Hair Skin & Nails Collagen Plus Formula

Hair Skin & Nails Collagen Plus Formula

Life Extension4.7 (8,170 ratings)
Format:Tablet Quantity: 120 Tablet(s) · 30 servings
Goals

Product analysis

61 out of 100

Hair Skin & Nails Collagen Plus Formula may offer modest help with skin elasticity and brittle nails, though the evidence is limited. Zinc oxide and copper sulfate are less compelling form choices, and some preparation details remain unclear.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality26

The zinc and copper forms are weaker choices for absorption. Several other preparations remain uncertain, including the exact collagen and silicon forms.

Ingredient Transparency93

All ingredient amounts and most forms are stated. Biotin and collagen preparation details are missing, limiting comparisons with particular products.

Value For Money52

Value is uneven across the formula. Keratin and collagen compare more favorably than zinc, while several other components remain uncertain.

Customer Satisfaction89

Customer ratings are very positive. Thousands of ratings provide a substantial base of feedback.

Product Focus71

The clearest possible benefits concern skin elasticity and brittle nails, but confidence is limited by the quality of the evidence. The broad blend also includes nutritional uses that matter mainly when intake is low.

Format
Tablet
Container
120 Tablet(s)
Per serving
$0.66
Customer rating
4.7 · 8,170 ratings
Report analysis

Goals

Impact
High effect
B- Ingredient FitF PathwaysA EvidenceA+ Formulation Logic
Biotin · 2500 mcgZinc · 15 mgKeratin · 500 mgCollagen · 2500 mg
Study evidence
Biotin Supportive 4 studies
Collagen Supportive 3 studies
Copper Adverse 4 studies
Keratin Disputed 14 studies
Niacin Disputed 2 studies
Silicon Supportive 2 studies
Zinc Supportive 22 studies
Nail Health
Impact
Highest effect
B Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Silicon · 3 mgCollagen · 2500 mgBiotin · 2500 mcgKeratin · 500 mg
Study evidence
Biotin Supportive 8 studies
Calcium Supportive 1 study
Collagen Supportive 4 studies
Keratin Adverse 7 studies
Silicon Supportive 2 studies
Zinc No effect 1 study
Skin Health
Impact
Highest effect
B+ Ingredient FitC PathwaysA+ EvidenceA+ Formulation Logic
Zinc · 15 mgCollagen · 2500 mgCopper · 1.65 mgSilicon · 3 mg
Study evidence
Biotin Supportive 10 studies
Collagen Supportive 62 studies
Copper Supportive 16 studies
Niacin Supportive 61 studies
Silicon Supportive 16 studies
Zinc Supportive 66 studies
Everyday Health
Impact
High effect
C+ Ingredient FitB PathwaysB- EvidenceA+ Formulation Logic
Collagen · 2500 mgZinc · 15 mg
Study evidence
Collagen Supportive 31 studies
Zinc Supportive 60 studies
Bone Health
Impact
High effect
C+ Ingredient FitC PathwaysA- EvidenceA+ Formulation Logic
Calcium · 83 mgCopper · 1.65 mgZinc · 15 mgCollagen · 2500 mg
Study evidence
Calcium Supportive 144 studies
Collagen Supportive 16 studies
Copper Disputed 20 studies
Silicon Supportive 13 studies
Zinc Supportive 33 studies
Immunity
Impact
High effect
C- Ingredient FitD- PathwaysA+ EvidenceA+ Formulation Logic
Zinc · 15 mg
Study evidence
Zinc Supportive 73 studies

Ingredients

IngredientAmount per servingScore
Niacin (Niacinamide)
18 mg NE
Vitamin B6 (Pyridoxine Hydrochloride)
2 mg
Biotin
2500 mcg 78
Pantothenic Acid (D-Calcium Pantothenate)
13.68 mg
Calcium (Dicalcium Phosphate)
83 mg
Zinc (Zinc Oxide)
15 mg 50
Copper (Copper Sulfate)
1.65 mg 59
Verisol Bioactive Collagen Peptides
2500 mg 40
Cynatine HNS (Keratin)
500 mg 100
Silicon (Bamboo extract)
3 mg 48
Adults 18–50
Report overview
Keratin · 500 mg OverallScore100
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
Biotin · 2500 mcg OverallScore78
B+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyC Value
2500 mcg per serving is within a range used for hair and nail support. The cost per amount of biotin is high, but the price also covers other vitamins and minerals. The label says biotin but does not specify the isomer.
How this ingredient is rated

Active Ingredient Quality & Bioavailability82

The label says biotin but does not specify the isomer. The available Other Ingredients evidence indicates no artificial colors or sweeteners.
Biologically Active d-Biotin Isomer
The label says biotin but does not specify the isomer.
Excipient Purity
The available Other Ingredients evidence indicates no artificial colors or sweeteners.

Dose, Safety & Label Transparency84

2500 mcg per serving is within a range used for hair and nail support. The amount is stated on the label.
Biotin Potency for Health Goals
2500 mcg per serving is within a range used for hair and nail support.
Label Transparency & Exact Disclosure
The label states the biotin amount as 2,500 mcg per serving.

Value60

The cost per amount of biotin is high, but the price also covers other vitamins and minerals.
Price per 5,000 mcg Biotin
The cost per amount of biotin is high, but the price also covers other vitamins and minerals.
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value
The serving provides 1.65 mg of copper. The cost per serving is moderate. It uses copper sulfate, an inorganic copper salt. It also contains 15 mg of zinc.
How this ingredient is rated

Active Ingredient Quality & Bioavailability37

The copper amount and copper sulfate source are both named.
Copper Form Bioavailability
Copper sulfate is an inorganic copper salt.
Elemental Copper Labeling Clarity
The label names both the copper amount and its source.

Dose, Safety & Label Transparency86

The serving provides 1.65 mg of copper. The same serving has 15 mg of zinc.
Copper Dosage Safety & Efficacy
Each selected serving contains 1.65 mg of copper.
Zinc-to-Copper Balance
The serving pairs 15 mg of zinc with 1.65 mg of copper.

Value50

The cost per serving is moderate.
Price Per Serving Efficiency
The serving price is moderate.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  2. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  3. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  4. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  5. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  6. Effect of Calcium and Vitamin D Supplementation With and Without Collagen Peptides on Volumetric and Areal Bone Mineral Density, Bone Geometry and Bone Turnover in Postmenopausal Women With Osteopenia.
    Lampropoulou-Adamidou K; Karlafti E; Argyrou C; Makris K; Trovas G; Dontas IA; Tournis S; Triantafyllopoulos IK · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry · 2022
    Randomized trial51 participantsBone Health forCollagen
  7. Bone turnover and bone collagen maturation in osteoporosis: effects of antiresorptive therapies.
    Byrjalsen I; Leeming DJ; Qvist P; Christiansen C; Karsdal MA · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008
    Randomized trialBone Health forCollagen
  8. A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial.
    Elam ML; Johnson SA; Hooshmand S; Feresin RG; Payton ME; Gu J; Arjmandi BH · Journal of medicinal food · 2015
    Randomized trial39 participantsBone Health forCollagen
  9. Assessment of Osteoporosis in Lumbar Spine: In Vivo Quantitative MR Imaging of Collagen Bound Water in Trabecular Bone.
    Liu J; Liao JW; Li W; Chen XJ; Feng JX; Yao L; Huang PH; Su ZH; Lu H; Liao YT; Li SL; Ma YJ · Frontiers in endocrinology · 2022
    Methods validation study189 participantsBone Health forCollagen
  10. Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia.
    Argyrou C; Karlafti E; Lampropoulou-Adamidou K; Tournis S; Makris K; Trovas G; Dontas I; Triantafyllopoulos IK · Journal of musculoskeletal & neuronal interactions · 2021
    Randomized trial51 participantsBone Health forCollagen
  11. The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
    Ju Y; Xiong W; Pang Y; Chen Z; Hou J; Zheng S; Li Z; Liu T; Xia H; Xia M; Zhong Y; Li J; Jiang X · Biological trace element research · 2026
    Scoping review18 studies pooledBone Health forCopper
  12. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
    Chen M; Jia L; Gao R · Frontiers in nutrition · 2024
    Cohort study5,286 participantsBone Health forCopper
  13. Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
    Hu M; Wang Z; Li C; Zheng Y; Hu J · Medicine · 2025
    Cross-sectional studyBone Health forCopper
  14. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsBone Health forCopper
  15. Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
    Cui A; Yan J; Li H; Fan Z; Wei X; Wang H; Zhuang Y · PloS one · 2024
    Cross-sectional study6,965 participantsBone Health forCopper
  16. The effect of choline-stabilized orthosilicic acid in patients with peri-implantitis: an exploratory randomized, double-blind, placebo controlled study.
    Teughels W; Celik GU; Tarce M; De Cock I; Persyn SM; Haytac MC · BMC oral health · 2021
    Randomized trial21 participantsBone Health forSilicon
  17. Calcium Phosphate Modified with Silicon vs. Bovine Hydroxyapatite for Alveolar Ridge Preservation: Densitometric Evaluation, Morphological Changes and Histomorphometric Study.
    Cadenas-Vacas G; Martínez-Rodríguez N; Barona-Dorado C; Sánchez-Labrador L; Cortés-Bretón Brinkmann J; Meniz-García C; Martínez-González JM · Materials (Basel, Switzerland) · 2021
    Non-randomized trialBone Health forSilicon
  18. Silicon: a review of its potential role in the prevention and treatment of postmenopausal osteoporosis.
    Price CT; Koval KJ; Langford JR · International journal of endocrinology · 2013
    Narrative reviewBone Health forSilicon
  19. Osteogenic Effect of a Bioactive Calcium Alkali Phosphate Bone Substitute in Humans.
    Knabe C; Adel-Khattab D; Rezk M; Cheng J; Berger G; Gildenhaar R; Wilbig J; Günster J; Rack A; Heiland M; Knauf T; Stiller M · Bioengineering (Basel, Switzerland) · 2023
    Clinical trial38 participantsBone Health forSilicon
  20. Silicon and bone health.
    Jugdaohsingh R · The journal of nutrition, health & aging · 2007
    Narrative reviewBone Health forSilicon