St. John's Wort 300 mg

St. John's Wort 300 mg

NOW4.5 (3,740 ratings)
Format:Capsule Quantity: 250 Capsule(s) · 250 servings
Goals
$16.99 $0.06 per serving
AmazonLowest$16.99Daily Vita$19.70Pure Formulas$20.23iHerb$20.81Vitacost$22.59

Product analysis

63 out of 100

St. John's Wort 300 mg is a focused mood supplement whose effects depend on the extract. It interacts with many medicines and other ingredients that affect serotonin, so check compatibility with a pharmacist before use.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality40

The named hypericin component does not establish the quality or equivalence of the full extract. Preparation differences matter when comparing mood-related effects.

Ingredient Transparency100

The ingredient amount and named form are disclosed. That supports a basic comparison, without establishing equivalence between extracts.

Value For Money40

Value cannot be judged confidently from the available cost information. The named component alone does not establish an economical purchase.

Customer Satisfaction84

Customer feedback is positive across thousands of ratings. The broad review base describes satisfaction without establishing effectiveness or safety.

Product Focus67

One botanical keeps the formula centered on mood support. Effects vary by preparation and population, and medicine interactions are a significant suitability concern.

Format
Capsule
Container
250 Capsule(s)
Per serving
$0.06
Customer rating
4.5 · 3,740 ratings
Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
B- Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic

St. John's wort has evidence for mood symptoms in diagnosed mild-to-moderate depression, but effects vary by preparation and trial. Its 300 mg serving is below the daily extract exposure used in the cited research. This does not establish routine mood improvement in healthy adults. St. John's wort also interacts with many medicines and serotonergic ingredients.

How this product is rated for Mood Support

Ingredient fit73

The recognized ingredients relate to mood support, although the product may also serve other goals. The serving amounts fall short of several saved comparisons, limiting the amount-based findings without proving ineffectiveness.
Goal fit
The recognized ingredients relate to mood support, although the product may also serve other goals.
Dose adequacy
The serving amounts fall short of several saved comparisons, limiting the amount-based findings without proving ineffectiveness.

Pathways11

The strongest represented aspect is monoamine signalling, with limited representation from the recognized ingredients. No aspect reaches the saved coverage comparison; the ingredient roles remain limited rather than broadly established.
Depth
The strongest represented aspect is monoamine signalling, with limited representation from the recognized ingredients.
Breadth
No aspect reaches the saved coverage comparison; the ingredient roles remain limited rather than broadly established.

Evidence84

St. John's Wort provides the strongest recognized evidence here, subject to its population and preparation limitations. The saved result recognizes the qualifying preparations as studied; this does not establish benefit for every user.
Evidence strength
St. John's Wort provides the strongest recognized evidence here, subject to its population and preparation limitations.
Studied preparation
The saved result recognizes the qualifying preparations as studied; this does not establish benefit for every user.

Formulation logic100

The recognized ingredients have their required partners or can stand alone, and no listed conflict was matched. Their amounts meet the saved minimum comparisons.
Partner coverage
The recognized ingredients do not lack a required partner under the supplied checks; this does not demonstrate synergy.
Conflicts
No listed ingredient conflict was matched. This check does not establish medication compatibility.
Effective doses
All recognized ingredients meet the saved minimum amount comparison, which is not a proven clinical effect threshold.
Study evidence

Ingredients

IngredientAmount per servingScore
St. John's Wort extract (Hypericin)
 300 mg 100
Gluten Free Men 18–50 Vegan Kosher Dairy Free Women Vegetarian
Report overview
St. John's Wort (Hypericin) · 300 mg OverallScore100
A+ Composition And Label Disclosure
A serving lists 300 mg of St. John's wort herb extract. The evaluation records an ingredient-specific warning, but its wording is not available in the saved facts.
How this ingredient is rated

Composition and Label Disclosure

No separate source or delivery criteria were evaluated.

Composition and Label Disclosure100

An ingredient-specific warning is recorded; the saved facts do not provide its wording.
Explicit Label Detail
The evaluation records an ingredient-specific warning, but its wording is not available in the saved facts.

Commercial Price and Usability

No price criterion was evaluated.
View ingredientView products
88 Performance

Full Spectrum St. John's Wort Extract 600 mg

Planetary Herbals
A standardized, substantial Saint John’s wort blend offers focused mood support with stronger potency clarity than nonstandardized options; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
84 Performance

Feeling Positive St. John's Wort 300 mg

Sundown
Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort Extract

Swanson Superior Herbs
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
78 Budget

St. John's Wort 375 mg

Swanson Premium Brand
A focused herb amount offers basic value, but missing standardization limits consistency; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
89 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; it is among the lowest-cost eligible options, although it is not cheaper than the original when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

Nature's Bounty
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

Perika St. John's Wort

Nature's Way
The named extract supports consistent quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  2. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  3. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  4. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  5. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort