Glycine 1000 mg

Glycine 1000 mg

Life Extension4.8 (15,892 ratings)
Format:Capsule Quantity: 100 Capsule(s) · 100 servings
Goals

Product analysis

60 out of 100

Glycine 1000 mg provides a focused, reasonably priced source of glycine, a building block for glutathione.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality20

Glycine’s form is not specified. Its form quality therefore remains uncertain.

Ingredient Transparency63

The glycine amount is clearly stated. Its form is unspecified, leaving less detail for comparison.

Value For Money85

The serving offers reasonable value for its glycine content. The single-ingredient formula makes the cost contribution clear.

Customer Satisfaction92

Customer ratings are very positive across a large number of reviews. The extensive feedback does not establish inflammation or detox benefits.

Product Focus71

The single ingredient has a clear biochemical role as a glutathione building block. Evidence for routine inflammation relief or general toxin removal remains limited.

Format
Capsule
Container
100 Capsule(s)
Per serving
$0.12
Customer rating
4.8 · 15,892 ratings
Report analysis

Goals

Impact
High effect
B Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Glycine · 1000 mg

Glycine is a building block for glutathione, which gives it a biochemical connection to detoxification processes. The supplied human research tested glycine together with NAC in a small older-adult cohort, measuring glutathione and aging-related outcomes. It does not isolate glycine's effect or demonstrate general toxin elimination; 1000 mg per serving receives only partial amount recognition.

How this product is rated for Liver & Detox

Ingredient fit77

Glycine gives the formula a focused connection to the goal. The relevant amounts receive partial recognition overall; biochemical roles do not turn those servings into proven toxin-clearance doses.
Goal fit
Glycine gives the formula a focused connection to the goal.
Dose adequacy
The relevant amounts receive partial recognition overall; biochemical roles do not turn those servings into proven toxin-clearance doses.

Pathways17

Glycine has a limited saved contribution to glutathione-related processes. No pathway reaches the saved breadth threshold.
Depth
Glycine has a limited saved contribution to glutathione-related processes.
Breadth
No pathway reaches the saved breadth threshold.

Evidence84

Combination GlyNAC evidence does not isolate glycine or establish general toxin elimination. Preparation recognition is favorable.
Evidence strength
Combination GlyNAC evidence does not isolate glycine or establish general toxin elimination.
Studied preparation
The saved findings accept the counted preparation, without establishing equivalence across active compounds or disease-specific regimens.

Formulation logic100

No required partner is missing among the counted ingredients, and no configured conflict was identified. All counted ingredients meet the saved amount threshold, which is not proof of clinical effectiveness.
Partner coverage
The counted ingredients work independently or have their required partner.
Conflicts
No configured ingredient conflict was identified; this does not assess every possible interaction.
Effective doses
All counted ingredients meet the saved amount threshold, which is not proof of clinical effectiveness.
Study evidence
Glycine Supportive 5 studies
Inflammation
Impact
High effect
B Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Glycine · 1000 mg

Glycine is connected to inflammatory signalling through cellular mechanisms and selected metabolic-disease findings. Those observations do not establish routine anti-inflammatory efficacy or a transferable clinical regimen. The 1 g serving receives a partial amount comparison, without demonstrating broad clinical benefit.

How this product is rated for Inflammation

Ingredient fit77

The relevant contribution comes from glycine. The amount comparison is partial.
Goal fit
The relevant ingredients are focused on glycine, although their roles extend to other goals.
Dose adequacy
The serving provides a partial comparison with the saved reference amount; that comparison does not establish a clinically effective dose.

Pathways19

The main connection involves inflammatory gene signalling. The coverage is concentrated rather than broad.
Depth
The strongest connection is to inflammatory gene signalling; this describes the supplied mechanism findings rather than a proven clinical outcome.
Breadth
The signalling connection remains too limited to count as broad pathway coverage.

Evidence96

Mechanisms and selected metabolic-disease observations do not establish routine clinical anti-inflammatory efficacy.
Evidence strength
Mechanisms and selected metabolic-disease observations do not establish routine clinical anti-inflammatory efficacy.
Studied preparation
The saved finding accepts the contributing preparation comparison; this does not remove the population and clinical-outcome limitations.

Formulation logic100

The contributing ingredients have no unmet partner requirement or identified conflict, and meet the retained amount threshold.
Partner coverage
The contributing ingredients have no unmet partner requirement in the supplied findings.
Conflicts
No ingredient conflict was identified in the supplied calculation.
Effective doses
The retained contributor meets the saved amount threshold, which is not proof of an effective clinical dose.
Study evidence
Glycine Supportive 7 studies

Ingredients

IngredientAmount per servingScore
Glycine
1000 mg 50
Adults 18–50
Report overview
Glycine · 1000 mg OverallScore50
F Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyA- Value
The labeled serving provides 1,000 mg of glycine. The whole-product price works out to about $0.12 per 1,000 mg of glycine.
How this ingredient is rated

Active Ingredient Quality & Bioavailability0

The available facts do not establish a specific glycine grade, purity certification or manufacturing-practices claim.
Glycine Sourcing and Purity Standards
The available facts do not establish a specific glycine grade, purity certification or manufacturing-practices claim.

Dose, Safety & Label Transparency82

The glycine amount is disclosed, making it easy to compare. The available facts also recognize ordinary excipients.
Clinically Relevant Dosage
The labeled serving provides 1,000 mg of glycine, a moderate amount.
Label Transparency and Yield Disclosure
The label records 1,000 mg of glycine per vegetarian capsule.
Clean Label and Excipient Quality
The available facts recognize ordinary excipients; they do not establish a minimal ingredient list.

Value85

The whole-product price works out to about $0.12 per 1,000 mg of glycine.
Cost Efficiency per 1,000mg of Glycine
The whole-product price works out to about $0.12 per 1,000 mg of glycine.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes.
    Cruz M; Maldonado-Bernal C; Mondragón-Gonzalez R; Sanchez-Barrera R; Wacher NH; Carvajal-Sandoval G; Kumate J · Journal of endocrinological investigation · 2009
    Randomized trial74 participantsInflammation forGlycine
  2. Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial.
    Vargas MH; Del-Razo-Rodríguez R; López-García A; Lezana-Fernández JL; Chávez J; Furuya MEY; Marín-Santana JC · BMC pulmonary medicine · 2018
    Randomized trial13 participantsInflammation forGlycine
  3. Subgingival air polishing (glycine powder) versus minocycline hydrochloride: efficacy in residual periodontal pockets following endoscope-assisted scaling and root planing.
    Guo X; Bai H; Lu X; Guo J; Qi Y; Huo X; Li S · Clinical oral investigations · 2026
    Randomized trial80 participantsInflammation forGlycine
  4. Long-term Implant Maintenance: A Systematic Review of Home and Professional Care Strategies in Supportive Implant Therapy.
    Araújo TG; Moreira CS; Neme RA; Luan H; Bertolini M · Brazilian dental journal · 2024
    Systematic review13 studies pooledInflammation forGlycine
  5. Analysis of the factors influencing the occurrence of peri-implantitis in patients with implant-supported restoration and study on the maintenance effect of subgingival sandblasting.
    Pan T; Meng W; Zhang M; Xie Y; Chen Z; Zhou M; Yin L; Xie H · BMC oral health · 2026
    Randomized trial198 participantsInflammation forGlycine
  6. The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
    Tan HC; Hsu JW; Tai ES; Chacko S; Kovalik JP; Jahoor F · Frontiers in endocrinology · 2024
    Cohort study42 participantsLiver & Detox forGlycine
  7. Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
    Tan HC; Hsu JW; Tai ES; Chacko S; Wu V; Yen PM; Kovalik JP; Jahoor F · Scientific reports · 2025
    Single-arm trial19 participantsLiver & Detox forGlycine
  8. Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.
    Irwin C; van Reenen M; Mason S; Mienie LJ; Westerhuis JA; Reinecke CJ · PloS one · 2017
    Non-randomized trial21 participantsLiver & Detox forGlycine
  9. Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
    Furuya KN; Durie PR; Roberts EA; Soldin SJ; Verjee Z; Yung-Jato L; Giesbrecht E; Ellis L · Clinical biochemistry · 1996
    Methods validation study74 participantsLiver & Detox forGlycine
  10. The treatment of isovaleric acidemia with glycine supplement
    M Naglak, R Salvo, K Madsen, P Dembure, L Elsas · Pediatric research · 1988
    Non-randomized trial2 participantsLiver & Detox forGlycine