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Liver Detox & Blood Refresh

Irwin Naturals
4.7
★ ★ ★ ★ ★
(1116 ratings)
Milk Thistle 270 mg
Turmeric 50 mg
Chlorella 40 mg
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Score69
A strong silymarin amount anchors a broad liver formula, but many token-dose extras and interaction-prone botanicals reduce clarity.
How scoring works
Quantity:60 Softgel(s) • (30 servings)
Goals:
Detoxification

Score 69

A strong silymarin amount anchors a broad liver formula, but many token-dose extras and interaction-prone botanicals reduce clarity.
How scoring works
$20.50($0.68 per serving)
iHerb
$ 24.99
Amazon
$ 20.50
Pure Formulas
$ 24.99
Vitacost
$ 24.99
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Analysis

Silymarin is the strongest active at 270 mg, supported by an oil base that may help solubility. Vitamin C, zinc, selenium, burdock, and dandelion broaden antioxidant and digestive support.

Turmeric, chlorella, spirulina, cayenne, red clover, echinacea, marshmallow, and fennel appear at small amounts. The extensive list creates breadth, but many supporting ingredients are unlikely to contribute much at their disclosed doses.

Two softgels provide the serving in a fat-containing format. Cayenne may aggravate reflux, while BioPerine and red clover make medication review particularly important.

Who is it for
  • Adults seeking milk-thistle-led liver support
  • People who prefer oil-based softgels
Best for
  • Silymarin supplementation
  • Broad liver and antioxidant routines

Pros

  • Meaningful silymarin amount
  • Oil-based softgel delivery
  • Includes vitamin C, zinc, and selenium
  • All supporting amounts are listed

Cons

  • Many herbs and algae are lightly dosed
  • Silymarin standardization percentage is absent
  • Turmeric amount is small
  • Busy formula increases interaction complexity

Warnings

  • Cayenne may worsen heartburn or digestive irritation.
  • BioPerine can increase exposure to medicines by changing absorption and metabolism.
  • Red clover may add to anticoagulant effects and may not suit hormone-sensitive conditions.

Nutrient quality

73 High impact

Meaningful silymarin and several good nutrient forms provide a credible liver-support core. Many tiny secondary botanicals make the formula crowded and filler-heavy despite no obvious overdose.

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Ingredient transparency

71 High impact

Most meaningful actives and forms are clearly quantified. A small hidden complex plus missing directions and excipients prevent complete transparency.

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Customer satisfaction

71 High impact

The aggregate rating is strong, but it provides no specific experience evidence. The large review count gives the broad signal a useful volume base, while no detailed feedback supports taste, tolerance, or recurring-problem assessment.

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Value for money

60 Moderate impact

A meaningful silymarin amount supports fair serving value. Numerous low-dose extras reduce efficiency and category competitiveness.

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Goals

Detoxification
Detoxification
Impact
High effect
A- Goal FitA- Strength of SupportB CoverageC- Formula Quality
Selenium · 50 mcgMagnesium · 12.5 mgMilk Thistle · 270 mgZinc · 7.5 mgVitamin C · 50 mg

A strong disclosed silymarin amount anchors direct liver-cell and antioxidant support. Selenium, vitamin C, and several botanicals broaden the formula into antioxidant, bile, and digestive pathways.

Many supporting herbs, algae, and powders are present at small amounts that are unlikely to contribute meaningfully. Cayenne and concentrated herbs may also aggravate digestive irritation in sensitive users.

Study evidence
Milk Thistle Supportive 46 studies
Selenium Supportive 10 studies
Vitamin C Supportive 9 studies

Ingredients

IngredientAmount per serving
Calories
25 Calorie(s)
Total Fat
1.5 Gram(s)
Total Carbohydrates
1 Gram(s)
Protein
1 Gram(s)
Vitamin C (Ascorbic Acid)
 50 mg
Magnesium (Magnesium Citrate)
 12.5 mg
Zinc (Zinc Citrate)
 7.5 mg
Selenium (L-Selenomethionine)
 50 mcg
Flaxseed Oil
1600 mg
Milk Thistle Seed Extract (Silymarin)
 270 mg
Burdock Root Extract (Arctium lappa L. Root Extract)
 100 mg
Dandelion Root Extract (Taraxacum officinale Root Extract)
 100 mg
Echinacea purpurea root extract
75 mg
Marshmallow root extract
75 mg
Fennel seed extract
50 mg
Turmeric, Powder
50 mg
Chlorella, Powder
40 mg
Spirulina, Powder (Arthrospira platensis)
 40 mg
Cayenne, Powder
30 mg
Red Clover Aerial Extract
15 mg
BioPerine Complex
3 mg
Adults 18–50 Women
Report overview
Milk Thistle (Silymarin) · 270 mg OverallScore64
C Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD- Value

A 270 mg silymarin amount is supplied in an oil-based softgel that may improve solubility. The stated silymarin amount is effective, but no standardization percentage or total extract weight is provided. The serving cost is high but partly supported by the effective active dose.

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Turmeric · 50 mg OverallScore20
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyD- Value

Turmeric is present only as a small, unstandardized root powder, so active curcuminoid potency cannot be confirmed. The flaxseed-oil softgel may improve absorption somewhat, but the black pepper complex falls below the amount needed for full credit. The serving cost is relatively high for such limited turmeric evidence.

View ingredientView products
Loading alternative details
74 Performance

Active Liver

New Nordic
<p>Artichoke, milk thistle, and turmeric create a concise formula with stronger emphasis on core liver-support botanicals. Chlorella is absent and active-marker yields are not disclosed.</p>
81 Performance

Milk Thistle Phytosome 150 mg

Natural Factors HerbalFactors
<p>Phytosome delivery improves the absorption case for milk thistle, while turmeric, artichoke, and dandelion add focused support. The formula omits chlorella and does not state the active silymarin yield.</p>
65 Performance

Super Thisilyn

Nature's Way
<p>Milk thistle, artichoke, NAC, methionine, turmeric, and alpha-lipoic acid cover several liver-related pathways. Most companion ingredients are modest, chlorella is absent, and part of the vegetable blend is undisclosed.</p>
80 Budget

Silymarin Complex

California Gold Nutrition
<p>Milk thistle, dandelion, artichoke, turmeric, ginger, and black pepper retain a broad liver-support strategy at much lower serving cost. Chlorella and the original nutrient additions are absent, while silymarin potency is not stated.</p>
74 Budget

Liv-Gall Cleanse

Natural Factors HerbalFactors
<p>Milk thistle, artichoke, turmeric, and dandelion provide a focused liver blend at much lower serving cost. The extracts are modest and unstandardized, and chlorella is not included.</p>
78 Budget

Silymarin Milk Thistle Extract 150 mg

NOW
<p>Milk-thistle flavonoids and a substantial turmeric amount provide inexpensive coverage of two main ingredients. Chlorella is missing and the active silymarin and curcuminoid yields remain unclear.</p>
79 Value

Silymarin Complex

California Gold Nutrition
<p>Milk thistle, dandelion, artichoke, turmeric, ginger, and piperine provide broad liver-focused value at very low serving cost. Chlorella is missing and the label does not quantify active silymarin.</p>
70 Value

Milk Thistle Liver Detox

Irwin Naturals
<p>Milk thistle, artichoke, dandelion, turmeric, and schisandra keep a broad liver-support approach at lower serving cost. Chlorella is absent, active yields are unclear, and licorice may matter for people with blood-pressure or potassium concerns.</p>
76 Value

Silymarin Milk Thistle Extract 150 mg

NOW
<p>Milk thistle and turmeric provide a simpler, lower-cost version of the two strongest botanical themes. It omits chlorella and the original supporting nutrients, while active-marker yields are not stated.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  2. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  3. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  4. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle
  5. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  6. Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer.
    Vieira ML; Fonseca FL; Costa LG; Beltrame RL; Chaves CM; Cartum J; Alves SI; Azzalis LA; Junqueira VB; Pereria EC; Rocha KC · Journal of medicinal food · 2015
    Randomized trialDetoxification forSelenium
  7. [Selenium and oxidative stress in cancer patients].
    Gorozhanskaia ÉG; Sviridova SP; Dobrovol'skaia MM; Zybrikhina GN; Kashnia ShR · Biomeditsinskaia khimiia · 2014
    Single-arm trial40 participantsDetoxification forSelenium
  8. Comprehensive Insights into the Health Effects of Selenium Exposure and Supplementation Among the Chinese Community Middle-Aged and Elderly: a Combined Retrospective Cohort Study and Intervention Study.
    Li C; Peng X; Zheng J; Shi K; Qin L; Yang Q; Wang Z; Liu Y; Huang L · Biological trace element research · 2024
    Other40 participantsDetoxification forSelenium
  9. Heavy metals and metalloids exposure and liver function in Chinese adults - A nationally representative cross-sectional study.
    Wang S; Lyu Y; Ji S; Liu N; Wu B; Zhao F; Li Z; Qu Y; Zhu Y; Xie L; Li Y; Zhang Z; Song H; Hu X; Qiu Y; Zheng X; Zhang W; Yang Y; Li F; Cai J; Zhu Y; Cao Z; Tan F; Shi X · Environmental research · 2024
    Cross-sectional study9,445 participantsDetoxification forSelenium
  10. Selenium-Biofortified Strawberries Improve Glucose Homeostasis and Hepatic Function: A 30-Day Randomized Controlled Trial in Healthy Adults.
    Vasto S; Di Rosa L; Ferrantelli V; Fiore AS; Giordano CP; Cannizzaro A; Sabatino L; Macaluso A; Caldarella R; Caldara GF; Baldassano S · Nutrients · 2026
    Randomized trial35 participantsDetoxification forSelenium
  11. Vitamin C supplementation ameliorates liver function profile and antiviral treatment response in Hepatitis C patients.
    Nayila I; Javed MS; Khan MA; Hussain G; Raza Naqvi SA; Ali S; Jabeen Z; Shahnawaz S; Akram R; Iman T; Hassan Dogar MZ; Malik SA · Pakistan journal of pharmaceutical sciences · 2022
    Non-randomized trial200 participantsDetoxification forVitamin C
  12. Effect of ascorbic acid-rich diet on in vivo-induced oxidative stress.
    Alleva R; Di Donato F; Strafella E; Staffolani S; Nocchi L; Borghi B; Pignotti E; Santarelli L; Tomasetti M · The British journal of nutrition · 2012
    Non-randomized trial46 participantsDetoxification forVitamin C
  13. Dietary Vitamin C Intake Is Associated With Improved Liver Function and Glucose Metabolism in Chinese Adults.
    Luo X; Zhang W; He Z; Yang H; Gao J; Wu P; Ma ZF · Frontiers in nutrition · 2022
    Observational study8,307 participantsDetoxification forVitamin C
  14. Plasma ascorbate deficiency is associated with impaired reduction of sulfamethoxazole-nitroso in HIV infection.
    Trepanier LA; Yoder AR; Bajad S; Beckwith MD; Bellehumeur JL; Graziano FM · Journal of acquired immune deficiency syndromes (1999) · 2005
    Observational studyDetoxification forVitamin C
  15. Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso.
    Lavergne SN; Kurian JR; Bajad SU; Maki JE; Yoder AR; Guzinski MV; Graziano FM; Trepanier LA · Toxicology · 2006
    Clinical trial53 participantsDetoxification forVitamin C