Hair Skin and Nails

Hair Skin and Nails

Dr. Mercola4.6 (198 ratings)
Format:Capsule Quantity: 30 Capsule(s) · 30 servings
Goals
$39.59 $1.31 per serving

Product analysis

49 out of 100

Hair Skin and Nails may help brittle nails, though support for biotin comes from small, mostly uncontrolled trials. The formula is relatively costly for the biotin and keratin supplied.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality25

The hyaluronic acid form is identified, but the biotin and keratin forms are unspecified. That limits comparisons of ingredient quality across the formula.

Ingredient Transparency75

All three ingredient amounts are disclosed, making servings easier to compare. Only the hyaluronic acid form is specified.

Value For Money28

Biotin and keratin are relatively costly for what the serving supplies. Hyaluronic acid offers more moderate value, so the combination is not especially economical.

Customer Satisfaction71

Customer ratings are positive. The review base is more modest, so it may reflect a narrower range of experiences.

Product Focus72

Biotin has its clearest hair and skin role when intake is low, while brittle-nail support is limited. The hyaluronic acid amount is below the skin-trial amounts, and the keratin preparation is not matched to the research.

Format
Capsule
Container
30 Capsule(s)
Per serving
$1.31
Customer rating
4.6 · 198 ratings
Report analysis

Goals

Impact
High effect
A+ Ingredient FitF PathwaysB- EvidenceA+ Formulation Logic
Biotin · 5000 mcgKeratin · 500 mg
Study evidence
Biotin Supportive 4 studies
Keratin Disputed 14 studies
Nail Health
Impact
Highest effect
A- Ingredient FitB- PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 5000 mcgKeratin · 500 mg
Study evidence
Biotin Supportive 8 studies
Keratin Adverse 7 studies
Skin Health
Impact
Moderate effect
A+ Ingredient FitF PathwaysD+ EvidenceA+ Formulation Logic
Hyaluronic Acid · 20 mg
Study evidence
Biotin Supportive 10 studies

Ingredients

IngredientAmount per servingScore
Biotin
5000 mcg 77
Keratin
500 mg 48
Low density Hyaluronic Acid (Sodium Hyaluronate)
20 mg 51
Adults 18–50
Report overview
Biotin · 5000 mcg OverallScore77
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
Each serving provides 5000 mcg of biotin; the cost for that amount is high. The amount is used for hair and nail support. The label names biotin but does not specify its isomer.
How this ingredient is rated

Active Ingredient Quality & Bioavailability82

The label names biotin but does not specify its isomer. The listed ingredients show no artificial colors or sweeteners.
Biologically Active d-Biotin Isomer
The label names biotin but does not specify its isomer.
Excipient Purity
The listed ingredients show no artificial colors or sweeteners.

Dose, Safety & Label Transparency100

A serving provides 5000 mcg of biotin for hair and nail support. The amount is listed separately.
Biotin Potency for Health Goals
A serving provides 5000 mcg of biotin for hair and nail support.
Label Transparency & Exact Disclosure
The biotin amount is listed separately in micrograms.

Value20

The cost for the amount of biotin is high.
Price per 5,000 mcg Biotin
The cost for the amount of biotin is high.
Keratin · 500 mg OverallScore48
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
D+ Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyD+ Value
Hair Skin and Nails provides 20 mg of sodium hyaluronate per serving at a high selected-serving cost. The source and production method are not available.
How this ingredient is rated

Active Ingredient Quality & Bioavailability53

The form is sodium hyaluronate, a salt of hyaluronic acid. The source and production method are not available.
Molecular Weight & Form Optimization
The form is sodium hyaluronate, a salt of hyaluronic acid.
Source Transparency & Purity Signals
The source and production method are not available.

Dose, Safety & Label Transparency51

The selected serving contains 20 mg of hyaluronic acid.
Hyaluronic Acid Dosage Potency
The selected serving contains 20 mg of hyaluronic acid.
Label Precision & Transparency
The selected serving contains 20 mg of hyaluronic acid.

Value50

The selected-serving cost is high.
Price Per Active Dose
The selected serving costs a high amount.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health Nail Health Skin Health forBiotin
  2. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health Skin Health forBiotin
  3. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  4. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  5. Efficacy and safety of non-cross-linked hyaluronic acid compound in the treatment of keratosis pilaris: A split-body randomized clinical trial.
    Li Y; Wang SW; Liu YH; Zou MY; Wu JX; Luo SK; Hong WJ · Journal of cosmetic dermatology · 2024
    Randomized trialHair Health forHyaluronic Acid
  6. Intradermal Injections of 10% Glucose (Sihler G) for Scalp Hair Regrowth: A Randomized, Evaluator-Blinded Pilot Study.
    Yi KH; Sydorchuk O; Lee S; Sobchyshyn M; Kim TH; Lee SR; Park S; Chang-Il Y; Kyu-Eun L · Aesthetic plastic surgery · 2026
    Observational studyHair Health forHyaluronic Acid
  7. Efficacy of Dr. SKS Hair Booster Serum in the Treatment of Female Pattern Alopecia in Patients With PCOS: An Open-Label, Non-randomized, Prospective Study.
    Khare S · Cureus · 2023
    Randomized trialHair Health forHyaluronic Acid
  8. Efficacy and safety of needle-free jet injector-assisted intralesional treatments in dermatology-a systematic review.
    Bekkers VZ; Bik L; van Huijstee JC; Wolkerstorfer A; Prens EP; van Doorn MBA · Drug delivery and translational research · 2023
    Systematic reviewHair Health forHyaluronic Acid
  9. Revitalizing Effect on the Scalp After Injection with a Mechanically Stabilized Hyaluronic Acid Complex in Subjects with Androgenetic Alopecia.
    Siquier-Dameto G; Boisnic S; Verdú E · Journal of clinical medicine · 2024
    Clinical trial26 participantsHair Health forHyaluronic Acid
  10. The Effects of an Oral Supplementation of a Natural Keratin Hydrolysate on Skin Aging: A Randomized, Double-Blind, Placebo-Controlled Clinical Study in Healthy Women.
    Tursi F; Nobile V; Cestone E; De Ponti I; Lepoudere A; Sergheraert R; Soulard JP · Journal of cosmetic dermatology · 2025
    Randomized trialHair Health Nail Health forKeratin
  11. Halloysite/Keratin Nanocomposite for Human Hair Photoprotection Coating.
    Cavallaro G; Milioto S; Konnova S; Fakhrullina G; Akhatova F; Lazzara G; Fakhrullin R; Lvov Y · ACS applied materials & interfaces · 2021
    In vitro / ex vivo studyHair Health forKeratin
  12. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial.
    Tenore GC; Caruso D; Buonomo G; D'Avino M; Santamaria R; Irace C; Piccolo M; Maisto M; Novellino E · Journal of medicinal food · 2018
    Randomized trialHair Health forKeratin
  13. Keratin/alginate hybrid hydrogels filled with halloysite clay nanotubes for protective treatment of human hair.
    Cavallaro G; Caruso MR; Milioto S; Fakhrullin R; Lazzara G · International journal of biological macromolecules · 2022
    In vitro / ex vivo studyHair Health forKeratin
  14. Patient Satisfaction and Adverse Effects Following the use of Topical Hair Fiber Fillers.
    Babadjouni A; Juhasz M; Pham C; Csuka E; Hedayati B; Evron E; Mesinkovska NA · International journal of trichology · 2024
    Cross-sectional study40 participantsHair Health forKeratin
  15. Biotin for the treatment of nail disease: what is the evidence?
    Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
    Narrative reviewNail Health forBiotin
  16. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
    Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
    Other32 participantsNail Health forBiotin
  17. Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
    Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
    Randomized trial50 participantsNail Health forBiotin
  18. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forBiotin
  19. Comparative Analysis of Type I Keratin Expression By Nail Consistency: An Immunohistochemistry Study.
    Mingorance Álvarez E; Rodríguez-León J; Pérez Pico AM; Mayordomo R · Applied immunohistochemistry & molecular morphology : AIMM · 2022
    Cross-sectional study32 participantsNail Health forKeratin
  20. Exposure to toxic agents alters organic elemental composition in human fingernails.
    Schumacher E; Dindorf W; Dittmar M · The Science of the total environment · 2009
    Cross-sectional study120 participantsNail Health forKeratin