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Liver

Host Defense MycoBotanicals
4.7
★ ★ ★ ★ ★
(508 ratings)
Milk Thistle 230 mg
Turmeric 250 mg
Chaga 200 mg
Reishi mushroom 100 mg
Product Image
Score70
A coherent milk thistle, turmeric, and mushroom blend has good breadth, but missing active standards and black-pepper interactions limit precision.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Detoxification

Score 70

A coherent milk thistle, turmeric, and mushroom blend has good breadth, but missing active standards and black-pepper interactions limit precision.
How scoring works
$23.96($0.79 per serving)
Pure Formulas
$ 23.96
iHerb
$ 23.97
Amazon
$ 23.96
Vitacost
$ 23.97
Vitacost
$ 23.99
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Analysis

Milk thistle seed extract supplies 230 mg and turmeric adds 250 mg. Those botanicals form the most relevant liver-oriented core of the blend.

Chaga, mesima, reishi, and turkey tail add 500 mg of combined mushroom material. No mushroom extraction or beta-glucan information is given, and milk thistle lacks a silymarin yield.

Black pepper may improve botanical uptake but also changes how some medicines are absorbed or metabolized. The capsule suits broad liver-support routines better than precise, standardized milk thistle use.

Who is it for
  • Adults seeking broad botanical liver support
  • People who want milk thistle plus mushrooms
Best for
  • Liver-oriented antioxidant support
  • Multi-botanical detoxification routines

Pros

  • Uses milk thistle seed extract
  • Meaningful turmeric amount
  • Four disclosed mushroom ingredients
  • All active amounts are visible

Cons

  • Silymarin yield is unknown
  • Turmeric is unstandardized
  • Mushrooms lack beta-glucan data
  • No clear mushroom extraction details

Warnings

  • Black pepper may increase exposure to medicines by changing absorption or metabolism.
  • Milk thistle and turmeric may add to anticoagulant or antiplatelet effects.
  • Medicinal mushrooms may conflict with immunosuppressant therapy.

Nutrient quality

71 High impact

Milk thistle and turmeric form a coherent liver-support core without obvious overdosing. Missing active standards and several modest mushroom additions reduce potency confidence and focus.

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Ingredient transparency

77 High impact

Every active amount is explicit without a hidden blend, and the milk thistle source is reasonably specific. Missing active yields, directions, and excipients prevent full evaluation.

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Customer satisfaction

70 High impact

The aggregate rating is strong, but it provides no specific experience evidence. The substantial review count gives the broad signal a useful volume base, while no detailed feedback supports taste, tolerance, or recurring-problem assessment.

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Value for money

57 Moderate impact

A coherent liver-support core provides fair value, but potency remains uncertain. The relatively high serving cost and modest secondary ingredients limit competitiveness.

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Goals

Detoxification
Impact
Moderate effect
B- Goal FitF Strength of SupportD+ CoverageC+ Formula Quality
Milk Thistle · 230 mg

Milk thistle and turmeric provide relevant liver-protective and antioxidant support, while black pepper may aid botanical uptake. The mushroom ingredients broaden the formula toward general immune and antioxidant functions.

Milk thistle standardization and active silymarin yield are not stated, so its potency cannot be confirmed. Several mushrooms add complexity without clear evidence that their disclosed amounts improve metabolic clearance.

Study evidence
Milk Thistle Supportive 46 studies

Ingredients

IngredientAmount per serving
Turmeric
250 mg
Milk Thistle (Silybum marianum) seed extract
230 mg
Chaga
200 mg
Mesima
100 mg
Reishi
100 mg
Turkey Tails
100 mg
Black Pepper
20 mg
Gluten Free Adults 18–50 Organic
Report overview
Milk Thistle · 230 mg OverallScore13
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The extract comes from the seed, which is the appropriate milk thistle plant part. However, the label gives no silymarin standardization or active yield, and the dry capsule lacks a named absorption system. Its active potency cannot be verified, making the relatively high serving cost hard to justify for milk thistle alone.

Turmeric · 250 mg OverallScore6
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The turmeric amount is disclosed, but its active curcuminoid content is not. Plain black pepper may accompany the blend, yet the label does not identify a standardized absorption enhancer. Value is limited by the unclear active dose and above-average serving cost.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  3. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  4. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  5. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  6. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  7. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  8. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  9. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  10. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle