SynaQuell

SynaQuell

Thorne4.7 (167 ratings)
Format:Powder Quantity: 8 Ounce(s) · 30 servings
Goals
$75.00 $2.50 per serving

Product analysis

39 out of 100

SynaQuell combines nutrients involved in normal energy use and cellular protection. Its high cost and limited disclosure of ingredient forms make it harder to justify for everyday use.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality20

The quality of most ingredient forms remains uncertain. That limits confidence in how well the full combination can be used by the body.

Ingredient Transparency56

Most amounts are listed, but most ingredient forms are omitted. Some combination details also remain unclear, making a close comparison harder.

Value For Money10

The price is high for several of the declared ingredients. Paying more does not establish a greater benefit from the combination.

Customer Satisfaction73

Customers give generally favorable ratings. The review pool is modest, so it gives a less settled picture of satisfaction.

Product Focus58

The combination has some support for normal energy use and cellular protection. The evidence is mixed and does not establish a faster metabolism.

Format
Powder
Container
8 Ounce(s)
Per serving
$2.50
Customer rating
4.7 · 167 ratings
Report analysis

Goals

Inflammation
Impact
Moderate effect
C- Ingredient FitF PathwaysC EvidenceA+ Formulation Logic
Coenzyme Q-10 · 50 mgGlutathione · 250 mgCurcumin · 125 mg

Trans-resveratrol at 125 mg has a limited, inconsistent connection to inflammatory markers. Glutathione at 250 mg supports cellular redox balance, while the smaller curcumin, CoQ10, DHA and magnesium amounts contribute less in the saved assessment.

How this product is rated for Inflammation

Ingredient fit57

The formula has broader nutritional purposes, with a smaller share directly relevant to this goal. The known amounts provide relatively substantial support in the saved assessment.
Goal fit
The formula has broader nutritional purposes, with a smaller share directly relevant to this goal.
Dose adequacy
The known amounts provide relatively substantial support in the saved assessment.

Pathways16

The main connection is cellular inflammatory signaling, with limited coverage in the saved findings. The saved findings show limited coverage across the reviewed inflammation mechanisms.
Depth
The main connection is cellular inflammatory signaling, with limited coverage in the saved findings.
Breadth
The saved findings show limited coverage across the reviewed inflammation mechanisms.

Evidence62

Resveratrol provides the strongest evidence among the ingredients counted at a meaningful amount. Its support for this broad goal is limited.
Evidence strength
Resveratrol provides the strongest evidence among the ingredients counted at a meaningful amount. Its support for this broad goal is limited.
Studied preparation
The ingredients counted at meaningful amounts match preparations accepted in the saved assessment.

Formulation logic100

The relevant ingredients can contribute on their own or have their required partner. No ingredient conflicts were identified in the saved assessment.
Partner coverage
The relevant ingredients can contribute on their own or have their required partner.
Conflicts
No ingredient conflicts were identified in the saved assessment.
Effective doses
2 of 2 relevant ingredients reach the saved meaningful-amount threshold.
Study evidence
Curcumin Supportive 68 studies
Magnesium Supportive 41 studies
Metabolism Support
Impact
High effect
C- Ingredient FitD PathwaysB+ EvidenceA+ Formulation Logic
Niacin · 207.5 mgRiboflavin · 25 mgMagnesium · 59 mgResveratrol · 125 mgCurcumin · 125 mgCoenzyme Q-10 · 50 mg

Riboflavin and CoQ10 help with normal energy transfer, while resveratrol is connected with mitochondrial and insulin-related functions. Those roles do not establish a faster whole-body metabolic rate, and resveratrol research includes a small study with lower resting expenditure. Nicotinamide riboside findings are mixed, and the declared hydrogen-malate compound amount is not equivalent to free nicotinamide riboside.

How this product is rated for Metabolism Support

Ingredient fit56

Resveratrol, riboflavin and CoQ10 provide the ingredient connections retained in the saved findings. Their amount comparisons describe the declared serving rather than a demonstrated metabolism-boosting regimen.
Goal fit
Resveratrol, riboflavin and CoQ10 account for the goal-related ingredient findings, while the product's range of other uses and other active ingredients make it less focused on this goal.
Dose adequacy
The declared amounts receive partial amount findings overall; meeting these comparisons does not establish a proven calorie-burning dose.

Pathways47

The strongest saved connection concerns mitochondrial energy and fat oxidation; these mechanisms do not by themselves demonstrate faster whole-body energy expenditure. Only one meets the saved coverage threshold.
Depth
The strongest saved connection concerns mitochondrial energy and fat oxidation; these mechanisms do not by themselves demonstrate faster whole-body energy expenditure.
Breadth
Only one pathway meets the saved coverage threshold, so the mechanistic coverage is narrow.

Evidence81

Resveratrol provides the strongest saved evidence finding among the qualifying amounts; this does not itself demonstrate a general metabolism boost.
Evidence strength
Resveratrol provides the strongest saved evidence finding among the qualifying amounts; this does not itself demonstrate a general metabolism boost.
Studied preparation
The qualifying ingredients are treated as matching studied preparations in the saved findings; preparation matching alone does not establish a rise in energy expenditure.

Formulation logic100

The retained ingredients have no missing required partner or matched configured conflict. They meet the saved amount criterion, which does not establish additional calorie burning.
Partner coverage
The included ingredient contributions do not lack a required partner; this does not establish extra benefit from combining them.
Conflicts
No configured ingredient conflict was matched in the supplied facts; this finding does not establish overall safety.
Effective doses
All ingredients retained for this amount check meet its comparison criterion; that criterion is not a proven dose for increased calorie burning.
Study evidence
Curcumin Supportive 19 studies
Magnesium Supportive 61 studies

Ingredients

IngredientAmount per servingScore
Calories
23 Calorie(s)
Total Carbohydrates
1 Gram(s)
Riboflavin (Riboflavin 5-Phosphate Sodium)
25 mg 77
Magnesium (Magnesium Beta-Hydroxybutyrate)
59 mg
L-Leucine
1.25 Gram(s)
L-Isoleucine
625 mg 63
L-Valine
625 mg 70
Beta Hydroxybutyrate (Magnesium Beta Hydroxybutyrate)
500 mg
Glutathione, Reduced
250 mg 48
Nicotinamide Riboside Hydrogen Malate
207.5 mg 65
Meriva (Curcumin Phytosome)
125 mg 0
Docosahexaenoic Acid (Algal Oil)
125 mg 35
Trans-Resveratrol
125 mg 73
Ubiqsome (Coenzyme Q10 Phytosome)
50 mg 34
Betaine Anhydrous (Trimethylglycine)
42.5 mg
Gluten Free Adults 18–50 Women
Report overview
Niacin · 207.5 mg OverallScore65
A- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value
F Composition And Label DisclosureF Composition And Label DisclosureF Commercial Price And Usability
Valine · 625 mg OverallScore70
A+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value
The serving provides a modest 625 mg of L-valine. A sport-specific certification is recorded, and the whole-product price works out to about $3.99 per gram of valine.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

L-valine is the recorded form, and a sport-specific third-party certification is recorded.
Valine Isomer and Source Type
The recorded form is L-valine.
Third-Party Sport Certifications
The saved facts record a sport-specific third-party certification.

Dose, Safety & Label Transparency70

The amount and form are clearly recorded: 625 mg of L-valine per serving. It is a modest amount for the athletic use considered.
Valine Dosage Efficacy
The serving provides 625 mg of valine, a modest amount for the athletic use considered.
Label Transparency and Proprietary Blends
The amount and L-valine form are recorded for each serving.

Value10

The whole-product serving price works out to about $3.99 per gram of valine.
Price Per Gram of Valine
The whole-product serving price works out to about $3.99 per gram of valine.

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.
    Taghizadeh S; Izadi A; Shirazi S; Parizad M; Pourghassem Gargari B · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2021
    Randomized trial43 participantsInflammation forCoenzyme Q-10
  2. The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome.
    Karamali M; Gholizadeh M · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
    Randomized trial55 participantsInflammation forCoenzyme Q-10
  3. Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.
    Hou S; Tian Z; Zhao D; Liang Y; Dai S; Ji Q; Fan Z; Liu Z; Liu M; Yang Y · Molecular nutrition & food research · 2023
    Meta-analysis1,517 participants31 studies pooledInflammation forCoenzyme Q-10
  4. Can coenzyme Q10 supplementation effectively reduce human tumor necrosis factor-α and interleukin-6 levels in chronic inflammatory diseases? A systematic review and meta-analysis of randomized controlled trials.
    Farsi F; Heshmati J; Keshtkar A; Irandoost P; Alamdari NM; Akbari A; Janani L; Morshedzadeh N; Vafa M · Pharmacological research · 2020
    Meta-analysis509 participants9 studies pooledInflammation forCoenzyme Q-10
  5. Promising efficacy of coenzyme Q10 supplementation as adjunctive therapy in juvenile idiopathic arthritis: a randomized-controlled pilot study.
    Elsherif N; Shousha G; Sabri NA; Shawki MA · Immunopharmacology and immunotoxicology · 2026
    Randomized trial58 participantsInflammation forCoenzyme Q-10
  6. Effect of curcumin on inflammatory markers and disease activity in patients with rheumatoid arthritis: A meta-analysis.
    Zhang F; Niu B · Medicine · 2025
    Meta-analysis7 studies pooledInflammation forCurcumin
  7. Effect of curcumin on C-reactive protein as a biomarker of systemic inflammation: An updated meta-analysis of randomized controlled trials.
    Gorabi AM; Abbasifard M; Imani D; Aslani S; Razi B; Alizadeh S; Bagheri-Hosseinabadi Z; Sathyapalan T; Sahebkar A · Phytotherapy research : PTR · 2022
    Meta-analysis32 studies pooledInflammation forCurcumin
  8. Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials.
    Derosa G; Maffioli P; Simental-Mendía LE; Bo S; Sahebkar A · Pharmacological research · 2018
    Meta-analysis9 studies pooledInflammation forCurcumin
  9. Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial.
    Jazayeri-Tehrani SA; Rezayat SM; Mansouri S; Qorbani M; Alavian SM; Daneshi-Maskooni M; Hosseinzadeh-Attar MJ · Nutrition & metabolism · 2024
    Randomized trial84 participantsInflammation forCurcumin
  10. Is Curcumin Intake Really Effective for Chronic Inflammatory Metabolic Disease? A Review of Meta-Analyses of Randomized Controlled Trials.
    Lee YM; Kim Y · Nutrients · 2024
    Systematic review54 studies pooledInflammation forCurcumin
  11. Serum type III procollagen, procollagen V, tumour necrosis factor-a, interleukin-6 in liver cirrhosis after antiviral treatment.
    Li W; Liu X; Bi F · Journal of medical biochemistry · 2025
    Randomized trial92 participantsInflammation forGlutathione
  12. Evaluation of the antioxidant and anti-inflammatory effect of sublingual glutathione on COPD patients.
    Farag A; Abass W; Qassem H · Journal of medicine and life · 2024
    Cohort study50 participantsInflammation forGlutathione
  13. Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review.
    Dibaba DT; Xun P; He K · European journal of clinical nutrition · 2014
    Meta-analysis32,918 participants7 studies pooledInflammation forMagnesium
  14. Efficacy and safety of magnesium glycinate as add on therapy in hypomagnesemic asthma and chronic obstructive pulmonary disease patients: A randomised controlled study assessing inflammatory biomarkers.
    Maddirevula MK; Rajanandh MG; Wesley B · Pulmonary pharmacology & therapeutics · 2026
    Randomized trial224 participantsInflammation forMagnesium
  15. Magnesium Supplementation and the Effects on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Razzaghi R; Pidar F; Momen-Heravi M; Bahmani F; Akbari H; Asemi Z · Biological trace element research · 2018
    Randomized trial70 participantsInflammation Metabolism Support forMagnesium
  16. The effect of long-term magnesium intake on inflammatory markers in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.
    Wang W; Wang J; Yang Y; Shi Y · Frontiers in nutrition · 2025
    Meta-analysis444 participants8 studies pooledInflammation forMagnesium
  17. Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.
    Veronese N; Pizzol D; Smith L; Dominguez LJ; Barbagallo M · Nutrients · 2022
    Meta-analysis889 participants17 studies pooledInflammation forMagnesium
  18. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial.
    Mahjabeen W; Khan DA; Mirza SA · Complementary therapies in medicine · 2022
    Randomized trial110 participantsInflammation forResveratrol
  19. Resveratrol decreases local inflammatory markers and systemic endotoxin in patients with aggressive periodontitis.
    Zhang Q; Xu S; Xu W; Zhou Y; Luan H; Wang D · Medicine · 2022
    Randomized trial160 participantsInflammation forResveratrol
  20. Effects of resveratrol supplementation on inflammatory markers, fatigue scale, fasting blood sugar and lipid profile in relapsing-remitting multiple sclerosis patients: a double-blind, randomized placebo-controlled trial.
    Keramatzadeh S; Hosseini SA; Majdinasab N; Cheraghian B; Zilaee M · Nutritional neuroscience · 2025
    Randomized trial55 participantsInflammation forResveratrol