St. John's Wort 450

St. John's Wort 450

Source Naturals4.4 (433 ratings)
Format:Tablet Quantity: 180 Tablet(s) · 180 servings
Goals
$23.46 $0.13 per serving
iHerbLowest$23.46Amazon$24.05

Product analysis

45 out of 100

St. John's Wort 450 has mood-related evidence in people with diagnosed depression, though its unspecified extract limits how well those findings apply. It can weaken oral contraceptives, blood-thinning medicines and many other medicines.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality20

The extract is not specified, so its preparation quality is unclear. It cannot be confidently matched to the particular preparations behind the mood findings.

Ingredient Transparency63

The herb amount is stated, making the serving size clear. The extract form is missing, which limits comparison with other preparations.

Value For Money40

Value cannot be compared confidently for the herb. The available information does not support a clear judgment about the price.

Customer Satisfaction70

Customer feedback is generally positive, though the number of ratings is modest. The feedback does not establish mood benefits or compatibility with medicines.

Product Focus57

The formula has a single mood-related focus, with evidence mainly from people with diagnosed depression. The unspecified extract and its potential to weaken many medicines are meaningful limits to suitability.

Format
Tablet
Container
180 Tablet(s)
Per serving
$0.13
Customer rating
4.4 · 433 ratings
Report analysis

Goals

Mood Support
Mood Support
Impact
Moderate effect
B+ Ingredient FitF PathwaysF EvidenceA+ Formulation Logic

St. John's wort can help with depressive symptoms in some people with diagnosed depression, but that doesn't translate directly into everyday mood improvement in healthy adults. The extract here isn't identified as one of the specific preparations tied to that benefit. It can also weaken oral contraceptives, anticoagulants and many other medicines, so its effects on medication matter alongside its possible mood effects.

How this product is rated for Mood Support

Ingredient fit80

St. John's Wort has a connection to this goal, with limits on how directly that translates into everyday mood improvement.
Goal fit
St.
Dose adequacy
St. John's Wort 450 mg per serving; these amounts describe exposure, not a guarantee of mood benefit.

Pathways8

A connection to chemical signalling or stress responses is different from a demonstrated improvement in how you feel.
Depth
A connection to chemical signalling or stress responses is different from a demonstrated improvement in how you feel.
Breadth
Several biological connections do not by themselves demonstrate several distinct emotional benefits.

Evidence27

Effects depend on the ingredient and preparation; possible mood-related effects do not guarantee a noticeable everyday benefit.
Evidence strength
Effects depend on the ingredient and preparation; possible mood-related effects do not guarantee a noticeable everyday benefit.
Studied preparation
The standardized extract is not identified as a specific named preparation associated with depressive-symptom benefits.

Formulation logic100

No particular ingredient conflict or missing required partner is identified. Combining ingredients does not by itself demonstrate an added mood benefit.
Partner coverage
No additional partner ingredient is required by the available ingredient-specific information.
Conflicts
No particular conflict between the declared ingredients is identified.
Effective doses
St. John's Wort 450 mg per serving; these amounts describe exposure, not a guarantee of mood benefit.
Study evidence

Ingredients

IngredientAmount per servingScore
St. John's Wort
450 mg 100
Gluten Free Adults 18–50 Dairy Free Sugar Free Vegetarian
Report overview
St. John's Wort · 450 mg OverallScore100
A+ Composition And Label Disclosure
The evaluation records an ingredient-specific warning for St. John's wort, but its wording is unavailable. Each serving lists 450 mg of St. John's wort.
How this ingredient is rated

Composition and Label Disclosure

Each serving lists 450 mg of St. John's wort; no composition rule was evaluated.

Composition and Label Disclosure100

An ingredient-specific warning is recorded in the saved evaluation, though its details are not supplied.
Explicit Label Detail
The saved facts indicate a specific warning, but do not provide its wording.

Commercial Price and Usability

A whole-product serving costs about $0.13; no price rule was evaluated.
View ingredientView products
84 Performance

Feeling Positive St. John's Wort 300 mg

Sundown
Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

Perika St. John's Wort

Nature's Way
The named extract supports consistent quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort Extract

Swanson Superior Herbs
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort 300 mg

NOW
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
89 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

Nature's Bounty
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Value

St. John's Wort

Paradise
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  2. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  3. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  4. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  5. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort