits depending on the person's starting inflammation.
Goal fit
Vitamin C is the relevant ingredient, with benefits depending on the person's starting inflammation. Flavonoid (mixture has no distinct anti-inflammatory benefit identified here.
Dose adequacy
Vitamin C: 500 mg. These are label-serving amounts, not an assumed daily regimen.

Pathways17

The connection concerns oxidative stress, a process involving reactive molecules; it doesn't promise relief from inflammatory symptoms.
Depth
The connection concerns oxidative stress, a process involving reactive molecules; it doesn't promise relief from inflammatory symptoms.
Breadth
The connection is concentrated in oxidative stress rather than spanning several distinct inflammation-related processes.

Evidence87

Vitamin C's possible effect on CRP depends on elevated starting levels. The vitamin C form is identified, but buffered forms have no clear anti-inflammatory advantage.
Evidence strength
Vitamin C's possible effect on CRP depends on elevated starting levels.
Studied preparation
The vitamin C form is identified, but buffered forms have no clear anti-inflammatory advantage.

Formulation logic100

The relevant ingredient can act without an additional partner. No particular ingredient conflict is identified.
Partner coverage
No additional partner ingredient is required for the relevant ingredient’s individual role.
Conflicts
No particular ingredient conflict is identified.
Effective doses
Vitamin C: 500 mg. These are label-serving amounts, not an assumed daily regimen.
Study evidence
Vitamin C Supportive 50 studies
Skin Health
Impact
High effect
B Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Vitamin C · 500 mg

Vitamin C is needed to form collagen, and correcting low intake can improve the impaired healing and skin fragility caused by deficiency. Extra vitamin C has no established skin benefit when intake is adequate. The serving amount does not establish better hydration, fewer wrinkles or improved UV protection.

How this product is rated for Skin Health

Ingredient fit80

Vitamin C provides the main relevant connection in this formula. Its declared amount reaches the supplied comparison range.
Goal fit
The formula includes relevant nutrient roles alongside ingredients serving other goals.
Dose adequacy
Vitamin C reaches the supplied exposure reference, without proving additional skin benefit at that amount.

Pathways0

No skin mechanism receives coverage in the supplied findings. Nutrient functions alone do not establish a routine cosmetic effect.
Depth
No pathway has a qualifying contribution in the supplied findings.
Breadth
No mechanism reaches the supplied coverage threshold.

Evidence100

Vitamin C leads the supplied evidence finding. The meaningful benefit is mainly nutritional adequacy, rather than established improvement in already well-nourished skin.
Evidence strength
Vitamin C leads this finding, but normal nutrient requirements do not establish extra skin benefit when intake is adequate.
Studied preparation
The qualifying nutrient declarations meet the supplied preparation criteria; forms alone do not establish greater cosmetic efficacy.

Formulation logic100

No required partner is missing and no specified formulation conflict is identified. This does not establish extra benefit from the combination.
Partner coverage
All counted ingredients work without an additional required partner or have that partner present.
Conflicts
No specified formulation conflict was matched in the supplied facts.
Effective doses
All ingredients counted for this finding clear its minimum exposure threshold, without establishing a clinically effective skin dose.
Study evidence
Vitamin C Supportive 53 studies
Impact
High effect
B Ingredient FitD PathwaysC+ EvidenceA+ Formulation Logic
Vitamin C · 500 mg

Vitamin C is the relevant ingredient for antioxidant-related eye nutrition. Its clinical support comes from a defined AREDS combination in selected people with AMD, rather than vitamin C alone improving routine visual performance or preventing eye disease. The declared serving amount receives full recognition in the saved amount assessment, but this does not establish a proven standalone vision dose.

How this product is rated for Eye Health

Ingredient fit80

Vitamin C provide the relevant matches, alongside several ingredients serving other purposes. Vitamin C reaches the saved amount reference; larger amounts do not establish greater vision benefit.
Goal fit
Vitamin C provide the relevant matches, alongside several ingredients serving other purposes.
Dose adequacy
Vitamin C reaches the saved amount reference; larger amounts do not establish greater vision benefit.

Pathways47

The saved findings concentrate on retinal and lens antioxidant defense.
Depth
The saved findings concentrate on retinal and lens antioxidant defense.
Breadth
Only one area reaches the saved coverage threshold, leaving the other visual functions without comparable coverage.

Evidence68

Vitamin C's strongest clinical context is a complete AREDS regimen in selected AMD populations.
Evidence strength
Vitamin C's strongest clinical context is a complete AREDS regimen in selected AMD populations.
Studied preparation
The saved findings recognize the contributing preparations as studied; that does not extend population-specific trial benefits to everyone.

Formulation logic100

The saved findings identify no missing required partner or matching ingredient conflict.
Partner coverage
The saved findings identify no missing required partner among the contributing ingredients.
Conflicts
The zinc-without-copper concern is inapplicable because a required ingredient is absent.
Effective doses
Vitamin C meets the saved minimum amount threshold.
Study evidence
Vitamin C Disputed 24 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Ascorbic Acid)
500 mg 58
Citrus Bioflavonoids (Citrus spp., Hesperidin)
139 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
F Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD+ Value
Each serving provides 500 mg of vitamin C as ascorbic acid. The whole-product price works out to about $0.26 per gram of vitamin C.
How this ingredient is rated

Active Ingredient Quality & Bioavailability30

Ascorbic acid is the vitamin C source; it is an acidic form, with no buffering or stomach-friendly claim captured.
Vitamin C Chemical Form & Delivery System
Ascorbic acid is the vitamin C source; no advanced delivery claim is captured.
Gastric Comfort & pH Balance
Ascorbic acid is an acidic form, and the saved facts do not establish buffering or a stomach-friendly claim.

Dose, Safety & Label Transparency91

Each serving provides 500 mg of vitamin C. The amount and source are identified in the saved facts.
Optimal Dosage Targeting
Each serving provides 500 mg of vitamin C.
Purity & Excipient Quality
The other-ingredient panel includes standard excipients; no sweeteners, artificial colors or preservatives were flagged.
Mineral & Source Transparency
The vitamin C amount and ascorbic acid source are given; a matching mineral amount is not applicable.

Value50

The whole-product serving price works out to about $0.26 per gram of vitamin C.
Price per Gram of Vitamin C
The whole-product serving price works out to about $0.26 per gram of vitamin C.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledEveryday Health forVitamin C
  2. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEveryday Health forVitamin C
  3. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsEveryday Health forVitamin C
  4. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsEveryday Health forVitamin C
  5. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsEveryday Health forVitamin C
  6. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsEye Health forVitamin C
  7. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyEye Health forVitamin C
  8. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewEye Health forVitamin C
  9. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsEye Health forVitamin C
  10. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsEye Health forVitamin C
  11. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  12. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  13. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  14. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  15. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  16. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsInflammation forVitamin C
  17. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledInflammation forVitamin C
  18. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledInflammation forVitamin C
  19. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledInflammation forVitamin C
  20. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsInflammation forVitamin C