St. John's Wort 375 mg

St. John's Wort 375 mg

Swanson Premium Brand4.7 (8,437 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 120 servings
Goals
$4.89 $0.04 per serving
iHerbLowest$4.89iHerb$5.99Amazon$9.38

Product analysis

47 out of 100

St. John's Wort 375 mg is intended for mood support, though benefits depend on the preparation and everyday mood improvement remains uncertain. It can weaken many medicines, including oral contraceptives and blood thinners.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality20

The St. John’s wort preparation is not specified. That makes it difficult to connect the ingredient with the particular extracts that have supporting evidence.

Ingredient Transparency63

The ingredient amount is stated, but its form is omitted. The exact preparation therefore remains unclear.

Value For Money40

Value for money cannot be judged reliably. There is not enough information to compare the serving cost with the contribution of the specific preparation.

Customer Satisfaction89

Customer feedback is highly positive across thousands of ratings. The large response count provides a broad picture of satisfaction.

Product Focus46

Everyday mood support remains uncertain because benefits depend on the specific extract. Medicine interactions, including problems with ingredients that raise serotonin, materially limit suitability.

Format
Capsule
Container
120 Capsule(s)
Per serving
$0.04
Customer rating
4.7 · 8,437 ratings
Report analysis

Goals

Mood Support
Mood Support
Impact
Moderate effect
B- Ingredient FitF PathwaysF EvidenceA+ Formulation Logic

St. John's wort may reduce symptoms in mild to moderate depression, but that doesn't mean it reliably lifts everyday mood in otherwise healthy adults. Benefits depend on the extract, and different preparations aren't interchangeable. It can also weaken oral contraceptives, anticoagulants and many other medicines, and combining it with ingredients that increase serotonin can cause problems.

How this product is rated for Mood Support

Ingredient fit74

St. John's wort relates to depressive symptoms, with benefits depending on the extract and treatment context.
Goal fit
St. John's wort relates to depressive symptoms, with benefits depending on the extract and treatment context.
Dose adequacy
St. John's Wort 375 mg per serving; this amount alone doesn't predict the size of a mood benefit.

Pathways7

The ingredient relates to mood-related chemical signalling, which alone cannot predict an emotional benefit.
Depth
The ingredient relates to mood-related chemical signalling, which alone cannot predict an emotional benefit.
Breadth
The relevant connection is concentrated in one biological area, without implying a broad mood benefit.

Evidence27

The declared preparation does not identify an extract with directly transferable effects.
Evidence strength
St. John's wort relates to depressive symptoms, with benefits depending on the extract and treatment context.
Studied preparation
The declared preparation does not identify an extract with directly transferable effects.

Formulation logic100

The ingredients have no identified requirement for an additional partner, and no particular conflict within the listed combination is identified.
Partner coverage
No additional required ingredient partner is identified for the ingredients here.
Conflicts
No particular conflict among the listed ingredients is identified.
Effective doses
The declared amounts allow comparison with the relevant ingredient amounts, without guaranteeing an emotional effect.
Study evidence
Stress Relief
Stress Relief
Impact
Lower effect
A+ Ingredient FitF PathwaysF EvidenceA+ Formulation Logic
Study evidence

Ingredients

IngredientAmount per servingScore
St. John's Wort
375 mg 100
Adults 18–50
Report overview
St. John's Wort · 375 mg OverallScore100
A+ Composition And Label Disclosure
A serving lists 375 mg of St. John's wort. An ingredient-specific warning is recorded, but its wording is not included in the saved facts.
How this ingredient is rated

Composition and Label Disclosure

No separate quality or bioavailability assessment is provided in the saved evaluation.

Composition and Label Disclosure100

A serving lists 375 mg of St. John's wort. An ingredient-specific warning is recorded, but its wording is not included in the saved facts.
Explicit Label Detail
An ingredient-specific warning is recorded, but its wording is not included in the saved facts.

Commercial Price and Usability

The whole-product serving costs about $0.04; no separate value assessment is provided.
View ingredientView products
84 Performance

Feeling Positive St. John's Wort 300 mg

Sundown
Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

Perika St. John's Wort

Nature's Way
The named extract supports consistent quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort Extract

Swanson Superior Herbs
Marker standardization supports consistent extract quality, though the daily amount is moderate; it is among the lowest-cost eligible options, although it is not cheaper than the original when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort 300 mg

NOW
Marker standardization supports consistent extract quality, though the daily amount is moderate; it is among the lowest-cost eligible options, although it is not cheaper than the original when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
89 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; it is among the lowest-cost eligible options, although it is not cheaper than the original when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

Nature's Bounty
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Value

St. John's Wort

Paradise
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  2. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  3. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  4. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  5. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort
  6. Comparison of St John's wort and imipramine for treating depression: randomised controlled trial.
    Woelk H · BMJ (Clinical research ed.) · 2000
    Randomized trial324 participantsStress Relief forSt. John's Wort
  7. Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John's wort.
    Friede M; Henneicke von Zepelin HH; Freudenstein J · Pharmacopsychiatry · 2002
    Randomized trial240 participantsStress Relief forSt. John's Wort
  8. Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.
    Sarris J; Kavanagh DJ · Journal of alternative and complementary medicine (New York, N.Y.) · 2009
    Systematic reviewStress Relief forSt. John's Wort
  9. Do early changes in the HAM-D-17 anxiety/somatization factor items affect the treatment outcome among depressed outpatients? Comparison of two controlled trials of St John's wort (Hypericum perforatum) versus a SSRI.
    Bitran S; Farabaugh AH; Ameral VE; LaRocca RA; Clain AJ; Fava M; Mischoulon D · International clinical psychopharmacology · 2012
    Other475 participantsStress Relief forSt. John's Wort
  10. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.
    Lakhan SE; Vieira KF · Nutrition journal · 2011
    Systematic review2,619 participants24 studies pooledStress Relief forSt. John's Wort