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Ester-C with Citrus Bioflavonoids

American Health
4.9
★ ★ ★ ★ ★
(17216 ratings)
Vitamin C 1000 mg
Flavonoid (mixture) 400 mg
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Score87
Buffered vitamin C, clearly disclosed calcium, and a useful bioflavonoid amount make this a strong routine option, although the serving is relatively high.
How scoring works
Quantity:225 Tablet(s) • (112 servings)
Goals:
General Health
Immunity
Skin Health
Anti-Inflammatory Support
Vision Support

Score 87

Buffered vitamin C, clearly disclosed calcium, and a useful bioflavonoid amount make this a strong routine option, although the serving is relatively high.
How scoring works

Also available as

7 options
240 servings Flavonoid (mixture) 400 mg, C 1000 mg • 60 Capsule(s) • 120 servings $9.16 ($0.07 per serving) 450 servings Flavonoid (mixture) 400 mg, C 1000 mg • 450 Tablet(s) • 225 servings $34.99 ($0.15 per serving) 1000 mg • 180 Tablet(s) servings Flavonoid (mixture) 200 mg, C 1000 mg • 180 Tablet(s) • 180 servings $30.79 ($0.17 per serving) 1000 mg • 90 Tablet(s) servings Flavonoid (mixture) 200 mg, C 1000 mg • 90 Tablet(s) • 90 servings $17.00 ($0.18 per serving) 1000 mg • 120 Tablet(s) servings Flavonoid (mixture) 200 mg, C 1000 mg • 120 Tablet(s) • 120 servings $22.67 ($0.18 per serving) 90 servings C 1000 mg, Flavonoid (mixture) 400 mg • 90 Tablet(s) • 45 servings $9.58 ($0.21 per serving) 240 servings Flavonoid (mixture) 400 mg, C 1000 mg • 240 Capsule(s) • 120 servings $29.39 ($0.24 per serving)
$18.89($0.16 per serving)
Vitacost
$ 20.79
Vitacost
$ 20.79
iHerb
$ 18.89
Daily Vita
$ 18.89
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Analysis

Buffered calcium ascorbate delivers a substantial vitamin C amount with better expected stomach comfort than plain ascorbic acid. The separately stated calcium contribution makes the mineral content easy to understand.

Citrus bioflavonoids provide a meaningful companion amount rather than a token label addition. Together, the ingredients suit general antioxidant, collagen, and immune-support routines without an overly complicated formula.

The long supply makes regular use practical, but the full serving requires two tablets. People who only need moderate daily vitamin C may prefer a lower-dose option that is easier to adjust.

Who is it for
  • Adults seeking buffered vitamin C
  • People with a sensitive stomach
  • Users wanting bioflavonoids alongside vitamin C
Best for
  • Routine vitamin C supplementation
  • Skin and collagen support
  • Immune and antioxidant support

Pros

  • Buffered Ester-C form
  • Substantial citrus bioflavonoid amount
  • Calcium contribution is disclosed
  • Long supply offers good value

Cons

  • Full serving requires two tablets
  • High amount may exceed routine needs
  • Tablet size may be less convenient than capsules

Warnings

  • A full serving may cause loose stools or stomach discomfort in sensitive users; a smaller divided amount may be easier to tolerate.

Nutrient quality

90 Highest impact

Calcium ascorbate is a well-tolerated buffered vitamin C form. Vitamin C and citrus bioflavonoids are present at useful amounts.

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Ingredient transparency

84 Highest impact

Every listed active has a specific amount. A complete excipient list is not available in the supplied data.

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Customer satisfaction

79 High impact

The average rating is very strong. The large rating volume provides a reliable satisfaction signal.

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Value for money

95 Highest impact

The long bottle supply makes each serving economical. The formula avoids low-value extras.

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Report analysis

Goals

General Health
General Health
Impact
Highest effect
A- Goal FitA+ Strength of SupportC+ CoverageA Formula Quality
Vitamin C · 1000 mg

Buffered calcium ascorbate supplies a substantial vitamin C amount with good digestive tolerability. Citrus bioflavonoids add related antioxidant compounds without obscuring the main active.

The formula provides strong depth for antioxidant, collagen, and immune-related support but remains narrow. It does not cover the full range of foundational wellness needs.

Study evidence
Vitamin C Supportive 56 studies
Immunity
Immunity
Impact
Highest effect
A- Goal FitA+ Strength of SupportC+ CoverageA Formula Quality
Vitamin C · 1000 mg

Buffered calcium ascorbate supplies a substantial vitamin C amount with good digestive tolerability. Citrus bioflavonoids add related antioxidant compounds without obscuring the main active.

The formula provides strong depth for antioxidant, collagen, and immune-related support but remains narrow. It does not cover the full range of foundational wellness needs.

Study evidence
Vitamin C Supportive 53 studies
Skin Health
Skin Health
Impact
Highest effect
B+ Goal FitA+ Strength of SupportB- CoverageA Formula Quality
Vitamin C · 1000 mg

Vitamin C directly supports collagen synthesis and antioxidant protection, making it relevant to skin structure and environmental stress. Citrus bioflavonoids may reinforce antioxidant support but do not replace collagen or a hydration active.

The 1000 mg Ester-C amount is substantial and clearly disclosed. The focused formula offers strong depth for one pathway while leaving barrier hydration and structural building blocks unaddressed.

Study evidence
Vitamin C Supportive 53 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
C+ Goal FitA Strength of SupportD+ CoverageA Formula Quality
Vitamin C · 1000 mg

A full serving of buffered vitamin C provides substantial antioxidant support that may help limit oxidative stress linked with inflammatory signaling. Citrus bioflavonoids add complementary antioxidant compounds, although their active composition is not standardized.

The formula is better suited to foundational antioxidant coverage than targeted modulation of major inflammatory enzymes. Its clearly stated vitamin C amount and focused design are strengths, while pathway breadth remains limited.

Study evidence
Vitamin C Supportive 50 studies
Vision Support
Vision Support
Impact
High effect
D+ Goal FitA Strength of SupportD+ CoverageB Formula Quality
Vitamin C · 1000 mg

A full serving supplies a well-disclosed dose of buffered vitamin C, which may support antioxidant protection in ocular tissues. Citrus bioflavonoids add complementary antioxidant compounds, but the formula lacks macular carotenoids and retinal lipids.

The focused design gives meaningful depth for vitamin C while covering only one part of vision support. It is better viewed as supplemental antioxidant support than as a complete eye formula.

Study evidence
Vitamin C Disputed 24 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ester-C Calcium Ascorbate)
 1000 mg
Calcium (Ester-C Calcium Ascorbate)
 110 mg
Citrus Bioflavonoids Complex
400 mg
Gluten Free Adults 18–50 Vegan Dairy Free Sugar Free Vegetarian
Report overview
Vitamin C (Ester-C Calcium Ascorbate) · 1000 mg OverallScore90
A- Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value

Ester-C calcium ascorbate provides a buffered vitamin C form that should be easier on the stomach than plain ascorbic acid. The full-gram serving falls within the preferred dose range, and elemental calcium is clearly disclosed. Citrus bioflavonoids add supporting compounds, while the large supply offers favorable value.

View ingredientView products
Loading alternative details
89 Performance

C-500 Calcium Ascorbate-C

NOW
<p>The ingredient profile makes it a stronger quality-focused alternative for the same vitamin C goals. Buffered calcium ascorbate delivers a practical vitamin C amount with clear mineral disclosure and exceptional relative value. The small bioflavonoid addition is unlikely to contribute much but does not undermine the strong core formula.</p>
86 Performance

C

Swanson
<p>The ingredient profile makes it a stronger quality-focused alternative for the same vitamin C goals. Fully buffered calcium ascorbate provides a meaningful vitamin C serving with good stomach-comfort potential. The focused formula keeps the active nutrient clear and avoids decorative additions.</p>
86 Performance

Buffered Vitamin C + Citrus Bioflavonoids

Jarrow Formulas
<p>The ingredient profile makes it a stronger quality-focused alternative for the same vitamin C goals. Buffered vitamin C and bioflavonoids form a focused, useful daily formula. A generous supply and simple design support strong value, although full excipient and intake details are absent.</p>
89 Budget

Pure Buffered Calcium Ascorbate

NOW
<p>The lower serving cost makes it a more economical alternative while retaining the same vitamin C focus. the buffered mineral ascorbate form supplies a meaningful vitamin C amount with a digestive-comfort advantage over plain ascorbic acid. Clear active dosing and favorable serving value are strengths, though complete use directions and inactive ingredients are not supplied.</p>
87 Budget

100% Pure Vitamin C Powder

Swanson Premium Brand
<p>The lower serving cost makes it a more economical alternative while retaining the same vitamin C focus. The pure powder supplies a flexible, meaningful vitamin C serving with exceptional economy and no active padding. Plain ascorbic acid remains acidic, so sensitive users may prefer a buffered form.</p>
87 Budget

C 500 mg

Mason Natural
<p>The lower serving cost makes it a more economical alternative while retaining the same vitamin C focus. A simple moderate-dose tablet provides useful vitamin C at excellent relative value and with extensive aggregate feedback. Generic ascorbic acid and missing inactive-ingredient details are the main limitations.</p>
87 Value

Pure Buffered Magnesium Ascorbate

NOW
<p>The formula offers a more favorable balance of vitamin C quality and serving value than the original. Magnesium ascorbate provides a substantial fully buffered vitamin C serving with excellent relative value and clear mineral disclosure. Feedback volume is limited, and detailed use directions or non-active ingredients are not supplied.</p>
83 Value

C 500 mg

21st Century
<p>The formula offers a more favorable balance of vitamin C quality and serving value than the original. A large supply of straightforward vitamin C provides meaningful daily support with excellent value. Basic ascorbic acid and incomplete inactive-ingredient details keep the formula from feeling premium.</p>
84 Value

Ester-C 500 mg With Citrus Bioflavoinds

American Health
<p>The formula offers a more favorable balance of vitamin C quality and serving value than the original. Buffered Ester-C provides a substantial vitamin C serving with good stomach-comfort potential. Citrus bioflavonoids add compatible plant compounds without distracting from the core nutrient.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  2. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  3. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  4. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  5. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  6. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  7. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  8. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  9. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  10. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  11. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  12. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  13. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  14. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  15. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  16. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  17. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  18. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  19. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  20. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  21. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  22. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  23. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  24. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  25. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C