SAMe 200 mg + Cofactors
Goals
$73.00 $1.21 per serving
Product analysis
SAMe 200 mg + Cofactors supplies B vitamins that may help fill dietary gaps affecting normal blood formation and tiredness. Its SAMe contribution offers limited value at the full serving cost.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality33
Several vitamin and mineral forms are identified, but their quality remains uncertain. The folate and SAMe forms are not specified, adding further uncertainty.
Ingredient Transparency88
All ingredient amounts and most forms are stated, helping with comparisons. The folate and SAMe forms are the main missing details.
Value For Money37
The SAMe contribution offers limited value at the full serving cost. The value of the other nutrients remains uncertain.
Customer Satisfaction71
Customer ratings are very positive. The smaller review base limits confidence in how widely that satisfaction is shared.
Product Focus71
The clearest role is filling B-vitamin gaps that can affect blood formation, tiredness and concentration. Normal metabolic roles do not establish general toxin removal or extra energy when intake is adequate.
- Format
Capsule - Container
- 60 Capsule(s)
- Per serving
- $1.21
- Customer rating
- 4.7 · 80 ratings
Goals
Impact
Highest effect
Folate · 333 mcg DFEVitamin B12 · 500 mcgVitamin B6 · 2 mgMagnesium · 20 mgSAMe · 200 mg
Vitamin B6 Not classified
No linked studies yet.
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
Vitamin B6 (Pyridoxal 5-Phosphate) | 2 mg | |
Folate | 333 mcg DFE | |
Vitamin B12 (Methylcobalamin) | 500 mcg | |
Calcium (Calcium Citrate) | 20 mg | |
Magnesium (Magnesium Bisglycinate) | 20 mg | |
SAMe | 200 mg |
Vitamin B12 (Methylcobalamin) · 500 mcg OverallScore79
SAMe · 200 mg OverallScore70
200 mg of SAMe per serving comes at a high cost for the amount. The source includes S-Adenosyl-L-Methionine Disulfate P-Toluenesulfonate, but its proportion is unclear. Moisture protection from blister packaging is unclear. The active amount is disclosed.
How this ingredient is rated
Active Ingredient Quality & Bioavailability77
The SAMe source includes S-Adenosyl-L-Methionine Disulfate P-Toluenesulfonate; its share is not stated. Blister packaging is not documented, leaving moisture protection unclear.
Stabilized Salt Form
The SAMe source includes S-Adenosyl-L-Methionine Disulfate P-Toluenesulfonate; its share is not stated.
Packaging Integrity
Blister packaging is not documented, leaving moisture protection unclear.
Dose, Safety & Label Transparency88
The serving lists 200 mg of SAMe. The active SAMe amount is stated separately from its salt.
Active Dosage Strength
The serving lists 200 mg of SAMe.
Net SAMe Yield Transparency
The active SAMe amount is stated separately from its salt.
Value20
The cost for the listed SAMe amount is high. Enteric coating or delayed release is not documented.
Price Per 400mg Active Dose
The cost for the listed SAMe amount is high. Enteric coating or delayed release is not documented.
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Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Comparison of efficacy of folic acid and silymarin in the management of antiepileptic drug induced liver injury: a randomized clinical trial.
- Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation.
- Serum folate levels and urinary arsenic methylation profiles in the US population: NHANES, 2003-2012.
- Association between serum folate levels and blood concentrations of cadmium and lead in US adults.
- Effects of Folic Acid Supplementation on Liver Enzymes, Lipid Profile, and Insulin Resistance in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial.
- Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics.
- Magnesium Sulfate Administration in Moderate Coronary Artery Disease Patients Improves Atherosclerotic Risk Factors: A Double-Blind Clinical Trial Study.
- Effects of Synbiotic Food Consumption on Serum Minerals, Liver Enzymes, and Blood Pressure in Patients with Type 2 Diabetes: A Double-blind Randomized Cross-over Controlled Clinical Trial.
- Clinical experience with 781 cases of alcoholism evaluated and treated on an inpatient basis by various methods.
- Ionized hypomagnesemia in patients undergoing orthotopic liver transplantation: a complication of citrate intoxication.
- Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review.
- Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial.
- S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis.
- Protective effect of S-adenosylmethionine on hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic HBV infection.
- S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial.
- Antidotes for acute cyanide poisoning.
- Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation.
- Comment on "Rapid visual detection of blood cyanide" by C. Männel-Croisé and F. Zelder, Analytical Methods, 2012, 4, 2632.
- [Acute intoxication in adults - what you should know].
- Investigating vitamin B12 levels in children with obesity: the role of metformin.