5-HTP Enhanced with Vitamins B6 and C

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best4.8 (10,334 ratings)
Format:Capsule Quantity: 120 Veggie Cap(s) · 120 servings
Goals

Product analysis

78 out of 100

5-HTP Enhanced with Vitamins B6 and C offers a focused mood and stress formula with good value for its main ingredients. The mood-related role of B6 is clearest when intake is low, while everyday benefits from 5-HTP remain uncertain.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality59

B6 has a clearly identified form, making the type supplied easy to check. Form quality for 5-HTP and vitamin C remains uncertain.

Ingredient Transparency100

Amounts and forms are disclosed for all active ingredients. That makes the contents straightforward to compare with alternatives.

Value For Money83

5-HTP and B6 offer very good value relative to the serving cost. Vitamin C value remains uncertain, so that part of the comparison is incomplete.

Customer Satisfaction92

Customer feedback is very positive across many thousands of reviews. The large review base describes satisfaction without confirming mood or sleep benefits.

Product Focus66

The short formula focuses mainly on mood and stress, with more limited sleep-related support. Everyday improvement from 5-HTP remains uncertain, while B6 mainly helps maintain normal nutrient functions.

Format
Capsule
Container
120 Veggie Cap(s)
Per serving
$0.14
Customer rating
4.8 · 10,334 ratings
Report analysis

Goals

Mood Support
Impact
Highest effect
B Ingredient FitC PathwaysA+ EvidenceA+ Formulation Logic
Vitamin B6 · 15 mg5-HTP · 100 mg
Study evidence
5-HTP Supportive 9 studies
Vitamin B6 Supportive 19 studies
Impact
Moderate effect
D+ Ingredient FitF PathwaysC EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 5 studies
Impact
Moderate effect
B Ingredient FitC PathwaysC- EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 1 study
Stress Relief
Impact
High effect
B Ingredient FitD+ PathwaysB- EvidenceA Formulation Logic
Vitamin B6 · 15 mgVitamin C · 200 mg
Study evidence
5-HTP Supportive 18 studies
Vitamin C Supportive 11 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Ascorbic Acid)
200 mg
Vitamin B6 (Pyridoxine Hydrochloride)
15 mg 86
5-HTP (Griffonia simplicifolia Seed Extract)
100 mg 88
Gluten Free Adults 18–50 Vegan Vegetarian
Report overview
A+ Ingredient Form & Label QualityC+ Dose, Safety & Label TransparencyA Value
15 mg of b6 per serving comes at a low cost per mg. The source is pyridoxine hydrochloride. The serving exceeds the European adult upper limit of 12 mg per day.
How this ingredient is rated

Ingredient Form & Label Quality100

The B6 comes from pyridoxine hydrochloride. The other ingredients show no listed artificial dyes, titanium dioxide, or talc.
Vitamin B6 Form Identification
The B6 comes from pyridoxine hydrochloride.
Clean Label and Excipient Purity
The other ingredients show no listed artificial dyes, titanium dioxide, or talc.

Dose, Safety & Label Transparency69

Each serving provides 15 mg of B6, above the European adult upper limit of 12 mg per day; total intake also includes food and other supplements. The chemical source is named.
Vitamin B6 Dose & Safety Policy
Each serving provides 15 mg of B6, above the European adult upper limit of 12 mg per day; total intake also includes food and other supplements.
Label Transparency
The chemical source is named as pyridoxine hydrochloride.

Value92

The cost per mg of B6 is low.
Vitamin B6 Price Efficiency
The cost per mg of B6 is low.
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
Each serving supplies 100 mg of 5-HTP; its estimated cost per 100 mg is low. The Griffonia simplicifolia source is named, but its standardization percentage is unclear. The label includes a medication interaction warning.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The 5-HTP comes from Griffonia simplicifolia, but its standardization percentage is not given.
Botanical Source & Standardization
The 5-HTP comes from Griffonia simplicifolia, but its standardization percentage is not given.

Dose, Safety & Label Transparency100

Each serving provides 100 mg of 5-HTP. The label includes a warning about serotonin-related medication interactions.
Dosage Potency & Range
Each serving provides 100 mg of 5-HTP.
Safety Warnings & Label Clarity
The label includes a warning about serotonin-related medication interactions.

Value100

The estimated cost per 100 mg of 5-HTP is low. The estimate assigns the full product cost to 5-HTP and may overstate its cost.
Price per 100mg 5-HTP
The estimated cost per 100 mg of 5-HTP is low. The estimate assigns the full product cost to 5-HTP and may overstate its cost.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  2. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  6. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  7. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support Stress Relief forVitamin B6
  8. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  9. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  10. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  11. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  12. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  13. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  14. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  15. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  16. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  17. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  18. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  19. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  20. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP