$32.18 $1.07 per serving
Product analysis
SAMe 400 mg offers a single active ingredient for people specifically seeking SAMe. The specific preparation is not disclosed, limiting comparisons between forms.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality20
The specific SAMe preparation is not identified. Its quality therefore cannot be judged confidently from the ingredient name alone.
Ingredient Transparency63
The SAMe amount is disclosed, making the serving easier to compare. Its specific form remains unspecified.
Value For Money50
The SAMe amount offers moderate value at the serving cost. Unspecified preparation details limit comparisons with more fully described forms.
Customer Satisfaction73
Customer ratings are very favorable. A few hundred ratings provide a useful, though limited, picture of satisfaction.
Product Focus71
The single-ingredient composition keeps the formula concentrated. It is associated with several intended uses rather than a broad mixture of unrelated actives.
- Format
Tablet - Container
- 30 Tablet(s)
- Per serving
- $1.07
- Customer rating
- 4.7 · 209 ratings
Goals
Impact
High effect
SAMe · 400 mg
Impact
Highest effect
SAMe · 400 mg
Impact
High effect
SAMe · 400 mg
SAMe Not classified
No linked studies yet.
Impact
Moderate effect
SAMe · 400 mg
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
SAMe | 400 mg |
SAMe · 400 mg OverallScore90
The serving provides 400 mg of SAMe at a somewhat high cost per 400 mg. Blister packaging offers moisture protection. The active yield is distinguished from salt weight.
How this ingredient is rated
Active Ingredient Quality & Bioavailability100
SAMe Disulfate Tosylate is a stabilized salt form. Blister packaging helps protect SAMe from moisture.
Stabilized Salt Form
SAMe Disulfate Tosylate is a stabilized salt form.
Packaging Integrity
Blister packaging helps protect SAMe from moisture.
Dose, Safety & Label Transparency100
A serving lists 400 mg of SAMe. The active SAMe yield is distinguished from the salt amount.
Active Dosage Strength
A serving lists 400 mg of SAMe.
Net SAMe Yield Transparency
The active SAMe yield is distinguished from the salt amount.
Value50
The cost per 400 mg of SAMe is somewhat high.
Price Per 400mg Active Dose
The cost per 400 mg of SAMe is somewhat high.
Alternative products
Report alternatives
Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495].
- Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease.
- Double-blind multicentre study of the activity of S-adenosylmethionine in hip and knee osteoarthritis.
- A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis.
- Exploring the mechanisms behind S-adenosylmethionine (SAMe) in the treatment of osteoarthritis.
- Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review.
- Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial.
- S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis.
- Protective effect of S-adenosylmethionine on hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic HBV infection.
- S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial.
- Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies.
- A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder.
- Preliminary results of a randomized controlled trial carried out with a fixed combination of S-adenosyl-L-methionine and betaine versus amitriptyline in patients with mild depression.
- S-adenosylmethionine blood levels in major depression: changes with drug treatment.
- Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses.