Benfotiamine 300 mg
Doctor's Best
Benfotiamine 300 mg
4.6
★ ★ ★ ★ ★
(8890 ratings)
Thiamin 300 mg
Leucine 40 mg
Score 75.0
A well-dosed Benfotiamine supplement from a reputable brand, primarily beneficial for nerve and cardiovascular health, though its L-Leucine content is too low to impact muscle-related goals.
Quantity: 60 Veggie Cap(s)Servings size: 1 Veggie Capsule(s) (60 servings)
Selected goals:
Other goals:
Energy
Brain Health
Cognitive Support
Cardiovascular Support
Testosterone Support
leaderboard Score 75.0
A well-dosed Benfotiamine supplement from a reputable brand, primarily beneficial for nerve and cardiovascular health, though its L-Leucine content is too low to impact muscle-related goals.
insights Analysis
This product provides 300mg of Benfotiamine, a highly bioavailable form of Thiamine (Vitamin B1), which is excellent for supporting nerve health, managing blood sugar-related complications, and contributing to overall metabolic function. The inclusion of L-Leucine at 40mg is negligible for its purported benefits like muscle gain or fitness, as effective doses for these goals are typically in grams. While Benfotiamine is well-regarded for its specific benefits related to nerve and cardiovascular health, the broad range of stated goals like 'Testosterone Support' and 'Weight Gain' are not directly supported by its ingredients.
- High bioavailability Benfotiamine for superior absorption.
- Good dosage (300mg) for nerve and metabolic health benefits.
- From a reputable and well-reviewed brand (Doctor's Best).
- The L-Leucine dose (40mg) is negligible and ineffective for stated muscle-related goals.
- Some stated goals like 'Testosterone Support' and 'Weight Gain' are not directly supported by the ingredients.
- Price per serving is average compared to some more economical alternatives.
$15.88($0.26 per serving)
 Amazon | $ 15.88 | |
 iHerb | $ 15.88 | |
 Vitacost | $ 17.20 | |
 Pure Formulas | $ 18.40 |
bolt Effectiveness for goals
Leucine is an essential branched-chain amino acid (BCAA) primarily known for its critical role in stimulating muscle protein synthesis (MPS). It acts as a signaling molecule, initiating the molecular pathways necessary for muscle growth and repair. This makes it crucial for maintaining and building muscle mass.
Leucine is a crucial branched-chain amino acid (BCAA) that acts as a potent stimulator of muscle protein synthesis (MPS). It activates the mTOR pathway, a key regulator of muscle growth and repair. This makes it particularly important for individuals looking to build or maintain muscle mass.
Thiamin, or vitamin B1, is crucial for converting carbohydrates into energy, supporting the metabolism of glucose, amino acids, and lipids. It plays an essential role in numerous cellular functions, particularly nerve and muscle function. This makes it vital for energy production and overall cell health.
Leucine plays a significant role in reducing muscle protein breakdown and promoting muscle protein synthesis, both essential processes for recovery. Supplementing with leucine after exercise may help decrease muscle soreness and accelerate the repair of muscle tissue. This contributes to faster recovery and readiness for subsequent training.
Thiamin is crucial for converting carbohydrates into energy and plays a vital role in nerve function, muscle contraction, and heart health. It acts as a coenzyme in metabolic reactions essential for glucose metabolism. Maintaining adequate thiamin levels supports overall cellular energy production.
schedule Dosage, timing & forms
The recommended daily allowance (RDA) for thiamin for adult men is 1.2 mg per day, and for adult women, it is 1.1 mg per day. These recommendations are designed to meet the nutritional needs of most healthy individuals. Pregnant and lactating women may have slightly higher requirements.
Leucine is often recommended to be taken around workouts, particularly before or after, to help optimize muscle protein synthesis. It can also be beneficial between meals, especially if dietary protein intake is low. Spreading intake throughout the day can help maintain elevated leucine levels.
Yes, consuming Leucine immediately before, during, or after resistance exercise is a common strategy to maximize muscle protein synthesis. Some research suggests that consistent Leucine intake throughout the day, particularly during periods between meals, may also be beneficial. The 'Leucine threshold' concept highlights the importance of consuming a sufficient amount to trigger synthesis.
Thiamin is found in various foods, including whole grains, fortified cereals, pork, fish, and legumes. Nuts, seeds, and certain vegetables like peas and asparagus also contribute to dietary thiamin intake. A balanced diet typically provides sufficient thiamin for most individuals.
For muscle protein synthesis, common effective doses of Leucine range from 2.5 to 5 grams per serving. Doses are often part of a larger essential amino acid (EAA) or branched-chain amino acid (BCAA) supplement blend. Individual needs can vary based on activity level and dietary protein intake.
health_and_safety Safety & interactions
Yes, certain medications may interact with Thiamin. Diuretics, particularly loop diuretics, can increase Thiamin excretion, potentially leading to deficiency. Some chemotherapy agents may also interfere with Thiamin metabolism. It's advisable to consult a healthcare professional if you are taking medications.
Thiamin is water-soluble, and excess amounts are typically excreted in the urine. Due to this, adverse effects from oral thiamin supplementation are rare, even at high doses. In very rare cases, extremely high intravenous doses have been associated with allergic reactions.
Chronic alcohol consumption can significantly impair Thiamin absorption and utilization, often leading to Thiamin deficiency. While alcohol does not make Thiamin supplementation unsafe, individuals who consume alcohol regularly may require higher Thiamin intake. Supplementation is often crucial for alcoholics to prevent or treat deficiency-related complications.
Thiamin is generally considered safe when taken at recommended doses, and side effects are rare. In very high doses or with intravenous administration, some individuals might experience mild upset stomach or allergic reactions, though these are uncommon. Oral supplementation typically does not cause adverse effects.
Thiamin is a water-soluble vitamin, so excess amounts are typically excreted through urine. Acute toxicity from oral Thiamin supplementation is extremely rare and has not been reported even at very high doses. However, excessively high intravenous doses could potentially lead to adverse effects, though this is not relevant for oral supplements.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| Benfotiamine | 300 mg |
| L-Leucine | 40 mg |
Categories
Thiamin 90.0
The product features 300mg of Benfotiamine, a highly bioavailable and fat-soluble form of Thiamin, which is superior to standard thiamine for absorption and tissue uptake, making it excellent for addressing thiamine-related needs.
Leucine 20.0
While L-Leucine is present, the quantity of 40mg is extremely low and effectively negligible for achieving any of the well-known benefits associated with Leucine, such as muscle protein synthesis or recovery, which require doses in the gram range.
Goals
Brain Health 85.0
Benfotiamine's ability to cross the blood-brain barrier more effectively than standard thiamine makes it highly beneficial for brain health, protecting neural tissues from damage associated with oxidative stress and supporting optimal neurological function. It is particularly noted for its neuroprotective properties in diabetic conditions.
Benfotiamine has been researched for its potential to protect the cardiovascular system, particularly by mitigating advanced glycation end-product (AGE) formation, which can contribute to vascular damage in conditions like diabetes. This makes it a strong candidate for supporting heart and blood vessel health.
Cognitive Support 80.0
By contributing to healthy neuronal function and protecting brain cells from metabolic stress, Benfotiamine can indirectly support cognitive functions such as memory and focus, although it's not a primary cognitive enhancer for healthy individuals. Its benefit is more pronounced in conditions where thiamine deficiency or metabolic dysfunction impacts cognition.
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