St. John's Wort Extract

St. John's Wort Extract

21st Century4.5 (1,081 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals
$5.93 $0.09 per serving
AmazonLowest$0.00iHerb$5.93

Product analysis

62 out of 100

St. John's Wort Extract clearly discloses the assessed amounts and forms. Its appeal rests mainly on the disclosed formula.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality40

The supplied form-quality assessments are largely unresolved; unspecified forms are a separate labeling limitation.

Ingredient Transparency100

The assessed amount and form details are clearly disclosed.

Value For Money40

The supplied value assessments are unresolved, so a firm value judgment is not available.

Customer Satisfaction77

Customer ratings are positive overall; the size of the rating pool adds context.

Product Focus67

The formula aligns reasonably well with its assessed goals.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.09
Customer rating
4.5 · 1,081 ratings
Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
B- Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic

St. John's wort has evidence for defined extracts in diagnosed depression, rather than routine mood improvement in healthy adults. The 300 mg per serving is below the supplied daily trial comparison, and a serving does not establish daily exposure. Its drug interactions remain relevant despite no matched ingredient conflict.

How this product is rated for Mood Support

Ingredient fit73

St. John's Wort account for the main saved ingredient contribution. Amounts and preparation details constrain the comparison.
Goal fit
St. John's Wort is the main ingredients counted toward mood support.
Dose adequacy
The declared serving amounts receive partial consideration; this compares amounts with supplied reference ranges, without proving a mood effect.

Pathways11

The strongest saved connection is to monoamine signalling, based on the counted ingredients; this does not itself demonstrate emotional improvement.
Depth
The strongest saved connection is to monoamine signalling, based on the counted ingredients; this does not itself demonstrate emotional improvement.
Breadth
No area reaches the saved coverage threshold; the identified connection remains limited.

Evidence84

St. John's Wort provides the strongest saved evidence contribution here; its population and outcome limitations still apply.
Evidence strength
St. John's Wort provides the strongest saved evidence contribution here; its population and outcome limitations still apply.
Studied preparation
The counted ingredients meet the saved preparation criteria; this does not make all labelled forms interchangeable with every clinical trial.

Formulation logic100

The counted ingredients have no unmet partner requirement or matched ingredient conflict. Their amount criteria describe the saved comparison rather than proven effectiveness.
Partner coverage
The counted ingredients require no missing partner under the supplied findings; this does not imply an added benefit from combining them.
Conflicts
No listed ingredient conflict was matched in the supplied findings; this does not establish medication compatibility.
Effective doses
The counted ingredients meet the saved minimum amount criterion.
Study evidence

Ingredients

IngredientAmount per servingScore
St. John's Wort extract (Hypericum perforatum)
 300 mg 50
Gluten Free Adults 18–50 Vegetarian
Report overview
St. John's Wort (Hypericum perforatum) · 300 mg OverallScore50
D+ Composition And Label Disclosure
A serving lists 300 mg of St. John's wort. The evaluation records a general warning, but its wording is not available in the saved facts.
How this ingredient is rated

Composition and Label Disclosure

No separate source or delivery criteria were evaluated.

Composition and Label Disclosure50

A general warning is recorded; the saved facts do not provide its wording or an ingredient-specific warning.
Explicit Label Detail
The evaluation records a general warning, but its wording is not available in the saved facts.

Commercial Price and Usability

No price criterion was evaluated.
View ingredientView products
84 Performance

Feeling Positive St. John's Wort 300 mg

Sundown
Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

Perika St. John's Wort

Nature's Way
The named extract supports consistent quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort Extract

Swanson Superior Herbs
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort 300 mg

NOW
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
89 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the lower serving cost improves economy when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

Nature's Bounty
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Value

St. John's Wort

Paradise
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  2. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  3. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  4. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  5. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort