Methyl B12
MegaFood
Score 85
A high-quality supplement with active Folate (L-5-Methyltetrahydrofolate), Methylcobalamin B12, P-5-P B6, and whole food ingredients for comprehensive B vitamin support.
Score 85
A high-quality supplement with active Folate (L-5-Methyltetrahydrofolate), Methylcobalamin B12, P-5-P B6, and whole food ingredients for comprehensive B vitamin support.
Analysis
MegaFood Methyl B12 is a robust B vitamin supplement, specifically designed with active and bioavailable forms of key nutrients. It provides Folate as L-5-Methyltetrahydrofolate and Vitamin B12 as Methylcobalamin, which are the body-ready forms preferred for optimal utilization, especially for individuals with methylation challenges. It also includes Pyridoxal 5-Phosphate (P-5-P) for Vitamin B6, another excellent active form.
A distinctive feature of MegaFood products is the inclusion of whole food ingredients, here with organic brown rice for B6 and beet root. While the primary B vitamins are clearly listed and highly active, the dual listing of Vitamin B12 as both Methylcobalamin and S. cerevisiae (a yeast known to produce B vitamins) is a bit unusual. However, the emphasis on Methylcobalamin is key.
This product is an excellent choice for those seeking high-quality, activated B vitamin support, particularly for methylation, energy, and nervous system health. The whole-food approach adds to its appeal for consumers who prefer supplements derived from or enhanced with natural food matrices.
Pros
- Features active forms of Folate (L-5-Methyltetrahydrofolate) and B12 (Methylcobalamin)
- Includes active Vitamin B6 (Pyridoxal 5-Phosphate - P-5-P)
- Contains organic whole food ingredients (brown rice, beet)
- Reputable brand known for quality and 'food-paired' nutrients
- Reasonable price for activated B vitamins
Cons
- Dual listing of B12 (Methylcobalamin and S. cerevisiae) could be confusing, though Methylcobalamin is the primary active form
- Higher potency than some may require for daily maintenance
- Tablet form may not be preferred by all users
Warnings
- B vitamins can cause urine to become a brighter yellow; this is a normal physiological effect.
- Individuals taking other supplements containing B vitamins should be mindful of total intake.
- Consult a healthcare professional if you are pregnant, nursing, or have any specific health concerns.
$29.59($0.32 per serving)
 Vitacost | $ 29.59 | |
 Pure Formulas | $ 30.99 | |
 iHerb | $ 30.99 | |
 Amazon | $ 30.99 |
Goals
Impact
Highest effect
This product offers superior support for brain health through its active B vitamin forms, which are vital for nerve cell maintenance, DNA repair, and optimal neurological function.
Impact
Highest effect
The highly bioavailable forms of B vitamins are fundamental for supporting all aspects of brain health, including cognitive function, nerve protection, and cellular repair.
Impact
Highest effect
The active forms of Folate, B12, and B6 are crucial for neurotransmitter synthesis, myelin formation, and overall brain cell health, providing excellent support for cognitive function.
Impact
Highest effect
Active B vitamins play a central role in the methylation cycle, which is essential for the production of mood-regulating neurotransmitters like serotonin and dopamine, significantly supporting emotional balance.
Impact
Highest effect
By providing highly bioavailable B vitamins essential for countless metabolic processes, this supplement offers comprehensive support for overall cellular health and general well-being.
Impact
Highest effect
Optimized B vitamin status, particularly with active forms, can significantly enhance neural communication and energy availability in the brain, leading to improved mental clarity and sustained focus.
Impact
Highest effect
The active forms of Folate and B12 are cornerstone nutrients for the methylation cycle, a critical pathway for the liver's detoxification of various compounds in the body.
Impact
Highest effect
The active forms of B6, Folate, and B12 are excellent for maintaining healthy homocysteine levels, a critical factor in supporting the health of the heart and blood vessels.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B6 | 8 mg |
Folate | 340 mcg DFE |
Vitamin B12 | 500 mcg |
Beet | 225 mg |
Vitamin B12 95
The product provides Vitamin B12 as Methylcobalamin, which is the active and most bioavailable form, ensuring optimal utilization by the body.
Vitamin B6 90
The inclusion of Pyridoxal 5-Phosphate (P-5-P) for Vitamin B6 is excellent, as it is the active coenzyme form and readily utilized by the body for various metabolic roles.
Alternative products
92 Value 
Sublingual Methylcobalamin (Vitamon B12) 5000 mcg
Solgar
Provides a very high dose of active Methylcobalamin B12 with an excellent score at a more affordable price per serving, offering superior quality and potency for targeted B12 supplementation.
85 Value 
Methyl B12 3000 mcg Berry Flavor
Country Life
This product combines high-dose active Methylcobalamin B12 with Folate. Its solid score and inclusion of these key active forms make it a strong value choice for foundational B vitamin intake.
88 Value 
Methyl B-12 5000 mcg Cherry Flavor
Jarrow Formulas
Delivers a substantial dose of active Methylcobalamin B12 with a strong score. While slightly higher in price, it offers high potency and quality for targeted B12 support.
92 Performance 
Fully Active B Complex with Quatrefolic
Doctor's Best
Offers a comprehensive spectrum of highly active B vitamins including P5P B6, Quatrefolic Folate, and Methylcobalamin B12, providing a more potent and broad-ranging support for energy, mood, and cognitive health.
93 Performance 
PureGenomics B-Complex
Pure Encapsulations
This premium B-complex provides a wide array of highly active and well-utilized B vitamin forms, including different active B12s and P5P, ensuring superior absorption and efficacy for overall vitality and metabolic support.
92 Performance 
HomocysteX Plus
Seeking Health
Features superior, active forms of B vitamins like P5P B6, Quatrefolic Folate, and MecobalActive B12, alongside TMG, offering a highly bioavailable and targeted solution for metabolic processes and energy.
89 Budget 
B12 Methylcobalamin 1000 mcg
Natural Factors
Provides a good dose of the active Methylcobalamin B12 at a significantly more affordable price per serving, offering great value for focused active B12 supplementation.
70 Budget 
Folic Acid B6 & B12
Mason Natural
Delivers a foundational blend of B6, Folate, and B12 at a much lower cost, providing essential support for energy and metabolic health.
85 Budget 
Sublingual Methylcobalamin 1000 mcg
Solgar
Offers active Methylcobalamin B12 in a convenient sublingual form, contributing to energy and nerve health at a competitive, lower price point.
92 Value
Sublingual Methylcobalamin (Vitamon B12) 5000 mcg
Solgar
Provides a very high dose of active Methylcobalamin B12 with an excellent score at a more affordable price per serving, offering superior quality and potency for targeted B12 supplementation.
85 Value
Methyl B12 3000 mcg Berry Flavor
Country Life
This product combines high-dose active Methylcobalamin B12 with Folate. Its solid score and inclusion of these key active forms make it a strong value choice for foundational B vitamin intake.
88 Value
Methyl B-12 5000 mcg Cherry Flavor
Jarrow Formulas
Delivers a substantial dose of active Methylcobalamin B12 with a strong score. While slightly higher in price, it offers high potency and quality for targeted B12 support.
92 Performance
Fully Active B Complex with Quatrefolic
Doctor's Best
Offers a comprehensive spectrum of highly active B vitamins including P5P B6, Quatrefolic Folate, and Methylcobalamin B12, providing a more potent and broad-ranging support for energy, mood, and cognitive health.
93 Performance
PureGenomics B-Complex
Pure Encapsulations
This premium B-complex provides a wide array of highly active and well-utilized B vitamin forms, including different active B12s and P5P, ensuring superior absorption and efficacy for overall vitality and metabolic support.
92 Performance
HomocysteX Plus
Seeking Health
Features superior, active forms of B vitamins like P5P B6, Quatrefolic Folate, and MecobalActive B12, alongside TMG, offering a highly bioavailable and targeted solution for metabolic processes and energy.