Ester-C with Citrus Bioflavonoids

Ester-C with Citrus Bioflavonoids

American Health4.9 (17,216 ratings)
Format:Tablet Quantity: 225 Tablet(s) · 112 servings
Goals

Product analysis

69 out of 100

Ester-C with Citrus Bioflavonoids offers good value for vitamin C, which supports normal immune function and collagen formation when intake falls short.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality37

The vitamin C and calcium forms are identified, but a quality advantage cannot be established confidently. The flavonoid preparation is unspecified.

Ingredient Transparency88

All listed amounts and the main nutrient forms are disclosed. The flavonoid mixture is less clearly described, limiting direct comparisons.

Value For Money74

Value is very favorable for the vitamin C amount. The extra calcium and flavonoids do not have enough information for a reliable value comparison.

Customer Satisfaction96

Customer feedback is very positive across a large number of ratings. That gives a broad picture of satisfaction without confirming health effects.

Product Focus74

Vitamin C is the main nutritional focus, with support for normal immune function and collagen formation. Extra intake and the named delivery form do not establish added benefits once needs are met.

Format
Tablet
Container
225 Tablet(s)
Per serving
$0.16
Customer rating
4.9 · 17,216 ratings
Report analysis

Goals

Everyday Health
Impact
High effect
B Ingredient FitD+ PathwaysB- EvidenceA+ Formulation Logic
Vitamin C · 1000 mg

Vitamin C contribute to normal antioxidant and immune functions. These nutritional contributions are useful when intake falls short; extra benefit above adequate intake is not established.

How this product is rated for Everyday Health

Ingredient fit80

Vitamin C supply the main nutritional contributions.
Goal fit
Vitamin C supplies the main relevant contribution. Other actives broaden the formula beyond these roles.
Dose adequacy
The relevant serving amounts reach the saved comparison endpoints; these do not establish extra benefit above adequate intake.

Pathways54

The strongest supported area is antioxidant and immune defence.
Depth
The strongest supported area is antioxidant and immune defence.
Breadth
The broader contribution covers antioxidant and immune defence.

Evidence74

The nutrient findings concern filling dietary gaps, with no established extra benefit when intake is adequate.
Evidence strength
Vitamin C leads the saved comparison; the supported contribution is nutritional availability when intake is low.
Studied preparation
The saved findings accept the relevant preparations; this does not demonstrate superior forms or improved outcomes in adequately nourished adults.

Formulation logic100

The relevant ingredients have no missing required partners or triggered listed conflicts.
Partner coverage
The relevant ingredients can contribute independently or have their required partners; this does not establish an added combination benefit.
Conflicts
No listed ingredient conflict was triggered by the supplied facts.
Effective doses
All ingredients retained in this finding meet its amount threshold; that threshold is not a proven clinical dose.
Study evidence
Vitamin C Supportive 56 studies
Immunity
Impact
Highest effect
B Ingredient FitC PathwaysA+ EvidenceA+ Formulation Logic
Vitamin C · 1000 mg

Vitamin C supports normal immune-cell and antioxidant functions. Regular supplementation has modest support for shortening cold duration, which does not mean preventing infection or treating an established cold. The selected serving contributes vitamin C, but a single serving does not establish the repeated exposure used in regular-use studies, and larger amounts do not prove greater protection.

How this product is rated for Immunity

Ingredient fit80

Relevant ingredients support immune-related roles, while additional actives broaden the formula beyond those contributions.
Goal fit
Relevant ingredients support immune-related roles, while additional actives broaden the formula beyond those contributions.
Dose adequacy
The recognized amount reaches the saved reference; this does not establish an optimal dose, greater protection or safety at higher exposure.

Pathways60

Innate immune-cell activity reaches the saved threshold; barrier and oxidative contributions remain smaller.
Depth
The strongest recognized area is innate immune-cell activity; this describes the saved functional finding rather than observed infection protection.
Breadth
Innate immune-cell activity reaches the saved threshold; barrier and oxidative contributions remain smaller.

Evidence100

Vitamin C drives the strongest saved evidence finding, within the supplied limits on normal immune function and respiratory outcomes.
Evidence strength
Vitamin C drives the strongest saved evidence finding, within the supplied limits on normal immune function and respiratory outcomes.
Studied preparation
The saved result recognizes the preparations meeting its amount threshold; this does not establish superiority of particular nutrient forms.

Formulation logic100

No configured ingredient conflict was triggered; this covers only the evaluated combinations. All recognized ingredients meet the saved minimum amount threshold; this does not establish a clinical response.
Partner coverage
Recognized ingredients work independently or have their required partners; no extra combination benefit is established.
Conflicts
No configured ingredient conflict was triggered; this covers only the evaluated combinations.
Effective doses
All recognized ingredients meet the saved minimum amount threshold; this does not establish a clinical response.
Study evidence
Vitamin C Supportive 53 studies
Skin Health
Impact
High effect
B- Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Vitamin C · 1000 mg

Vitamin C is needed to build collagen and maintain normal wound healing. Correcting low intake can restore these functions, but extra vitamin C has no established skin benefit when intake is adequate. The supplied evidence does not show added cosmetic or UV-protection benefits from the large serving amount or the named delivery form.

How this product is rated for Skin Health

Ingredient fit73

Relevant ingredients share this formula with actives aimed at other purposes. The relevant amount reaches the recorded exposure comparison; this does not establish added skin benefit.
Goal fit
Relevant ingredients share this formula with actives aimed at other purposes.
Dose adequacy
The relevant amount reaches the recorded exposure comparison; this does not establish added skin benefit.

Pathways0

No direct contribution to the four tracked skin mechanisms was recorded, despite vitamin C’s normal nutritional role.
Depth
No direct contribution to the four tracked skin mechanisms was recorded, despite vitamin C’s normal nutritional role.
Breadth
No tracked skin mechanism reaches the recorded coverage threshold.

Evidence100

Vitamin C’s role in collagen and deficiency-related healing is established; extra cosmetic benefit in adequately nourished adults is not.
Evidence strength
Vitamin C’s role in collagen and deficiency-related healing is established; extra cosmetic benefit in adequately nourished adults is not.
Studied preparation
The recorded preparation comparison is satisfied, but preparation-specific study findings do not automatically transfer to every ingredient or finished product.

Formulation logic100

No required partner was missing and no defined conflict was identified. The relevant amounts meet the recorded minimum comparison; this is not proof of a clinically effective skin dose.
Partner coverage
No required partner was missing in the recorded findings; this does not establish an added combination benefit.
Conflicts
No defined ingredient conflict was identified in the supplied findings.
Effective doses
The relevant amounts meet the recorded minimum comparison; this is not proof of a clinically effective skin dose.
Study evidence
Vitamin C Supportive 53 studies
Impact
High effect
B- Ingredient FitD+ PathwaysA- EvidenceA+ Formulation Logic
Vitamin C · 1000 mg

Vitamin C contributes antioxidant activity, but its inflammation findings depend on baseline context. A large trial was null overall, with a CRP reduction confined to people starting with elevated CRP. That subgroup result does not establish a routine anti-inflammatory effect, and buffered forms do not establish an extra advantage.

How this product is rated for Inflammation

Ingredient fit73

Vitamin C provides the main relevant connection. Known eligible amounts meet the saved comparison range.
Goal fit
Vitamin C supplies the main relevant ingredient connection.
Dose adequacy
The known eligible amounts reach the saved comparison range, which is not proof of clinical effectiveness.

Pathways55

The strongest retained connection concerns oxidative and mitochondrial stress; this identifies a pathway link rather than proven clinical relief.
Depth
The strongest retained connection concerns oxidative and mitochondrial stress; this identifies a pathway link rather than proven clinical relief.
Breadth
One pathway reaches the saved coverage threshold; broader coverage is not established.

Evidence87

Vitamin C provides the strongest retained evidence connection, with limited or inconsistent human outcome findings.
Evidence strength
Vitamin C provides the strongest retained evidence connection, with limited or inconsistent human outcome findings.
Studied preparation
Eligible material meets the saved preparation criteria; this does not establish clinical benefit from the exact product.

Formulation logic100

No unmet required partner or configured conflict was identified. Meeting amount criteria does not establish added benefit from combining ingredients.
Partner coverage
No unmet required partner was identified for the retained ingredients; their combination does not establish extra benefit.
Conflicts
No configured ingredient conflict was identified in the supplied findings.
Effective doses
Eligible ingredients meet the saved amount threshold; this is not proof of an effective treatment dose.
Study evidence
Vitamin C Supportive 50 studies
Impact
High effect
B- Ingredient FitD PathwaysC+ EvidenceA+ Formulation Logic
Vitamin C · 1000 mg

Vitamin C contributes to antioxidant protection in the retina and lens. Its clinical vision evidence concerns a defined combination for selected people with AMD, rather than improved everyday vision from vitamin C alone.

How this product is rated for Eye Health

Ingredient fit73

The declared nutrients provide the relevant connection to vision. Their known amounts meet the saved reference amounts.
Goal fit
The relevant vision ingredients sit within a broader formulation with ingredients aimed at other goals.
Dose adequacy
The declared relevant amounts meet the saved reference amounts; this does not establish additional benefit at higher amounts.

Pathways47

The strongest ingredient connection is retinal and lens antioxidant defense. Other visual functions have limited coverage.
Depth
The strongest connection is retinal and lens antioxidant defense, based on the relevant declared ingredients.
Breadth
The findings concentrate on retinal and lens antioxidant defense, giving limited breadth across visual functions.

Evidence68

Vitamin C supplies the strongest retained evidence. Nutrient or selected AMD-population findings do not establish general vision improvement.
Evidence strength
Vitamin C provides the strongest retained evidence here; the population and outcome limitations still determine what benefit can be expected.
Studied preparation
The relevant preparations match the saved preparation criteria; this alone does not establish the same outcomes as a trial.

Formulation logic100

The saved partner and conflict checks identify no missing partner or configured conflict. Amount thresholds remain comparison references rather than proven effective doses.
Partner coverage
No required partner is missing under the saved ingredient criteria.
Conflicts
No configured ingredient conflict was identified from the known amounts.
Effective doses
All retained ingredients meet the saved amount threshold, which is a comparison reference rather than a proven effective dose.
Study evidence
Vitamin C Disputed 24 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Ester-C Calcium Ascorbate)
1000 mg 92
Calcium (Ester-C Calcium Ascorbate)
110 mg
Citrus Bioflavonoids Complex
400 mg
Gluten Free Adults 18–50 Vegan Dairy Free Sugar Free Vegetarian
Report overview
A- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value
Each serving supplies 1,000 mg of vitamin C as Ester-C, a buffered calcium ascorbate. The amount and associated calcium are recorded, and the price per gram of vitamin C is low.
How this ingredient is rated

Active Ingredient Quality & Bioavailability90

Ester-C uses buffered calcium ascorbate, and a non-acidic claim is recorded.
Vitamin C Chemical Form & Delivery System
Vitamin C is supplied as Ester-C, a branded calcium ascorbate form.
Gastric Comfort & pH Balance
Calcium ascorbate is a buffered form; the saved facts also record a non-acidic claim.

Dose, Safety & Label Transparency91

The serving provides 1000 mg of vitamin C.
Optimal Dosage Targeting
A serving supplies 1000 mg of vitamin C.
Purity & Excipient Quality
The evaluation identifies standard excipients among the other ingredients.
Mineral & Source Transparency
The vitamin C amount and source are recorded, along with 110 mg of calcium.

Value100

The whole-product price works out to about $0.17 per 1,000 mg of vitamin C.
Price per Gram of Vitamin C
The whole-product price works out to about $0.17 per 1,000 mg of vitamin C.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledEveryday Health forVitamin C
  2. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEveryday Health forVitamin C
  3. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsEveryday Health forVitamin C
  4. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsEveryday Health forVitamin C
  5. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsEveryday Health forVitamin C
  6. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsEye Health forVitamin C
  7. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyEye Health forVitamin C
  8. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewEye Health forVitamin C
  9. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsEye Health forVitamin C
  10. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsEye Health forVitamin C
  11. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  12. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  13. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  14. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  15. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  16. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsInflammation forVitamin C
  17. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledInflammation forVitamin C
  18. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledInflammation forVitamin C
  19. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledInflammation forVitamin C
  20. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsInflammation forVitamin C