Advanced Sleep Melatonin + 5-HTP Time Release
Natrol
Advanced Sleep Melatonin + 5-HTP Time Release
4.5
★ ★ ★ ★ ★
(8298 ratings)
5-HTP 50 mg
Vitamin B6 10 mg
Score 90.0
An excellent synergistic blend of time-release melatonin, 5-HTP, and Vitamin B6, specifically designed for comprehensive sleep and mood support. Highly rated by users, though the 'Energy' goal is an indirect benefit of improved sleep.
Quantity: 60 Tablet(s)Servings size: 1 Tablet(s) (60 servings)
Selected goals:
Other goals:
Stress Relief
Mood Support
Sleep Support
Energy
Brain Health
leaderboard Score 90.0
An excellent synergistic blend of time-release melatonin, 5-HTP, and Vitamin B6, specifically designed for comprehensive sleep and mood support. Highly rated by users, though the 'Energy' goal is an indirect benefit of improved sleep.
insights Analysis
The Natrol Advanced Sleep Melatonin + 5-HTP Time Release product is strategically formulated to address several key health goals, primarily focusing on sleep and mood support. Its strength lies in the synergistic combination of Melatonin, 5-HTP, and Vitamin B6, where each ingredient plays a complementary role in neurotransmitter synthesis and sleep regulation. The time-release mechanism for melatonin is a significant advantage, aiming to provide sustained sleep support throughout the night rather than just aiding initial sleep onset, a common criticism of standard melatonin supplements. While the product is highly effective for its core purpose, the inclusion of "Energy" as a stated goal can be misleading. The ingredients are designed to promote relaxation and sleep, meaning any "energy" benefit would be an indirect result of improved sleep quality rather than a direct stimulating effect. Nutritionists often emphasize that while Melatonin and 5-HTP are generally safe and effective for their intended purposes, users should be aware of potential interactions with other medications, particularly those affecting serotonin levels. The impressive number of online reviews generally indicates high user satisfaction for sleep and mood improvements, solidifying its reputation as a viable option for those seeking these benefits.
- Synergistic blend of Melatonin, 5-HTP, and Vitamin B6 for enhanced sleep and mood support.
- Time-release melatonin helps with sustained sleep throughout the night.
- Vitamin B6 supports the efficient conversion of 5-HTP to serotonin and subsequently melatonin.
- High number of positive online reviews indicates broad user satisfaction and efficacy.
- The inclusion of 'Energy' as a primary goal is potentially misleading, as the product primarily promotes relaxation and sleep.
- The specific quantity of Melatonin is mentioned in the product title but not explicitly listed in the provided ingredients for transparent dosing.
- Requires careful consideration of potential drug interactions, especially with SSRIs or other central nervous system depressants.
- May cause drowsiness; do not drive or operate heavy machinery after taking this product.
- Consult a healthcare professional before use if you are taking antidepressants (SSRIs), other medications, or have an existing medical condition.
- Not intended for use by pregnant or nursing women, or individuals under 18 years of age.
$12.55($0.20 per serving)
 Amazon | $ 12.55 | |
 Vitacost | $ 14.87 | |
 iHerb | $ 15.59 | |
 Walmart | $ 18.99 |
bolt Effectiveness for goals
Vitamin B6 acts as a necessary coenzyme for the conversion of 5-HTP into serotonin. Without adequate B6, the metabolism of 5-HTP may be inefficient. This interaction is key for 5-HTP's intended effects on neurotransmitter levels.
Because Vitamin B6 is required for the body to convert 5-HTP into serotonin, some suggest taking them together could optimize 5-HTP's action. This co-factor relationship is important for the intended biochemical pathway. However, the precise optimal dosing and balance are complex and still subjects of ongoing research.
Some research suggests 5-HTP may help support mood by increasing serotonin levels in the brain. Serotonin is a neurotransmitter involved in mood regulation. However, more extensive research is needed to confirm its efficacy for specific mood conditions.
Vitamin B6 is a crucial coenzyme involved in over 100 enzymatic reactions, including protein, fat, and carbohydrate metabolism. It plays vital roles in red blood cell formation, neurotransmitter synthesis, and maintaining normal homocysteine levels. It also supports immune function and brain health.
5-HTP is a precursor to serotonin, which can then be converted into melatonin, a hormone that regulates sleep-wake cycles. Preliminary studies indicate it might assist with sleep, but further robust research is needed to establish its full impact.
schedule Dosage, timing & forms
The recommended dietary allowance (RDA) for Vitamin B6 in adult men and women (19-50 years) is generally 1.3 mg per day. Needs can vary by age, pregnancy, or lactation status.
Typical starting dosages for 5-HTP often range from 50 to 100 mg per day. It is usually advised to begin with a lower dose and gradually increase if needed. Individual needs and responses can vary.
Vitamin B6 is a crucial cofactor for the enzyme that converts 5-HTP into serotonin. Some supplement protocols include Vitamin B6 to support this conversion. However, high doses of B6 could potentially affect peripheral 5-HTP conversion, which may be undesired.
5-HTP is often taken before bedtime due to its potential role in sleep, or divided into smaller doses throughout the day with meals to help minimize potential stomach upset. Optimal timing can vary based on individual goals and tolerance.
Some approaches suggest taking a moderate dose of P-5-P (the active form of B6) alongside 5-HTP to facilitate its conversion. The specific timing or ratio can be complex, and some sources recommend taking them at separate times or with specific forms of B6. Professional guidance is often sought for personalized strategies.
health_and_safety Safety & interactions
Combining 5-HTP with antidepressant medications, such as SSRIs, SNRIs, or MAOIs, is generally not recommended without strict medical supervision. This combination can lead to excessively high serotonin levels, potentially causing a serious and life-threatening condition known as serotonin syndrome. Always consult a healthcare professional before combining 5-HTP with any prescription medication.
Serotonin syndrome is a potentially serious condition caused by excessive serotonin levels in the brain. It can occur if 5-HTP is combined with other substances that increase serotonin, such as antidepressants or other serotonergic drugs. Symptoms can range from mild (agitation, rapid heart rate, tremors) to severe (fever, seizures, unconsciousness), requiring immediate medical attention.
Yes, because Vitamin B6 facilitates the conversion of 5-HTP to serotonin, taking them together could potentially lead to higher serotonin levels than 5-HTP alone, especially at higher doses. This may increase the risk of serotonin-related side effects such as nausea, gastrointestinal upset, or, in rare cases, serotonin syndrome when combined with other serotonergic substances.
Vitamin B6 is a crucial cofactor for the enzyme that converts 5-HTP into serotonin in the body. Taking both supplements might enhance the conversion of 5-HTP, potentially leading to increased serotonin levels. This interaction is often considered in the formulation of 5-HTP supplements.
Yes, Vitamin B6 can interact with several medications. For instance, it may reduce the effectiveness of certain anti-seizure medications like phenytoin and phenobarbital, and can also interfere with levodopa used for Parkinson's disease. Additionally, some drugs, like isoniazid, can deplete Vitamin B6 levels. It is advisable to consult a healthcare professional if you are on medication.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B6 | 10 mg |
5-HTP | 50 mg |
Categories
Vitamin B6 90.0
The 10mg of Vitamin B6 is appropriately dosed to act as a crucial cofactor for the conversion of 5-HTP to serotonin and subsequently to melatonin, maximizing the effectiveness of the other key ingredients for sleep and mood.
5-HTP 90.0
The 50mg dose of 5-HTP is a common and effective amount for supporting serotonin production, which aids in mood regulation and serves as a precursor to melatonin for sleep. Its presence is central to the product's intended effects.
Goals
Sleep Support 95.0
The product's primary design with time-release Melatonin and 5-HTP, which converts to melatonin with the help of B6, directly and effectively targets sleep initiation and maintenance. The synergistic blend is highly beneficial for comprehensive sleep support.
Mood Support 85.0
5-HTP is a direct precursor to serotonin, a crucial neurotransmitter for mood regulation, and Vitamin B6 is essential for this conversion. This combination is widely recognized by nutritionists for its potential to improve mood and emotional well-being.
Stress Relief 80.0
Improved sleep quality and balanced serotonin levels from 5-HTP can significantly contribute to stress reduction. The product helps the body enter a relaxed state conducive to managing stress more effectively, though it's not a direct anxiolytic.