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L-Proline L-Lysine 275 mg / 275 mg

4.7
★ ★ ★ ★ ★
(4559 ratings)
Vitamin C 1147 mg
Hawthorn 100 mg
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Score78
A coherent collagen-support combination of lysine, proline, and buffered vitamin C, offset by dose ambiguity and a four-tablet serving.
How scoring works
Tablet
Quantity:120 Tablet(s) • (30 servings)
Goals:
Skin Health
General Health
Immunity
Anti-Inflammatory Support

Score 78

A coherent collagen-support combination of lysine, proline, and buffered vitamin C, offset by dose ambiguity and a four-tablet serving.
How scoring works
$14.53($0.48 per serving)
iHerb
$ 15.78
Vitacost
$ 15.63
Pure Formulas
$ 14.53
iHerb
$ 15.78
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Analysis

Lysine and proline provide direct amino-acid building blocks for collagen, while buffered vitamin C supports normal collagen formation. Grape seed extract adds complementary antioxidant support to the connective-tissue focus.

Calcium and magnesium ascorbates are useful buffered forms, but identical vitamin C amounts beside both forms make the total unclear. Hawthorn lacks standardization details, and its role is secondary to the amino acids and vitamin C.

The formula is well suited to users prioritizing skin and connective-tissue nutrition rather than a general multivitamin. Four tablets and potentially high vitamin C intake may be inconvenient or poorly tolerated by sensitive users.

Who is it for
  • Adults seeking collagen-building nutrients
  • People who prefer buffered vitamin C
Best for
  • Skin and connective-tissue support
  • Lysine and proline supplementation

Pros

  • Substantial lysine and proline amounts
  • Buffered vitamin C forms
  • Includes grape seed antioxidant support

Cons

  • Vitamin C total is ambiguous
  • Four-tablet serving
  • Hawthorn extract is not standardized

Warnings

  • High total vitamin C intake may cause digestive upset or loose stools.
  • People prone to calcium-oxalate kidney stones should consider total vitamin C intake before regular use.
  • Hawthorn may add to the effects of blood-pressure or heart medicines.

Nutrient quality

84 Highest impact

Buffered vitamin C and substantial amino acids provide a credible structural-support core. Grape seed and hawthorn broaden antioxidant coverage, though repeated vitamin C entries create dose uncertainty.

Ingredient transparency

77 High impact

All listed actives have amounts and no proprietary blend hides them. Repeated vitamin C entries, missing non-active ingredients, and incomplete use directions reduce clarity.

Customer satisfaction

73 High impact

The average rating is strong, with a very large review count supporting the signal. No detailed reviews are supplied to assess recurring complaints or experiences tied to the intended use.

Value for money

78 High impact

Substantial amino acids and buffered vitamin C provide useful serving value. The multi-tablet serving and ambiguous vitamin C total keep the formula from standing out.

Report analysis

Goals

Skin Health
Skin Health
Impact
Highest effect
B+ Goal FitA- Strength of SupportB+ CoverageB+ Formula Quality
Vitamin C · 1147 mgProline · 1.1 Gram(s)

L-proline and L-lysine provide collagen amino acids, while vitamin C is an essential collagen-synthesis cofactor. The substantial amino acid and vitamin amounts create a focused structural strategy despite not supplying collagen peptides directly.

Grape seed extract adds antioxidant support, while hawthorn is less relevant to skin. The high vitamin C amount may cause digestive upset in sensitive users.

Study evidence
Proline Disputed 4 studies
Vitamin C Supportive 53 studies
General Health
General Health
Impact
Highest effect
B Goal FitA- Strength of SupportB CoverageA- Formula Quality
Magnesium · 46 mgVitamin C · 1147 mg

Vitamin C, lysine, and proline provide a coherent base for collagen and connective-tissue support. Buffered ascorbates and substantial amino acid amounts give the main pathway meaningful depth.

Grape seed and hawthorn extend the formula toward antioxidant and circulatory support without overwhelming the core. The result remains more structural and cardiovascular in focus than broadly nutritional.

Study evidence
Vitamin C Supportive 56 studies
Immunity
Immunity
Impact
Highest effect
B Goal FitA Strength of SupportB- CoverageB+ Formula Quality
Magnesium · 46 mgVitamin C · 1147 mg

Buffered vitamin C provides strong antioxidant support alongside substantial lysine and proline. Grape seed and hawthorn extracts add related antioxidant activity.

The amino-acid focus is more closely tied to collagen support than to a broad immune strategy. Missing extract standardization also leaves the botanical contribution uncertain.

Study evidence
Lysine Supportive 2 studies
Vitamin C Supportive 53 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B- Goal FitA- Strength of SupportB- CoverageB Formula Quality
Vitamin C · 1147 mg

Buffered vitamin C and grape-seed polyphenols provide meaningful antioxidant support, while lysine and proline focus more on collagen structure than inflammation. Hawthorn adds another polyphenol source but is not a primary anti-inflammatory active.

The main ingredients are supplied at substantial and clearly disclosed amounts. The multi-pathway formula is coherent for connective and vascular support, though only part of it directly serves inflammatory balance.

Study evidence
Vitamin C Supportive 50 studies
Vision Support
Vision Support
Impact
Moderate effect
D- Goal FitA- Strength of SupportD+ CoverageC+ Formula Quality
Vitamin C · 1147 mg

Vitamin C provides relevant ocular antioxidant support, while lysine and proline mainly serve connective-tissue synthesis rather than established vision pathways. Grape seed and hawthorn add antioxidant or circulation concepts, but direct evidence for meaningful eye outcomes is limited.

The active amounts are disclosed and the buffered vitamin C forms may improve stomach tolerance. Hawthorn can interact with heart or blood-pressure medicines, and the high vitamin C amount may be unsuitable for people prone to calcium-oxalate kidney stones.

Study evidence
Vitamin C Disputed 24 studies

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Total Carbohydrates
2 Gram(s)
Vitamin C (Calcium Ascorbate, Magnesium Ascorbate)
 1147 mg
Calcium (Calcium Ascorbate)
 66 mg
Magnesium (Magnesium Ascorbate)
 46 mg
L-Lysine
1.1 Gram(s)
L-Proline
1.1 Gram(s)
Proanthodyn (Grape Seed Extract)
 100 mg
Hawthorn Berry Extract
100 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free Vegetarian
Report overview
Vitamin C (Calcium Ascorbate, Magnesium Ascorbate) · 1147 mg OverallScore68
B+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value

Calcium and magnesium ascorbates provide fully buffered vitamin C with clear elemental mineral amounts. The dose is slightly above the most efficient range, and the carbohydrate-containing tablet format is less clean than a simple capsule. Value is modest despite the high-quality buffered forms.

View ingredientView products
Hawthorn · 100 mg OverallScore45
F Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyD- Value

The small berry extract lacks standardization and species disclosure. Its amount is significantly below the effective extract range. The moderate serving cost cannot fully offset the underdosing.

View ingredientView products
Loading alternative details
82 Performance

Liposomal Vitamin C 1000 mg

SunLipid
<p>Sodium ascorbate with a phospholipid complex offers a clearly disclosed delivery strategy for 1,000 mg of vitamin C. Lysine, proline, grape seed, and hawthorn are absent, so it improves vitamin C focus but not the original's structural or botanical breadth.</p>
84 Performance

Blood Pressure Health

NOW
<p>Standardized hawthorn and 150 mg of grape seed polyphenols provide stronger and clearer coverage of the original's two botanical components. It omits buffered vitamin C, lysine, and proline, making it a more focused cardiovascular formula rather than a structural-support replacement.</p>
86 Performance

Ester-C Plus 1000 mg Vitamin C

Solgar
<p>Ester-C and citrus bioflavonoids provide a clear buffered vitamin C formula without the original's duplicated vitamin C entries. It loses lysine, proline, grape seed, and hawthorn, so the improvement is transparency and vitamin C delivery rather than full formula coverage.</p>
89 Budget

Pure Buffered Calcium Ascorbate

NOW
<p>A very low-cost serving retains buffered calcium ascorbate and provides 890 mg of vitamin C in a simple powder. It drops lysine, proline, grape seed, and hawthorn, so the saving suits vitamin C-focused use rather than the original's structural formula.</p>
81 Budget

Hawthorn Berry 565 mg

Swanson
<p>A low recurring cost provides much more hawthorn than the original's 100 mg berry extract. Vitamin C, lysine, proline, and grape seed are absent, making it a focused hawthorn option rather than a complete substitute.</p>
85 Budget

Hawthorn 300 mg

Nature's Way
<p>Standardized leaf-and-flower extract plus additional hawthorn provides greater botanical depth at a lower serving cost. It does not preserve the original's buffered vitamin C, amino acids, or grape seed, so the benefit is limited to hawthorn-focused use.</p>
87 Value

Pure Buffered Magnesium Ascorbate

NOW
<p>A low-cost serving retains magnesium ascorbate and provides a clear 820 mg vitamin C amount without the original's duplicate listing. The formula omits lysine, proline, grape seed, and hawthorn, but offers efficient value for buffered vitamin C.</p>
84 Value

Full Spectrum Hawthorn Extract

Planetary Herbals
<p>A standardized leaf-and-flower extract with additional hawthorn gives much deeper botanical exposure at a lower serving cost. It does not supply the original's vitamin C, lysine, proline, or grape seed, so it is valuable only when hawthorn is the priority.</p>
84 Value

Ester-C 24 Hour Immune Support 1000 mg

NatureSmart
<p>Buffered vitamin C and citrus bioflavonoids provide a concise formula at a substantially lower recurring cost. The lower cost comes with narrower coverage because lysine, proline, grape seed, and hawthorn are all omitted.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  2. Association between hemoglobin A1c, Vitamin C, and microbiome in diabetic foot ulcers and intact skin: A cross-sectional study.
    Tong KPS; Green SJ; Ortiz J; Wu SC · Health science reports · 2024
    Cross-sectional study42 participantsSkin Health forVitamin C
  3. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  4. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  5. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  6. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  7. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  8. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  9. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  10. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  11. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  12. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  13. Lysine-fortified wheat flour improves the nutritional and immunological status of wheat-eating families in northern China.
    Zhao W; Zhai F; Zhang D; An Y; Liu Y; He Y; Ge K; Scrimshaw NS · Food and nutrition bulletin · 2004
    Clinical trial264 participantsImmunity forLysine
  14. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis
    R S Griffith, D E Walsh, K H Myrmel, R W Thompson, A Behforooz · Dermatologica · 1987
    Non-randomized trial52 participantsImmunity forLysine
  15. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  16. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  17. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  18. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  19. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  20. Improvement of crow's feet lines by topical application of 1-carbamimidoyl-L-proline (CLP).
    Kawashima M; Yokose U; Hachiya A; Fujimura T; Tsukahara K; Kawada H; Kitahara T; Takema Y; Terui T; Nakagawa H · European journal of dermatology : EJD · 2014
    Randomized trial126 participantsSkin Health forProline
  21. Collagen synthesis in human musculoskeletal tissues and skin.
    Babraj JA; Cuthbertson DJ; Smith K; Langberg H; Miller B; Krogsgaard MR; Kjaer M; Rennie MJ · American journal of physiology. Endocrinology and metabolism · 2005
    Methods validation studySkin Health forProline
  22. Genotype-phenotype spectrum of PYCR1-related autosomal recessive cutis laxa.
    Dimopoulou A; Fischer B; Gardeitchik T; Schröter P; Kayserili H; Schlack C; Li Y; Brum JM; Barisic I; Castori M; Spaich C; Fletcher E; Mahayri Z; Bhat M; Girisha KM; Lachlan K; Johnson D; Phadke S; Gupta N; Simandlova M; Kabra M; David A; Nijtmans L; Chitayat D; Tuysuz B; Brancati F; Mundlos S; Van Maldergem L; Morava E; Wollnik B; Kornak U · Molecular genetics and metabolism · 2014
    Case series33 participantsSkin Health forProline
  23. Collagen structure in skin from fibromyalgia patients.
    Ribel-Madsen S; Gronemann ST; Bartels EM; Danneskiold-Samsøe B; Bliddal H · International journal of tissue reactions · 2006
    Case-control study35 participantsSkin Health forProline
  24. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  25. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  26. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  27. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  28. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  29. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  30. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  31. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  32. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C