Nitri Oxide Support

Nitri Oxide Support

Pure Encapsulations4.7 (26 ratings)
Format:Powder Quantity: 5 Ounce(s) · 30 servings
Goals
$30.60 $1.02 per serving

Product analysis

59 out of 100

Nitri Oxide Support combines arginine and citrulline for possible blood-flow support, though evidence for noticeable everyday energy benefits is limited and inconsistent.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality40

All three ingredient preparations are identified, allowing clear comparisons of what is included. The named forms alone do not establish a quality advantage.

Ingredient Transparency100

Ingredient amounts and forms are disclosed. The citrulline-malate declaration still leaves its comparable active exposure uncertain.

Value For Money34

Citrulline is costly relative to its contribution, limiting the formula’s value. Arginine offers middling value, while vitamin C remains uncertain.

Customer Satisfaction69

Customer feedback is very positive. Only a few dozen ratings leave a small base for judging satisfaction.

Product Focus67

The formula concentrates on possible blood-flow support rather than a reliable daily energy effect. The modest citrulline amount and malate preparation make comparison with the small trials uncertain.

Format
Powder
Container
5 Ounce(s)
Per serving
$1.02
Customer rating
4.7 · 26 ratings
Report analysis

Goals

Cardiovascular Support
Impact
High effect
B Ingredient FitF PathwaysB- EvidenceA+ Formulation Logic
Arginine · 2050 mgVitamin C · 200 mgCitrulline · 715 mg
Study evidence
Arginine Supportive 47 studies
Citrulline Supportive 33 studies
Vitamin C Supportive 101 studies
Impact
High effect
B+ Ingredient FitD- PathwaysC+ EvidenceA+ Formulation Logic
Study evidence
Arginine No effect 7 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Ascorbic Acid)
200 mg
L-Arginine (Arginine Alpha-Ketoglutarate)
2050 mg 80
Citrulline (Citrulline Malate)
715 mg 36
Gluten Free Adults 18–50
Report overview
A Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value
Each serving supplies 2050 mg of arginine at a moderately high cost for the amount supplied. The form is Arginine Alpha-Ketoglutarate. The amount is clearly stated.
How this ingredient is rated

Active Ingredient Quality & Bioavailability90

The form is Arginine Alpha-Ketoglutarate.
Arginine Form & Sourcing Purity
The form is Arginine Alpha-Ketoglutarate.

Dose, Safety & Label Transparency85

Each serving provides 2050 mg, a substantial amount.
Arginine Dose Per Serving
Each serving provides 2050 mg, a substantial amount.

Value50

The cost is moderately high for the arginine amount, using the full serving price.
Price Per Gram of Arginine
The cost is moderately high for the arginine amount, using the full serving price.
D Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyF Value
The serving lists 715 mg of citrulline malate; the amount of L-citrulline is uncertain without the ratio. The estimated cost per gram of L-citrulline is high, but may be understated because the malate ratio is unknown. Citrulline malate is named, but its citrulline-to-malate ratio is not specified. No citrulline sourcing, grade, or purity details are available.
How this ingredient is rated

Active Ingredient Quality & Bioavailability49

Citrulline malate is named, but its citrulline-to-malate ratio is not specified. No citrulline sourcing, grade, or purity details are available.
Citrulline Form Specificity
Citrulline malate is named, but its citrulline-to-malate ratio is not specified.
Purity and Sourcing Markers
No citrulline sourcing, grade, or purity details are available.

Dose, Safety & Label Transparency40

The serving lists 715 mg of citrulline malate; the amount of L-citrulline is uncertain without the ratio. The ratio is needed to determine the active amount.
L-Citrulline Dosage Efficacy
The serving lists 715 mg of citrulline malate; the amount of L-citrulline is uncertain without the ratio.
Label Clarity and Transparency
The mixture amount is listed, but its ratio is missing, so its L-citrulline content is unclear.

Value0

The estimated cost per gram of L-citrulline is high, but may be understated because the malate ratio is unknown.
Price per Gram of L-Citrulline
The estimated cost per gram of L-citrulline is high, but may be understated because the malate ratio is unknown.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Reassessment of the effect of oral l-arginine on blood pressure: A systematic review and meta-analysis based on ambulatory blood pressure monitoring.
    Shi Y; Liu Y; Zhou Z; Xu S; Luo P · Nitric oxide : biology and chemistry · 2026
    Meta-analysis202 participants5 studies pooledCardiovascular Support forArginine
  2. Effect of Long-Term L-Arginine Supplementation on Arterial Compliance and Metabolic Parameters in Patients with Multiple Cardiovascular risk Factors: Randomized, Placebo-Controlled Study.
    Guttman H; Zimlichman R; Boaz M; Matas Z; Shargorodsky M · Journal of cardiovascular pharmacology · 2024
    Randomized trial90 participantsCardiovascular Support forArginine
  3. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials.
    Bai Y; Sun L; Yang T; Sun K; Chen J; Hui R · The American journal of clinical nutrition · 2009
    Meta-analysis492 participants13 studies pooledCardiovascular Support forArginine
  4. L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease.
    Yin WH; Chen JW; Tsai C; Chiang MC; Young MS; Lin SJ · Clinical nutrition (Edinburgh, Scotland) · 2006
    Randomized trial31 participantsCardiovascular Support forArginine
  5. Oral L-Arginine Administration Improves Anthropometric and Biochemical Indices Associated With Cardiovascular Diseases in Obese Patients: A Randomized, Single Blind Placebo Controlled Clinical Trial.
    Dashtabi A; Mazloom Z; Fararouei M; Hejazi N · Research in cardiovascular medicine · 2016
    Randomized trial90 participantsCardiovascular Support forArginine
  6. Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.
    Luo P; Chen J; Liu K; Zhang J · Clinical nutrition ESPEN · 2025
    Meta-analysis415 participants15 studies pooledCardiovascular Support forCitrulline
  7. Micronutrient Supplementation to Reduce Cardiovascular Risk.
    An P; Wan S; Luo Y; Luo J; Zhang X; Zhou S; Xu T; He J; Mechanick JI; Wu WC; Ren F; Liu S · Journal of the American College of Cardiology · 2022
    Meta-analysis883,627 participants884 studies pooledCardiovascular Support forCitrulline
  8. l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.
    Bailey SJ; Blackwell JR; Lord T; Vanhatalo A; Winyard PG; Jones AM · Journal of applied physiology (Bethesda, Md. : 1985) · 2016
    Randomized trial10 participantsCardiovascular Support forCitrulline
  9. Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.
    Maharaj A; Fischer SM; Dillon KN; Kang Y; Martinez MA; Figueroa A · Nutrients · 2022
    Randomized trial25 participantsCardiovascular Support forCitrulline
  10. Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men.
    Ochiai M; Hayashi T; Morita M; Ina K; Maeda M; Watanabe F; Morishita K · International journal of cardiology · 2012
    Randomized trial15 participantsCardiovascular Support forCitrulline
  11. Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis.
    Rozemeijer S; Hemilä H; van Baaren M; de Man AME · BMC cardiovascular disorders · 2023
    Meta-analysis872 participants7 studies pooledCardiovascular Support forVitamin C
  12. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.
    Taddei S; Virdis A; Ghiadoni L; Magagna A; Salvetti A · Circulation · 1998
    Clinical trial49 participantsCardiovascular Support forVitamin C
  13. Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: A randomized, placebo-controlled, cross-over study.
    Boonthongkaew C; Tong-Un T; Kanpetta Y; Chaungchot N; Leelayuwat C; Leelayuwat N · The Chinese journal of physiology · 2021
    Randomized trial24 participantsCardiovascular Support forVitamin C
  14. Vascular benefits of vitamin C supplementation against fine particulate air pollution in healthy adults: A double-blind randomised crossover trial.
    Ren J; Liang J; Wang J; Yin B; Zhang F; Li X; Zhu S; Tian H; Cui Q; Song J; Liu G; Ling W; Ma Y · Ecotoxicology and environmental safety · 2022
    Randomized trial58 participantsCardiovascular Support forVitamin C
  15. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes.
    Mullan BA; Young IS; Fee H; McCance DR · Hypertension (Dallas, Tex. : 1979) · 2003
    Randomized trial30 participantsCardiovascular Support forVitamin C
  16. Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.
    Kavcı Z; Ozan M; Buzdağlı Y; Savaş A; Uçar H · Journal of the International Society of Sports Nutrition · 2024
    Randomized trial15 participantsEnergy forArginine
  17. The Effects of Arginine-Based Supplements on Fatigue Levels following COVID-19 Infection: A Prospective Study in Romania.
    Turcu-Stiolica A; Ionele CM; Ungureanu BS; Subtirelu MS · Healthcare (Basel, Switzerland) · 2023
    Non-randomized trial505 participantsEnergy forArginine
  18. Isolated but not combined ergogenic effects of caffeine and L-arginine during an isokinetic knee extension.
    Zart S; Brachtendorf M; Becker S; Fröhlich M · Frontiers in nutrition · 2024
    Randomized trial29 participantsEnergy forArginine
  19. L-Arginine but not L-glutamine likely increases exogenous carbohydrate oxidation during endurance exercise.
    Rowlands DS; Clarke J; Green JG; Shi X · European journal of applied physiology · 2012
    Randomized trial8 participantsEnergy forArginine
  20. Effect of L-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study.
    Boon MR; Hanssen MJW; Brans B; Hülsman CJM; Hoeks J; Nahon KJ; Bakker C; van Klinken JB; Havekes B; Schaart G; Jazet IM; Rensen PCN; van Marken Lichtenbelt WD · Diabetologia · 2019
    Randomized trial20 participantsEnergy forArginine