Advanced Sleep Melatonin + 5-HTP Time Release

Advanced Sleep Melatonin + 5-HTP Time Release

Natrol4.5 (8,639 ratings)
Format:Tablet Quantity: 60 Tablet(s) · 60 servings
Goals
$12.99 $0.21 per serving
AmazonLowest$12.99Walmart$12.99Pure Formulas$12.99Vitacost$15.59iHerb$15.59

About this product

The disclosed actives are 50 mg of Griffonia-derived 5-HTP and 10 mg of vitamin B6 in a time-release tablet. That combination may support gradual serotonin-pathway exposure and is less aggressive than a high-strength 5-HTP serving.

The product name references melatonin, but the supplied ingredient list does not include a melatonin amount. Without that information, the full sleep effect, dose suitability, and next-day sedation risk cannot be assessed reliably.

Griffonia standardization is also not stated, and mood or stress support remains secondary to the sleep-oriented format. Interaction screening is essential because 5-HTP can compound serotonin-raising medicines even at a lower amount.

Who is it for
  • People seeking lower-dose time-release 5-HTP for sleep
  • Users who can verify the full melatonin label separately
Best for
  • Gradual overnight 5-HTP delivery
  • A lower starting amount with vitamin B6

Pros

  • Provides a modest 50 mg 5-HTP amount
  • Uses time-release delivery
  • Includes vitamin B6

Cons

  • No melatonin amount is supplied despite the product name
  • Griffonia standardization is absent
  • Full sleep and next-day effects cannot be assessed

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, triptans, or other serotonin-raising medicines without medical supervision.
  • The undisclosed melatonin amount prevents a reliable assessment of combined sedation and next-day drowsiness.
  • Time-release 5-HTP may prolong nausea, vivid dreams, or drowsiness if poorly tolerated.

Product analysis

75 out of 100
Time-release 5-HTP and B6 may suit gradual overnight support. The missing melatonin amount in the supplied ingredient data prevents a complete assessment of the named sleep formula.

AI assessment of the formula, label and price. How scoring works

Nutrient quality83

Griffonia simplicifolia is identified as the source, but the plant part and active standardization are not both clear. The 50 mg 5-HTP serving is a cautious starting amount, while the added nutrients provide mixed additional value.

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Ingredient transparency82

All supplied active ingredients have specific amounts, and no proprietary blend hides key doses. Serving count is available, but full intake directions, excipients, and a serotonin-medication warning are absent from the supplied label details.

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Customer satisfaction68

The supplied aggregate rating is favorable but not exceptional, and review volume determines how much confidence it deserves. No review text is provided to identify repeated complaints or firsthand experiences tied to the intended uses.

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Value for money60

Cost efficiency per equivalent active amount appears limited, with the starting-level dose shaping practical value. Vitamin B6 supports conversion pathways, though the disclosed amount is more than needed as a basic cofactor.

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Format
Tablet
Container
60 Tablet(s)
Per serving
$0.21
Customer rating
4.5 · 8,639 ratings
Report analysis

Goals

Sleep Support
Sleep Support
Impact
Moderate effect
B Ingredient FitD+ PathwaysC- EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 1 study
Vitamin B6 Disputed 7 studies
Mood Support
Mood Support
Impact
High effect
B Ingredient FitD PathwaysA+ EvidenceA+ Formulation Logic
Vitamin B6 · 10 mg5-HTP · 50 mg
Study evidence
5-HTP Supportive 9 studies
Vitamin B6 Supportive 19 studies
Stress Relief
Stress Relief
Impact
Moderate effect
B Ingredient FitF PathwaysC- EvidenceA+ Formulation Logic
Vitamin B6 · 10 mg
Study evidence
5-HTP Supportive 18 studies
Vitamin B6 Supportive 10 studies

Ingredients

IngredientAmount per servingScore
Vitamin B6 (Pyridoxine Hydrochloride)
 10 mg
5-HTP (Griffonia simplicifolia)
 50 mg 72
Adults 18–50 Dairy Free Women Vegetarian
Report overview
5-HTP (Griffonia simplicifolia) · 50 mg OverallScore72
B- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyC Value
Advanced Sleep Melatonin + 5-HTP Time Release lists 50 mg of 5-HTP per tablet and names Griffonia simplicifolia, though the saved facts don't give the extract's 5-HTP percentage. A specific warning names medicines that affect serotonin. Its cost per 100 mg is above the collection median.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

It names Griffonia simplicifolia, but the saved facts don't give the extract's 5-HTP percentage.
Botanical Source & Standardization
Griffonia simplicifolia is named, but the saved facts give no percentage of the extract standardized as 5-HTP.

Dose, Safety & Label Transparency79

It provides 50 mg per serving, and a specific warning about medicines that affect serotonin is recorded.
Dosage Potency & Range
The serving contains 50 mg, the standard starting amount in the supplied context.
Safety Warnings & Label Clarity
A specific warning names SSRIs, antidepressants, or other medicines that affect serotonin.

Value60

The cost per 100 mg is higher than the collection median.
Price per 100mg 5-HTP
The cost per 100 mg is above the collection median.
View ingredientView products
Loading alternative details
85 Performance

5-HTP 100 mg

NOW
Clearer botanical sourcing makes this a stronger quality alternative. Its 100 mg 5-HTP serving is more substantial than the original’s 50 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP 100 mg Extra Strength

Swanson
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. Its 100 mg 5-HTP serving is more substantial than the original’s 50 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. Its 100 mg 5-HTP serving is more substantial than the original’s 50 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
84 Budget

5-HTP 50 mg

NOW
The lower recurring cost makes this a more economical eligible choice. Its 50 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
85 Budget

5-HTP 100 mg

Doctor's Best
The lower recurring cost makes this a more economical eligible choice. Its 100 mg 5-HTP serving is more substantial than the original’s 50 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
82 Budget

5-HTP 50 mg

Swanson Premium Brand
The lower recurring cost makes this a more economical eligible choice. Its 50 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP 200mg

Best Naturals
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP with Vitamin B6 & Vitamin C

Lake Avenue Nutrition
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. The active amount is disclosed, but botanical-source detail remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
82 Value

5-HTP 200 mg Maximum Strength

Swanson
Focused 5-HTP dosing and strong formula value make this a practical value alternative. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  2. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  3. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  4. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  5. Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients.
    Maes M; Vandewoude M; Schotte C; Maes L; Martin M; Blockx P · Acta psychiatrica Scandinavica · 1990
    Clinical trial120 participantsStress Relief for5-HTP
  6. Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).
    Bertolini F; Robertson L; Bisson JI; Meader N; Churchill R; Ostuzzi G; Stein DJ; Williams T; Barbui C · The Cochrane database of systematic reviews · 2022
    Systematic review2,023 participants13 studies pooledStress Relief for5-HTP
  7. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  8. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  9. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  10. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  11. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  12. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  13. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  14. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  15. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support Stress Relief forVitamin B6
  16. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  17. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  18. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  19. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  20. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  21. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  22. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  23. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  24. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  25. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forVitamin B6
  26. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  27. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  28. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6