5-HTP 100 mg

5-HTP 100 mg

NOW4.7 (53,361 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 120 servings
Goals
$13.42 $0.11 per serving
AmazonLowest$13.42Pure Formulas$16.68iHerb$16.79Vitacost$18.47Daily Vita$18.50

Product analysis

76 out of 100

5-HTP 100 mg may support fullness and may help some poor sleepers, with limited evidence for predictable day-to-day benefits.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality40

Griffonia seed extract identifies the source of 5-HTP. Its form quality remains uncertain from the available detail.

Ingredient Transparency100

The stated 5-HTP amount and plant source are disclosed. Those details make the ingredient easy to identify and compare.

Value For Money100

The 5-HTP amount offers strong value for the serving cost. That is most relevant when 5-HTP is the specific ingredient being sought.

Customer Satisfaction91

Customer ratings are strongly positive across a very large set of reviews. The feedback offers broad evidence of satisfaction, though it does not demonstrate health effects.

Product Focus66

The single-ingredient formula concentrates on possible 5-HTP effects on sleep, mood and appetite. Reliable everyday improvements remain uncertain, particularly for mood and stress.

Format
Capsule
Container
120 Capsule(s)
Per serving
$0.11
Customer rating
4.7 · 53,361 ratings
Report analysis

Goals

Mood Support
Mood Support
Impact
Highest effect
A Ingredient FitC- PathwaysA EvidenceA+ Formulation Logic
5-HTP · 100 mg
Study evidence
5-HTP Supportive 9 studies
Sleep Support
Sleep Rhythm
Sleep Support
Impact
Moderate effect
A Ingredient FitC PathwaysC- EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 1 study
Stress Relief
Stress Relief
Impact
Moderate effect
A Ingredient FitD PathwaysC- EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 18 studies
Weight Loss
Cravings
Weight Loss
Impact
Moderate effect
B- Ingredient FitF PathwaysC EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 5 studies

Ingredients

IngredientAmount per servingScore
5-HTP (Griffonia simplicifolia Seed Extract)
 100 mg 88
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
5-HTP (Griffonia simplicifolia Seed Extract) · 100 mg OverallScore88
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
Each serving provides 100 mg of 5-HTP. The cost per 100 mg of 5-HTP is low. Griffonia simplicifolia is named as the source, but its 5-HTP standardization percentage is unknown. The label includes a warning about interactions with serotonin-modulating medication.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Griffonia simplicifolia is named as the source, but its 5-HTP standardization percentage is unknown.
Botanical Source & Standardization
Griffonia simplicifolia is named as the source, but its 5-HTP standardization percentage is unknown.

Dose, Safety & Label Transparency100

Each serving provides 100 mg of 5-HTP. The label includes a warning about interactions with serotonin-modulating medication.
Dosage Potency & Range
Each serving provides 100 mg of 5-HTP.
Safety Warnings & Label Clarity
The label includes a warning about interactions with serotonin-modulating medication.

Value100

The cost per 100 mg of 5-HTP is low.
Price per 100mg 5-HTP
The cost per 100 mg of 5-HTP is low.
View ingredientView products
83 Performance

5-HTP 100 mg Extra Strength

Swanson
A focused 5-HTP formula offers a useful alternative dosing and package profile. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP 100 mg

NOW
A focused 5-HTP formula offers a useful alternative dosing and package profile. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
A focused 5-HTP formula offers a useful alternative dosing and package profile. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
84 Budget

5-HTP 50 mg

NOW
The lower recurring cost makes this a more economical eligible choice. Its 50 mg 5-HTP serving offers a more cautious starting option than the original’s 100 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
85 Budget

5-HTP 100 mg

Doctor's Best
The lower recurring cost makes this a more economical eligible choice. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
82 Budget

5-HTP 50 mg

Swanson Premium Brand
The lower recurring cost makes this a more economical eligible choice. Its 50 mg 5-HTP serving offers a more cautious starting option than the original’s 100 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP 200mg

Best Naturals
Focused 5-HTP dosing and strong formula value make this a practical value alternative. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP with Vitamin B6 & Vitamin C

Lake Avenue Nutrition
Focused 5-HTP dosing and strong formula value make this a practical value alternative. The active amount is disclosed, but botanical-source detail remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
82 Value

5-HTP 200 mg Maximum Strength

Swanson
Focused 5-HTP dosing and strong formula value make this a practical value alternative. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  2. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  6. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  7. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  8. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  9. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  10. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  11. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  12. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  13. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  14. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  15. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  16. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP