Ester-C 500 mg with Citrus Bioflavonoids

Ester-C 500 mg with Citrus Bioflavonoids

American Health4.9 (17,972 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 60 servings
Goals

Product analysis

69 out of 100

Ester-C 500 mg with Citrus Bioflavonoids offers reasonably priced vitamin C support for normal immune function and collagen formation, particularly when dietary intake is low.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality37

The vitamin C and calcium sources are named, while the bioflavonoid form is unspecified. A separate quality advantage for the combination cannot be established.

Ingredient Transparency88

The declared ingredient amounts and the vitamin C and calcium forms are listed. The unspecified bioflavonoid form limits comparison of that part of the blend.

Value For Money74

The vitamin C content compares favorably for the price. Value for the calcium and bioflavonoid portions remains uncertain.

Customer Satisfaction96

Customer feedback is very positive across many thousands of ratings. The extensive response provides a broad picture of satisfaction without establishing extra health benefits.

Product Focus74

Vitamin C provides the main support for normal immune, skin and everyday nutritional needs. Ester-C and accompanying bioflavonoids do not establish extra benefits once those needs are met.

Format
Capsule
Container
120 Capsule(s)
Per serving
$0.23
Customer rating
4.9 · 17,972 ratings
Report analysis

Goals

Everyday Health
Impact
High effect
B Ingredient FitD+ PathwaysB- EvidenceA+ Formulation Logic
Vitamin C · 1000 mg

Vitamin C is the main nutritional contribution when intake is low. The supplied information does not establish an extra general-health benefit for Ester-C or citrus bioflavonoids. Calcium is declared, but its amount is below the saved inclusion threshold rather than absent.

How this product is rated for Everyday Health

Ingredient fit80

The relevant nutrients offer conditional nutritional support. Calcium is present but not counted at the declared amounts.
Goal fit
Relevant nutrients contribute to general health, while other ingredients serve purposes outside the supplied routine-health evidence.
Dose adequacy
Declared nutrient amounts make varying contributions to the saved comparison; larger quantities do not establish extra benefit when intake is adequate.

Pathways54

The strongest connection is antioxidant and immune defence. Coverage is concentrated in a limited set of functional areas.
Depth
The strongest ingredient association is with antioxidant and immune defence, reflecting nutrient availability rather than a demonstrated change in health outcomes.
Breadth
Coverage reaches the saved threshold in one functional area; the remaining areas receive less or no contribution.

Evidence74

Vitamin C leads the counted contribution. The supplied evidence supports a nutritional role when intake is low, without proving improved outcomes from this exact product.
Evidence strength
Vitamin C provides the strongest counted contribution; its relevance remains nutritional availability when intake is low, rather than proven improvement above adequacy.
Studied preparation
The counted preparations are accepted for the nutrient comparison. This does not establish an advantage for the chemical forms, delivery method or exact product.

Formulation logic100

The counted nutrients require no missing partner, and no configured conflict was found. Their combination does not establish an extra health benefit.
Partner coverage
All counted ingredients can contribute independently or have their required partner; no added benefit from combining them is established.
Conflicts
No configured conflict was found; the applicable nutrient amounts and partner declarations do not trigger the listed concerns.
Effective doses
All counted ingredients meet the saved inclusion threshold, which is a comparison boundary rather than a proven supplement-response dose.
Study evidence
Vitamin C Supportive 56 studies
Immunity
Impact
Highest effect
B Ingredient FitC PathwaysA+ EvidenceA+ Formulation Logic
Vitamin C · 1000 mg

Vitamin C contributes to normal immune function and has modest regular-use evidence for shorter colds. The selected serving contains 1000 mg of declared vitamin C, independently of the product name and accompanying source materials. Ester-C and bioflavonoids do not establish superior outcomes, and the evidence does not show infection prevention or treatment from a single serving.

How this product is rated for Immunity

Ingredient fit80

Vitamin C provide the relevant immune contribution. The selected serving supplies a nutritional amount rather than a verified daily regimen.
Goal fit
The meaningful immune connection comes from vitamin c; other product uses do not establish additional immune outcomes.
Dose adequacy
The declared amount reaches the supplied comparison endpoint; it is not a proven prevention dose or biological limit.

Pathways60

The strongest contribution concerns innate immune-cell activity. One immune area has substantial representation.
Depth
Innate immune-cell activity is the strongest represented area.
Breadth
One immune area has substantial representation.

Evidence100

Vitamin C leads the evidence finding. Regular vitamin C use may modestly shorten colds; prevention and treatment from one serving are not established.
Evidence strength
Regular vitamin C use may modestly shorten colds; prevention and treatment from one serving are not established.
Studied preparation
The included preparations meet the supplied comparison; named forms and delivery methods do not establish superior clinical outcomes.

Formulation logic100

No configured ingredient conflict was identified; that finding is not an overall safety judgment. The included ingredients meet the amount threshold and have no missing required partner.
Partner coverage
The included ingredients work independently or have their required partner; this does not demonstrate extra benefit from combining them.
Conflicts
No configured ingredient conflict was identified; that finding is not an overall safety judgment.
Effective doses
The included ingredients meet the supplied amount threshold; this does not prove clinical effectiveness.
Study evidence
Vitamin C Supportive 53 studies
Skin Health
Impact
High effect
B- Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Vitamin C · 1000 mg

Vitamin C supports collagen formation and helps correct impaired wound healing associated with low intake. The serving provides ample vitamin C, but higher intake does not establish extra skin improvement when nutritional needs are met. Ester-C, calcium ascorbate and fruit-source ingredients do not demonstrate a separate cosmetic advantage.

How this product is rated for Skin Health

Ingredient fit73

Vitamin C drives the saved skin-related finding. The credited amounts meet the saved criteria.
Goal fit
Vitamin C is the principal ingredient receiving a skin-related contribution; the product’s other uses also affect its focus.
Dose adequacy
The credited ingredients meet the saved amount criteria; this does not establish additional benefit above nutritional needs.

Pathways0

The saved findings assign no coverage to the evaluated skin routes.
Depth
No contribution was assigned to the evaluated structural, hydration, barrier-lipid or UV-related routes.
Breadth
No evaluated route reached the breadth criterion.

Evidence100

Vitamin C is essential for collagen and deficiency-related wound healing; extra cosmetic benefit with adequate intake is unestablished.
Evidence strength
Vitamin C is essential for collagen and deficiency-related wound healing; extra cosmetic benefit with adequate intake is unestablished.
Studied preparation
The saved preparation criteria are met; this does not remove population, combination or nutrient-sufficiency limits in the supplied evidence.

Formulation logic100

No unmet partner requirement or evaluated conflict was identified. The credited ingredients meet the saved minimum amount criterion.
Partner coverage
The credited ingredients have no unmet partner requirement in the supplied findings; this does not establish added benefits from combining them.
Conflicts
No ingredient conflict was identified by the evaluated rules.
Effective doses
All credited ingredients meet the saved minimum amount criterion; that threshold is not a proven effective skin dose.
Study evidence
Vitamin C Supportive 53 studies
Impact
High effect
B- Ingredient FitD+ PathwaysA- EvidenceA+ Formulation Logic
Vitamin C · 1000 mg

Vitamin C contributes to antioxidant biology, with a CRP reduction reported in a subgroup with elevated starting CRP rather than across the whole trial. This does not establish routine clinical anti-inflammatory benefit, and calcium ascorbate has no established anti-inflammatory advantage. Rutin remains unresolved because its stored declaration is missing from the imported inventory, so no amount or contribution was assumed.

How this product is rated for Inflammation

Ingredient fit73

The recognized anti-inflammatory ingredients sit within a broader formula, reducing its focus on this goal. The recognized amounts contribute fully to the saved comparison; this does not establish a proven clinical dose.
Goal fit
The recognized anti-inflammatory ingredients sit within a broader formula, reducing its focus on this goal.
Dose adequacy
The recognized amounts contribute fully to the saved comparison; this does not establish a proven clinical dose.

Pathways55

Oxidative and mitochondrial stress is the strongest recorded mechanism, without establishing broad clinical benefit.
Depth
Oxidative and mitochondrial stress is the strongest recorded mechanism, without establishing broad clinical benefit.
Breadth
Only one inflammatory mechanism reached the required coverage level.

Evidence87

Vitamin C leads the saved evidence finding, with its population and outcome limitations still applying.
Evidence strength
Vitamin C leads the saved evidence finding, with its population and outcome limitations still applying.
Studied preparation
Contributing preparations matched those recognized in the saved result; this does not establish a clinical trial of the complete product.

Formulation logic100

No missing required partner or configured conflict reduced the recognized contributions. All counted amounts reached the minimum comparison threshold.
Partner coverage
No missing required partner reduced the recognized contributions; this does not demonstrate extra benefit from combining ingredients.
Conflicts
No configured ingredient conflict was identified in the supplied calculation.
Effective doses
All counted ingredients reached the minimum comparison threshold, which is not a proven minimum effective clinical dose.
Study evidence
Vitamin C Supportive 50 studies
Impact
High effect
B- Ingredient FitD PathwaysC+ EvidenceA+ Formulation Logic
Vitamin C · 1000 mg

Vitamin C has an antioxidant role, but its vision evidence comes from a defined multi-ingredient AREDS regimen in selected macular-degeneration populations. Taking vitamin C alone does not establish prevention of eye disease or improved visual performance.

How this product is rated for Eye Health

Ingredient fit73

The relevant declarations provide mixed nutritional coverage for vision, with the amount findings reflecting the individual ingredients.
Goal fit
The formula includes relevant nutritional ingredients alongside ingredients serving other purposes.
Dose adequacy
The known amounts meet the supplied comparison references, without establishing a proven vision-effective dose.

Pathways47

The ingredients connect to selected vision-related processes, without demonstrating vision improvement through those mechanisms.
Depth
The main connection is to retinal and lens antioxidant defense, which does not itself establish improved hair growth.
Breadth
Coverage is concentrated in one vision-related process.

Evidence68

The strongest evidence contribution and preparation matches describe different aspects of the ingredients; neither guarantees vision improvement.
Evidence strength
Vitamin C supplies the strongest evidence contribution, subject to the ingredient’s specific limitations.
Studied preparation
Eligible declarations are recognized as studied forms; this does not establish improved vision in people with adequate nutrient intake.

Formulation logic100

The formula has no matched missing partner or listed conflict. The amount findings distinguish meaningful declarations from small or unresolved quantities.
Partner coverage
No required ingredient partner is missing from the supplied findings.
Conflicts
No listed ingredient conflict was matched; this finding does not establish the absence of every possible interaction.
Effective doses
The ingredients counted here clear the minimum comparison amount; that threshold is not a proven effective vision-effective dose.
Study evidence
Vitamin C Disputed 24 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Ester-C Calcium Ascorbate)
1000 mg 92
Calcium (Ester-C Calcium Ascorbate)
110 mg
Citrus Bioflavonoids Complex
400 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
A- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value
A serving supplies 1,000 mg of vitamin C as buffered Ester-C calcium ascorbate. The saved facts also record non-acidic and gentle-on-the-stomach claims.
How this ingredient is rated

Active Ingredient Quality & Bioavailability90

The vitamin C is Ester-C calcium ascorbate, a buffered mineral form.
Vitamin C Chemical Form & Delivery System
Vitamin C is recorded as Ester-C, a calcium ascorbate form.
Gastric Comfort & pH Balance
Calcium ascorbate is buffered; the saved facts also record non-acidic and gentle-on-the-stomach claims.

Dose, Safety & Label Transparency91

A serving provides 1,000 mg of vitamin C. The vitamin C source is recorded in the saved facts.
Optimal Dosage Targeting
A serving provides 1,000 mg of vitamin C.
Purity & Excipient Quality
No configured sweeteners, artificial colors or preservatives are flagged in the available ingredient facts.
Mineral & Source Transparency
The vitamin C amount, calcium ascorbate form and a calcium amount are recorded.

Value100

Whole-product serving costs correspond to about $0.23 per gram of vitamin C.
Price per Gram of Vitamin C
Whole-product serving costs correspond to about $0.23 per gram of vitamin C.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledEveryday Health forVitamin C
  2. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEveryday Health forVitamin C
  3. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsEveryday Health forVitamin C
  4. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsEveryday Health forVitamin C
  5. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsEveryday Health forVitamin C
  6. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsEye Health forVitamin C
  7. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyEye Health forVitamin C
  8. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewEye Health forVitamin C
  9. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsEye Health forVitamin C
  10. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsEye Health forVitamin C
  11. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  12. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  13. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  14. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  15. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  16. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsInflammation forVitamin C
  17. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledInflammation forVitamin C
  18. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledInflammation forVitamin C
  19. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledInflammation forVitamin C
  20. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsInflammation forVitamin C