5-HTP 50 mg

5-HTP 50 mg

NOW4.7 (14,558 ratings)
Format:Capsule Quantity: 90 Capsule(s) · 90 servings
Goals
$6.10 $0.06 per serving
Daily VitaLowest$6.10Daily Vita$6.40Amazon$9.99Daily Vita$10.40iHerb$11.01Vitacost$11.79

Product analysis

75 out of 100

5-HTP 50 mg may offer limited sleep-quality support for people who already sleep poorly, at a favorable cost. Reliable everyday mood or stress benefits remain uncertain.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality40

The plant source of 5-HTP is identified. That alone does not establish how its preparation compares with other options.

Ingredient Transparency100

The 5-HTP amount and plant source are disclosed. Those details make like-for-like comparisons easier.

Value For Money100

The cost is favorable for the amount of 5-HTP provided. That gives it a useful price advantage when comparing similar amounts.

Customer Satisfaction90

Customer ratings indicate high satisfaction. A very large review pool provides a broad base for that feedback.

Product Focus62

The single active keeps the formula focused on the related areas of mood, sleep and stress. Sleep-quality support is possible, while dependable mood or everyday stress effects remain uncertain.

Format
Capsule
Container
90 Capsule(s)
Per serving
$0.06
Customer rating
4.7 · 14,558 ratings
Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
B Ingredient FitF PathwaysA EvidenceA+ Formulation Logic
5-HTP · 50 mg
Study evidence
5-HTP Supportive 9 studies
Sleep Support
Sleep Rhythm
Sleep Support
Impact
Moderate effect
B Ingredient FitD- PathwaysC- EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 1 study
Stress Relief
Stress Relief
Impact
Moderate effect
B Ingredient FitF PathwaysC- EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 18 studies

Ingredients

IngredientAmount per servingScore
5-HTP (Griffonia simplicifolia Seed Extract)
 50 mg 80
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
5-HTP (Griffonia simplicifolia Seed Extract) · 50 mg OverallScore80
B- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyA+ Value
A serving provides 50 mg of 5-HTP, at a low cost per 100 mg. The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated. The label includes a warning about serotonin-related medication interactions.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated.
Botanical Source & Standardization
The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated.

Dose, Safety & Label Transparency79

The serving contains 50 mg of 5-HTP. The label includes a warning about serotonin-related medication interactions.
Dosage Potency & Range
The serving provides 50 mg of 5-HTP.
Safety Warnings & Label Clarity
The label includes a warning about serotonin-related medication interactions.

Value100

The cost per 100 mg of 5-HTP is low.
Price per 100mg 5-HTP
The cost per 100 mg of 5-HTP is low.
View ingredientView products
85 Performance

5-HTP 100 mg

NOW
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. Its 100 mg 5-HTP serving is more substantial than the original’s 50 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP 100 mg Extra Strength

Swanson
A standard 100 mg serving offers a more conventional balance of potency and flexibility. Its 100 mg 5-HTP serving is more substantial than the original’s 50 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
A standard 100 mg serving offers a more conventional balance of potency and flexibility. Its 100 mg 5-HTP serving is more substantial than the original’s 50 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
82 Budget

5-HTP 50 mg

NOW
No eligible option here is clearly cheaper, but this is among the closest-cost supplied choices. Its 50 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
85 Budget

5-HTP 100 mg

Doctor's Best
No eligible option here is clearly cheaper, but this is among the closest-cost supplied choices. Its 100 mg 5-HTP serving is more substantial than the original’s 50 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
82 Budget

5-HTP 50 mg

Swanson Premium Brand
No eligible option here is clearly cheaper, but this is among the closest-cost supplied choices. Its 50 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP 200mg

Best Naturals
Focused 5-HTP dosing and strong formula value make this a practical value alternative. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP with Vitamin B6 & Vitamin C

Lake Avenue Nutrition
Focused 5-HTP dosing and strong formula value make this a practical value alternative. The active amount is disclosed, but botanical-source detail remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
82 Value

5-HTP 200 mg Maximum Strength

Swanson
Focused 5-HTP dosing and strong formula value make this a practical value alternative. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  2. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  6. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  7. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  8. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  9. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  10. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  11. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP